development and validation of analytical methods



Herman Lam Practical Approaches to Method Validation and Essential Instrument Qualification Herman Lam Practical Approaches to Method Validation and Essential Instrument Qualification Новинка

Herman Lam Practical Approaches to Method Validation and Essential Instrument Qualification

9372.71 руб.
Practical approaches to ensure that analytical methods and instruments meet GMP standards and requirements Complementing the authors' first book, Analytical Method Validation and Instrument Performance Verification, this new volume provides coverage of more advanced topics, focusing on additional and supplemental methods, instruments, and electronic systems that are used in pharmaceutical, biopharmaceutical, and clinical testing. Readers will gain new and valuable insights that enable them to avoid common pitfalls in order to seamlessly conduct analytical method validation as well as instrument operation qualification and performance verification. Part 1, Method Validation, begins with an overview of the book's risk-based approach to phase appropriate validation and instrument qualification; it then focuses on the strategies and requirements for early phase drug development, including validation of specific techniques and functions such as process analytical technology, cleaning validation, and validation of laboratory information management systems Part 2, Instrument Performance Verification, explores the underlying principles and techniques for verifying instrument performance—coverage includes analytical instruments that are increasingly important to the pharmaceutical industry, such as NIR spectrometers and particle size analyzers—and offers readers a variety of alternative approaches for the successful verification of instrument performance based on the needs of their labs At the end of each chapter, the authors examine important practical problems and share their solutions. All the methods covered in this book follow Good Analytical Practices (GAP) to ensure that reliable data are generated in compliance with current Good Manufacturing Practices (cGMP). Analysts, scientists, engineers, technologists, and technical managers should turn to this book to ensure that analytical methods and instruments are accurate and meet GMP standards and requirements.
Madden Timothy L. Analytical Methods for Therapeutic Drug Monitoring and Toxicology Madden Timothy L. Analytical Methods for Therapeutic Drug Monitoring and Toxicology Новинка

Madden Timothy L. Analytical Methods for Therapeutic Drug Monitoring and Toxicology

14413.99 руб.
This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.
Joachim Ermer Method Validation in Pharmaceutical Analysis. A Guide to Best Practice Joachim Ermer Method Validation in Pharmaceutical Analysis. A Guide to Best Practice Новинка

Joachim Ermer Method Validation in Pharmaceutical Analysis. A Guide to Best Practice

16286.89 руб.
This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing. As in the first edition, the fundamental requirements for analytical method validation are covered, but the second edition describes how these are applied systematically throughout the entire analytical lifecycle. QbD principles require adoption of a systematic approach to development and validation that begin with predefined objectives. For analytical methods these predefined objectives are established as an Analytical Target Profile (ATP). The book chapters are aligned with recently introduced standards and guidelines for manufacturing processes validation and follow the three stages of the analytical lifecycle: Method Design, Method Performance Qualification, and Continued Method Performance Verification. Case studies and examples from the pharmaceutical industry illustrate the concepts and guidelines presented, and the standards and regulations from the US (FDA), European (EMA) and global (ICH) regulatory authorities are considered throughout. The undisputed gold standard in the field.
Tapan Das K. Biophysical Methods for Biotherapeutics. Discovery and Development Applications Tapan Das K. Biophysical Methods for Biotherapeutics. Discovery and Development Applications Новинка

Tapan Das K. Biophysical Methods for Biotherapeutics. Discovery and Development Applications

9910.62 руб.
With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods • Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity • With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.
Pratik Mehta Novel Spectrophotometric and HPLC Method Development and Validation Pratik Mehta Novel Spectrophotometric and HPLC Method Development and Validation Новинка

Pratik Mehta Novel Spectrophotometric and HPLC Method Development and Validation

4749 руб.
Drug manufacturing control requires high level and intensive analytical and chemical support of all stages to ensure the drug's quality and safety. Highly specific and sensitive analytical techniques hold the key to the design, development, standardization and quality control of medicinal products. The book is focussed on development and validation of RP-HPLC method for simultaneous estimation of bromhexine HCl, dextromethorphan HBr, and guaiphenesin, colorimetric method for estimation of ferrous fumarate and zinc sulphate, and UV spectrophotometric method for simultaneous estimation of ambroxol HCl, cetirizine HCl, and dextromethorphan HBr, form their combined dosage form. The analysis should be useful to some pharmaceutical companies, students of pharmacy field or anyone else seeking knowledge in the respective field.
Oona McPolin Validation of Analytical Methods for Pharmaceutical Analysis Oona McPolin Validation of Analytical Methods for Pharmaceutical Analysis Новинка

Oona McPolin Validation of Analytical Methods for Pharmaceutical Analysis

7652 руб.
This book provides a comprehensive guide on validating analytical methods. Key features: Full review of the available regulatory guidelines on validation and in particular, ICH. Sections of the guideline, Q2(R1), have been reproduced in this book with the kind permission of the ICH Secretariat; Thorough discussion of each of the validation characteristics (Specificity; Linearity; Range; Accuracy; Precision; Detection Limit; Quantitation Limit; Robustness; System Suitability) plus practical tips on how they may be studied; What to include in a validation protocol with advice on the experimental procedure to follow and selection of appropriate acceptance criteria; How to interpret and calculate the results of a validation study including the use of suitable statistical calculations; A fully explained case study demonstrating how to plan a validation study, what to include in the protocol, experiments to perform, setting acceptance criteria, interpretation of the results and reporting the study.
Herbert W. Seliger Second Language Research Methods Herbert W. Seliger Second Language Research Methods Новинка

Herbert W. Seliger Second Language Research Methods

2705.43 руб.
Based on a set of four research parameters, this book discusses the development of research questions and hypotheses, naturalistic and experimental research, data collection, and validation of research instruments. Each chapter includes examples and activities.
Jian Wang Chemical Analysis of Antibiotic Residues in Food Jian Wang Chemical Analysis of Antibiotic Residues in Food Новинка

Jian Wang Chemical Analysis of Antibiotic Residues in Food

9756.83 руб.
An insightful exploration of the key aspects concerning the chemical analysis of antibiotic residues in food The presence of excess residues from frequent antibiotic use in animals is not only illegal, but can pose serious health risks by contaminating products for human consumption such as meat and milk. Chemical Analysis of Antibiotic Residues in Food is a single-source reference for readers interested in the development of analytical methods for analyzing antibiotic residues in food. It covers themes that include quality assurance and quality control, antibiotic chemical properties, pharmacokinetics, metabolism, distribution, food safety regulations, and chemical analysis. In addition, the material presented includes background information valuable for understanding the choice of marker residue and target animal tissue to use for regulatory analysis. This comprehensive reference: Includes topics on general issues related to screening and confirmatory methods Presents updated information on food safety regulation based on routine screening and confirmatory methods, especially LC-MS Provides general guidance for method development, validation, and estimation of measurement uncertainty Chemical Analysis of Antibiotic Residues in Food is written and organized with a balance between practical use and theory to provide laboratories with a solid and reliable reference on antibiotic residue analysis. Thorough coverage elicits the latest scientific findings to assist the ongoing efforts toward refining analytical methods for producing safe foods of animal origin.
Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena Новинка

Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena

11087.68 руб.
A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field. Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include: A general discussion of challenges and proven approaches in the development of ligand-binding assays More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules A practical approach to «fit-for-purpose» validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.
Mohammed Khalid A.A. Pumps, Channels and Transporters. Methods of Functional Analysis Mohammed Khalid A.A. Pumps, Channels and Transporters. Methods of Functional Analysis Новинка

Mohammed Khalid A.A. Pumps, Channels and Transporters. Methods of Functional Analysis

9603.03 руб.
Describes experimental methods for investigating the function of pumps, channels and transporters Covers new emerging analytical methods used to study ion transport membrane proteins such as single-molecule spectroscopy Details a wide range of electrophysiological techniques and spectroscopic methods used to analyze the function of ion channels, ion pumps and transporters Covers state-of-the art analytical methods to study ion pumps, channels, and transporters, and where analytical chemistry can make further contributions
Sridhar Thota,Raj Kumar Venisetty and Deepika Ponugoti Analytical methods for the estimation of DPP-IV inhibitors Sridhar Thota,Raj Kumar Venisetty and Deepika Ponugoti Analytical methods for the estimation of DPP-IV inhibitors Новинка

Sridhar Thota,Raj Kumar Venisetty and Deepika Ponugoti Analytical methods for the estimation of DPP-IV inhibitors

2890 руб.
Dipeptidyl peptidase-IV inhibitors, also commonly called gliptins, are a relatively novel class of drugs for the treatment of type 2 diabetes. Various analytical methods are available for the determination of gliptins in bulk drugs, pharmaceutical formulations and biological fluids. Numerous analytical procedures including chromatographic, spectrometric and electrophoretic techniques were reported and there is a great need to review the analytical work reported so far in the literature. The present book provides a brief overview of an assortment of validated analytical methods for the analysis of gliptins. This book covers the time period from 1987 to 2013 during which several analytical methods including all types of chromatographic, spectrophotometric and voltammetric techniques. The book mainly concerns the analysis of chosen gliptins from pharmaceutical formulations and biological samples.
Rakshit Thumar,Nishendu Nadpara and Umang Hirani Validation: Essential Requirement in Pharmaceutical Industries Rakshit Thumar,Nishendu Nadpara and Umang Hirani Validation: Essential Requirement in Pharmaceutical Industries Новинка

Rakshit Thumar,Nishendu Nadpara and Umang Hirani Validation: Essential Requirement in Pharmaceutical Industries

3212 руб.
In the pharmaceutical, medical device, food, blood establishments, tissue establishments, and clinical trials industries, validation is the documented act of demonstrating that a procedure, process, and activity will consistently lead to the expected results. It often includes the qualification of systems and equipment. It is a requirement for good manufacturing practices and other regulatory requirements. Since a wide variety of procedures, processes, and activities need to be validated, the field of validation is divided into a number of subsections including the following: Cleaning validation Process validation Analytical method validation Computer system validation this book give the basic idea to the student for under standing to how to validate the process an other cleaning validation
Dimiter Dimitrov M. Statistical Methods for Validation of Assessment Scale Data in Counseling and Related Fields Dimiter Dimitrov M. Statistical Methods for Validation of Assessment Scale Data in Counseling and Related Fields Новинка

Dimiter Dimitrov M. Statistical Methods for Validation of Assessment Scale Data in Counseling and Related Fields

5539.88 руб.
“Dr. Dimitrov has constructed a masterpiece—a classic resource that should adorn the shelf of every counseling researcher and graduate student serious about the construction and validation of high quality research instruments. —Bradley T. Erford, PhD Loyola University Maryland Past President, American Counseling Association “This book offers a comprehensive treatment of the statistical models and methods needed to properly examine the psychometric properties of assessment scale data. It is certain to become a definitive reference for both novice and experienced researchers alike.” —George A. Marcoulides, PhD University of California, Riverside This instructive book presents statistical methods and procedures for the validation of assessment scale data used in counseling, psychology, education, and related fields. In Part I, measurement scales, reliability, and the unified construct-based model of validity are discussed, along with key steps in instrument development. Part II describes factor analyses in construct validation, including exploratory factor analysis, confirmatory factor analysis, and models of multitrait-multimethod data analysis. Traditional and Rasch-based analyses of binary and rating scales are examined in Part III. Dr. Dimitrov offers students, researchers, and clinicians step-by-step guidance on contemporary methodological principles, statistical methods, and psychometric procedures that are useful in the development or validation of assessment scale data. Numerous examples, tables, and figures provided throughout the text illustrate the underlying principles of measurement in a clear and concise manner for practical application. *Requests for digital versions from the ACA can be found on wiley.com. *To request print copies, please visit the ACA website.
Dennis Dirkmaat A Companion to Forensic Anthropology Dennis Dirkmaat A Companion to Forensic Anthropology Новинка

Dennis Dirkmaat A Companion to Forensic Anthropology

18132.32 руб.
A Companion to Forensic Anthropology presents the most comprehensive assessment of the philosophy, goals, and practice of forensic anthropology currently available, with chapters by renowned international scholars and experts. Highlights the latest advances in forensic anthropology research, as well as the most effective practices and techniques used by professional forensic anthropologists in the field Illustrates the development of skeletal biological profiles and offers important new evidence on statistical validation of these analytical methods. Evaluates the goals and methods of forensic archaeology, including the preservation of context at surface-scattered remains, buried bodies and fatal fire scenes, and recovery and identification issues related to large-scale mass disaster scenes and mass grave excavation.
Miguel de la Guardia Handbook of Green Analytical Chemistry Miguel de la Guardia Handbook of Green Analytical Chemistry Новинка

Miguel de la Guardia Handbook of Green Analytical Chemistry

15601.95 руб.
The emerging field of green analytical chemistry is concerned with the development of analytical procedures that minimize consumption of hazardous reagents and solvents, and maximize safety for operators and the environment. In recent years there have been significant developments in methodological and technological tools to prevent and reduce the deleterious effects of analytical activities; key strategies include recycling, replacement, reduction and detoxification of reagents and solvents. The Handbook of Green Analytical Chemistry provides a comprehensive overview of the present state and recent developments in green chemical analysis. A series of detailed chapters, written by international specialists in the field, discuss the fundamental principles of green analytical chemistry and present a catalogue of tools for developing environmentally friendly analytical techniques. Topics covered include: Concepts: Fundamental principles, education, laboratory experiments and publication in green analytical chemistry. The Analytical Process: Green sampling techniques and sample preparation, direct analysis of samples, green methods for capillary electrophoresis, chromatography, atomic spectroscopy, solid phase molecular spectroscopy, derivative molecular spectroscopy and electroanalytical methods. Strategies: Energy saving, automation, miniaturization and photocatalytic treatment of laboratory wastes. Fields of Application: Green bioanalytical chemistry, biodiagnostics, environmental analysis and industrial analysis. This advanced handbook is a practical resource for experienced analytical chemists who are interested in implementing green approaches in their work.
Harsha U. Patel,Ankit N. Patel and C. N. Patel Analytical methods for balofloxacin Harsha U. Patel,Ankit N. Patel and C. N. Patel Analytical methods for balofloxacin Новинка

Harsha U. Patel,Ankit N. Patel and C. N. Patel Analytical methods for balofloxacin

3167 руб.
This book includes introduction to HPLC and HPTLC technique for estimation of drugs and ICH guidelines parameters for the method validation. Apart from this it contains HPLC and HPTLC method for the estimation of balofloxacin in bulk and tablets. These methods are stability indicating.Force degradation study showed that balofloxacin moderately degradable in acidic and oxidative conditions and relatively stable to alkaline, neutral hydolysis, thermal and photolytic stress.
Leveraging Applications of Formal Methods, Verification, and Validation. 6th International Symposium, ISoLA 2014, Corfu, Greece, October 8-11, 2014, and 5th International Symposium, ISoLA 2012, Heraklion, Crete, Greece, October 15-18, 2012, Revise... Leveraging Applications of Formal Methods, Verification, and Validation. 6th International Symposium, ISoLA 2014, Corfu, Greece, October 8-11, 2014, and 5th International Symposium, ISoLA 2012, Heraklion, Crete, Greece, October 15-18, 2012, Revise... Новинка

Leveraging Applications of Formal Methods, Verification, and Validation. 6th International Symposium, ISoLA 2014, Corfu, Greece, October 8-11, 2014, and 5th International Symposium, ISoLA 2012, Heraklion, Crete, Greece, October 15-18, 2012, Revise...

10052 руб.
Книга "Leveraging Applications of Formal Methods, Verification, and Validation. 6th International Symposium, ISoLA 2014, Corfu, Greece, October 8-11, 2014, and 5th International Symposium, ISoLA 2012, Heraklion, Crete, Greece, October 15-18, 2012, Revised Selec".
Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment Новинка

Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment

10450.14 руб.
Urban Remote Sensing is designed for upper level undergraduates, graduates, researchers and practitioners, and has a clear focus on the development of remote sensing technology for monitoring, synthesis and modeling in the urban environment. It covers four major areas: the use of high-resolution satellite imagery or alternative sources of image date (such as high-resolution SAR and LIDAR) for urban feature extraction; the development of improved image processing algorithms and techniques for deriving accurate and consistent information on urban attributes from remote sensor data; the development of analytical techniques and methods for deriving indicators of socioeconomic and environmental conditions that prevail within urban landscape; and the development of remote sensing and spatial analytical techniques for urban growth simulation and predictive modeling.
Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment Новинка

Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment

10137.3 руб.
Urban Remote Sensing is designed for upper level undergraduates, graduates, researchers and practitioners, and has a clear focus on the development of remote sensing technology for monitoring, synthesis and modeling in the urban environment. It covers four major areas: the use of high-resolution satellite imagery or alternative sources of image date (such as high-resolution SAR and LIDAR) for urban feature extraction; the development of improved image processing algorithms and techniques for deriving accurate and consistent information on urban attributes from remote sensor data; the development of analytical techniques and methods for deriving indicators of socioeconomic and environmental conditions that prevail within urban landscape; and the development of remote sensing and spatial analytical techniques for urban growth simulation and predictive modeling.
Richard Brereton G. Chemometrics for Pattern Recognition Richard Brereton G. Chemometrics for Pattern Recognition Новинка

Richard Brereton G. Chemometrics for Pattern Recognition

12671.64 руб.
Over the past decade, pattern recognition has been one of the fastest growth points in chemometrics. This has been catalysed by the increase in capabilities of automated instruments such as LCMS, GCMS, and NMR, to name a few, to obtain large quantities of data, and, in parallel, the significant growth in applications especially in biomedical analytical chemical measurements of extracts from humans and animals, together with the increased capabilities of desktop computing. The interpretation of such multivariate datasets has required the application and development of new chemometric techniques such as pattern recognition, the focus of this work. Included within the text are: ‘Real world’ pattern recognition case studies from a wide variety of sources including biology, medicine, materials, pharmaceuticals, food, forensics and environmental science; Discussions of methods, many of which are also common in biology, biological analytical chemistry and machine learning; Common tools such as Partial Least Squares and Principal Components Analysis, as well as those that are rarely used in chemometrics such as Self Organising Maps and Support Vector Machines; Representation in full colour; Validation of models and hypothesis testing, and the underlying motivation of the methods, including how to avoid some common pitfalls. Relevant to active chemometricians and analytical scientists in industry, academia and government establishments as well as those involved in applying statistics and computational pattern recognition.
Richard Brereton G. Chemometrics for Pattern Recognition Richard Brereton G. Chemometrics for Pattern Recognition Новинка

Richard Brereton G. Chemometrics for Pattern Recognition

12292.61 руб.
Over the past decade, pattern recognition has been one of the fastest growth points in chemometrics. This has been catalysed by the increase in capabilities of automated instruments such as LCMS, GCMS, and NMR, to name a few, to obtain large quantities of data, and, in parallel, the significant growth in applications especially in biomedical analytical chemical measurements of extracts from humans and animals, together with the increased capabilities of desktop computing. The interpretation of such multivariate datasets has required the application and development of new chemometric techniques such as pattern recognition, the focus of this work. Included within the text are: ‘Real world’ pattern recognition case studies from a wide variety of sources including biology, medicine, materials, pharmaceuticals, food, forensics and environmental science; Discussions of methods, many of which are also common in biology, biological analytical chemistry and machine learning; Common tools such as Partial Least Squares and Principal Components Analysis, as well as those that are rarely used in chemometrics such as Self Organising Maps and Support Vector Machines; Representation in full colour; Validation of models and hypothesis testing, and the underlying motivation of the methods, including how to avoid some common pitfalls. Relevant to active chemometricians and analytical scientists in industry, academia and government establishments as well as those involved in applying statistics and computational pattern recognition.
Kavita Birhman and Sanju Nanda Animal Alternative Methods in Drug Approval Process Kavita Birhman and Sanju Nanda Animal Alternative Methods in Drug Approval Process Новинка

Kavita Birhman and Sanju Nanda Animal Alternative Methods in Drug Approval Process

5707 руб.
Animals have been in use in the drug research and development process in lieu of providing safety and efficacy data in the past several decades, especially after the thalidomide and sulphanilamide tragedies. But due to various reasons like continuous pressure from animal welfare groups all over the world and continuous advancements in the field of non-animal alternative testing strategies, demand for substitution of animals to ascertain drug safety is catching momentum. The 3R'principle i.e. reduction, refinement and replacement approach has become the motto of humane treatment towards experimental animals around the world. In this process validation of different alternative methods is the need of the hour and hence different national and international organizations like Organization for Economic Cooperation and Development, International Cooperation on the Validation of Alternative Methods, etc. are making and implementing guidelines for it. Keeping in view the changing scenario in regard to restriction on testing of animals across the globe, this book updates reasons and development of alternatives to the use of animals in drug research and approval process.
Michael Rychlik Fortified Foods with Vitamins. Analytical Concepts to Assure Better and Safer Products Michael Rychlik Fortified Foods with Vitamins. Analytical Concepts to Assure Better and Safer Products Новинка

Michael Rychlik Fortified Foods with Vitamins. Analytical Concepts to Assure Better and Safer Products

2215.41 руб.
Unique in its review of modern analytical approaches to vitamin fortification, this book emphasizes fast, sensitive, and accurate methods, along with assays enabling the detection of various isomers and multiple vitamins. The expert contributors describe the concepts as well as analytical and assay methods to study fortification, along with applications to create better and safer foods. Taking into considerations regulatory matters, they include data on sampling and extraction methods, and discuss the various pros and cons of each. As a result, readers are able to determine, which type of analytical method is best suited for added vitamins. A practical guide for food chemists and technologists, as well as analytical laboratories and biochemists.
Dominique Bonneau Hydrodynamic Bearings Dominique Bonneau Hydrodynamic Bearings Новинка

Dominique Bonneau Hydrodynamic Bearings

9141.65 руб.
This Series provides the necessary elements to the development and validation of numerical prediction models for hydrodynamic bearings. This book describes the rheological models and the equations of lubrication. It also presents the numerical approaches used to solve the above equations by finite differences, finite volumes and finite elements methods.
Giuseppe Cirillo Food Safety. Innovative Analytical Tools for Safety Assessment Giuseppe Cirillo Food Safety. Innovative Analytical Tools for Safety Assessment Новинка

Giuseppe Cirillo Food Safety. Innovative Analytical Tools for Safety Assessment

17286.19 руб.
Food safety and quality are key objectives for food scientists and industries all over the world. To achieve this goal, several analytical techniques (based on both destructive detection and nondestructive detection) have been proposed to fit the government regulations. The book aims to cover all the analytical aspects of the food quality and safety assessment. For this purpose, the volume describes the most relevant techniques employed for the determination of the major food components (e.g. protein, polysaccharides, lipds, vitamins, etc.), with peculiar attention to the recent development in the field. Furthermore, the evaluation of the risk associated with food consumption is performed by exploring the recent advances in the detection of the key food contaminants (e.g. biogenic amines, pesticides, toxins, etc.). Chapters tackle such subject as: GMO Analysis Methods in Food Current Analytical Techniques for the Analysis of Food Lipids Analytical Methods for the Analysis of Sweeteners in Food Analytical Methods for Pesticides Detection in Foodstuffs Food and Viral Contamination Application of Biosensors to Food Analysis
Harald Seitz Biomarker Validation. Technological, Clinical and Commercial Aspects Harald Seitz Biomarker Validation. Technological, Clinical and Commercial Aspects Новинка

Harald Seitz Biomarker Validation. Technological, Clinical and Commercial Aspects

12676.73 руб.
Built on a decade of experience with novel molecular diagnostics, this practice-oriented guide shows how to cope with validation issues during all stages of biomarker development, from the first clinical studies to the eventual commercialization of a new diagnostic test.
Ashutosh Shukla K. Analytical Characterization Methods for Crude Oil and Related Products Ashutosh Shukla K. Analytical Characterization Methods for Crude Oil and Related Products Новинка

Ashutosh Shukla K. Analytical Characterization Methods for Crude Oil and Related Products

11907.76 руб.
Basic theory, applications, and recent trends in analytical techniques used in crude oil and related products analysis This book covers the application of different spectroscopic methods to characterize crude oil and related products. Its topics are presented in a pedagogical manner so that those new to the subject can better understand the content. The book begins by familiarizing the reader with the rheological characterization of crude oil and related products. Subsequent chapters are directed towards the current trends of different spectroscopic methods for the characterization of crude oil. Analytical Characterization Methods for Crude Oil and Related Products features chapters on: optical interrogation of petroleum asphaltenes (myths and reality); ESR characterization of organic free radicals in petroleum products; high-field, pulsed, and double resonance studies of crude oils and their derivatives; NMR spectroscopy in bitumen characterization; applications of Raman spectroscopy in crude oil and bitumen characterization; and more. Uses a bottom-up approach—starting from the basic theory of the technique followed by its applications and recent trends in crude oil analysis Includes informative content so as to take a technician to the level of using a particular analytical method Covers relevany information so as to enable a manager in the industry to make purchasing decisions Analytical Characterization Methods for Crude Oil and Related Products is aimed at researchers in academia as well as technicians and developers of new analytical methods in the oil industry and related areas. It will also be of interest to professionals, scientists, and graduate students in analytical sciences dealing with oil and environmental analysis.
Yuliang Zhao Toxicology of Nanomaterials Yuliang Zhao Toxicology of Nanomaterials Новинка

Yuliang Zhao Toxicology of Nanomaterials

14597.34 руб.
This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.
Formal Methods and Software Development. Proceedings of the International Joint Conference on Theory and Practice of Software Development (TAPSOFT), Berlin, March 25-29, 1985. Volume 2: Colloquium on Software Engineering (CSE) Formal Methods and Software Development. Proceedings of the International Joint Conference on Theory and Practice of Software Development (TAPSOFT), Berlin, March 25-29, 1985. Volume 2: Colloquium on Software Engineering (CSE) Новинка

Formal Methods and Software Development. Proceedings of the International Joint Conference on Theory and Practice of Software Development (TAPSOFT), Berlin, March 25-29, 1985. Volume 2: Colloquium on Software Engineering (CSE)

8814 руб.
Книга "Formal Methods and Software Development. Proceedings of the International Joint Conference on Theory and Practice of Software Development (TAPSOFT), Berlin, March 25-29, 1985. Volume 2: Colloquium on Software Engineering (CSE)".
Behnam Davani Pharmaceutical Analysis for Small Molecules Behnam Davani Pharmaceutical Analysis for Small Molecules Новинка

Behnam Davani Pharmaceutical Analysis for Small Molecules

9603.03 руб.
A comprehensive introduction for scientists engaged in new drug development, analysis, and approvals Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates—especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors—into its ranks. However, because of their limited background in pharmaceutical analysis most of those new recruits find making the transition from academia to industry very difficult. Designed to assist both recent graduates, as well as experienced chemists or scientists with limited regulatory, compendial or pharmaceutical analysis background, make that transition, Pharmaceutical Analysis for Small Molecules is a concise, yet comprehensive introduction to the drug development process and analysis of chemically synthesized, small molecule drugs. It features contributions by distinguished experts in the field, including editor and author, Dr. Behnam Davani, an analytical chemist with decades of technical management and teaching experience in compendial, regulatory, and industry. This book provides an introduction to pharmaceutical analysis for small molecules (non-biologics) using commonly used techniques for drug characterization and performance tests. The driving force for industry to perform pharmaceutical analyses is submission of such data and supporting documents to regulatory bodies for drug approval in order to market their products. In addition, related required supporting studies including good laboratory/documentation practices including analytical instrument qualification are highlighted in this book. Topics covered include: Drug Approval Process and Regulatory Requirements (private standards) Pharmacopeias and Compendial Approval Process (public standards) Common methods in pharmaceutical analysis (typically compendial) Common Calculations for assays and impurities and other specific tests Analytical Method Validation, Verification, Transfer Specifications including how to handle out of specification (OOS) and out of trend (OOT) Impurities including organic, inorganic, residual solvents and elemental impurities Good Documentation Practices for regulatory environment Management of Analytical Laboratories Analytical Instrument Qualifications including IQ, OQ, PQ and VQ Due to global nature of pharmaceutical industry, other topics on both regulatory (ICH) and Compendial harmonization are also highlighted. Pharmaceutical Analysis for Small Molecules is a valuable working resource for scientists directly or indirectly involved with the drug development process, including analytical chemists, pharmaceutical scientists, pharmacists, and quality control/quality assurance professionals. It also is an excellent text/reference for graduate students in analytical chemistry, pharmacy, pharmaceutical and regulatory sciences.
David Goodson Z. Mathematical Methods for Physical and Analytical Chemistry David Goodson Z. Mathematical Methods for Physical and Analytical Chemistry Новинка

David Goodson Z. Mathematical Methods for Physical and Analytical Chemistry

9182.98 руб.
Mathematical Methods for Physical and Analytical Chemistry presents mathematical and statistical methods to students of chemistry at the intermediate, post-calculus level. The content includes a review of general calculus; a review of numerical techniques often omitted from calculus courses, such as cubic splines and Newton’s method; a detailed treatment of statistical methods for experimental data analysis; complex numbers; extrapolation; linear algebra; and differential equations. With numerous example problems and helpful anecdotes, this text gives chemistry students the mathematical knowledge they need to understand the analytical and physical chemistry professional literature.
Mark Vitha F. Hydrophilic Interaction Chromatography. A Guide for Practitioners Mark Vitha F. Hydrophilic Interaction Chromatography. A Guide for Practitioners Новинка

Mark Vitha F. Hydrophilic Interaction Chromatography. A Guide for Practitioners

8523.56 руб.
Discover how to use HILIC to analyze and better understand polar compounds An increasingly popular analytical method, hydrophilic interaction chromatography (HILIC) has the ability to retain and separate polar compounds that are often difficult to analyze by reversed-phase high-performance liquid chromatography (HPLC) or other analytical methods. Offering a comprehensive review, this book enables readers to develop a fundamental understanding of how HILIC works and then apply that knowledge to develop and implement a variety of practical applications. Hydrophilic Interaction Chromatography begins with discussions of HILIC retention mechanisms, stationary phases, and general method development. This sets the foundation for the book's extensive coverage of applications. The authors address unique separation challenges for bioanalytical, environmental, pharmaceutical, and biochemical applications. Moreover, there is a thorough discussion of HILIC in two-dimensional chromatography. With contributions from leading analytical scientists who have extensive experience in HILIC as well as HPLC, Hydrophilic Interaction Chromatography serves as a practical guide for researchers, featuring: Detailed examples of HILIC methods and development approaches Thorough explanations of retention mechanisms and the impact of stationary phase and mobile phase properties on separations Step-by-step guidance for developing efficient, sensitive, and robust HILIC methods References to the primary literature at the end of each chapter Hydrophilic Interaction Chromatography is written for scientists who use or develop analytical methods for the separation of polar compounds. In particular, these researchers will discover how HILIC can be used to analyze and better understand the composition of pharmaceutical, bioanalytical, biochemical, chemical, food, and environmental samples.
Ugur Akinci Mesh Generation and CFD Modeling in Gas Turbines Ugur Akinci Mesh Generation and CFD Modeling in Gas Turbines Новинка

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8364 руб.
The aim of this study is to develop efficient and reliable automation methods resulting in improved CFD predictions and thus, high accuracy in the CFD chain. This master thesis work mainly involves: modeling of turbine cavities based on CAD drawings, simplification and parametrisation of cavities, development of automated mesh generation templates as well as extention and adaptation of them onto different geometries (scripting in Python), compressor leakage air modeling, test and validation of the modules.
Jian Wang Chemical Analysis of Non-antimicrobial Veterinary Drug Residues in Food Jian Wang Chemical Analysis of Non-antimicrobial Veterinary Drug Residues in Food Новинка

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14981.46 руб.
Provides a single-source reference for readers interested in the development of analytical methods for analyzing non-antimicrobial veterinary drug residues in food Provides a comprehensive set of information in the area of consumer food safety and international trade Covers general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods Details many techniques including nanotechnology and aptamer based assays covering current and potential applications for non-antimicrobial veterinary drugs Provides guidance for analysis of banned drugs including natural and synthetic steroids, Resorcylic acid lactones, and Beta-agonists
Sergio Petrozzi Practical Instrumental Analysis. Methods, Quality Assurance and Laboratory Management Sergio Petrozzi Practical Instrumental Analysis. Methods, Quality Assurance and Laboratory Management Новинка

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2215.41 руб.
This practical book in instrumental analytics conveys an overview of important methods of analysis and enables the reader to realistically learn the (principally technology-independent) working techniques the analytical chemist uses to develop methods and conduct validation. What is to be conveyed to the student is the fact that analysts in their capacity as problem-solvers perform services for certain groups of customers, i.e., the solution to the problem should in any case be processed in such a way as to be «fit for purpose». The book presents sixteen experiments in analytical chemistry laboratory courses. They consist of the classical curriculum used at universities and universities of applied sciences with chromatographic procedures, atom spectrometric methods, sensors and special methods (e.g. field flow fractionation , flow injection analysis and N-determination according to Kjeldahl). The carefully chosen combination of theoretical description of the methods of analysis and the detailed instructions given are what characterizes this book. The instructions to the experiments are so detailed that the measurements can, for the most part, be taken without the help of additional literature. The book is complemented with tips for effective literature and database research on the topics of organisation and the practical workflow of experiments in analytical laboratory, on the topic of the use of laboratory logs as well as on writing technical reports and grading them (Evaluation Guidelines for Laboratory Experiments). A small introduction to Quality Management, a brief glance at the history of analytical chemistry as well as a detailed appendix on the topic of safety in analytical laboratories and a short introduction to the new system of grading and marking chemicals using the «Globally Harmonized System of Classification and Labelling of Chemicals (GHS)», round off this book. This book is therefore an indispensable workbook for students, internship assistants and lecturers (in the area of chemistry, biotechnology, food technology and environmental technology) in the basic training programme of analytics at universities and universities of applied sciences.
Cunningham David D. In Vivo Glucose Sensing Cunningham David D. In Vivo Glucose Sensing Новинка

Cunningham David D. In Vivo Glucose Sensing

11087.68 руб.
In Vivo Glucose Sensing is a key reference for scientists and engineers working on the development of glucose sensing technologies for the management of diabetes and other medical conditions. It discusses the analytical chemistry behind the strategies currently used for measuring glucose in vivo. It focuses on analyzing samples in the real world and discusses the biological complexities that make glucose sensing difficult. Covering current implantable devices, next-generation implantable sensing methods, and non-invasive methods for measuring glucose, this book concludes with an overview of possible applications other than diabetes.
Sergio Petrozzi Practical Instrumental Analysis. Methods, Quality Assurance and Laboratory Management Sergio Petrozzi Practical Instrumental Analysis. Methods, Quality Assurance and Laboratory Management Новинка

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5608.03 руб.
This practical book in instrumental analytics conveys an overview of important methods of analysis and enables the reader to realistically learn the (principally technology-independent) working techniques the analytical chemist uses to develop methods and conduct validation. What is to be conveyed to the student is the fact that analysts in their capacity as problem-solvers perform services for certain groups of customers, i.e., the solution to the problem should in any case be processed in such a way as to be «fit for purpose». The book presents sixteen experiments in analytical chemistry laboratory courses. They consist of the classical curriculum used at universities and universities of applied sciences with chromatographic procedures, atom spectrometric methods, sensors and special methods (e.g. field flow fractionation , flow injection analysis and N-determination according to Kjeldahl). The carefully chosen combination of theoretical description of the methods of analysis and the detailed instructions given are what characterizes this book. The instructions to the experiments are so detailed that the measurements can, for the most part, be taken without the help of additional literature. The book is complemented with tips for effective literature and database research on the topics of organisation and the practical workflow of experiments in analytical laboratory, on the topic of the use of laboratory logs as well as on writing technical reports and grading them (Evaluation Guidelines for Laboratory Experiments). A small introduction to Quality Management, a brief glance at the history of analytical chemistry as well as a detailed appendix on the topic of safety in analytical laboratories and a short introduction to the new system of grading and marking chemicals using the «Globally Harmonized System of Classification and Labelling of Chemicals (GHS)», round off this book. This book is therefore an indispensable workbook for students, internship assistants and lecturers (in the area of chemistry, biotechnology, food technology and environmental technology) in the basic training programme of analytics at universities and universities of applied sciences.
Wilfred Welday Scott Standard Methods of Chemical Analysis: A Manual of Analytical Methods and General Reference for the Analytical Chemist and for the Advanced Student, Volume 2 Wilfred Welday Scott Standard Methods of Chemical Analysis: A Manual of Analytical Methods and General Reference for the Analytical Chemist and for the Advanced Student, Volume 2 Новинка

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1167 руб.
Эта книга — репринт оригинального издания, созданный на основе электронной копии высокого разрешения, которую очистили и обработали вручную, сохранив структуру и орфографию оригинального издания. Редкие, забытые и малоизвестные книги, изданные с петровских времен до наших дней, вновь доступны в виде печатных книг.
Karl Witt Josef Grundbau-Taschenbuch. Teil 2: Geotechnische Verfahren Karl Witt Josef Grundbau-Taschenbuch. Teil 2: Geotechnische Verfahren Новинка

Karl Witt Josef Grundbau-Taschenbuch. Teil 2: Geotechnische Verfahren

2147.29 руб.
The second part of the Geotechnical Engineering Handbook is dealing with the geotechnical procedures and their methods of global analysis and analytical procedures: Soil engineering, ground improvement, injection- and anchorage methods, driving and drilling, damp-proofing and waterproofing of structures, soil freezing, ground water lowering up to engineering-biological methods of slope protection.
Wilfred Welday Scott Standard Methods of Chemical Analysis: A Manual of Analytical Methods and General Reference for the Analytical Chemist and for the Advanced Student, Volume 1 Wilfred Welday Scott Standard Methods of Chemical Analysis: A Manual of Analytical Methods and General Reference for the Analytical Chemist and for the Advanced Student, Volume 1 Новинка

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1197 руб.
Эта книга — репринт оригинального издания, созданный на основе электронной копии высокого разрешения, которую очистили и обработали вручную, сохранив структуру и орфографию оригинального издания. Редкие, забытые и малоизвестные книги, изданные с петровских времен до наших дней, вновь доступны в виде печатных книг.
Wilfred Welday Scott Standard Methods of Chemical Analysis: A Manual of Analytical Methods and General Reference for the Analytical Chemist and for the Advanced Student Wilfred Welday Scott Standard Methods of Chemical Analysis: A Manual of Analytical Methods and General Reference for the Analytical Chemist and for the Advanced Student Новинка

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1251 руб.
Эта книга — репринт оригинального издания, созданный на основе электронной копии высокого разрешения, которую очистили и обработали вручную, сохранив структуру и орфографию оригинального издания. Редкие, забытые и малоизвестные книги, изданные с петровских времен до наших дней, вновь доступны в виде печатных книг.
Yiyang Dong Aptamers for Analytical Applications. Affinity Acquisition and Method Design Yiyang Dong Aptamers for Analytical Applications. Affinity Acquisition and Method Design Новинка

Yiyang Dong Aptamers for Analytical Applications. Affinity Acquisition and Method Design

14648.94 руб.
An essential guide that puts the focus on method developments and applications in aptamers In recent years, aptamer-based systems have been developed for a wide-range of analytical and medical applications. Aptamers for Analytical Applications offers an introduction to the topic, outlines the common protocols for aptamer synthesis, as well as providing information on the different optimization strategies that can obtain higher affinities to target molecules. The contributors?noted experts on the topic?provide an in-depth review of the characterization of aptamer-target molecule interaction and immobilization strategies and discuss the developments of methods for all the relevant applications. The book outlines different schemes to efficiently immobilize aptamers on substrates as well as summarizing the characterization methods for aptamer-ligand complexes. In addition, aptamer-based colorimetric, enzyme-linked, fluorescent, electrochemical, lateral flow and non-labeling analytical methods are presented. The book also reflects state-of-the-art and emerging applications of aptamer-based methods. This important resource: -Provides a guide to aptamers which provide highly specific and sensitive molecular recognition, with affinities in the range of antibodies and are much cheaper to produce -Offers a discussion of the analytical method developments and improvements with established systems and beyond -Offers a comprehensive guide to all the relevant application areas -Presents an authoritative book from contributors who are noted experts in the field Written for analytical chemists, biochemists, analytical researchers, Aptamers for Analytical Applications is a comprehensive book that adopts a methodological point of view to the important aspects of aptamer generation and modification with a strong emphasis on method developments for relevant applications.
Mark Gardener Community Ecology. Analytical Methods Using R and Excel Mark Gardener Community Ecology. Analytical Methods Using R and Excel Новинка

Mark Gardener Community Ecology. Analytical Methods Using R and Excel

9364 руб.
Interactions between species are of fundamental importance to all living systems and the framework we have for studying these interactions is community ecology. This is important to our understanding of the planets biological diversity and how species interactions relate to the functioning of ecosystems at all scales. Species do not live in isolation and the study of community ecology is of practical application in a wide range of conservation issues.The study of ecological community data involves many methods of analysis. In this book you will learn many of the mainstays of community analysis including: diversity, similarity and cluster analysis, ordination and multivariate analyses. This book is for undergraduate and postgraduate students and researchers seeking a step-by-step methodology for analysing plant and animal communities using R and Excel.Microsoft's Excel spreadsheet is virtually ubiquitous and familiar to most computer users. It is a robust program that makes an excellent storage and manipulation system for many kinds of data, including community data. The R program is a powerful and flexible analytical system able to conduct a huge variety of analytical methods, which means that the user only has to learn one program to address many research questions. Its other advantage is that it is open source and therefore completely free. Novel analytical methods are being added constantly to the already comprehensive suite of tools available in R.Mark Gardener is bot...
Abu Md. Saifuddoha Design and Development of a multimedia projector trolley Abu Md. Saifuddoha Design and Development of a multimedia projector trolley Новинка

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2890 руб.
Product development process is the sequence of steps or activities which an enterprise employs to conceive, design and commercialize a product. We focus on product development activities that benefit from the participation of all core functions of a firm or industry. This paper consists of methods for completing development methods. The methods are structure and it is followed by step-by-step approach. That’s why the product development of multimedia projector trolley is accomplished by following sequential steps of product planning, identifying customer needs, product specification, concept generation, concept selection phases. This paper addresses successful accomplishment product design and development of a multimedia projector trolley according to properly specified customer needs and specifications.
Yuly Sokolovsky, Vladimir Rotkin THEORETICAL AND TECHNICAL BASIS FOR THE OPTIMIZATION OF WIND ENERGY PLANTS Yuly Sokolovsky, Vladimir Rotkin THEORETICAL AND TECHNICAL BASIS FOR THE OPTIMIZATION OF WIND ENERGY PLANTS Новинка

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2964 руб.
Description: The work contains an analytical review of modern wind energy, based on different physical principles. We consider wind installations with horizontal-axial and vertical-axial configurations, innovative designs for wind turbines. Also, modern methods and possibilities for scaling and optimal regulation of wind parks are considered. Mathematical models for the interaction of airflow with blades of collinear and orthogonal plants have been developed, and methods for optimal regulation have been identified that increase the energy efficiency of plants. A number of patent developments represent promising directions for the development of wind energy: horizontal and vertical collinear installations, vertical-axial orthogonal devices with unregulated and self-regulating blades and with optimal control systems based on the author methods of optimizing.
David Elder ICH Quality Guidelines. An Implementation Guide David Elder ICH Quality Guidelines. An Implementation Guide Новинка

David Elder ICH Quality Guidelines. An Implementation Guide

26888.49 руб.
Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. • Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies • Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implementation of ICH guidelines • Uses case studies to help readers understand and apply ICH guidelines • Provides valuable insights into guidelines development, with chapters by authors involved in generating or with experience implementing the guidelines • Includes coverage of stability testing, analytical method validation, impurities, biotechnology drugs and products, and good manufacturing practice (GMP)
A. Gould Lawrence Statistical Methods for Evaluating Safety in Medical Product Development A. Gould Lawrence Statistical Methods for Evaluating Safety in Medical Product Development Новинка

A. Gould Lawrence Statistical Methods for Evaluating Safety in Medical Product Development

8153.41 руб.
This book gives professionals in clinical research valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It also provides understanding and practical guidance on the application of contemporary statistical methods to contemporary issues in safety evaluation during medical product development. Each chapter provides sufficient detail to the reader to undertake the design and analysis of experiments at various stages of product development, including comprehensive references to the relevant literature. Provides a guide to statistical methods and application in medical product development Assists readers in undertaking design and analysis of experiments at various stages of product development Features case studies throughout the book, as well as, SAS and R code
Blair Schoene Geochronology and Thermochronology Blair Schoene Geochronology and Thermochronology Новинка

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11523.64 руб.
This book is a welcome introduction and reference for users and innovators in geochronology. It provides modern perspectives on the current state-of-the art in most of the principal areas of geochronology and thermochronology, while recognizing that they are changing at a fast pace. It emphasizes fundamentals and systematics, historical perspective, analytical methods, data interpretation, and some applications chosen from the literature. This book complements existing coverage by expanding on those parts of isotope geochemistry that are concerned with dates and rates and insights into Earth and planetary science that come from temporal perspectives. Geochronology and Thermochronology offers chapters covering: Foundations of Radioisotopic Dating; Analytical Methods; Interpretational Approaches: Making Sense of Data; Diffusion and Thermochronologic Interpretations; Rb-Sr, Sm-Nd, Lu-Hf; Re-Os and Pt-Os; U-Th-Pb Geochronology and Thermochronology; The K-Ar and 40Ar/39Ar Systems; Radiation-damage Methods of Geo- and Thermochronology; The (U-Th)/He System; Uranium-series Geochronology; Cosmogenic Nuclides; and Extinct Radionuclide Chronology. Offers a foundation for understanding each of the methods and for illuminating directions that will be important in the near future Presents the fundamentals, perspectives, and opportunities in modern geochronology in a way that inspires further innovation, creative technique development, and applications Provides references to rapidly evolving topics that will enable readers to pursue future developments Geochronology and Thermochronology is designed for graduate and upper-level undergraduate students with a solid background in mathematics, geochemistry, and geology.
Okelo Wilfred Human Growth and Development for Universities and Colleges Okelo Wilfred Human Growth and Development for Universities and Colleges Новинка

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8177 руб.
Human Growth and Development is an introductory text for universities and colleges. It has two sections: fundamentals of human growth and development and areas of development. Section I has six topics, namely: introduction, historical account, research methods/design, theories and determinants, prenatal development and the neonate. Section II has ten topics, namely: physical/motor development, perceptual development, cognitive development, language development, personality development, social development, emotional development, moral development, adolescent growth and development and adult development.
Henrik Birgersson Development and Assessment of Regeneration Methods for Commercial Automotive Three-Way Catalysts Henrik Birgersson Development and Assessment of Regeneration Methods for Commercial Automotive Three-Way Catalysts Новинка

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Книга "Development and Assessment of Regeneration Methods for Commercial Automotive Three-Way Catalysts".
Jacek Lipkowski Bioelectrochemistry. Fundamentals, Applications and Recent Developments Jacek Lipkowski Bioelectrochemistry. Fundamentals, Applications and Recent Developments Новинка

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16671.01 руб.
Bioelectrochemistry is a fast growing field at the interface between electrochemistry and other sciences such as biochemistry, analytical chemistry and medicinal chemistry. In the recent years, the methods and the understanding of the fundamentals have seen significant progress, which has led to rapid development in the field. Here, the expert editors have carefully selected contributions to best reflect the latest developments in this hot and rapidly growing interdisciplinary topic. The resulting excellent and timely overview of this multifaceted field covers recent methodological advances, as well as a range of new applications for analytical detection, drug screening, tumor therapy, and for energy conversion in biofuel cells. This book is a must-have for all Electrochemists, Biochemists, Analytical Chemists, and Medicinal Chemists.
Sean Ekins Predictive Approaches in Drug Discovery and Development. Biomarkers and In Vitro / In Vivo Correlations Sean Ekins Predictive Approaches in Drug Discovery and Development. Biomarkers and In Vitro / In Vivo Correlations Новинка

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11523.64 руб.
Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Jean-François Sigrist Fluid-Structure Interaction. An Introduction to Finite Element Coupling Jean-François Sigrist Fluid-Structure Interaction. An Introduction to Finite Element Coupling Новинка

Jean-François Sigrist Fluid-Structure Interaction. An Introduction to Finite Element Coupling

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Fluid-Structure Interaction: An Introduction to Finite Element Coupling fulfils the need for an introductive approach to the general concepts of Finite and Boundary Element Methods for FSI, from the mathematical formulation to the physical interpretation of numerical simulations. Based on the author’s experience in developing numerical codes for industrial applications in shipbuilding and in teaching FSI to both practicing engineers and within academia, it provides a comprehensive and self–contained guide that is geared toward both students and practitioners of mechanical engineering. Composed of six chapters, Fluid–Structure Interaction: An Introduction to Finite Element Coupling progresses logically from formulations and applications involving structure and fluid dynamics, fluid and structure interactions and opens to reduced order-modelling for vibro-acoustic coupling. The author describes simple yet fundamental illustrative examples in detail, using analytical and/or semi–analytical formulation & designed both to illustrate each numerical method and also to highlight a physical aspect of FSI. All proposed examples are simple enough to be computed by the reader using standard computational tools such as MATLAB, making the book a unique tool for self–learning and understanding the basics of the techniques for FSI, or can serve as verification and validation test cases of industrial FEM/BEM codes rendering the book valuable for code verification and validation purposes.
Balachandran Balakumar Applied Nonlinear Dynamics. Analytical, Computational and Experimental Methods Balachandran Balakumar Applied Nonlinear Dynamics. Analytical, Computational and Experimental Methods Новинка

Balachandran Balakumar Applied Nonlinear Dynamics. Analytical, Computational and Experimental Methods

16948.31 руб.
A unified and coherent treatment of analytical, computational and experimental techniques of nonlinear dynamics with numerous illustrative applications. Features a discourse on geometric concepts such as Poincare maps. Discusses chaos, stability and bifurcation analysis for systems of differential and algebraic equations. Includes scores of examples to facilitate understanding.
Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster Новинка

Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster

15437.74 руб.
This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. • Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification • Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance • Explains the role of natural products in chemistry and their formation • Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application
Dennis Smith A. Metabolite Safety in Drug Development Dennis Smith A. Metabolite Safety in Drug Development Новинка

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A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA. • Reviews the analytical techniques and experimental designs critical for metabolite studies • Covers methods including chirality, species differences, mass spectrometry, radiolabels, and in vitro / in vivo correlation • Discusses target pharmacology, in vitro systems aligned to toxicity tests, and drug-drug interactions • Includes perspectives from authors with firsthand involvement in industry and the study of drug metabolites, including viewpoints that have influenced regulatory guidelines
Litwin Virginia Flow Cytometry in Drug Discovery and Development Litwin Virginia Flow Cytometry in Drug Discovery and Development Новинка

Litwin Virginia Flow Cytometry in Drug Discovery and Development

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This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.
Martin Hermann, Masoud Saravi A First Course in Ordinary Differential Equations. Analytical and Numerical Methods Martin Hermann, Masoud Saravi A First Course in Ordinary Differential Equations. Analytical and Numerical Methods Новинка

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9127 руб.
Книга "A First Course in Ordinary Differential Equations. Analytical and Numerical Methods".
Albert C. J. Luo Toward Analytical Chaos in Nonlinear Systems Albert C. J. Luo Toward Analytical Chaos in Nonlinear Systems Новинка

Albert C. J. Luo Toward Analytical Chaos in Nonlinear Systems

11904.12 руб.
Exact analytical solutions to periodic motions in nonlinear dynamical systems are almost not possible. Since the 18th century, one has extensively used techniques such as perturbation methods to obtain approximate analytical solutions of periodic motions in nonlinear systems. However, the perturbation methods cannot provide the enough accuracy of analytical solutions of periodic motions in nonlinear dynamical systems. So the bifurcation trees of periodic motions to chaos cannot be achieved analytically. The author has developed an analytical technique that is more effective to achieve periodic motions and corresponding bifurcation trees to chaos analytically. Toward Analytical Chaos in Nonlinear Systems systematically presents a new approach to analytically determine periodic flows to chaos or quasi-periodic flows in nonlinear dynamical systems with/without time-delay. It covers the mathematical theory and includes two examples of nonlinear systems with/without time-delay in engineering and physics. From the analytical solutions, the routes from periodic motions to chaos are developed analytically rather than the incomplete numerical routes to chaos. The analytical techniques presented will provide a better understanding of regularity and complexity of periodic motions and chaos in nonlinear dynamical systems. Key features: Presents the mathematical theory of analytical solutions of periodic flows to chaos or quasieriodic flows in nonlinear dynamical systems Covers nonlinear dynamical systems and nonlinear vibration systems Presents accurate, analytical solutions of stable and unstable periodic flows for popular nonlinear systems Includes two complete sample systems Discusses time-delayed, nonlinear systems and time-delayed, nonlinear vibrational systems Includes real world examples Toward Analytical Chaos in Nonlinear Systems is a comprehensive reference for researchers and practitioners across engineering, mathematics and physics disciplines, and is also a useful source of information for graduate and senior undergraduate students in these areas.
Analytical and Computational Methods in Probability Theory. First International Conference, ACMPT 2017, Moscow, Russia, October 23-27, 2017, Proceedings Analytical and Computational Methods in Probability Theory. First International Conference, ACMPT 2017, Moscow, Russia, October 23-27, 2017, Proceedings Новинка

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5377 руб.
Книга "Analytical and Computational Methods in Probability Theory. First International Conference, ACMPT 2017, Moscow, Russia, October 23-27, 2017, Proceedings".

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A comprehensive introduction for scientists engaged in new drug development, analysis, and approvals Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates—especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors—into its ranks. However, because of their limited background in pharmaceutical analysis most of those new recruits find making the transition from academia to industry very difficult. Designed to assist both recent graduates, as well as experienced chemists or scientists with limited regulatory, compendial or pharmaceutical analysis background, make that transition, Pharmaceutical Analysis for Small Molecules is a concise, yet comprehensive introduction to the drug development process and analysis of chemically synthesized, small molecule drugs. It features contributions by distinguished experts in the field, including editor and author, Dr. Behnam Davani, an analytical chemist with decades of technical management and teaching experience in compendial, regulatory, and industry. This book provides an introduction to pharmaceutical analysis for small molecules (non-biologics) using commonly used techniques for drug characterization and performance tests. The driving force for industry to perform pharmaceutical analyses is submission of such data and supporting documents to regulatory bodies for drug approval in order to market their products. In addition, related required supporting studies including good laboratory/documentation practices including analytical instrument qualification are highlighted in this book. Topics covered include: Drug Approval Process and Regulatory Requirements (private standards) Pharmacopeias and Compendial Approval Process (public standards) Common methods in pharmaceutical analysis (typically compendial) Common Calculations for assays and impurities and other specific tests Analytical Method Validation, Verification, Transfer Specifications including how to handle out of specification (OOS) and out of trend (OOT) Impurities including organic, inorganic, residual solvents and elemental impurities Good Documentation Practices for regulatory environment Management of Analytical Laboratories Analytical Instrument Qualifications including IQ, OQ, PQ and VQ Due to global nature of pharmaceutical industry, other topics on both regulatory (ICH) and Compendial harmonization are also highlighted. Pharmaceutical Analysis for Small Molecules is a valuable working resource for scientists directly or indirectly involved with the drug development process, including analytical chemists, pharmaceutical scientists, pharmacists, and quality control/quality assurance professionals. It also is an excellent text/reference for graduate students in analytical chemistry, pharmacy, pharmaceutical and regulatory sciences.
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