development dynamics and pathology of neuronal networks from molecules to functional circuits147



Guanrong Chen Fundamentals of Complex Networks. Models, Structures and Dynamics Guanrong Chen Fundamentals of Complex Networks. Models, Structures and Dynamics Новинка

Guanrong Chen Fundamentals of Complex Networks. Models, Structures and Dynamics

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Complex networks such as the Internet, WWW, transportation networks, power grids, biological neural networks, and scientific cooperation networks of all kinds provide challenges for future technological development. • The first systematic presentation of dynamical evolving networks, with many up-to-date applications and homework projects to enhance study • The authors are all very active and well-known in the rapidly evolving field of complex networks • Complex networks are becoming an increasingly important area of research • Presented in a logical, constructive style, from basic through to complex, examining algorithms, through to construct networks and research challenges of the future
Alexei Verkhratsky Glial Physiology and Pathophysiology Alexei Verkhratsky Glial Physiology and Pathophysiology Новинка

Alexei Verkhratsky Glial Physiology and Pathophysiology

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Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases – for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides
J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria Новинка

J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria

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This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders
Dr. Abhay Krishna Singh Dynamics of Urban Development in Less Developed States of India Dr. Abhay Krishna Singh Dynamics of Urban Development in Less Developed States of India Новинка

Dr. Abhay Krishna Singh Dynamics of Urban Development in Less Developed States of India

This book is an endeavor to look into the various aspects of urbanisation and its dynamics. The work offers policy alternatives for the sustainable Urban Planning and Development in less developed States of India.
Charter Edward Functional Food Product Development Charter Edward Functional Food Product Development Новинка

Charter Edward Functional Food Product Development

19895.36 руб. или Купить в рассрочку!
According to an August 2009 report from PricewaterhouseCoopers, the United States market for functional foods in 2007 was US$ 27 billion. Forecasts of growth range from between 8.5% and 20% per year, or about four times that of the food industry in general. Global demand by 2013 is expected to be about $100 billion. With this demand for new products comes a demand for product development and supporting literature for that purpose. There is a wealth of research and development in this area and great scope for commercialization, and this book provides a much-needed review of important opportunities for new products, written by authors with in-depth knowledge of as yet unfulfilled health-related needs. This book addresses functional food product development from a number of perspectives: the process itself; health research that may provide opportunities; idea creation; regulation; and processes and ingredients. It also features case studies that illustrate real product development and commercialization histories. Written for food scientists and technologists, this book presents practical information for use in functional food product development. It is an essential resource for practitioners in functional food companies and food technology centres and is also of interest to researchers and students of food science. Key features: A comprehensive review of the latest opportunities in this commercially important sector of the food industry Includes chapters highlighting functional food opportunities for specific health issues such as obesity, immunity, brain health, heart disease and the development of children. New technologies of relevance to functional foods are also addressed, such as emulsion delivery systems and nanoencapsulation. Includes chapters on product design and the use of functional ingredients such as antioxidants, probiotics and prebiotics as well as functional ingredients from plant and dairy sources Specific examples of taking products to market are provided in the form of case studies e.g. microalgae functional ingredients Part of the Functional Food Science and Technology book series (Series Editor: Fereidoon Shahidi)
Henning Sanneck LTE Self-Organising Networks (SON). Network Management Automation for Operational Efficiency Henning Sanneck LTE Self-Organising Networks (SON). Network Management Automation for Operational Efficiency Новинка

Henning Sanneck LTE Self-Organising Networks (SON). Network Management Automation for Operational Efficiency

9535.75 руб. или Купить в рассрочку!
Covering the key functional areas of LTE Self-Organising Networks (SON), this book introduces the topic at an advanced level before examining the state-of-the-art concepts. The required background on LTE network scenarios, technologies and general SON concepts is first given to allow readers with basic knowledge of mobile networks to understand the detailed discussion of key SON functional areas (self-configuration, -optimisation, -healing). Later, the book provides details and references for advanced readers familiar with LTE and SON, including the latest status of 3GPP standardisation. Based on the defined next generation mobile networks (NGMN) and 3GPP SON use cases, the book elaborates to give the full picture of a SON-enabled system including its enabling technologies, architecture and operation. ”Heterogeneous networks” including different cell hierarchy levels and multiple radio access technologies as a new driver for SON are also discussed. Introduces the functional areas of LTE SON (self-optimisation, -configuration and –healing) and its standardisation, also giving NGMN and 3GPP use cases Explains the drivers, requirements, challenges, enabling technologies and architectures for a SON-enabled system Covers multi-technology (2G/3G) aspects as well as core network and end-to-end operational aspects Written by experts who have been contributing to the development and standardisation of the LTE self-organising networks concept since its inception Examines the impact of new network architectures (“Heterogeneous Networks”) to network operation, for example multiple cell layers and radio access technologies
Wayne Durham Aircraft Flight Dynamics and Control Wayne Durham Aircraft Flight Dynamics and Control Новинка

Wayne Durham Aircraft Flight Dynamics and Control

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Aircraft Flight Dynamics and Control addresses airplane flight dynamics and control in a largely classical manner, but with references to modern treatment throughout. Classical feedback control methods are illustrated with relevant examples, and current trends in control are presented by introductions to dynamic inversion and control allocation. This book covers the physical and mathematical fundamentals of aircraft flight dynamics as well as more advanced theory enabling a better insight into nonlinear dynamics. This leads to a useful introduction to automatic flight control and stability augmentation systems with discussion of the theory behind their design, and the limitations of the systems. The author provides a rigorous development of theory and derivations and illustrates the equations of motion in both scalar and matrix notation. Key features: Classical development and modern treatment of flight dynamics and control Detailed and rigorous exposition and examples, with illustrations Presentation of important trends in modern flight control systems Accessible introduction to control allocation based on the author's seminal work in the field Development of sensitivity analysis to determine the influential states in an airplane's response modes End of chapter problems with solutions available on an accompanying website Written by an author with experience as an engineering test pilot as well as a university professor, Aircraft Flight Dynamics and Control provides the reader with a systematic development of the insights and tools necessary for further work in related fields of flight dynamics and control. It is an ideal course textbook and is also a valuable reference for many of the necessary basic formulations of the math and science underlying flight dynamics and control.
Alan Wilson G. Global Dynamics. Approaches from Complexity Science Alan Wilson G. Global Dynamics. Approaches from Complexity Science Новинка

Alan Wilson G. Global Dynamics. Approaches from Complexity Science

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A world model: economies, trade, migration, security and development aid. This bookprovides the analytical capability to understand and explore the dynamics of globalisation. It is anchored in economic input-output models of over 200 countries and their relationships through trade, migration, security and development aid. The tools of complexity science are brought to bear and mathematical and computer models are developed both for the elements and for an integrated whole. Models are developed at a variety of scales ranging from the global and international trade through a European model of inter-sub-regional migration to piracy in the Gulf and the London riots of 2011. The models embrace the changing technology of international shipping, the impacts of migration on economic development along with changing patterns of military expenditure and development aid. A unique contribution is the level of spatial disaggregation which presents each of 200+ countries and their mutual interdependencies – along with some finer scale analyses of cities and regions. This is the first global model which offers this depth of detail with fully work-out models, these provide tools for policy making at national, European and global scales. Global dynamics: Presents in depth models of global dynamics. Provides a world economic model of 200+ countries and their interactions through trade, migration, security and development aid. Provides pointers to the deployment of analytical capability through modelling in policy development. Features a variety of models that constitute a formidable toolkit for analysis and policy development. Offers a demonstration of the practicalities of complexity science concepts. This book is for practitioners and policy analysts as well as those interested in mathematical model building and complexity science as well as advanced undergraduate and postgraduate level students.
Luonan Chen Biomolecular Networks. Methods and Applications in Systems Biology Luonan Chen Biomolecular Networks. Methods and Applications in Systems Biology Новинка

Luonan Chen Biomolecular Networks. Methods and Applications in Systems Biology

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Alternative techniques and tools for analyzing biomolecular networks With the recent rapid advances in molecular biology, high-throughput experimental methods have resulted in enormous amounts of data that can be used to study biomolecular networks in living organisms. With this development has come recognition of the fact that a complicated living organism cannot be fully understood by merely analyzing individual components. Rather, it is the interactions of components or biomolecular networks that are ultimately responsible for an organism's form and function. This book addresses the important need for a new set of computational tools to reveal essential biological mechanisms from a systems biology approach. Readers will get comprehensive coverage of analyzing biomolecular networks in cellular systems based on available experimental data with an emphasis on the aspects of network, system, integration, and engineering. Each topic is treated in depth with specific biological problems and novel computational methods: GENE NETWORKS—Transcriptional regulation; reconstruction of gene regulatory networks; and inference of transcriptional regulatory networks PROTEIN INTERACTION NETWORKS—Prediction of protein-protein interactions; topological structure of biomolecular networks; alignment of biomolecular networks; and network-based prediction of protein function METABOLIC NETWORKS AND SIGNALING NETWORKS—Analysis, reconstruction, and applications of metabolic networks; modeling and inference of signaling networks; and other topics and new trends In addition to theoretical results and methods, many computational software tools are referenced and available from the authors' Web sites. Biomolecular Networks is an indispensable reference for researchers and graduate students in bioinformatics, computational biology, systems biology, computer science, and applied mathematics.
Guanrong Chen Propagation Dynamics on Complex Networks. Models, Methods and Stability Analysis Guanrong Chen Propagation Dynamics on Complex Networks. Models, Methods and Stability Analysis Новинка

Guanrong Chen Propagation Dynamics on Complex Networks. Models, Methods and Stability Analysis

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Explores the emerging subject of epidemic dynamics on complex networks, including theories, methods, and real-world applications Throughout history epidemic diseases have presented a serious threat to human life, and in recent years the spread of infectious diseases such as dengue, malaria, HIV, and SARS has captured global attention; and in the modern technological age, the proliferation of virus attacks on the Internet highlights the emergent need for knowledge about modeling, analysis, and control in epidemic dynamics on complex networks. For advancement of techniques, it has become clear that more fundamental knowledge will be needed in mathematical and numerical context about how epidemic dynamical networks can be modelled, analyzed, and controlled. This book explores recent progress in these topics and looks at issues relating to various epidemic systems. Propagation Dynamics on Complex Networks covers most key topics in the field, and will provide a valuable resource for graduate students and researchers interested in network science and dynamical systems, and related interdisciplinary fields. Key Features: Includes a brief history of mathematical epidemiology and epidemic modeling on complex networks. Explores how information, opinion, and rumor spread via the Internet and social networks. Presents plausible models for propagation of SARS and avian influenza outbreaks, providing a reality check for otherwise abstract mathematical modeling. Considers various infectivity functions, including constant, piecewise-linear, saturated, and nonlinear cases. Examines information transmission on complex networks, and investigates the difference between information and epidemic spreading.
Wuwei Chen Integrated Vehicle Dynamics and Control Wuwei Chen Integrated Vehicle Dynamics and Control Новинка

Wuwei Chen Integrated Vehicle Dynamics and Control

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A comprehensive overview of integrated vehicle system dynamics exploring the fundamentals and new and emerging developments This book provides a comprehensive coverage of vehicle system dynamics and control, particularly in the area of integrated vehicle dynamics control. The book consists of two parts, (1) development of individual vehicle system dynamic model and control methodology; and (2) development of integrated vehicle dynamic model and control methodology. The first part focuses on investigating vehicle system dynamics and control according to the three directions of vehicle motions, including longitudinal, vertical, and lateral. Corresponding individual control systems, e.g. Anti-lock Brake System (ABS), Active Suspension, Electric Power Steering System (EPS), are introduced and developed respectively. Particular attention is paid in the second part of the book to develop integrated vehicle dynamic control system. Integrated vehicle dynamics control system is an advanced system that coordinates all the chassis control systems and components to improve the overall vehicle performance including safety, comfort, and economy. Integrated vehicle dynamics control has been an important research topic in the area of vehicle dynamics and control over the past two decades. The research topic on integrated vehicle dynamics control is investigated comprehensively and intensively in the book through both theoretical analysis and experimental study. In this part, two types of control architectures, i.e. centralized and multi-layer, have been developed and compared to demonstrate their advantages and disadvantages. Integrated vehicle dynamics control is a hot topic in automotive research; this is one of the few books to address both theory and practice of integrated systems Comprehensively explores the research area of integrated vehicle dynamics and control through both theoretical analysis and experimental study Addresses a full range of vehicle system topics including tyre dynamics, chassis systems, control architecture, 4 wheel steering system and design of control systems using Linear Matrix Inequality (LMI) Method
Jyrki T. J. Penttinen The LTE / SAE Deployment Handbook Jyrki T. J. Penttinen The LTE / SAE Deployment Handbook Новинка

Jyrki T. J. Penttinen The LTE / SAE Deployment Handbook

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Describing the essential aspects that need to be considered during the deployment and operational phases of 3GPP LTE/SAE networks, this book gives a complete picture of LTE systems, as well as providing many examples from operational networks. It demystifies the structure, functioning, planning and measurements of both the radio and core aspects of the evolved 3G system. The content includes an overview of the LTE/SAE environment, architectural and functional descriptions of the radio and core network, functionality of the LTE applications, international roaming principles, security solutions and network measurement methods. In addition, this book gives essential guidelines and recommendations about the transition from earlier mobile communications systems towards the LTE/SAE era and the next generation of LTE, LTE-Advanced. The book is especially suitable for the operators that face new challenges in the planning and deployment phases of LTE/SAE, and is also useful for network vendors, service providers, telecommunications consultancy companies and technical institutes as it provides practical information about the realities of the system. Presents the complete end-to-end planning and measurement guidelines for the realistic deployment of networks Explains the essential and realistic aspects of commercial LTE systems as well as the future possibilities An essential tool during the development of transition strategies from other network solutions towards LTE/SAE Contains real-world case studies and examples to help readers understand the practical side of the system
Ivan Stojmenovic Mobile Ad Hoc Networking. The Cutting Edge Directions Ivan Stojmenovic Mobile Ad Hoc Networking. The Cutting Edge Directions Новинка

Ivan Stojmenovic Mobile Ad Hoc Networking. The Cutting Edge Directions

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"An excellent book for those who are interested in learning the current status of research and development . . . [and] who want to get a comprehensive overview of the current state-of-the-art." —E-Streams This book provides up-to-date information on research and development in the rapidly growing area of networks based on the multihop ad hoc networking paradigm. It reviews all classes of networks that have successfully adopted this paradigm, pointing out how they penetrated the mass market and sparked breakthrough research. Covering both physical issues and applications, Mobile Ad Hoc Networking: Cutting Edge Directions offers useful tools for professionals and researchers in diverse areas wishing to learn about the latest trends in sensor, actuator, and robot networking, mesh networks, delay tolerant and opportunistic networking, and vehicular networks. Chapter coverage includes: Multihop ad hoc networking Enabling technologies and standards for mobile multihop wireless networking Resource optimization in multiradio multichannel wireless mesh networks QoS in mesh networks Routing and data dissemination in opportunistic networks Task farming in crowd computing Mobility models, topology, and simulations in VANET MAC protocols for VANET Wireless sensor networks with energy harvesting nodes Robot-assisted wireless sensor networks: recent applications and future challenges Advances in underwater acoustic networking Security in wireless ad hoc networks Mobile Ad Hoc Networking will appeal to researchers, developers, and students interested in computer science, electrical engineering, and telecommunications.
Dehmer Matthias Analysis of Complex Networks. From Biology to Linguistics Dehmer Matthias Analysis of Complex Networks. From Biology to Linguistics Новинка

Dehmer Matthias Analysis of Complex Networks. From Biology to Linguistics

19899.13 руб. или Купить в рассрочку!
Mathematical problems such as graph theory problems are of increasing importance for the analysis of modelling data in biomedical research such as in systems biology, neuronal network modelling etc. This book follows a new approach of including graph theory from a mathematical perspective with specific applications of graph theory in biomedical and computational sciences. The book is written by renowned experts in the field and offers valuable background information for a wide audience.
Nicole Campione-Barr Power, Control, and Influence in Sibling Relationships across Development. New Directions for Child and Adolescent Development, Number 156 Nicole Campione-Barr Power, Control, and Influence in Sibling Relationships across Development. New Directions for Child and Adolescent Development, Number 156 Новинка

Nicole Campione-Barr Power, Control, and Influence in Sibling Relationships across Development. New Directions for Child and Adolescent Development, Number 156

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Take a close look at sibling relationships–particularly how siblings navigate power, control, and influence and how the relationship affects the development of the individuals involved. While such relationships are both complementary and reciprocal, they transforms rather dramatically: from hierarchical in early and middle childhood, to egalitarian by early adulthood. This issue to examines: the processes and consequences of such dynamic power shifts for our broader understanding of how these relationship dynamics change and develop throughout the life course, how such dynamics may be similar or different cross-culturally, and how they influence the quality of the sibling relationship, as well as the well-being of youth. To do so, the authors present research from each developmental period from early childhood through young adulthood, as well as cross-cultural research, in order to further understanding of the developmental and contextual themes that allow for drawing broader conclusions. This is the 156th volume in this Jossey-Bass series New Directions for Child and Adolescent Development. Its mission is to provide scientific and scholarly presentations on cutting edge issues and concepts in this subject area. Each volume focuses on a specific new direction or research topic and is edited by experts from that field.
Kühn Oliver Charge and Energy Transfer Dynamics in Molecular Systems Kühn Oliver Charge and Energy Transfer Dynamics in Molecular Systems Новинка

Kühn Oliver Charge and Energy Transfer Dynamics in Molecular Systems

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This 3rd edition has been expanded and updated to account for recent developments, while new illustrative examples as well as an enlarged reference list have also been added. It naturally retains the successful concept of its predecessors in presenting a unified perspective on molecular charge and energy transfer processes, thus bridging the regimes of coherent and dissipative dynamics, and establishing a connection between classic rate theories and modern treatments of ultrafast phenomena. Among the new topics are: – Time-dependent density functional theory – Heterogeneous electron transfer, e.g. between molecules and metal or semiconductor surfaces – Current flows through a single molecule. While serving as an introduction for graduate students and researchers, this is equally must-have reading for theoreticians and experimentalists, as well as an aid to interpreting experimental data and accessing the original literature.
Simon Haykin Fundamentals of Cognitive Radio Simon Haykin Fundamentals of Cognitive Radio Новинка

Simon Haykin Fundamentals of Cognitive Radio

8939.24 руб. или Купить в рассрочку!
A comprehensive treatment of cognitive radio networks and the specialized techniques used to improve wireless communications The human brain, as exemplified by cognitive radar, cognitive radio, and cognitive computing, inspires the field of Cognitive Dynamic Systems. In particular, cognitive radio is growing at an exponential rate. Fundamentals of Cognitive Radio details different aspects of the human brain and provides examples of how it can be mimicked by cognitive dynamic systems. The text offers a communication-theoretic background, including information on resource allocation in wireless networks and the concept of robustness. The authors provide a thorough mathematical background with data on game theory, variational inequalities, and projected dynamic systems. They then delve more deeply into resource allocation in cognitive radio networks. The text investigates the dynamics of cognitive radio networks from the perspectives of information theory, optimization, and control theory. It also provides a vision for the new world of wireless communications by integration of cellular and cognitive radio networks. This groundbreaking book: Shows how wireless communication systems increasingly use cognition to enhance their networks Explores how cognitive radio networks can be viewed as spectrum supply chain networks Derives analytic models for two complementary regimes for spectrum sharing (open-access and market-driven) to study both equilibrium and disequilibrium behaviors of networks Studies cognitive heterogeneous networks with emphasis on economic provisioning for resource sharing Introduces a framework that addresses the issue of spectrum sharing across licensed and unlicensed bands aimed for Pareto optimality Written for students of cognition, communication engineers, telecommunications professionals, and others, Fundamentals of Cognitive Radio offers a new generation of ideas and provides a fresh way of thinking about cognitive techniques in order to improve radio networks.
Carla-Fabiana Chiasserini Analytical Modeling of Wireless Communication Systems Carla-Fabiana Chiasserini Analytical Modeling of Wireless Communication Systems Новинка

Carla-Fabiana Chiasserini Analytical Modeling of Wireless Communication Systems

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Wireless networks represent an inexpensive and convenient way to connect to the Internet. However, despite their applications across several technologies, one challenge still remains: to understand the behavior of wireless sensor networks and assess their performance in large-scale scenarios. When a large number of network nodes need to interact, developing suitable analytical models is essential to ensure the appropriate coverage and throughput of these networks and to enhance user mobility. This is intrinsically difficult due to the size and number of different network nodes and users. This book highlights some examples which show how this problem can be overcome with the use of different techniques. An intensive parameter analysis shows the reader how to the exploit analytical models for an effective development and management of different types of wireless networks.
Laurie Starkey S. Introduction to Strategies for Organic Synthesis Laurie Starkey S. Introduction to Strategies for Organic Synthesis Новинка

Laurie Starkey S. Introduction to Strategies for Organic Synthesis

The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities. Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis. Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made. Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.
Hugo Kubinyi Chemokine Receptors as Drug Targets Hugo Kubinyi Chemokine Receptors as Drug Targets Новинка

Hugo Kubinyi Chemokine Receptors as Drug Targets

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Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.
Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators Новинка

Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators

12663.92 руб. или Купить в рассрочку!
Many small molecules occur naturally as «messenger» chemicals which regulate the behaviour and functions of microbes, plants, insects and animals. Examples include hormones, pheromones, phytoalexins, and antifeedants. These biofunctional molecules are of great interest to researchers in helping develop our understanding of biological function and in the development of new drugs. However extracting them from nature can be prohibitively expensive, so there is great interest in devising methods of synthesising them from simple starting materials in the laboratory. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is an introduction to the techniques and strategies for the synthesis of biofunctional small molecules. Topics include: what are biofunctional molecules? why must biofunctional molecules be synthesized? how can we synthesize biofunctional molecules? the synthesis of phytohormones, phytoalexins and other biofunctional molecules of plant origin the synthesis of insect juvenile hormones and antifeedants the synthesis of pheromones and the significance of chirality in pheromone science the synthesis of microbial hormones and pheromones, antibiotics, and other biofunctional molecules of microbial origin the synthesis of marine antifeedants and medicinal candidates a synthetic examination of incorrectly proposed structures of biomolecules reflections on science as a human endeavor Drawing on a career of almost 50 years researching and teaching this subject, Kenji Mori's Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is a must-have textbook for students and researchers of organic synthesis and natural products, and a stimulating and inspiring account of a distinguished chemical career.
Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators Новинка

Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators

12813.83 руб. или Купить в рассрочку!
Many small molecules occur naturally as «messenger» chemicals which regulate the behaviour and functions of microbes, plants, insects and animals. Examples include hormones, pheromones, phytoalexins, and antifeedants. These biofunctional molecules are of great interest to researchers in helping develop our understanding of biological function and in the development of new drugs. However extracting them from nature can be prohibitively expensive, so there is great interest in devising methods of synthesising them from simple starting materials in the laboratory. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is an introduction to the techniques and strategies for the synthesis of biofunctional small molecules. Topics include: what are biofunctional molecules? why must biofunctional molecules be synthesized? how can we synthesize biofunctional molecules? the synthesis of phytohormones, phytoalexins and other biofunctional molecules of plant origin the synthesis of insect juvenile hormones and antifeedants the synthesis of pheromones and the significance of chirality in pheromone science the synthesis of microbial hormones and pheromones, antibiotics, and other biofunctional molecules of microbial origin the synthesis of marine antifeedants and medicinal candidates a synthetic examination of incorrectly proposed structures of biomolecules reflections on science as a human endeavor Drawing on a career of almost 50 years researching and teaching this subject, Kenji Mori's Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is a must-have textbook for students and researchers of organic synthesis and natural products, and a stimulating and inspiring account of a distinguished chemical career.
Sabu Thomas Handbook of Biopolymer-Based Materials. From Blends and Composites to Gels and Complex Networks Sabu Thomas Handbook of Biopolymer-Based Materials. From Blends and Composites to Gels and Complex Networks Новинка

Sabu Thomas Handbook of Biopolymer-Based Materials. From Blends and Composites to Gels and Complex Networks

28084.96 руб. или Купить в рассрочку!
This first systematic scientific reference in the area of micro- and nanostructured biopolymer systems discusses in two volumes the morphology, structure, dynamics, properties and applications of all important biopolymers, as well as their blends, composites, interpenetrating networks and gels. Selected leading researchers from industry, academia, government and private research institutions around the globe comprehensively review recent accomplishments in the field. They examine the current state of the art, new challenges, and opportunities, discussing all the synthetic routes to the generation of both micro- and nano-morphologies, as well as the synthesis, characterization and application of porous biopolymers. An outstanding resource for anyone involved in the fi eld of eco-friendly biomaterials for advanced technologies.
Binghe Wang Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications Binghe Wang Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications Новинка

Binghe Wang Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications

18400.08 руб. или Купить в рассрочку!
Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as: Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions Cross reactivity of zinc-enzyme inhibitors and activators The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins Clinical applications An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.
Vinko Jovic Analysis and Modelling of Non-Steady Flow in Pipe and Channel Networks Vinko Jovic Analysis and Modelling of Non-Steady Flow in Pipe and Channel Networks Новинка

Vinko Jovic Analysis and Modelling of Non-Steady Flow in Pipe and Channel Networks

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Analysis and Modelling of Non-Steady Flow in Pipe and Channel Networks deals with flows in pipes and channel networks from the standpoints of hydraulics and modelling techniques and methods. These engineering problems occur in the course of the design and construction of hydroenergy plants, water-supply and other systems. In this book, the author presents his experience in solving these problems from the early 1970s to the present day. During this period new methods of solving hydraulic problems have evolved, due to the development of computers and numerical methods. This book is accompanied by a website which hosts the author's software package, Simpip (an abbreviation of simulation of pipe flow) for solving non-steady pipe flow using the finite element method. The program also covers flows in channels. The book presents the numerical core of the SimpipCore program (written in Fortran). Key features: Presents the theory and practice of modelling different flows in hydraulic networks Takes a systematic approach and addresses the topic from the fundamentals Presents numerical solutions based on finite element analysis Accompanied by a website hosting supporting material including the SimpipCore project as a standalone program Analysis and Modelling of Non-Steady Flow in Pipe and Channel Networks is an ideal reference book for engineers, practitioners and graduate students across engineering disciplines.
Ghafouri-Shiraz Hooshang Optical CDMA Networks. Principles, Analysis and Applications Ghafouri-Shiraz Hooshang Optical CDMA Networks. Principles, Analysis and Applications Новинка

Ghafouri-Shiraz Hooshang Optical CDMA Networks. Principles, Analysis and Applications

11309.04 руб. или Купить в рассрочку!
This book focuses heavily on the principles, analysis and applications of code-division multiple-access (CDMA) techniques in optical communication systems and networks. In this book, the authors intimately discuss modern optical networks and their applications in current and emerging communication technologies, evaluating the quality, speed and number of supported services. In particular, principles and fundamentals of optical CDMA techniques from beginner to advanced levels are heavily covered. Furthermore, the authors concentrate on methods and techniques of various encoding and decoding schemes and their structures, as well as analysis of optical CDMA systems with various transceiver models including advanced multi-level incoherent and coherent modulations with the architecture of access/aggregation networks in mind. Moreover, authors examine intriguing topics of optical CDMA networking, compatibility with IP networks, and implementation of optical multi-rate multi-service CDMA networks. Key features: Expanded coverage of optical CDMA networks, starts from principles and fundamentals Comprehensive mathematical modelling and analysis from signal to system levels Addresses the applications of modern optical networking in the current and emerging communication technologies Greater focus on advanced optical multi-level incoherent and coherent modulations, spreading codes, and transceiver designs Detailed hardware specifications, system-level block diagrams, and network nodes’ functionalities This book appeals to researchers, practicing engineers, and advanced students. It is a practical resource for readers with an interest in optical communications and networks.
Roald Hoffmann Chemistry as a Game of Molecular Construction. The Bond-Click Way Roald Hoffmann Chemistry as a Game of Molecular Construction. The Bond-Click Way Новинка

Roald Hoffmann Chemistry as a Game of Molecular Construction. The Bond-Click Way

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Chemistry as a Game of Molecular Construction: The Bond-Click Way utilizes an innovative and engaging approach to introduce students to the basic concepts and universal aspects of chemistry, with an emphasis on molecules’ beauty and their importance in our lives. • Offers a unique approach that portrays chemistry as a window into mankind’s material-chemical essence • Reveals the beauty of molecules through the “click” method, a teaching methodology comprised of the process of constructing molecules from building blocks • Styles molecular construction in a way that reveals the universal aspect of chemistry • Allows students to construct molecules, from the simple hydrogen molecule all the way to complex strands of DNA, thereby showing the overarching unity of matter • Provides problems sets and solutions for each chapter
Kyalo Josphat Management Structures Kyalo Josphat Management Structures Новинка

Kyalo Josphat Management Structures

The use of both structured and wireless networks has increased tremendously by the management entities of most Business Organizations. The integration of such networks with the Internet has led to increased exchange of Information whose security stands out as a challenging issue to most Management Units. Very little literature exist that points to the effective establishment, stable nature and managerial requirements of a wireless networks which are prone to attacks and intrusion. The Management Structures need a thorough representation and understanding of how to establish, enforce security and have effective management of the networks. This book therefore, provides for an elaborate and secure approach to the establishment and subsequent management of the wireless networks, with minimum risks to security threats and compromise to organizational information. A framework is presented that can be used by these policy makers to evaluate their Institution's state of Computer Networks and take cognizance of parameters (indicators) that need to be considered for implementation of an effective and efficient functional Wireless Network.
Sertac Cetiner XML Based Service Provisioning in Converged Voice and Data Networks Sertac Cetiner XML Based Service Provisioning in Converged Voice and Data Networks Новинка

Sertac Cetiner XML Based Service Provisioning in Converged Voice and Data Networks

Diploma Thesis from the year 2001 in the subject Electrotechnology, grade: 1,7, University of Ulm, 34 entries in the bibliography, language: English, abstract: In today's world, there are mainly two types of communication networks: circuitswitched networks and packet-switched networks. The current telephone networks are mostly based on the circuit-switched networks, whereas the Internet is mainly based on the packetswitched networks, which are also called IP networks. However, there is a strong tendency to combine both of these networks, which points to the direction that the IP networks are going to replace services provided by current telephone networks. This would eventually mean that IP networks might replace the telephone networks, in the future.Following are some reasons why IP networks seem to replace the circuit-switchednetworks:· First of all, the IP networks provide cheaper communication. Considering thatthe Internet access is nearly free, the cost advantage of IP networks gets clearer[25].· Secondly, IP networks provide the ability of integrating the data and voiceapplications, and even some other applications, like video-conferencing,integrated voice mail, e-mail, and the like [26].· Another important reason is that IP networks allow open implementation ofend systems. With a reasonable programming knowledge everybody couldimplement an end system for IP networks. In the classical telephony end userscannot implement any end system, but have to use whatever provi...
Yuanqiu Luo The ComSoc Guide to Passive Optical Networks. Enhancing the Last Mile Access Yuanqiu Luo The ComSoc Guide to Passive Optical Networks. Enhancing the Last Mile Access Новинка

Yuanqiu Luo The ComSoc Guide to Passive Optical Networks. Enhancing the Last Mile Access

4913.47 руб. или Купить в рассрочку!
Describes the major architectures, standards, and technologies of Passive Optical Networks (PONs) The ComSoc Guide to Passive Optical Networks provides readers with a concise explanation of the key features of Passive Optical Networks (PONs); the different types of PON architectures and standards; key issues of PON devices, management, and implementation; and the promising business opportunities in access networks. Written for a broad audience, ranging from developers to users, this indispensable book provides an understanding o the evolutionary path of PON access systems and their positioning with respect to the cable, copper, and wireless competitors for broadband access networks. In addition, The ComSoc Guide to Passive Optical Networks: Provides brief, high-level overviews of the architectures and applications of Fiber-to-the-Home (FTTH) or Fiber-to-the-Curb (FTTC) access networks and the alternative HFC, subscriber line, and WiMAX access systems Awards readers with a clear understanding of what BPON, GPON, WDM-PON and EPON are and how they work, together with an introduction to their respective standards Carefully defines all acronyms and technical terms, making the book accessible to those who may not be specialists in this area Gives readers an appreciation of the last mile problems in telecommunications access networks, and the opportunities in optical-wireless integration
Amleset Kelati Application of IEEE 802.1X in HiperLAN type 2 Amleset Kelati Application of IEEE 802.1X in HiperLAN type 2 Новинка

Amleset Kelati Application of IEEE 802.1X in HiperLAN type 2

Master's Thesis from the year 2001 in the subject Computer Science - Internet, New Technologies, Chalmers University of Technology Foundation Göteborg (Ericsson Enterprise AB), language: English, abstract: The research within Information Technology has been subject to a tremendous speed-up in the latest years, mainly due to the reduced prices of the related technology and, consequently, to a strongly increased interest of the users. This causes a positive feedback loop, since many companies decide to invest more money in such area, reducing further the prices and accelerating this process.One of the major issues in this big race has been the concept "Be connected always and everywhere", which translated in an increased development of public networks on one side and in a further growth of big corporation networks on the other side. The common factors of these big areas are mobility, which implies wireless networks, and availability of services, which also means access to more or less important information.Increased size, mobility and availability of services on networks that become bigger and bigger increases tremendously the importance of data-security. Trust, authentication, and authorization have become vital key words within the design of big, mobile networks.IEEE 802.1X, also known as "Port Based Network Access Control" is a means for providing authentication and authorization for big networks that offer the possibility to many devices to attach to the...
Cornelia Steinhauer Protein Microarrays Based on Recombinant Antibody Fragments Cornelia Steinhauer Protein Microarrays Based on Recombinant Antibody Fragments Новинка

Cornelia Steinhauer Protein Microarrays Based on Recombinant Antibody Fragments

DNA microarray is a well-established technology for gene expression profiling throughout biological research and clinical diagnostics. However, the development of comparable technologies on protein level has turned out to be complicated by the distinct nature of individual protein molecules. Here, we suggest the use of structurally uniform recombinant antibody molecules as catcher molecules for protein analytes. In the scope of this thesis, the catcher molecule has been discussed in terms of sensitivity of detection, on-chip stability and the format antibody-molecules can be spotted onto the solid support. At the same time, different carriers have been evaluated with regard to their structure (1-, 2- or 3-dimensional) and coupling chemistries (adsorption, covalent coupling or affinity coupling). Thus, this thesis provides important technological insides, of use for anyone intending to perform protein profiling in large scale and high throughput manner.
Elizabeth McInnes Pathology for Toxicologists. Principles and Practices of Laboratory Animal Pathology for Study Personnel Elizabeth McInnes Pathology for Toxicologists. Principles and Practices of Laboratory Animal Pathology for Study Personnel Новинка

Elizabeth McInnes Pathology for Toxicologists. Principles and Practices of Laboratory Animal Pathology for Study Personnel

Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: Colour diagrams explaining how lesions are caused by either external compounds or spontaneously The anatomic variations and background lesions of laboratory animals Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data A chapter on the haematology and biochemistry of laboratory animals Full colour photographs of common macroscopic lesions encountered in laboratory animals A comprehensive glossary
Vasudevan Sujalakshmy, K. S. Sivanandan Modelling the Dynamics Vasudevan Sujalakshmy, K. S. Sivanandan Modelling the Dynamics Новинка

Vasudevan Sujalakshmy, K. S. Sivanandan Modelling the Dynamics

This paper addresses the development of an average value based model, for the network dynamics of a predominantly scattered and geographically dependent consumer distribution system. The continuous observation of the load currents in three different phases of distribution transformers, fixation of its average values on real time basis, mathematical model development with the above average value as base factor are the basic steps of this method, which subsequently leads to a time based dynamics. The validation of the so developed model is done by experimenting in a working system.
Sherali Zeadally Energy Efficiency in Wireless Networks Sherali Zeadally Energy Efficiency in Wireless Networks Новинка

Sherali Zeadally Energy Efficiency in Wireless Networks

5885.28 руб. или Купить в рассрочку!
The last decade has witnessed an unprecedented development and growth in global wireless communications systems, technologies and network “traffic” generated over network infrastructures. This book presents state-of-the-art energy-efficient techniques, designs and implementations that pertain to wireless communication networks such as cellular networks, wireless local area networks (WLANs) and wireless ad hoc networks (WAHNs) including mobile ad hoc networks (MANETs), and wireless sensor networks (WSNs) as they are deployed across the world to facilitate “always on” reliable high-speed wireless access from anywhere, at anytime to accommodate the new paradigm of the “Internet of Things” (IoT). The pervasive and exponential growth of Wi-Fi and the impact of bandwidth-intensive applications on the energy consumption of Wi-Fi-enabled devices are discussed along with energy harvesting as an advantageous option to power WAHNs. The book aims to serve as a useful reference for researchers, students, regulatory authorities, and educators.
Malek Benslama Ad Hoc Networks Telecommunications and Game Theory Malek Benslama Ad Hoc Networks Telecommunications and Game Theory Новинка

Malek Benslama Ad Hoc Networks Telecommunications and Game Theory

8120.09 руб. или Купить в рассрочку!
Random SALOHA and CSMA protocols that are used to access MAC in ad hoc networks are very small compared to the multiple and spontaneous use of the transmission channel. So they have low immunity to the problems of packet collisions. Indeed, the transmission time is the critical factor in the operation of such networks. The simulations demonstrate the positive impact of erasure codes on the throughput of the transmission in ad hoc networks. However, the network still suffers from the intermittency and volatility of its efficiency throughout its operation, and it switches quickly to the saturation zone. In this context, game theory has demonstrated his ability to lead the network to a more efficient equilibrium. This, we were led to propose our model code set that formalizes the behavior of nodes during transmission within SALOHA networks and CSMA respectively
Pascale Vicat-Blanc Computing Networks. From Cluster to Cloud Computing Pascale Vicat-Blanc Computing Networks. From Cluster to Cloud Computing Новинка

Pascale Vicat-Blanc Computing Networks. From Cluster to Cloud Computing

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“Computing Networks” explores the core of the new distributed computing infrastructures we are using today: the networking systems of clusters, grids and clouds. It helps network designers and distributed-application developers and users to better understand the technologies, specificities, constraints and benefits of these different infrastructures’ communication systems. Cloud Computing will give the possibility for millions of users to process data anytime, anywhere, while being eco-friendly. In order to deliver this emerging traffic in a timely, cost-efficient, energy-efficient, and reliable manner over long-distance networks, several issues such as quality of service, security, metrology, network-resource scheduling and virtualization are being investigated since 15 years. “Computing Networks” explores the core of clusters, grids and clouds networks, giving designers, application developers and users the keys to better construct and use these powerful infrastructures.
Oliver Ibe C. Fundamentals of Stochastic Networks Oliver Ibe C. Fundamentals of Stochastic Networks Новинка

Oliver Ibe C. Fundamentals of Stochastic Networks

10932.07 руб. или Купить в рассрочку!
An interdisciplinary approach to understanding queueing and graphical networks In today's era of interdisciplinary studies and research activities, network models are becoming increasingly important in various areas where they have not regularly been used. Combining techniques from stochastic processes and graph theory to analyze the behavior of networks, Fundamentals of Stochastic Networks provides an interdisciplinary approach by including practical applications of these stochastic networks in various fields of study, from engineering and operations management to communications and the physical sciences. The author uniquely unites different types of stochastic, queueing, and graphical networks that are typically studied independently of each other. With balanced coverage, the book is organized into three succinct parts: Part I introduces basic concepts in probability and stochastic processes, with coverage on counting, Poisson, renewal, and Markov processes Part II addresses basic queueing theory, with a focus on Markovian queueing systems and also explores advanced queueing theory, queueing networks, and approximations of queueing networks Part III focuses on graphical models, presenting an introduction to graph theory along with Bayesian, Boolean, and random networks The author presents the material in a self-contained style that helps readers apply the presented methods and techniques to science and engineering applications. Numerous practical examples are also provided throughout, including all related mathematical details. Featuring basic results without heavy emphasis on proving theorems, Fundamentals of Stochastic Networks is a suitable book for courses on probability and stochastic networks, stochastic network calculus, and stochastic network optimization at the upper-undergraduate and graduate levels. The book also serves as a reference for researchers and network professionals who would like to learn more about the general principles of stochastic networks.
Mogens Nielsen Brøndsted Organic Synthesis and Molecular Engineering Mogens Nielsen Brøndsted Organic Synthesis and Molecular Engineering Новинка

Mogens Nielsen Brøndsted Organic Synthesis and Molecular Engineering

11919.69 руб. или Купить в рассрочку!
The theory, methods, and practices needed to build molecules and supramolecular systems Using a synthetic approach to organic materials chemistry, this book sets forth tested and proven methods and practices that make it possible to engineer organic molecules offering special properties and functions. Throughout the book, plenty of real-world examples demonstrate the countless possibilities of creating one-of-a-kind molecules and supramolecular systems to support a broad range of applications. The book explores applications in both materials and bioorganic chemistry, including molecular electronics, energy storage, sensors, nanomedicine, and enzyme engineering. Organic Synthesis and Molecular Engineering consists of fourteen chapters, each one contributed by one or more leading international experts in the field. The contributions are based on a thorough review and analysis of the current literature as well as the authors' firsthand experience in the lab engineering new organic molecules. Designed as a practical lab reference, the book offers: Tested and proven synthetic approaches to organic materials chemistry Methods and practices to successfully engineer functionality into organic molecules Explanations of the principles and concepts underlying self-assembly and supramolecular chemistry Guidance in selecting appropriate structural units used in the design and synthesis of functional molecules and materials Coverage of the full range of applications in materials and bioorganic chemistry A full chapter on graphene, a new topic generating intense research Organic Synthesis and Molecular Engineering begins with core concepts, molecular building blocks, and synthetic tools. Next, it explores molecular electronics, supramolecular chemistry and self-assembly, graphene, and photoresponsive materials engineering. In short, it offers everything researchers need to fully grasp the underlying theory and then build new molecules and supramolecular systems.
Conradi Edward Psychology and pathology of speech development of the child Conradi Edward Psychology and pathology of speech development of the child Новинка

Conradi Edward Psychology and pathology of speech development of the child

Эта книга — репринт оригинального издания (издательство "Pedagogical seminary", 1904 год), созданный на основе электронной копии высокого разрешения, которую очистили и обработали вручную, сохранив структуру и орфографию оригинального издания. Редкие, забытые и малоизвестные книги, изданные с петровских времен до наших дней, вновь доступны в виде печатных книг.Psychology and pathology of speech development of the child
Alexandros Stavdas Core and Metro Networks Alexandros Stavdas Core and Metro Networks Новинка

Alexandros Stavdas Core and Metro Networks

12439.94 руб. или Купить в рассрочку!
Find out everything you need to know about how current networks will have to evolve to provide for future broadband services In this book, the authors provide an overview of the status, challenges, architectures, and technological solutions for core and metropolitan networks. Furthermore, the book describes the current state of core and metropolitan telecommunication networks, as well as the drivers and motives behind the current paradigm shift in the telecommunications industry. Moreover, the authors elaborate system design guidelines for both point-to-point and multi-hop optical networks taking into consideration the analogue nature of the transmission channel. Key Features: Provides coverage of all aspects of core and metro networks supporting future broadband services, and a detailed description of the state-of-the-art Presents a clear path for migrating from point-to-point to data-centric, dynamic, multi-hop optical networks Shows how current systems will need to evolve over the coming years, summarizing challenges and issues to be investigated in future research Covers a wide range of topics from network architectures, to control plane, to key optical and optoelectronic devices, and best practice in transmission and system design Provides results, best practices and guidelines for various technical problems, including numerous hands-on examples Written by authors from cutting-edge companies such as Alcatel-Lucent, Siemens, Lucent, France Telecom, BT, and Telefonica Optical Core and Metro Networks will be of interest to researchers in industry and academia, and advanced (final year undergraduate) and postgraduate students undertaking communications, networking and optics courses.
Alexandros Stavdas Core and Metro Networks Alexandros Stavdas Core and Metro Networks Новинка

Alexandros Stavdas Core and Metro Networks

12292.16 руб. или Купить в рассрочку!
Find out everything you need to know about how current networks will have to evolve to provide for future broadband services In this book, the authors provide an overview of the status, challenges, architectures, and technological solutions for core and metropolitan networks. Furthermore, the book describes the current state of core and metropolitan telecommunication networks, as well as the drivers and motives behind the current paradigm shift in the telecommunications industry. Moreover, the authors elaborate system design guidelines for both point-to-point and multi-hop optical networks taking into consideration the analogue nature of the transmission channel. Key Features: Provides coverage of all aspects of core and metro networks supporting future broadband services, and a detailed description of the state-of-the-art Presents a clear path for migrating from point-to-point to data-centric, dynamic, multi-hop optical networks Shows how current systems will need to evolve over the coming years, summarizing challenges and issues to be investigated in future research Covers a wide range of topics from network architectures, to control plane, to key optical and optoelectronic devices, and best practice in transmission and system design Provides results, best practices and guidelines for various technical problems, including numerous hands-on examples Written by authors from cutting-edge companies such as Alcatel-Lucent, Siemens, Lucent, France Telecom, BT, and Telefonica Optical Core and Metro Networks will be of interest to researchers in industry and academia, and advanced (final year undergraduate) and postgraduate students undertaking communications, networking and optics courses.
David Lopez-Perez Small Cell Networks. Deployment, Management, and Optimization David Lopez-Perez Small Cell Networks. Deployment, Management, and Optimization Новинка

David Lopez-Perez Small Cell Networks. Deployment, Management, and Optimization

10057.35 руб. или Купить в рассрочку!
The first and only up-to-date guide offering complete coverage of HetNets—written by top researchers and engineers in the field Small Cell Networks: Deployment, Management, and Optimization addresses key problems of the cellular network evolution towards HetNets. It focuses on the latest developments in heterogeneous and small cell networks, as well as their deployment, operation, and maintenance. It also covers the full spectrum of the topic, from academic, research, and business to the practice of HetNets in a coherent manner. Additionally, it provides complete and practical guidelines to vendors and operators interested in deploying small cells. The first comprehensive book written by well-known researchers and engineers from Nokia Bell Labs, Small Cell Networks begins with an introduction to the subject—offering chapters on capacity scaling and key requirements of future networks. It then moves on to sections on coverage and capacity optimization, and interference management. From there, the book covers mobility management, energy efficiency, and small cell deployment, ending with a section devoted to future trends and applications. The book also contains: The latest review of research outcomes on HetNets based on both theoretical analyses and network simulations Over 200 sources from 3GPP, the Small Cell Forum, journals and conference proceedings, and all prominent topics in HetNet An overview of indoor coverage techniques such as metrocells, picocells and femtocells, and their deployment and optimization Real case studies as well as innovative research results based on both simulation and measurements Detailed information on simulating heterogeneous networks as used in the examples throughout the book Given the importance of HetNets for future wireless communications, Small Cell Networks: Deployment, Management, and Optimization is sure to help decision makers as they consider the migration of services to HetNets. It will also appeal to anyone involved in information and communication technology.
Lian Lu-Yun Protein NMR Spectroscopy. Practical Techniques and Applications Lian Lu-Yun Protein NMR Spectroscopy. Practical Techniques and Applications Новинка

Lian Lu-Yun Protein NMR Spectroscopy. Practical Techniques and Applications

9650.38 руб. или Купить в рассрочку!
Nuclear Magnetic Resonance (NMR) spectroscopy, a physical phenomenon based upon the magnetic properties of certain atomic nuclei, has found a wide range of applications in life sciences over recent decades. The dramatic advances in NMR techniques have led to corresponding advances in the ability of NMR to study structure, dynamics and interactions of biological macromolecules in solution under close to physiological conditions. This volume focuses on the use of NMR to study proteins. NMR can be used to determine detailed three-dimensional structures of proteins in solution. Furthermore, it provides information about conformational or chemical exchange, internal mobility and dynamics at timescales varying from pcoseconds to seconds. It is the primary technique used to obtain information on intrinsically disordered (unfolded) proteins, since these proteins will not crystallize easily. NMR is also a very powerful method for the study of interactions of protein with other molecules, whether small molecules (including drugs), nuclear acids or other proteins. This up-to-date volume covers NMR techiniques and their application to proteins, with a focus on practical details. This book will provide a newcomer to NMR with the practical guidance in order to carry out successful experiments with proteins and to analyze the resulting spectra. Those who are familiar with the chemical applications of NMR will also find is useful in understanding the special requirements of protien NMR.
Hideyuki Tokuda Enablers for Smart Cities Hideyuki Tokuda Enablers for Smart Cities Новинка

Hideyuki Tokuda Enablers for Smart Cities

10057.35 руб. или Купить в рассрочку!
Smart cities are a new vision for urban development. They integrate information and communication technology infrastructures – in the domains of artificial intelligence, distributed and cloud computing, and sensor networks – into a city, to facilitate quality of life for its citizens and sustainable growth. This book explores various concepts for the development of these new technologies (including agent-oriented programming, broadband infrastructures, wireless sensor networks, Internet-based networked applications, open data and open platforms), and how they can provide smart services and enablers in a range of public domains. The most significant research, both established and emerging, is brought together to enable academics and practitioners to investigate the possibilities of smart cities, and to generate the knowledge and solutions required to develop and maintain them.
David Chambers Femtocell Primer (Japanese Edition) David Chambers Femtocell Primer (Japanese Edition) Новинка

David Chambers Femtocell Primer (Japanese Edition)

(Japanese edition translated by Makoto Noda). Femtocells may well change the shape and operation of mobile networks over the next few years. These compact devices (the size of a paperback book) provide all the functionality of a 3G mobile cellsite, delivering high quality voice and data services to the home and office. These products are forecast to be commercially available from over 20 networks before the end of 2010. As with mobile phones, they must be sold in conjunction with a mobile phone operator because they use licensed spectrum. Initially, they are likely to be subsidised as part of a package deal. This book explains the technology, describes the key vendors, suggests likely business models and provides insights into this exciting new development of mobile networks.
Dougal Drysdale An Introduction to Fire Dynamics Dougal Drysdale An Introduction to Fire Dynamics Новинка

Dougal Drysdale An Introduction to Fire Dynamics

6480.08 руб. или Купить в рассрочку!
Drysdale's book is by far the most comprehensive – everyone in the office has a copy…now including me. It holds just about everything you need to know about fire science. (Review of An Introduction to Fire Dynamics, 2nd Edition) After 25 years as a bestseller, Dougal Drysdale's classic introduction has been brought up-to-date and expanded to incorporate the latest research and experimental data. Essential reading for all involved in the field from undergraduate and postgraduate students to practising fire safety engineers and fire prevention officers, An Introduction to Fire Dynamics is unique in that it addresses the fundamentals of fire science and fire dynamics, thus providing the scientific background necessary for the development of fire safety engineering as a professional discipline. An Introduction to Fire Dynamics Includes experimental data relevant to the understanding of fire behaviour of materials; Features numerical problems with answers illustrating the quantitative applications of the concepts presented; Extensively course-tested at Worcester Polytechnic Institute and the University of Edinburgh, and widely adopted throughout the world; Will appeal to all those working in fire safety engineering and related disciplines.
Ranjan Vepa Dynamics of Smart Structures Ranjan Vepa Dynamics of Smart Structures Новинка

Ranjan Vepa Dynamics of Smart Structures

12439.94 руб. или Купить в рассрочку!
Dynamics of Smart Structures is a practical, concise and integrated text that provides an introduction to the fundamental principles of a field that has evolved over the recent years into an independent and identifiable subject area. Bringing together the concepts, techniques and systems associated with the dynamics and control of smart structures, it comprehensively reviews the differing smart materials that are employed in the development of the smart structures and covers several recent developments in the field of structural dynamics. Dynamics of Smart Structures has been developed to complement the author's new interdisciplinary programme of study at Queen Mary, University of London that includes courses on emerging and new technologies such as biomimetic robotics, smart composite structures, micro-electro-mechanical systems (MEMS) and their applications and prosthetic control systems. It includes chapters on smart materials and structures, transducers for smart structures, fundamentals of structural control, dynamics of continuous structures, dynamics of plates and plate-like structures, dynamics of piezoelectric media, mechanics of electro-actuated composite structures, dynamics of thermo-elastic media: shape memory alloys, and controller designs for flexible structures.
Ranjan Vepa Dynamics of Smart Structures Ranjan Vepa Dynamics of Smart Structures Новинка

Ranjan Vepa Dynamics of Smart Structures

12292.16 руб. или Купить в рассрочку!
Dynamics of Smart Structures is a practical, concise and integrated text that provides an introduction to the fundamental principles of a field that has evolved over the recent years into an independent and identifiable subject area. Bringing together the concepts, techniques and systems associated with the dynamics and control of smart structures, it comprehensively reviews the differing smart materials that are employed in the development of the smart structures and covers several recent developments in the field of structural dynamics. Dynamics of Smart Structures has been developed to complement the author's new interdisciplinary programme of study at Queen Mary, University of London that includes courses on emerging and new technologies such as biomimetic robotics, smart composite structures, micro-electro-mechanical systems (MEMS) and their applications and prosthetic control systems. It includes chapters on smart materials and structures, transducers for smart structures, fundamentals of structural control, dynamics of continuous structures, dynamics of plates and plate-like structures, dynamics of piezoelectric media, mechanics of electro-actuated composite structures, dynamics of thermo-elastic media: shape memory alloys, and controller designs for flexible structures.
Glenn Parker M. Team Players and Teamwork. New Strategies for Developing Successful Collaboration Glenn Parker M. Team Players and Teamwork. New Strategies for Developing Successful Collaboration Новинка

Glenn Parker M. Team Players and Teamwork. New Strategies for Developing Successful Collaboration

1693.21 руб. или Купить в рассрочку!
Praise for Team Players and Teamwork «In the new edition of Team Players and Teamwork Glenn Parker updates his landmark compendium on the essential effect of cross-functional teamwork to encompass the added complexities of globalization facing team leaders and team members in the twenty-first century. Anyone participating on or managing members of a cross-functional team will benefit from reading this essential guide to successful teamwork.» -Jeffrey W. Warmke, vice president, global project management and leadership, Daiichi Sankyo Pharma Development «Glenn Parker has the unique combination of sound thinking and clear writing. In his recent version of Team Players and Teamwork he succeeds in taking this combination of skills to a higher level.» -Sivasilam «Thiagi» Thiagarajan, president, Workshops by Thiagi, Inc. «Glenn's book is a must-read for team leaders and team members who are looking for a comprehensive set of tools and ideas to help teams perform more effectively. Glenn offers practical wisdom-based on years of first-hand experience-that is unparalleled in the field of team dynamics.» -Robert Hoffman, executive director, organization development and talent management, oncology business unit, Norvartis Pharmaceuticals Corporation
Mohammed Daqaq F. Dynamics of Particles and Rigid Bodies. A Self-Learning Approach Mohammed Daqaq F. Dynamics of Particles and Rigid Bodies. A Self-Learning Approach Новинка

Mohammed Daqaq F. Dynamics of Particles and Rigid Bodies. A Self-Learning Approach

6596.94 руб. или Купить в рассрочку!
A unique approach to teaching particle and rigid body dynamics using solved illustrative examples and exercises to encourage self-learning The study of particle and rigid body dynamics is a fundamental part of curricula for students pursuing graduate degrees in areas involving dynamics and control of systems. These include physics, robotics, nonlinear dynamics, aerospace, celestial mechanics and automotive engineering, among others. While the field of particle and rigid body dynamics has not evolved significantly over the past seven decades, neither have approaches to teaching this complex subject. This book fills the void in the academic literature by providing a uniquely stimulating, “flipped classroom” approach to teaching particle and rigid body dynamics which was developed, tested and refined by the author and his colleagues over the course of many years of instruction at both the graduate and undergraduate levels. Complete with numerous solved illustrative examples and exercises to encourage self-learning in a flipped-classroom environment, Dynamics of Particles and Rigid Bodies: A Self-Learning Approach: Provides detailed, easy-to-understand explanations of concepts and mathematical derivations Includes numerous flipped-classroom exercises carefully designed to help students comprehend the material covered without actually solving the problem for them Features an extensive chapter on electromechanical modelling of systems involving particle and rigid body motion Provides examples from the state-of-the-art research on sensing, actuation, and energy harvesting mechanisms Offers access to a companion website featuring additional exercises, worked problems, diagrams and a solutions manual Ideal as a textbook for classes in dynamics and controls courses, Dynamics of Particles and Rigid Bodies: A Self-Learning Approach is a godsend for students pursuing advanced engineering degrees who need to master this complex subject. It will also serve as a handy reference for professional engineers across an array of industrial domains.
Raquel Walton M. Equine Clinical Pathology Raquel Walton M. Equine Clinical Pathology Новинка

Raquel Walton M. Equine Clinical Pathology

10026.72 руб. или Купить в рассрочку!
Equine Clinical Pathology is the first complete resource for hematology and clinical chemistry in horses. Encompassing the basic principles and advanced interpretation, the book’s single-species approach to pathology allows for focused coverage of the unique disease characteristics of equids. Equine Clinical Pathology is equally useful for anyone using clinical pathology as a diagnostic tool, from beginning student to experienced specialist. The heart of the book is organized by body system, making it easy to find and apply information. Chapters cover general laboratory medicine, including instruments and techniques, hematology, and proteins as well as specific organs, such as the kidney and liver. Equine Clinical Pathology is a useful bench-side reference for anyone involved in laboratory medicine for the horse.
Oliver Sturm Functional Programming in C#. Classic Programming Techniques for Modern Projects Oliver Sturm Functional Programming in C#. Classic Programming Techniques for Modern Projects Новинка

Oliver Sturm Functional Programming in C#. Classic Programming Techniques for Modern Projects

2638.15 руб. или Купить в рассрочку!
Take advantage of the growing trend in functional programming. C# is the number-one language used by .NET developers and one of the most popular programming languages in the world. It has many built-in functional programming features, but most are complex and little understood. With the shift to functional programming increasing at a rapid pace, you need to know how to leverage your existing skills to take advantage of this trend. Functional Programming in C# leads you along a path that begins with the historic value of functional ideas. Inside, C# MVP and functional programming expert Oliver Sturm explains the details of relevant language features in C# and describes theory and practice of using functional techniques in C#, including currying, partial application, composition, memoization, and monads. Next, he provides practical and versatile examples, which combine approaches to solve problems in several different areas, including complex scenarios like concurrency and high-performance calculation frameworks as well as simpler use cases like Web Services and business logic implementation. Shows how C# developers can leverage their existing skills to take advantage of functional programming Uses very little math theory and instead focuses on providing solutions to real development problems with functional programming methods, unlike traditional functional programming titles Includes examples ranging from simple cases to more complex scenarios Let Functional Programming in C# show you how to get in front of the shift toward functional programming.
Stefan Luckhaus Cost Estimation in Agile Software Development Stefan Luckhaus Cost Estimation in Agile Software Development Новинка

Stefan Luckhaus Cost Estimation in Agile Software Development

Whenever software is developed based on contracts with binding agreed conditions it is exposed to risks; conditions such as the delivery of a clearly defined functional scope at a fixed price and at an agreed delivery date. Many of these risks can be mitigated by the principles of agile development. Being able to navigate projects within all agreed parameters requires cost estimation methods to be integrated into planning and controlling processes. In order to prevent these methods from eroding the advantages of agile development, they must be rapidly applicable - ideally automatable - and allow for self-calibration after every sprint.This book illustrates, how size metrics can be utilised profitably in software development processes oriented towards agile values. It points out differences and restrictions, how the accuracy of cost estimations can be increased with each sprint and examines the feasibility of automated measurements.
Nagatoshi Nishiwaki Methods and Applications of Cycloaddition Reactions in Organic Syntheses Nagatoshi Nishiwaki Methods and Applications of Cycloaddition Reactions in Organic Syntheses Новинка

Nagatoshi Nishiwaki Methods and Applications of Cycloaddition Reactions in Organic Syntheses

15416.09 руб. или Купить в рассрочку!
Advanced tools for developing new functional materials and applications in chemical research, pharmaceuticals, and materials science Cycloadditions are among the most useful tools for organic chemists, enabling them to build carbocyclic and heterocyclic structures. These structures can then be used to develop a broad range of functional materials, including pharmaceuticals, agrochemicals, dyes, and optics. With contributions from an international team of leading experts and pioneers in cycloaddition chemistry, this book brings together and reviews recent advances, trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions in Organic Syntheses focuses on two component cycloadditions, with chapters covering such topics as: N1 unit transfer reaction to C–C double bonds [3+2] Cycloaddition of α, β-unsaturated metal-carbene complexes Formal [3+3] cycloaddition approach to natural product synthesis Development of new methods for the construction of heterocycles based on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of large π-conjugated compounds Transition metal-catalyzed or mediated [5+1] cycloadditions Readers will learn methods for seamlessly executing important reactions such as Diels-Alder and stereoselective dipolar reactions in order to fabricate heterocyclic compounds, natural products, and functional molecules. The book not only features cutting-edge topics, but also important background information, such as the contributors’ process for developing new methodologies, to help novices become fully adept in the field. References at the end of each chapter lead to original research papers and reviews for facilitating further investigation of individual topics. Covering the state of the science and technology, Methods and Applications of Cycloaddition Reactions in Organic Syntheses enables synthetic organic chemists to advance their research and develop new functional materials and applications in chemical research, pharmaceuticals, and materials science.
Maji Hailemariam Debena SOCIAL NETWORKS AS MEANS OF COPING IN ENVIRONMENT OF SOCIAL EXCLUSION Maji Hailemariam Debena SOCIAL NETWORKS AS MEANS OF COPING IN ENVIRONMENT OF SOCIAL EXCLUSION Новинка

Maji Hailemariam Debena SOCIAL NETWORKS AS MEANS OF COPING IN ENVIRONMENT OF SOCIAL EXCLUSION

This book is the first attempt in Ethiopia to perceive issues of minorities from strengths perspective. Prior research in the area mainly focuses on facts like exclusion, poverty, rights violation and the like that are resulted from social exclusion. Nevertheless, the strengths embedded in minority communities that enabled them to cope with the inhospitable living condition are neglected. This innovative manuscript vividly presents how social minorities are making use of their social networks for their economic and social wellbeing. Minorities, in the absence of formal and institutionalized social support mechanism tend to use their social networks as a form of insurance. Beyond this, the book also describes how minorities are using their social networks as the way out from social exclusion. The book argues that interventions targeting minorities should approach from the strengths existing in minority community.
Stefan Vogt A Design and Development Method for Artificial Neural Network Projects Stefan Vogt A Design and Development Method for Artificial Neural Network Projects Новинка

Stefan Vogt A Design and Development Method for Artificial Neural Network Projects

Inhaltsangabe:Abstract: In the 1980s research efforts and successes made artificial neural networks popular. Since the 1990s engineers have been using this foundation for problem solving. But artifiial neural network solutions for "real-world" problems are sometimes hard to find because of the complexity of the domain and because of the vast number of design attributes the engineer has to deal with. This thesis provides a structured overview of attributes in the design process of artificial neural networks and reviews technical process models. Current development methods for artificial neural networks are then reviewed and critiqued. The thesis concludes with a new design and development method for artificial neural networks. Inhaltsverzeichnis:Table of Contents: List of figuresx List of tablesxi Introduction1 1.Design attributes in ANN3 1.1ANN models4 1.1.1Node level7 1.1.2Network level9 1.1.3Training level9 1.2Data and data representation10 1.3Global system design12 1.4Hardware and software implementation13 1.5Characteristics of ANNs15 1.5.1Advantages of ANNs15 1.5.2Limitations and concerns16 2.Technical process models and engineering methods18 2.1Why use an engineering method?18 2.2Evolutionary model of engineering discipline20 2.3Overview of technical process models22 2.3.1Taxonomy of technical process models24 2.3.2Prototyping25 2.3.3Incremental method26 2.3.4Strict contractual approach26 2.3.5Deciding on process models and methods26 2.3.6Examples of process mode...
Nirwan Ansari Green Mobile Networks. A Networking Perspective Nirwan Ansari Green Mobile Networks. A Networking Perspective Новинка

Nirwan Ansari Green Mobile Networks. A Networking Perspective

8566.77 руб. или Купить в рассрочку!
Green communications is a very hot topic. As mobile networks evolve in terms of higher rates/throughput, a consequent impact on operating costs is due to (aggregate) network energy consumption. As such, design on 4G networks and beyond have increasingly started to focus on `energy efficiency’ or so-called ‘green’ networks. Many techniques and solutions have been proposed to enhance the energy efficiency of mobile networks, yet no book has provided an in-depth analysis of the energy consumption issues in mobile networks nor has detailed theories, tools and solutions for solving the energy efficiency problems. This book presents the techniques and solutions for enhancing energy efficiency of future mobile networks, and consists of three major parts. The first part presents a general description of mobile network evolution in terms of both capacity and energy efficiency. The second part discusses the advanced techniques to green mobile networks. The third part discusses the solutions that enhance mobile network energy efficiency as well as provides future directions. Whilst the reader is expected to have basic knowledge of wireless communications, the authors present a brief introduction of the evolution of mobile networks, providing the knowledge base for understanding the content of the book. In addition, complicated network problems are illustrated using simple examples. This will help the reader understand the concept and intuition of various techniques and solutions. Incorporates the latest research results from both academia and industry, providing an up-to-date overview of existing technologies and solutions on making mobile networks greener Consists of three sections with a gradually increasing technical depth on green mobile networks, providing the reader with a systematic view of the research area, and helping those with different technical backgrounds to better understand the content Covers existing enabling technologies for green mobile networking, including an innovative discussion of state-of-the-art solutions and algorithms
Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena Новинка

Findlay John W. Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena

10555.1 руб. или Купить в рассрочку!
A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field. Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include: A general discussion of challenges and proven approaches in the development of ligand-binding assays More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules A practical approach to «fit-for-purpose» validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.
Patrick Prouzet Value and Economy of Marine Resources Patrick Prouzet Value and Economy of Marine Resources Новинка

Patrick Prouzet Value and Economy of Marine Resources

11174.05 руб. или Купить в рассрочку!
Marine resources and their exploitation, recovery and economic networks they generate are here from the perspective now inevitable growing environmental constraints, policy management and technical innovation. The recent development of marine biotechnology , the discovery of a great pharmacopoeia especially in reef environments , the development of marine renewables , are examples which show that man can develop through these new technologies property and services of the ocean. But this development resources under pressure of global change requires not only taking into account technical, but also social and political. This is the price that the analysis of maritime activities will assess the sustainability and development of various economic sectors and coastal populations, faced with the objectives of a «blue growth» associated with a return to the "good state "of the marine environment.

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According to an August 2009 report from PricewaterhouseCoopers, the United States market for functional foods in 2007 was US$ 27 billion. Forecasts of growth range from between 8.5% and 20% per year, or about four times that of the food industry in general. Global demand by 2013 is expected to be about $100 billion. With this demand for new products comes a demand for product development and supporting literature for that purpose. There is a wealth of research and development in this area and great scope for commercialization, and this book provides a much-needed review of important opportunities for new products, written by authors with in-depth knowledge of as yet unfulfilled health-related needs. This book addresses functional food product development from a number of perspectives: the process itself; health research that may provide opportunities; idea creation; regulation; and processes and ingredients. It also features case studies that illustrate real product development and commercialization histories. Written for food scientists and technologists, this book presents practical information for use in functional food product development. It is an essential resource for practitioners in functional food companies and food technology centres and is also of interest to researchers and students of food science. Key features: A comprehensive review of the latest opportunities in this commercially important sector of the food industry Includes chapters highlighting functional food opportunities for specific health issues such as obesity, immunity, brain health, heart disease and the development of children. New technologies of relevance to functional foods are also addressed, such as emulsion delivery systems and nanoencapsulation. Includes chapters on product design and the use of functional ingredients such as antioxidants, probiotics and prebiotics as well as functional ingredients from plant and dairy sources Specific examples of taking products to market are provided in the form of case studies e.g. microalgae functional ingredients Part of the Functional Food Science and Technology book series (Series Editor: Fereidoon Shahidi)
Продажа development dynamics and pathology of neuronal networks from molecules to functional circuits147 лучших цены всего мира
Посредством этого сайта магазина - каталога товаров мы очень легко осуществляем продажу development dynamics and pathology of neuronal networks from molecules to functional circuits147 у одного из интернет-магазинов проверенных фирм. Определитесь с вашими предпочтениями один интернет-магазин, с лучшей ценой продукта. Прочитав рекомендации по продаже development dynamics and pathology of neuronal networks from molecules to functional circuits147 легко охарактеризовать производителя как превосходную и доступную фирму.