development and validation of spectrophotometric method for saquinavir



Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena Новинка

Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena

10802.53 руб.
A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field. Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include: A general discussion of challenges and proven approaches in the development of ligand-binding assays More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules A practical approach to «fit-for-purpose» validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.
Herman Lam Practical Approaches to Method Validation and Essential Instrument Qualification Herman Lam Practical Approaches to Method Validation and Essential Instrument Qualification Новинка

Herman Lam Practical Approaches to Method Validation and Essential Instrument Qualification

8926.6 руб.
Practical approaches to ensure that analytical methods and instruments meet GMP standards and requirements Complementing the authors' first book, Analytical Method Validation and Instrument Performance Verification, this new volume provides coverage of more advanced topics, focusing on additional and supplemental methods, instruments, and electronic systems that are used in pharmaceutical, biopharmaceutical, and clinical testing. Readers will gain new and valuable insights that enable them to avoid common pitfalls in order to seamlessly conduct analytical method validation as well as instrument operation qualification and performance verification. Part 1, Method Validation, begins with an overview of the book's risk-based approach to phase appropriate validation and instrument qualification; it then focuses on the strategies and requirements for early phase drug development, including validation of specific techniques and functions such as process analytical technology, cleaning validation, and validation of laboratory information management systems Part 2, Instrument Performance Verification, explores the underlying principles and techniques for verifying instrument performance—coverage includes analytical instruments that are increasingly important to the pharmaceutical industry, such as NIR spectrometers and particle size analyzers—and offers readers a variety of alternative approaches for the successful verification of instrument performance based on the needs of their labs At the end of each chapter, the authors examine important practical problems and share their solutions. All the methods covered in this book follow Good Analytical Practices (GAP) to ensure that reliable data are generated in compliance with current Good Manufacturing Practices (cGMP). Analysts, scientists, engineers, technologists, and technical managers should turn to this book to ensure that analytical methods and instruments are accurate and meet GMP standards and requirements.
Joachim Ermer Method Validation in Pharmaceutical Analysis. A Guide to Best Practice Joachim Ermer Method Validation in Pharmaceutical Analysis. A Guide to Best Practice Новинка

Joachim Ermer Method Validation in Pharmaceutical Analysis. A Guide to Best Practice

15511.7 руб.
This second edition of a global bestseller has been completely redesigned and extensively rewritten to take into account the new Quality by Design (QbD) and lifecycle concepts in pharmaceutical manufacturing. As in the first edition, the fundamental requirements for analytical method validation are covered, but the second edition describes how these are applied systematically throughout the entire analytical lifecycle. QbD principles require adoption of a systematic approach to development and validation that begin with predefined objectives. For analytical methods these predefined objectives are established as an Analytical Target Profile (ATP). The book chapters are aligned with recently introduced standards and guidelines for manufacturing processes validation and follow the three stages of the analytical lifecycle: Method Design, Method Performance Qualification, and Continued Method Performance Verification. Case studies and examples from the pharmaceutical industry illustrate the concepts and guidelines presented, and the standards and regulations from the US (FDA), European (EMA) and global (ICH) regulatory authorities are considered throughout. The undisputed gold standard in the field.
Madden Timothy L. Analytical Methods for Therapeutic Drug Monitoring and Toxicology Madden Timothy L. Analytical Methods for Therapeutic Drug Monitoring and Toxicology Новинка

Madden Timothy L. Analytical Methods for Therapeutic Drug Monitoring and Toxicology

14043.29 руб.
This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.
Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient Новинка

Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient

12804.35 руб.
Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
Harald Seitz Biomarker Validation. Technological, Clinical and Commercial Aspects Harald Seitz Biomarker Validation. Technological, Clinical and Commercial Aspects Новинка

Harald Seitz Biomarker Validation. Technological, Clinical and Commercial Aspects

12073.37 руб.
Built on a decade of experience with novel molecular diagnostics, this practice-oriented guide shows how to cope with validation issues during all stages of biomarker development, from the first clinical studies to the eventual commercialization of a new diagnostic test.
Guoping Wang Transfer Matrix Method for Multibody Systems. Theory and Applications Guoping Wang Transfer Matrix Method for Multibody Systems. Theory and Applications Новинка

Guoping Wang Transfer Matrix Method for Multibody Systems. Theory and Applications

14814.9 руб.
TRANSFER MATRIX METHOD FOR MULTIBODY SYSTEMS: THEORY AND APPLICATIONS Xiaoting Rui, Guoping Wang and Jianshu Zhang – Nanjing University of Science and Technology, China Featuring a new method of multibody system dynamics, this book introduces the transfer matrix method systematically for the first time. First developed by the lead author and his research team, this method has found numerous engineering and technological applications. Readers are first introduced to fundamental concepts like the body dynamics equation, augmented operator and augmented eigenvector before going in depth into precision analysis and computations of eigenvalue problems as well as dynamic responses. The book also covers a combination of mixed methods and practical applications in multiple rocket launch systems, self-propelled artillery as well as launch dynamics of on-ship weaponry. • Comprehensively introduces a new method of analyzing multibody dynamics for engineers • Provides a logical development of the transfer matrix method as applied to the dynamics of multibody systems that consist of interconnected bodies • Features varied applications in weaponry, aeronautics, astronautics, vehicles and robotics Written by an internationally renowned author and research team with many years' experience in multibody systems Transfer Matrix Method of Multibody System and Its Applications is an advanced level text for researchers and engineers in mechanical system dynamics. It is a comprehensive reference for advanced students and researchers in the related fields of aerospace, vehicle, robotics and weaponry engineering.
David Elder ICH Quality Guidelines. An Implementation Guide David Elder ICH Quality Guidelines. An Implementation Guide Новинка

David Elder ICH Quality Guidelines. An Implementation Guide

25608.71 руб.
Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. • Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies • Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implementation of ICH guidelines • Uses case studies to help readers understand and apply ICH guidelines • Provides valuable insights into guidelines development, with chapters by authors involved in generating or with experience implementing the guidelines • Includes coverage of stability testing, analytical method validation, impurities, biotechnology drugs and products, and good manufacturing practice (GMP)
Sean Ekins Predictive Approaches in Drug Discovery and Development. Biomarkers and In Vitro / In Vivo Correlations Sean Ekins Predictive Approaches in Drug Discovery and Development. Biomarkers and In Vitro / In Vivo Correlations Новинка

Sean Ekins Predictive Approaches in Drug Discovery and Development. Biomarkers and In Vitro / In Vivo Correlations

10975.16 руб.
Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Herbert W. Seliger Second Language Research Methods Herbert W. Seliger Second Language Research Methods Новинка

Herbert W. Seliger Second Language Research Methods

2765.94 руб.
Based on a set of four research parameters, this book discusses the development of research questions and hypotheses, naturalistic and experimental research, data collection, and validation of research instruments. Each chapter includes examples and activities.
Peter Blythe Attention, Balance and Coordination. The A.B.C. of Learning Success Peter Blythe Attention, Balance and Coordination. The A.B.C. of Learning Success Новинка

Peter Blythe Attention, Balance and Coordination. The A.B.C. of Learning Success

4248.45 руб.
An updated edition of the definitive handbook on the physical basis for learning for professionals involved in education and child development, written by the respected author of acclaimed titles in the field. A comprehensive overview of the relationship between neuromotor maturity and physical development on learning outcomes and behaviour in childhood and later life Explores why early reflexes are important, their functions in early development, their effects on learning and behavior if retained, and the possible effects on other aspects of development Brings together a specialist body of knowledge and makes it accessible to anyone involved in treating the symptoms of specific learning difficulties and emotional problems. Includes new information on the role of the vestibular system in anxiety and agoraphobia, a new chapter of case studies, and an Epilogue placing the INPP Method in a broader scientific context
Szabó Barna Introduction to Finite Element Analysis. Formulation, Verification and Validation Szabó Barna Introduction to Finite Element Analysis. Formulation, Verification and Validation Новинка

Szabó Barna Introduction to Finite Element Analysis. Formulation, Verification and Validation

9490.8 руб.
When using numerical simulation to make a decision, how can its reliability be determined? What are the common pitfalls and mistakes when assessing the trustworthiness of computed information, and how can they be avoided? Whenever numerical simulation is employed in connection with engineering decision-making, there is an implied expectation of reliability: one cannot base decisions on computed information without believing that information is reliable enough to support those decisions. Using mathematical models to show the reliability of computer-generated information is an essential part of any modelling effort. Giving users of finite element analysis (FEA) software an introduction to verification and validation procedures, this book thoroughly covers the fundamentals of assuring reliability in numerical simulation. The renowned authors systematically guide readers through the basic theory and algorithmic structure of the finite element method, using helpful examples and exercises throughout. Delivers the tools needed to have a working knowledge of the finite element method Illustrates the concepts and procedures of verification and validation Explains the process of conceptualization supported by virtual experimentation Describes the convergence characteristics of the h-, p- and hp-methods Covers the hierarchic view of mathematical models and finite element spaces Uses examples and exercises which illustrate the techniques and procedures of quality assurance Ideal for mechanical and structural engineering students, practicing engineers and applied mathematicians Includes parameter-controlled examples of solved problems in a companion website (www.wiley.com/go/szabo)
Litwin Virginia Flow Cytometry in Drug Discovery and Development Litwin Virginia Flow Cytometry in Drug Discovery and Development Новинка

Litwin Virginia Flow Cytometry in Drug Discovery and Development

10725.37 руб.
This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.
Dimiter Dimitrov M. Statistical Methods for Validation of Assessment Scale Data in Counseling and Related Fields Dimiter Dimitrov M. Statistical Methods for Validation of Assessment Scale Data in Counseling and Related Fields Новинка

Dimiter Dimitrov M. Statistical Methods for Validation of Assessment Scale Data in Counseling and Related Fields

5397.41 руб.
“Dr. Dimitrov has constructed a masterpiece—a classic resource that should adorn the shelf of every counseling researcher and graduate student serious about the construction and validation of high quality research instruments. —Bradley T. Erford, PhD Loyola University Maryland Past President, American Counseling Association “This book offers a comprehensive treatment of the statistical models and methods needed to properly examine the psychometric properties of assessment scale data. It is certain to become a definitive reference for both novice and experienced researchers alike.” —George A. Marcoulides, PhD University of California, Riverside This instructive book presents statistical methods and procedures for the validation of assessment scale data used in counseling, psychology, education, and related fields. In Part I, measurement scales, reliability, and the unified construct-based model of validity are discussed, along with key steps in instrument development. Part II describes factor analyses in construct validation, including exploratory factor analysis, confirmatory factor analysis, and models of multitrait-multimethod data analysis. Traditional and Rasch-based analyses of binary and rating scales are examined in Part III. Dr. Dimitrov offers students, researchers, and clinicians step-by-step guidance on contemporary methodological principles, statistical methods, and psychometric procedures that are useful in the development or validation of assessment scale data. Numerous examples, tables, and figures provided throughout the text illustrate the underlying principles of measurement in a clear and concise manner for practical application. *Requests for digital versions from the ACA can be found on wiley.com. *To request print copies, please visit the ACA website.
Dominique Bonneau Internal Combustion Engine Bearings Lubrication in Hydrodynamic Bearings Dominique Bonneau Internal Combustion Engine Bearings Lubrication in Hydrodynamic Bearings Новинка

Dominique Bonneau Internal Combustion Engine Bearings Lubrication in Hydrodynamic Bearings

10243.48 руб.
This Series provides the necessary elements to the development and validation of numerical prediction models for hydrodynamic bearings. This book with the specific case of internal combustion engine (ICE) journal bearing lubrication. Many examples, relating to various types of ICE, are presented.
Satinder Ahuja Chiral Separation Methods for Pharmaceutical and Biotechnological Products Satinder Ahuja Chiral Separation Methods for Pharmaceutical and Biotechnological Products Новинка

Satinder Ahuja Chiral Separation Methods for Pharmaceutical and Biotechnological Products

12191.43 руб.
Discusses chiral separations and offers guidance for selecting the optimum method for desired results Chiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds. This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development. Considering chiral separations in the biotechnological and pharmaceutical industries, as well as for food applications, Dr. Ahuja provides insights into a broad range of topics. Opening with a broad overview of chiral separations, regulatory considerations in drug product development, and basic issues in method development, the book: Covers a variety of modern methods such as gas chromatography, high performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity of small and large molecules Provides detailed information on useful chiral stationary phases (CSPs) for HPLC Includes handy information on selection of an appropriate CSP, including mechanistic studies Offers strategies for fast method development with HPLC, SFC, and CE Discusses preparatory methods utilized in the pharmaceutical industry With in-depth discussions of the current state of the field as well as suggestions to assist future developments, Chiral Separation Methods for Pharmaceutical and Biotechnological Products is an essential text for laboratory investigators, managers, and regulators who are involved in chiral separations in the pharmaceutical industry, as well as students preparing for careers in these fields.
Dominique Bonneau Thermo-hydrodynamic Lubrication in Hydrodynamic Bearings Dominique Bonneau Thermo-hydrodynamic Lubrication in Hydrodynamic Bearings Новинка

Dominique Bonneau Thermo-hydrodynamic Lubrication in Hydrodynamic Bearings

7166.83 руб.
This Series provides the necessary elements to the development and validation of numerical prediction models for hydrodynamic bearings. This book describes the thermo-hydrodynamic and the thermo-elasto-hydrodynamic lubrication. The algorithms are methodically detailed and each section is thoroughly illustrated.
Nicolas Larrieu Rapid Prototyping Software for Avionics Systems. Model-oriented Approaches for Complex Systems Certification Nicolas Larrieu Rapid Prototyping Software for Avionics Systems. Model-oriented Approaches for Complex Systems Certification Новинка

Nicolas Larrieu Rapid Prototyping Software for Avionics Systems. Model-oriented Approaches for Complex Systems Certification

7166.83 руб.
The design, implementation and validation of avionics and aeronautical systems have become extremely complex tasks due to the increase of functionalities that are deployed in current avionics systems and the need to be able certify them before putting them into production. This book proposes a methodology to enable the rapid prototyping of such a system by considering from the start the certification aspects of the solution produced. This method takes advantage of the model-based design approaches as well as the use of formal methods for the validation of these systems. Furthermore, the use of automatic software code generation tools using models makes it possible to reduce the development phase as well as the final solution testing. This book presents, firstly, an overview of the model-based design approaches such as those used in the field of aeronautical software engineering. Secondly, an original methodology that is perfectly adapted to the field of aeronautical embedded systems is introduced. Finally, the authors illustrate the use of this method using a case study for the design, implementation and testing of a new generation aeronautical router.
Marcin Kaminski The Stochastic Perturbation Method for Computational Mechanics Marcin Kaminski The Stochastic Perturbation Method for Computational Mechanics Новинка

Marcin Kaminski The Stochastic Perturbation Method for Computational Mechanics

11188.34 руб.
Probabilistic analysis is increasing in popularity and importance within engineering and the applied sciences. However, the stochastic perturbation technique is a fairly recent development and therefore remains as yet unknown to many students, researchers and engineers. Fields in which the methodology can be applied are widespread, including various branches of engineering, heat transfer and statistical mechanics, reliability assessment and also financial investments or economical prognosis in analytical and computational contexts. Stochastic Perturbation Method in Applied Sciences and Engineering is devoted to the theoretical aspects and computational implementation of the generalized stochastic perturbation technique. It is based on any order Taylor expansions of random variables and enables for determination of up to fourth order probabilistic moments and characteristics of the physical system response. Key features: Provides a grounding in the basic elements of statistics and probability and reliability engineering Describes the Stochastic Finite, Boundary Element and Finite Difference Methods, formulated according to the perturbation method Demonstrates dual computational implementation of the perturbation method with the use of Direct Differentiation Method and the Response Function Method Accompanied by a website (www.wiley.com/go/kaminski) with supporting stochastic numerical software Covers the computational implementation of the homogenization method for periodic composites with random and stochastic material properties Features case studies, numerical examples and practical applications Stochastic Perturbation Method in Applied Sciences and Engineering is a comprehensive reference for researchers and engineers, and is an ideal introduction to the subject for postgraduate and graduate students.
Pierre Saguet Numerical Analysis in Electromagnetics. The TLM Method Pierre Saguet Numerical Analysis in Electromagnetics. The TLM Method Новинка

Pierre Saguet Numerical Analysis in Electromagnetics. The TLM Method

8020.88 руб.
The aim of this book is to give a broad overview of the TLM (Transmission Line Matrix) method, which is one of the “time-domain numerical methods”. These methods are reputed for their significant reliance on computer resources. However, they have the advantage of being highly general. The TLM method has acquired a reputation for being a powerful and effective tool by numerous teams and still benefits today from significant theoretical developments. In particular, in recent years, its ability to simulate various situations with excellent precision, including complex materials, has been demonstrated. Application examples are included in the last two chapters of the book, enabling the reader to draw conclusions regarding the performance of the implemented techniques and, at the same time, to validate them. Contents 1. Basis of the TLM Method: the 2D TLM Method. 2. 3D Nodes. 3. Introduction of Discrete Elements and Thin Wires in the TLM Method. 4. The TLM Method in Matrix Form and the Z Transform. Appendix A. Development of Maxwell’s Equations using the Z Transform with a Variable Mesh. Appendix B. Treatment of Plasma using the Z Transform for the TLM Method.
Richard Lerner M. Handbook of Child Psychology and Developmental Science, Theory and Method Richard Lerner M. Handbook of Child Psychology and Developmental Science, Theory and Method Новинка

Richard Lerner M. Handbook of Child Psychology and Developmental Science, Theory and Method

16828.58 руб.
The essential reference for human development theory, updated and reconceptualized The Handbook of Child Psychology and Developmental Science, a four-volume reference, is the field-defining work to which all others are compared. First published in 1946, and now in its Seventh Edition, the Handbook has long been considered the definitive guide to the field of developmental science. Volume 1, Theory and Method, presents a rich mix of classic and contemporary theoretical perspectives, but the dominant views throughout are marked by an emphasis on the dynamic interplay of all facets of the developmental system across the life span, incorporating the range of biological, cognitive, emotional, social, cultural, and ecological levels of analysis. Examples of the theoretical approaches discussed in the volume include those pertinent to human evolution, self regulation, the development of dynamic skills, and positive youth development. The research, methodological, and applied implications of the theoretical models discussed in the volume are presented. Understand the contributions of biology, person, and context to development within the embodied ecological system Discover the relations among individual, the social world, culture, and history that constitute human development Examine the methods of dynamic, developmental research Learn person-oriented methodological approaches to assessing developmental change The scholarship within this volume and, as well, across the four volumes of this edition, illustrate that developmental science is in the midst of a very exciting period. There is a paradigm shift that involves increasingly greater understanding of how to describe, explain, and optimize the course of human life for diverse individuals living within diverse contexts. This Handbook is the definitive reference for educators, policy-makers, researchers, students, and practitioners in human development, psychology, sociology, anthropology, and neuroscience.
Abbie Griffin Open Innovation. New Product Development Essentials from the PDMA Abbie Griffin Open Innovation. New Product Development Essentials from the PDMA Новинка

Abbie Griffin Open Innovation. New Product Development Essentials from the PDMA

4390.06 руб.
A clear, practical guide to implementing Open Innovation for new product development Open Innovation: New Product Development Essentials from the PDMA is a comprehensive guide to the theory and practice of the Open Innovation method. Written by experts from the Product Development and Management Association, the book packages a collection of Open Innovation tools in a digestible and actionable format. Real-world case studies drawn from the authors' own successes and failures illustrate the concepts presented, providing accurate representation of the opportunities and challenges of Open Innovation implementation. Key tools are presented with a focus on immediate applications for business, allowing NPD professionals to easily discern where this cutting edge development method can push innovation forward. Open Innovation assumes that companies can and should use both internal and external ideas and paths to market, permeating the boundaries between firm and environment. Innovations transfer outward and inward through purchase, licensing, joint ventures, and spin-offs, allowing companies to expand beyond their own research and dramatically improve productivity through collaboration. PDMA Essentials provides practical guidance on exploiting the Open Innovation model to these ends, with clear guidance on all aspects of the new product development process. Topics include: Product platforming and idea competitions Customer immersion and interaction Collaborative product design and development Innovation networks, rewards, and incentives Many practitioners charged with innovation have only a vague understanding of the specific tools available for Open Innovation, and how they might be applied. As the marketplace shifts dramatically to keep pace with changing consumer behaviors, remaining relevant increasingly means ramping up innovation processes. PDMA Essentials provides the tools NPD practitioners need to implement a leading innovation method, and drive continued growth.
Mrityunjay Singh Design, Development, and Applications of Engineering Ceramics and Composites Mrityunjay Singh Design, Development, and Applications of Engineering Ceramics and Composites Новинка

Mrityunjay Singh Design, Development, and Applications of Engineering Ceramics and Composites

8926.6 руб.
This compilation of proceedings covering the latest scientific and technological developments in design, development, and applications of engineering ceramics and composites provides a useful one-stop resource for understanding the most important issues in design, development, and applications of engineering ceramics and composites. Logically organized and carefully selected articles give insight into design, development, and applications of engineering ceramics and composites and incorporates the latest developments related to design, development, and applications of engineering ceramics and composites including developments in engineering ceramics, advanced ceramic coatings, and geopolymers.
Kostas Nikolopoulos I. Forecasting With The Theta Method. Theory and Applications Kostas Nikolopoulos I. Forecasting With The Theta Method. Theory and Applications Новинка

Kostas Nikolopoulos I. Forecasting With The Theta Method. Theory and Applications

8333.38 руб.
The first book to be published on the Theta method, outlining under what conditions the method outperforms other forecasting methods This book is the first to detail the Theta method of forecasting – one of the most difficult-to-beat forecasting benchmarks, which topped the biggest forecasting competition in the world in 2000: the M3 competition. Written by two of the leading experts in the forecasting field, it illuminates the exact replication of the method and under what conditions the method outperforms other forecasting methods. Recent developments such as multivariate models are also included, as are a series of practical applications in finance, economics, and healthcare. The book also offers practical tools in MS Excel and guidance, as well as provisional access, for the use of R source code and respective packages. Forecasting with the Theta Method: Theory and Applications includes three main parts. The first part, titled Theory, Methods, Models & Applications details the new theory about the method. The second part, Applications & Performance in Forecasting Competitions, describes empirical results and simulations on the method. The last part roadmaps future research and also include contributions from another leading scholar of the method – Dr. Fotios Petropoulos. First ever book to be published on the Theta Method Explores new theory and exact conditions under which methods would outperform most forecasting benchmarks Clearly written with practical applications Employs R – open source code with all included implementations Forecasting with the Theta Method: Theory and Applications is a valuable tool for both academics and practitioners involved in forecasting and respective software development.
Jian Wang Chemical Analysis of Antibiotic Residues in Food Jian Wang Chemical Analysis of Antibiotic Residues in Food Новинка

Jian Wang Chemical Analysis of Antibiotic Residues in Food

9292.44 руб.
An insightful exploration of the key aspects concerning the chemical analysis of antibiotic residues in food The presence of excess residues from frequent antibiotic use in animals is not only illegal, but can pose serious health risks by contaminating products for human consumption such as meat and milk. Chemical Analysis of Antibiotic Residues in Food is a single-source reference for readers interested in the development of analytical methods for analyzing antibiotic residues in food. It covers themes that include quality assurance and quality control, antibiotic chemical properties, pharmacokinetics, metabolism, distribution, food safety regulations, and chemical analysis. In addition, the material presented includes background information valuable for understanding the choice of marker residue and target animal tissue to use for regulatory analysis. This comprehensive reference: Includes topics on general issues related to screening and confirmatory methods Presents updated information on food safety regulation based on routine screening and confirmatory methods, especially LC-MS Provides general guidance for method development, validation, and estimation of measurement uncertainty Chemical Analysis of Antibiotic Residues in Food is written and organized with a balance between practical use and theory to provide laboratories with a solid and reliable reference on antibiotic residue analysis. Thorough coverage elicits the latest scientific findings to assist the ongoing efforts toward refining analytical methods for producing safe foods of animal origin.
Chongmin Song The Scaled Boundary Finite Element Method. Introduction to Theory and Implementation Chongmin Song The Scaled Boundary Finite Element Method. Introduction to Theory and Implementation Новинка

Chongmin Song The Scaled Boundary Finite Element Method. Introduction to Theory and Implementation

9002.11 руб.
An informative look at the theory, computer implementation, and application of the scaled boundary finite element method This reliable resource, complete with MATLAB, is an easy-to-understand introduction to the fundamental principles of the scaled boundary finite element method. It establishes the theory of the scaled boundary finite element method systematically as a general numerical procedure, providing the reader with a sound knowledge to expand the applications of this method to a broader scope. The book also presents the applications of the scaled boundary finite element to illustrate its salient features and potentials. The Scaled Boundary Finite Element Method: Introduction to Theory and Implementation covers the static and dynamic stress analysis of solids in two and three dimensions. The relevant concepts, theory and modelling issues of the scaled boundary finite element method are discussed and the unique features of the method are highlighted. The applications in computational fracture mechanics are detailed with numerical examples. A unified mesh generation procedure based on quadtree/octree algorithm is described. It also presents examples of fully automatic stress analysis of geometric models in NURBS, STL and digital images. Written in lucid and easy to understand language by the co-inventor of the scaled boundary element method Provides MATLAB as an integral part of the book with the code cross-referenced in the text and the use of the code illustrated by examples Presents new developments in the scaled boundary finite element method with illustrative examples so that readers can appreciate the significant features and potentials of this novel method—especially in emerging technologies such as 3D printing, virtual reality, and digital image-based analysis The Scaled Boundary Finite Element Method: Introduction to Theory and Implementation is an ideal book for researchers, software developers, numerical analysts, and postgraduate students in many fields of engineering and science.
Young Daniel L. Systems Biology in Drug Discovery and Development Young Daniel L. Systems Biology in Drug Discovery and Development Новинка

Young Daniel L. Systems Biology in Drug Discovery and Development

9799.44 руб.
The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.
Ming-Li Shiu Quality Strategy for Research and Development Ming-Li Shiu Quality Strategy for Research and Development Новинка

Ming-Li Shiu Quality Strategy for Research and Development

8634.35 руб.
Provides a clear, useful framework and methods for R&D, including robust technology development, product planning, and product design and development management Quality Strategy for Research and Development integrates the Japanese and Western perspectives on Quality Function Deployment (QFD), updates the strategy of Robust Engineering (RE), and relates their unique frameworks to current, widely adopted philosophies of quality assurance. Featuring real-world case studies, more than thirty tables, and over seventy figures, this essential guide identifies key issues and proposes improvements in the current R&D paradigm. It offers in-depth coverage of technology development, product planning, and product design and development management. Quality Strategy for Research and Development: Updates the conventional approaches to QFD and RE, and provides the implementation model of combining them into a corporate operating system Identifies key issues in the current practice of R&D, and provides solutions for improving design quality and R&D productivity Includes the case studies of designing a functional circuit, magnetic component, measurement system, and machining equipment Offers the integration models of QFD and other breakthrough strategies including DFX (Design For eXcellence), DFSS (Design For Six Sigma), and Blue Ocean Strategy Written for R&D executives, managers, engineers, and quality practitioners, Quality Strategy for Research and Development is also an ideal text for professors and students of industrial and systems engineering, technology management, and business administration.
Dirk Kroese P. Simulation and the Monte Carlo Method Dirk Kroese P. Simulation and the Monte Carlo Method Новинка

Dirk Kroese P. Simulation and the Monte Carlo Method

9512.5 руб.
This accessible new edition explores the major topics in Monte Carlo simulation that have arisen over the past 30 years and presents a sound foundation for problem solving Simulation and the Monte Carlo Method, Third Edition reflects the latest developments in the field and presents a fully updated and comprehensive account of the state-of-the-art theory, methods and applications that have emerged in Monte Carlo simulation since the publication of the classic First Edition over more than a quarter of a century ago. While maintaining its accessible and intuitive approach, this revised edition features a wealth of up-to-date information that facilitates a deeper understanding of problem solving across a wide array of subject areas, such as engineering, statistics, computer science, mathematics, and the physical and life sciences. The book begins with a modernized introduction that addresses the basic concepts of probability, Markov processes, and convex optimization. Subsequent chapters discuss the dramatic changes that have occurred in the field of the Monte Carlo method, with coverage of many modern topics including: Markov Chain Monte Carlo, variance reduction techniques such as importance (re-)sampling, and the transform likelihood ratio method, the score function method for sensitivity analysis, the stochastic approximation method and the stochastic counter-part method for Monte Carlo optimization, the cross-entropy method for rare events estimation and combinatorial optimization, and application of Monte Carlo techniques for counting problems. An extensive range of exercises is provided at the end of each chapter, as well as a generous sampling of applied examples. The Third Edition features a new chapter on the highly versatile splitting method, with applications to rare-event estimation, counting, sampling, and optimization. A second new chapter introduces the stochastic enumeration method, which is a new fast sequential Monte Carlo method for tree search. In addition, the Third Edition features new material on: • Random number generation, including multiple-recursive generators and the Mersenne Twister • Simulation of Gaussian processes, Brownian motion, and diffusion processes • Multilevel Monte Carlo method • New enhancements of the cross-entropy (CE) method, including the “improved” CE method, which uses sampling from the zero-variance distribution to find the optimal importance sampling parameters • Over 100 algorithms in modern pseudo code with flow control • Over 25 new exercises Simulation and the Monte Carlo Method, Third Edition is an excellent text for upper-undergraduate and beginning graduate courses in stochastic simulation and Monte Carlo techniques. The book also serves as a valuable reference for professionals who would like to achieve a more formal understanding of the Monte Carlo method. Reuven Y. Rubinstein, DSc, was Professor Emeritus in the Faculty of Industrial Engineering and Management at Technion-Israel Institute of Technology. He served as a consultant at numerous large-scale organizations, such as IBM, Motorola, and NEC. The author of over 100 articles and six books, Dr. Rubinstein was also the inventor of the popular score-function method in simulation analysis and generic cross-entropy methods for combinatorial optimization and counting. Dirk P. Kroese, PhD, is a Professor of Mathematics and Statistics in the School of Mathematics and Physics of The University of Queensland, Australia. He has published over 100 articles and four books in a wide range of areas in applied probability and statistics, including Monte Carlo methods, cross-entropy, randomized algorithms, tele-traffic c theory, reliability, computational statistics, applied probability, and stochastic modeling.
Dominique Bonneau Hydrodynamic Bearings Dominique Bonneau Hydrodynamic Bearings Новинка

Dominique Bonneau Hydrodynamic Bearings

8706.54 руб.
This Series provides the necessary elements to the development and validation of numerical prediction models for hydrodynamic bearings. This book describes the rheological models and the equations of lubrication. It also presents the numerical approaches used to solve the above equations by finite differences, finite volumes and finite elements methods.
Nicolae-Doru Stanescu Classical and Modern Approaches in the Theory of Mechanisms Nicolae-Doru Stanescu Classical and Modern Approaches in the Theory of Mechanisms Новинка

Nicolae-Doru Stanescu Classical and Modern Approaches in the Theory of Mechanisms

8746.81 руб.
Classical and Modern Approaches in the Theory of Mechanisms is a study of mechanisms in the broadest sense, covering the theoretical background of mechanisms, their structures and components, the planar and spatial analysis of mechanisms, motion transmission, and technical approaches to kinematics, mechanical systems, and machine dynamics. In addition to classical approaches, the book presents two new methods: the analytic-assisted method using Turbo Pascal calculation programs, and the graphic-assisted method, outlining the steps required for the development of graphic constructions using AutoCAD; the applications of these methods are illustrated with examples. Aimed at students of mechanical engineering, and engineers designing and developing mechanisms in their own fields, this book provides a useful overview of classical theories, and modern approaches to the practical and creative application of mechanisms, in seeking solutions to increasingly complex problems.
Robert Gibbs J. Principles of Urban Retail Planning and Development Robert Gibbs J. Principles of Urban Retail Planning and Development Новинка

Robert Gibbs J. Principles of Urban Retail Planning and Development

6558.68 руб.
…Extraordinary: Gibbs has popped the hood and taken apart the engine of commercial design and development, showing us each individual part and explaining fit, form and function. —Yaromir Steiner, Founder, Chief Executive Officer, Steiner + Associates «…the most comprehensive and expansive book ever written on the subject of Retail Real Estate Development. Gibbs is by far the most prominent advocate for reforming retail planning and development in order to return American cities to economic and physical prominence.» –Stefanos Polyzoides, Moule & Polyzoides Architects & Urbanists The retail environment has evolved rapidly in the past few decades, with the retailing industry and its placement and design of «brick-and-mortar» locations changing with evolving demographics, shopping behavior, transportation options and a desire in recent years for more unique shopping environments. Written by a leading expert, this is a guide to planning for retail development for urban planners, urban designers and architects. It includes an overview of history of retail design, a look at retail and merchandising trends, and principles for current retail developments. Principles of Urban Retail Planning and Development will: Provide insight and techniques necessary for historic downtowns and new urban communities to compete with modern suburban shopping centers. Promote sustainable community building and development by making it more profitable for the shopping center industry to invest in historic cities or to develop walkable urban communities. Includes case studies of recent good examples of retail development
Claudio Carini Biomarkers in Drug Development. A Handbook of Practice, Application, and Strategy Claudio Carini Biomarkers in Drug Development. A Handbook of Practice, Application, and Strategy Новинка

Claudio Carini Biomarkers in Drug Development. A Handbook of Practice, Application, and Strategy

14926.49 руб.
Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.
Guomin Shan Immunoassays in Agricultural Biotechnology Guomin Shan Immunoassays in Agricultural Biotechnology Новинка

Guomin Shan Immunoassays in Agricultural Biotechnology

11342.66 руб.
A very broad range of professionals are using immunoassay technology daily to analyze genetically engineered (GE) crops and related areas, and many of these professionals are completely new to this technology. There is a great need for users to have a book containing technical and practical guidance, and describing limitations and pitfalls of applying immunoassay in agricultural biotechnology. This book focuses on the application of immunoassays to GE plants and related areas. A group of international experts from government agencies, academics and industries, who have many years of related experience, contribute high quality chapters in their areas of expertise. This book covers topics including principles of immunoassay, antibody engineering in AgBiotech, current technologies (formats, kit development, manufacturing and quality control), method validation, applications in trait discovery and product development, applications in grain products and food processing, applications in environmental monitoring, automation and high throughput, reference materials, data interpretation and source of error, and future perspectives and challenges. In addition, to meet the practical needs for a variety of readers from different backgrounds, methods and protocols are included as well.
Dominique Bonneau Mixed Lubrication in Hydrodynamic Bearings Dominique Bonneau Mixed Lubrication in Hydrodynamic Bearings Новинка

Dominique Bonneau Mixed Lubrication in Hydrodynamic Bearings

8706.54 руб.
This Series provides the necessary elements to the development and validation of numerical prediction models for hydrodynamic bearings. This book is dedicated to the mixed lubrication.
R. Sugirtharajah S. Exploring Postcolonial Biblical Criticism. History, Method, Practice R. Sugirtharajah S. Exploring Postcolonial Biblical Criticism. History, Method, Practice Новинка

R. Sugirtharajah S. Exploring Postcolonial Biblical Criticism. History, Method, Practice

7789.4 руб.
Exploring Postcolonial Biblical Criticism: History, Method, Practice offers a concise and multifaceted overview of the origins, development, and application of postcolonial criticism to biblical studies.? Offers a concise and accessible introduction to postcolonial biblical studies Provides a comprehensive overview of postcolonial studies by one of the field's most prominent figures Explains one of the most innovative and important developments in modern biblical studies Accessible enough to appeal to general readers interested in religion
Perumal Nithiarasu Fundamentals of the Finite Element Method for Heat and Mass Transfer Perumal Nithiarasu Fundamentals of the Finite Element Method for Heat and Mass Transfer Новинка

Perumal Nithiarasu Fundamentals of the Finite Element Method for Heat and Mass Transfer

7683.31 руб.
Fundamentals of the Finite Element Method for Heat and Mass Transfer, Second Edition is a comprehensively updated new edition and is a unique book on the application of the finite element method to heat and mass transfer. • Addresses fundamentals, applications and computer implementation • Educational computer codes are freely available to download, modify and use • Includes a large number of worked examples and exercises • Fills the gap between learning and research
Ulrich Mueller Handbook of Child Psychology and Developmental Science, Cognitive Processes Ulrich Mueller Handbook of Child Psychology and Developmental Science, Cognitive Processes Новинка

Ulrich Mueller Handbook of Child Psychology and Developmental Science, Cognitive Processes

16828.58 руб.
The essential reference for human development theory, updated and reconceptualized The Handbook of Child Psychology and Developmental Science, a four-volume reference, is the field-defining work to which all others are compared. First published in 1946, and now in its Seventh Edition, the Handbook has long been considered the definitive guide to the field of developmental science. Volume 2: Cognitive Processes describes cognitive development as a relational phenomenon that can be studied only as part of a larger whole of the person and context relational system that sustains it. In this volume, specific domains of cognitive development are contextualized with respect to biological processes and sociocultural contexts. Furthermore, key themes and issues (e.g., the importance of symbolic systems and social understanding) are threaded across multiple chapters, although every each chapter is focused on a different domain within cognitive development. Thus, both within and across chapters, the complexity and interconnectivity of cognitive development are well illuminated. Learn about the inextricable intertwining of perceptual development, motor development, emotional development, and brain development Understand the complexity of cognitive development without misleading simplification, reducing cognitive development to its biological substrates, or viewing it as a passive socialization process Discover how each portion of the developmental process contributes to subsequent cognitive development Examine the multiple processes – such as categorizing, reasoning, thinking, decision making and judgment – that comprise cognition The scholarship within this volume and, as well, across the four volumes of this edition, illustrate that developmental science is in the midst of a very exciting period. There is a paradigm shift that involves increasingly greater understanding of how to describe, explain, and optimize the course of human life for diverse individuals living within diverse contexts. This Handbook is the definitive reference for educators, policy-makers, researchers, students, and practitioners in human development, psychology, sociology, anthropology, and neuroscience.
Jocelyn Berard Accelerating Leadership Development. Practical Solutions for Building Your Organization's Potential Jocelyn Berard Accelerating Leadership Development. Practical Solutions for Building Your Organization's Potential Новинка

Jocelyn Berard Accelerating Leadership Development. Practical Solutions for Building Your Organization's Potential

2375.91 руб.
Proven strategies and innovative solutions for developing and retaining successful leaders Many organizations today are facing a crisis of leadership. As the Baby Boomer generation exits the workforce, companies are struggling to find qualified leaders to fill critical roles. Accelerating Leadership Development offers solutions for leadership development, management, and retention from award-winning development firm Global Knowledge. Accelerating Leadership Development provides a proven model to help companies develop high-potential employees with the competencies and knowledge capital to assume critical roles successfully. It includes practical and rigorous tools that enable organizations to identify targets and predict those targets' success with six measurable factors. With this proven development system, companies can develop a pipeline of ready leaders with high levels of engagement and retention. Features actionable, effective principles and strategies for leadership development using a results-oriented framework Chapters address communication and delegation strategies, effective feedback models, shifting of responsibility and accountability to direct reports, and contemporary coaching and development approaches Based on in-depth research and client interactions from one of the most prominent names in workforce development For any business that experiences a leadership failure or a lack of qualified leaders for vital positions, the consequences can be devastating. This practical and effective guide to leadership development offers real solutions for long-term excellence.
Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment Новинка

Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment

9654.81 руб.
Urban Remote Sensing is designed for upper level undergraduates, graduates, researchers and practitioners, and has a clear focus on the development of remote sensing technology for monitoring, synthesis and modeling in the urban environment. It covers four major areas: the use of high-resolution satellite imagery or alternative sources of image date (such as high-resolution SAR and LIDAR) for urban feature extraction; the development of improved image processing algorithms and techniques for deriving accurate and consistent information on urban attributes from remote sensor data; the development of analytical techniques and methods for deriving indicators of socioeconomic and environmental conditions that prevail within urban landscape; and the development of remote sensing and spatial analytical techniques for urban growth simulation and predictive modeling.
Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment Новинка

Xiaojun Yang Urban Remote Sensing. Monitoring, Synthesis and Modeling in the Urban Environment

10181.39 руб.
Urban Remote Sensing is designed for upper level undergraduates, graduates, researchers and practitioners, and has a clear focus on the development of remote sensing technology for monitoring, synthesis and modeling in the urban environment. It covers four major areas: the use of high-resolution satellite imagery or alternative sources of image date (such as high-resolution SAR and LIDAR) for urban feature extraction; the development of improved image processing algorithms and techniques for deriving accurate and consistent information on urban attributes from remote sensor data; the development of analytical techniques and methods for deriving indicators of socioeconomic and environmental conditions that prevail within urban landscape; and the development of remote sensing and spatial analytical techniques for urban growth simulation and predictive modeling.
Gerhard Girmscheid Bauprozesse und Bauverfahren des Tunnelbaus Gerhard Girmscheid Bauprozesse und Bauverfahren des Tunnelbaus Новинка

Gerhard Girmscheid Bauprozesse und Bauverfahren des Tunnelbaus

10496.17 руб.
The successful completion of a tunnelling project depends on the choice of a construction method and the operational development. In this book, tunnelling methods and all the operational working steps are explained, starting from the geological situation.
Stavros Kromidas The HPLC-MS Handbook for Practitioners Stavros Kromidas The HPLC-MS Handbook for Practitioners Новинка

Stavros Kromidas The HPLC-MS Handbook for Practitioners

8048.45 руб.
Filling the gap for an expert text dealing exclusively with the practical aspects of HPLC-MS coupling, this concise, compact, and clear book provides detailed information to enable users to employ the method most efficiently. Following an overview of the current state of HPLC-MS and its instrumentation, the text goes on to discuss all relevant aspects of method development. A chapter on tips and tricks is followed by user reports on the advantages – and pitfalls – of applying the method in real-life scenarios. The whole is rounded off by a look at future developments by renowned manufacturers.
Stanley Weiss I. Product and Systems Development. A Value Approach Stanley Weiss I. Product and Systems Development. A Value Approach Новинка

Stanley Weiss I. Product and Systems Development. A Value Approach

7789.4 руб.
A thorough treatment of product and systems development in terms of value to all stakeholders Product and Systems Development compiles more than twenty years of research and practice from a value perspective, from vision and marketing to design, manufacturing, delivery, operations, and maintenance. It defines stakeholder value and identifies specific stakeholders in the product and system development process; covers best practices in development; and examines systems engineering, current industry views, and the life cycle of a value stream. Featuring appendices written by professionals in the field on topics such as Design Structure Matrices, Lean Enablers for systems engineering, and MDAO and simulations, this indispensable guide: Explains why stakeholders' values can hold the key to fulfillment or defeat of the developer's vision Emphasizes the succession of value-contributing practices and tools that form a framework for development success Integrates the technical, productivity, and customer/end-user elements in product and system development Uses more than 100 tables and figures to illustrate the above processes, as well as corollary elements of risk, failure analysis, and fault-tolerant design Includes numerous case studies and links to online material Product and Systems Development is an excellent coursebook for senior and graduate students in aerospace, mechanical, civil, electrical, and material engineering, as well as management science and engineering. It is also a useful reference for practicing engineers in a variety of technology-based industries.
Anatoly Legtchenko Magnetic Resonance Imaging for Groundwater Anatoly Legtchenko Magnetic Resonance Imaging for Groundwater Новинка

Anatoly Legtchenko Magnetic Resonance Imaging for Groundwater

7386.19 руб.
This book presents the basics of the non-invasive geophysical method for groundwater investigation, called Magnetic Resonance Sounding (MRS) or Surface Nuclear Magnetic Resonance (SNMR), and its practical application to the problems of groundwater localization and aquifer characterization. The method is based on the nuclear magnetic resonance (NMR) phenomenon and is selectively sensitive to groundwater. The main aims of the author are to teach the reader the basic principles of the method as well as to formulate consistent approximate models, leading to reasonably simple inverse problems. Containing an extensive bibliography, numerous practical and numerical examples as well as a detailed presentation of the nuts and bolts of the method based on the long-term experience of SNMR development and practical use, this book is useful for students, scientists and professional engineers working in the field of hydrogeophysics and hydrogeology. Contents 1. SNMR Imaging for Groundwater. 2. The Basics of NMR. 3. Forward Modeling. 4. Inversion. 5. Link Between SNMR and Aquifer Parameters.
Patrizia Lombardi Future Challenges in Evaluating and Managing Sustainable Development in the Built Environment Patrizia Lombardi Future Challenges in Evaluating and Managing Sustainable Development in the Built Environment Новинка

Patrizia Lombardi Future Challenges in Evaluating and Managing Sustainable Development in the Built Environment

10975.16 руб.
Future Challenges in Sustainable Development within the Built Environment stimulates and reinterprets the demands of Responsible and Sustainable Development in the Built Environment for future action and development. It examines the methods of evaluation, the use of technology, the creation of new models and the role of human factors for examining and developing the subject over the next twenty years.
Wu Shen R. Introduction to the Explicit Finite Element Method for Nonlinear Transient Dynamics Wu Shen R. Introduction to the Explicit Finite Element Method for Nonlinear Transient Dynamics Новинка

Wu Shen R. Introduction to the Explicit Finite Element Method for Nonlinear Transient Dynamics

10571.05 руб.
A systematic introduction to the theories and formulations of the explicit finite element method As numerical technology continues to grow and evolve with industrial applications, understanding the explicit finite element method has become increasingly important, particularly in the areas of crashworthiness, metal forming, and impact engineering. Introduction to the Explicit Finite Element Method for Nonlinear Transient Dynamics is the first book to address specifically what is now accepted as the most successful numerical tool for nonlinear transient dynamics. The book aids readers in mastering the explicit finite element method and programming code without requiring extensive background knowledge of the general finite element. The authors present topics relating to the variational principle, numerical procedure, mechanical formulation, and fundamental achievements of the convergence theory. In addition, key topics and techniques are provided in four clearly organized sections: • Fundamentals explores a framework of the explicit finite element method for nonlinear transient dynamics and highlights achievements related to the convergence theory • Element Technology discusses four-node, three-node, eight-node, and two-node element theories • Material Models outlines models of plasticity and other nonlinear materials as well as the mechanics model of ductile damage • Contact and Constraint Conditions covers subjects related to three-dimensional surface contact, with examples solved analytically, as well as discussions on kinematic constraint conditions Throughout the book, vivid figures illustrate the ideas and key features of the explicit finite element method. Examples clearly present results, featuring both theoretical assessments and industrial applications. Introduction to the Explicit Finite Element Method for Nonlinear Transient Dynamics is an ideal book for both engineers who require more theoretical discussions and for theoreticians searching for interesting and challenging research topics. The book also serves as an excellent resource for courses on applied mathematics, applied mechanics, and numerical methods at the graduate level.
Kenneth Kahn B. The PDMA Handbook of New Product Development Kenneth Kahn B. The PDMA Handbook of New Product Development Новинка

Kenneth Kahn B. The PDMA Handbook of New Product Development

10416.73 руб.
New Product Development is one of the most important challenges facing organizations today. The Product Development and Management Association (PDMA) Handbook of New Product Development 3rd Edition provides an exceptional review of cutting edge topics for both new and experienced product development leaders. It offers a comprehensive and updated guide to the practices, processes and tools critical to achieving and sustaining new product/service development success in today’s world, delivering valuable information about the fundamentals as well as emerging practices such as venturing, virtual product development and the use of social media in NPD. As the premier global advocate for professionals and organizations working in the fields of new product/service development, PDMA has assembled in the Handbook unique content on the critical aspects of product development success including its 2012 Best Practices Research, Lessons Learned from its Outstanding Corporate Innovator Award Winners and keys to success from organizations with proven innovation track records. The 3rd Edition is an essential reference for anyone with responsibility for product development activities, from novices looking for fundamentals to experts seeking insights on emerging concepts, and is relevant for all functions and all product/service industries.
J. Mahan Robert The Monte Carlo Ray-Trace Method in Radiation Heat Transfer and Applied Optics J. Mahan Robert The Monte Carlo Ray-Trace Method in Radiation Heat Transfer and Applied Optics Новинка

J. Mahan Robert The Monte Carlo Ray-Trace Method in Radiation Heat Transfer and Applied Optics

12963.04 руб.
A groundbreaking guide dedicated exclusively to the MCRT method in radiation heat transfer and applied optics The Monte Carlo Ray-Trace Method in Radiation Heat Transfer and Applied Optics offers the most modern and up-to-date approach to radiation heat transfer modelling and performance evaluation of optical instruments. The Monte Carlo ray-trace (MCRT) method is based on the statistically predictable behavior of entities, called rays, which describe the paths followed by energy bundles as they are emitted, reflected, scattered, refracted, diffracted and ultimately absorbed. The author – a noted expert on the subject – covers a wide variety of topics including the mathematics and statistics of ray tracing, the physics of thermal radiation, basic principles of geometrical and physical optics, radiant heat exchange among surfaces and within participating media, and the statistical evaluation of uncertainty of results obtained using the method. The book is a guide to help formulate and solve models that accurately describe the distribution of radiant energy in thermal and optical systems of practical engineering interest. This important guide: Combines radiation heat transfer and applied optics into a single discipline Covers the MCRT method, which has emerged as the dominant tool for radiation heat transfer modelling Helps readers to formulate and solve models that describe the distribution of radiant energy Features pages of color images and a wealth of line drawings Written for faculty and graduate students in mechanical and aerospace engineering and applied optics professionals, The Monte Carlo Ray-Trace Method in Radiation Heat Transfer and Applied Optics is the first book dedicated exclusively to the MCRT method.
S. P. Peca Real Estate Development and Investment. A Comprehensive Approach S. P. Peca Real Estate Development and Investment. A Comprehensive Approach Новинка

S. P. Peca Real Estate Development and Investment. A Comprehensive Approach

7716.1 руб.
Real Estate Development and Investment A Comprehensive Approach Written by real estate industry veteran Stephen Peca, this timely guide skillfully outlines the various phases of the real estate development process and addresses some of the most important issues associated with this discipline. Using numerous illustrations and anecdotes, this book takes you through the development process, from historical considerations and idea formulation to financial feasibility and asset disposition, while covering the entire cycle of real estate development for various property types. Topics touched upon throughout these pages include: The key factors affecting demand for different land uses and development The interaction of market research, financing, planning, contract negotiation, marketing, leasing, and property management The need for universal, current, and broad knowledge The importance of ethics in the development process The role of different professionals and companies involved in the development process Environmental considerations in real estate development And much more Filled with in-depth insights and practical advice, this reliable resource will help you gain a firm understanding of the functional skills necessary to be successful in this field and familiarize you with several often-overlooked-but essential aspects of commercial real estate development.
Haikady Nagaraja N. Measuring Agreement. Models, Methods, and Applications Haikady Nagaraja N. Measuring Agreement. Models, Methods, and Applications Новинка

Haikady Nagaraja N. Measuring Agreement. Models, Methods, and Applications

8414.29 руб.
Presents statistical methodologies for analyzing common types of data from method comparison experiments and illustrates their applications through detailed case studies Measuring Agreement: Models, Methods, and Applications features statistical evaluation of agreement between two or more methods of measurement of a variable with a primary focus on continuous data. The authors view the analysis of method comparison data as a two-step procedure where an adequate model for the data is found, and then inferential techniques are applied for appropriate functions of parameters of the model. The presentation is accessible to a wide audience and provides the necessary technical details and references. In addition, the authors present chapter-length explorations of data from paired measurements designs, repeated measurements designs, and multiple methods; data with covariates; and heteroscedastic, longitudinal, and categorical data. The book also: • Strikes a balance between theory and applications • Presents parametric as well as nonparametric methodologies • Provides a concise introduction to Cohen’s kappa coefficient and other measures of agreement for binary and categorical data • Discusses sample size determination for trials on measuring agreement • Contains real-world case studies and exercises throughout • Provides a supplemental website containing the related datasets and R code Measuring Agreement: Models, Methods, and Applications is a resource for statisticians and biostatisticians engaged in data analysis, consultancy, and methodological research. It is a reference for clinical chemists, ecologists, and biomedical and other scientists who deal with development and validation of measurement methods. This book can also serve as a graduate-level text for students in statistics and biostatistics.
Ramm Alexander G. Dynamical Systems Method and Applications. Theoretical Developments and Numerical Examples Ramm Alexander G. Dynamical Systems Method and Applications. Theoretical Developments and Numerical Examples Новинка

Ramm Alexander G. Dynamical Systems Method and Applications. Theoretical Developments and Numerical Examples

12037.11 руб.
Demonstrates the application of DSM to solve a broad range of operator equations The dynamical systems method (DSM) is a powerful computational method for solving operator equations. With this book as their guide, readers will master the application of DSM to solve a variety of linear and nonlinear problems as well as ill-posed and well-posed problems. The authors offer a clear, step-by-step, systematic development of DSM that enables readers to grasp the method's underlying logic and its numerous applications. Dynamical Systems Method and Applications begins with a general introduction and then sets forth the scope of DSM in Part One. Part Two introduces the discrepancy principle, and Part Three offers examples of numerical applications of DSM to solve a broad range of problems in science and engineering. Additional featured topics include: General nonlinear operator equations Operators satisfying a spectral assumption Newton-type methods without inversion of the derivative Numerical problems arising in applications Stable numerical differentiation Stable solution to ill-conditioned linear algebraic systems Throughout the chapters, the authors employ the use of figures and tables to help readers grasp and apply new concepts. Numerical examples offer original theoretical results based on the solution of practical problems involving ill-conditioned linear algebraic systems, and stable differentiation of noisy data. Written by internationally recognized authorities on the topic, Dynamical Systems Method and Applications is an excellent book for courses on numerical analysis, dynamical systems, operator theory, and applied mathematics at the graduate level. The book also serves as a valuable resource for professionals in the fields of mathematics, physics, and engineering.
Jean-François Sigrist Fluid-Structure Interaction. An Introduction to Finite Element Coupling Jean-François Sigrist Fluid-Structure Interaction. An Introduction to Finite Element Coupling Новинка

Jean-François Sigrist Fluid-Structure Interaction. An Introduction to Finite Element Coupling

7497.26 руб.
Fluid-Structure Interaction: An Introduction to Finite Element Coupling fulfils the need for an introductive approach to the general concepts of Finite and Boundary Element Methods for FSI, from the mathematical formulation to the physical interpretation of numerical simulations. Based on the author’s experience in developing numerical codes for industrial applications in shipbuilding and in teaching FSI to both practicing engineers and within academia, it provides a comprehensive and self–contained guide that is geared toward both students and practitioners of mechanical engineering. Composed of six chapters, Fluid–Structure Interaction: An Introduction to Finite Element Coupling progresses logically from formulations and applications involving structure and fluid dynamics, fluid and structure interactions and opens to reduced order-modelling for vibro-acoustic coupling. The author describes simple yet fundamental illustrative examples in detail, using analytical and/or semi–analytical formulation & designed both to illustrate each numerical method and also to highlight a physical aspect of FSI. All proposed examples are simple enough to be computed by the reader using standard computational tools such as MATLAB, making the book a unique tool for self–learning and understanding the basics of the techniques for FSI, or can serve as verification and validation test cases of industrial FEM/BEM codes rendering the book valuable for code verification and validation purposes.
Marion Werner Global Displacements. The Making of Uneven Development in the Caribbean Marion Werner Global Displacements. The Making of Uneven Development in the Caribbean Новинка

Marion Werner Global Displacements. The Making of Uneven Development in the Caribbean

6947.46 руб.
Challenging the main ways we debate globalization, Global Displacements reveals how uneven geographies of capitalist development shape—and are shaped by—the aspirations and everyday struggles of people in the global South. Makes an original contribution to the study of globalization by bringing together critical development and feminist theoretical approaches Opens up new avenues for the analysis of global production as a long-term development strategy Contributes novel theoretical insights drawn from the everyday experiences of disinvestment and precarious work on people’s lives and their communities Represents the first analysis of increasing uneven development among countries in the Caribbean Calls for more rigorous studies of long accepted notions of the geographies of inequality and poverty in the global South
Michael Brazzel The NTL Handbook of Organization Development and Change. Principles, Practices, and Perspectives Michael Brazzel The NTL Handbook of Organization Development and Change. Principles, Practices, and Perspectives Новинка

Michael Brazzel The NTL Handbook of Organization Development and Change. Principles, Practices, and Perspectives

9951.23 руб.
The NTL Handbook of Organization Development and Change, Second Edition The NTL Handbook of Organization Development and Change is a vital tool for anyone who wants to know how to effectively bring about meaningful and sustainable change in organizations—even in the state of turbulence and complexity that today’s organizations encounter. Featuring contributions from leading practitioners and scholars in the field, each chapter explores a key aspect of organization development. In this new edition, each of the 34 chapters has been revised in response to recommendations from the contributors and NTL members. “These 34 chapters articulate exactly what grounds organization development! Issues and perspectives involving training, groups, practice, and the global world are current and thought provoking.” —Therese F. Yaeger Ph.D., professor, OB/OD Department, College of Business, Benedictine University “There is no other source that offers such a rich array of the most current and future-thinking topics from so many leaders in the field.” —Robert Gass, Ed.D., co-founder, Rockwood Leadership Institute “The editors accomplish the difficult task of including theory, concept, and method that will appeal to the academic community as well as those who are focused on being an effective practitioner.” —John D. Carter, Ph.D., president, Gestalt OSD Center
Wolfram Weckwerth Metabolomics in Practice. Successful Strategies to Generate and Analyze Metabolic Data Wolfram Weckwerth Metabolomics in Practice. Successful Strategies to Generate and Analyze Metabolic Data Новинка

Wolfram Weckwerth Metabolomics in Practice. Successful Strategies to Generate and Analyze Metabolic Data

9512.5 руб.
Unlike other handbooks in this emerging field, this guide focuses on the challenges and critical parameters in running a metabolomics study, including such often-neglected issues as sample preparation, choice of separation and detection method, recording and evaluating data as well as method validation. By systematically covering the entire workflow, from sample preparation to data processing, the insight and advice offered here helps to clear the hurdles in setting up and running a successful analysis, resulting in high-quality data from every experiment. Based on more than a decade of practical experience in developing, optimizing and validating metabolomics approaches as a routine technology in the academic and industrial research laboratory, the lessons taught here are highly relevant for all systems-level approaches, whether in systems biology, biotechnology, toxicology or pharmaceutical sciences. From the Contents: * Sampling and Sample Preparation in Microbial Metabolomics * Tandem Mass Spectrometry Hyphenated with HPLC and UHPLC for Targeted Metabolomics * GC-MS, LC-MS, CE-MS and Ultrahigh Resolution MS (FTICR-MS) in Metabolomics * NMR-based metabolomics analysis * Potential of Microfluidics and Single Cell Analysis in Metabolomics * Data Processing in Metabolomics * Validation and Measurement Uncertainty in Metabolomic Studies * Metabolomics and its Role in the Study of Mammalian Systems and in Plant Sciences * Metabolomics in Biotechnology and Nutritional Metabolomics and more.
Jozo Dujmović Soft Computing Evaluation Logic. The LSP Decision Method and Its Applications Jozo Dujmović Soft Computing Evaluation Logic. The LSP Decision Method and Its Applications Новинка

Jozo Dujmović Soft Computing Evaluation Logic. The LSP Decision Method and Its Applications

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A novel approach to decision engineering, with a verified framework for modeling human reasoning Soft Computing Evaluation Logic provides an in-depth examination of evaluation decision problems and presents comprehensive guidance toward the use of the Logic Scoring of Preference (LSP) method in modeling complex decision criteria. Fully aligned with current developments in computational intelligence, the discussion covers the design and use of LSP criteria for evaluation and comparison in diverse areas, such as search engines, medical conditions, real estate, space management, habitat mitigation projects in ecology, and land use and residential development suitability maps, with versatile transfer to other similar decision-modeling contexts. Human decision making is rife with fuzziness, imprecision, uncertainty, and half-truths—yet humans make evaluation decisions every day. In this book, such decision processes are observed, analyzed, and modeled. The result is graded logic, a soft computing mathematical infrastructure that provides both formal logic and semantic generalizations of classical Boolean logic. Graded logic is used for logic aggregation in the context of evaluation models consistent with observable properties of human reasoning. The LSP method, based on graded logic and logic aggregation, is a vital component of an industrial-strength decision engineering framework. Thus, the book: Provides detailed theoretical background for graded logic Provides a theory of logic aggregators Explains the LSP method for designing complex evaluation criteria and their use Shows techniques for evaluation, comparison, and selection of complex systems, as well as the cost/suitability analysis, optimization, sensitivity analysis, tradeoff analysis, and missingness-tolerant aggregation Includes a survey of available LSP software tools, including ISEE, ANSY and LSP.NT. With quantitative modeling of human reasoning, novel approaches to modeling decision criteria, and a verified decision engineering framework applicable to a broad array of applications, this book is an invaluable resource for graduate students, researchers, and practitioners working within the decision engineering realm.
Evgeniy Goryushkin Databases in DMS of Microsoft Access: methodical handbook on computer science Evgeniy Goryushkin Databases in DMS of Microsoft Access: methodical handbook on computer science Новинка

Evgeniy Goryushkin Databases in DMS of Microsoft Access: methodical handbook on computer science

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The educational and methodical manual is a complex set of tasks for the development of databases, as well as a set of tasks for independent work and control questions. There are tasks which are provided for work in the program MS Access, and included in the package of application programs Microsoft Office 2010. The development contains both theoretical and practical parts. This publication is recommended for the teacher for effective formation of both theoretical knowledge and practical skills of students of the international faculty of various specialties. It will be also useful for students who are starting to study this program for the first time and wish to increase and consolidate their level of knowledge and skills in the field of database development.
Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Новинка

Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

10975.16 руб.
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development

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This accessible new edition explores the major topics in Monte Carlo simulation that have arisen over the past 30 years and presents a sound foundation for problem solving Simulation and the Monte Carlo Method, Third Edition reflects the latest developments in the field and presents a fully updated and comprehensive account of the state-of-the-art theory, methods and applications that have emerged in Monte Carlo simulation since the publication of the classic First Edition over more than a quarter of a century ago. While maintaining its accessible and intuitive approach, this revised edition features a wealth of up-to-date information that facilitates a deeper understanding of problem solving across a wide array of subject areas, such as engineering, statistics, computer science, mathematics, and the physical and life sciences. The book begins with a modernized introduction that addresses the basic concepts of probability, Markov processes, and convex optimization. Subsequent chapters discuss the dramatic changes that have occurred in the field of the Monte Carlo method, with coverage of many modern topics including: Markov Chain Monte Carlo, variance reduction techniques such as importance (re-)sampling, and the transform likelihood ratio method, the score function method for sensitivity analysis, the stochastic approximation method and the stochastic counter-part method for Monte Carlo optimization, the cross-entropy method for rare events estimation and combinatorial optimization, and application of Monte Carlo techniques for counting problems. An extensive range of exercises is provided at the end of each chapter, as well as a generous sampling of applied examples. The Third Edition features a new chapter on the highly versatile splitting method, with applications to rare-event estimation, counting, sampling, and optimization. A second new chapter introduces the stochastic enumeration method, which is a new fast sequential Monte Carlo method for tree search. In addition, the Third Edition features new material on: • Random number generation, including multiple-recursive generators and the Mersenne Twister • Simulation of Gaussian processes, Brownian motion, and diffusion processes • Multilevel Monte Carlo method • New enhancements of the cross-entropy (CE) method, including the “improved” CE method, which uses sampling from the zero-variance distribution to find the optimal importance sampling parameters • Over 100 algorithms in modern pseudo code with flow control • Over 25 new exercises Simulation and the Monte Carlo Method, Third Edition is an excellent text for upper-undergraduate and beginning graduate courses in stochastic simulation and Monte Carlo techniques. The book also serves as a valuable reference for professionals who would like to achieve a more formal understanding of the Monte Carlo method. Reuven Y. Rubinstein, DSc, was Professor Emeritus in the Faculty of Industrial Engineering and Management at Technion-Israel Institute of Technology. He served as a consultant at numerous large-scale organizations, such as IBM, Motorola, and NEC. The author of over 100 articles and six books, Dr. Rubinstein was also the inventor of the popular score-function method in simulation analysis and generic cross-entropy methods for combinatorial optimization and counting. Dirk P. Kroese, PhD, is a Professor of Mathematics and Statistics in the School of Mathematics and Physics of The University of Queensland, Australia. He has published over 100 articles and four books in a wide range of areas in applied probability and statistics, including Monte Carlo methods, cross-entropy, randomized algorithms, tele-traffic c theory, reliability, computational statistics, applied probability, and stochastic modeling.
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