development of mushroom powder and its application in bread



Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development Новинка

Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development

10788.52 руб. или Купить в рассрочку!
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
Richard N. Hart Leavening Agents; Yeast, Leaven, Salt-Rising Fermentation, Baking Powder, Aerated Bread, Milk Powder Richard N. Hart Leavening Agents; Yeast, Leaven, Salt-Rising Fermentation, Baking Powder, Aerated Bread, Milk Powder Новинка

Richard N. Hart Leavening Agents; Yeast, Leaven, Salt-Rising Fermentation, Baking Powder, Aerated Bread, Milk Powder

Leavening Agents; Yeast, Leaven, Salt-Rising Fermentation, Baking Powder, Aerated Bread, Milk Powder. PREFACE This volume fills a gap in the literature of baking in this country. The baker knows a good deal about his flours and also how they are made, but he knows very little about his yeast and less still about his baking powder. He has been well supplied with literature on the technology and chemistry of flour, but much of the data on his aerating agents has either been aimed over his head or else has been purposely misleading. Aerated bread has been added because of its historical value and because of its possible future. Dry Milk is another recent important addition to baking materials. Yeast, is necessariIy a technical subject, has been treated in as condensed and simple a manner as possible. The author acknowledges his indebtedness to an anonymous friend for the section on the manufacture of yeast. This is the first exact and detailed description of yeast manufacture in English, and is an importarit addition to the literature of chemical technology. Baking powder is a subject on which the bakers and the public have been misinformed. The water has been so badly stirred up by the baking powder controversy...
A. Gould Lawrence Statistical Methods for Evaluating Safety in Medical Product Development A. Gould Lawrence Statistical Methods for Evaluating Safety in Medical Product Development Новинка

A. Gould Lawrence Statistical Methods for Evaluating Safety in Medical Product Development

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This book gives professionals in clinical research valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It also provides understanding and practical guidance on the application of contemporary statistical methods to contemporary issues in safety evaluation during medical product development. Each chapter provides sufficient detail to the reader to undertake the design and analysis of experiments at various stages of product development, including comprehensive references to the relevant literature. Provides a guide to statistical methods and application in medical product development Assists readers in undertaking design and analysis of experiments at various stages of product development Features case studies throughout the book, as well as, SAS and R code
Mitchell Cayen N. Early Drug Development. Strategies and Routes to First-in-Human Trials Mitchell Cayen N. Early Drug Development. Strategies and Routes to First-in-Human Trials Новинка

Mitchell Cayen N. Early Drug Development. Strategies and Routes to First-in-Human Trials

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The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in preparing and submitting an Investigational New Drug (IND) application. By explaining the nuts and bolts of preclinical development activities and their interplay in effectively identifying successful clinical candidates, the book helps pharmaceutical scientists determine what types of discovery and preclinical research studies are needed in order to support a submission to regulatory agencies.
K. Rainsford D. Ibuprofen. Discovery, Development and Therapeutics K. Rainsford D. Ibuprofen. Discovery, Development and Therapeutics Новинка

K. Rainsford D. Ibuprofen. Discovery, Development and Therapeutics

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Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.
Litwin Virginia Flow Cytometry in Drug Discovery and Development Litwin Virginia Flow Cytometry in Drug Discovery and Development Новинка

Litwin Virginia Flow Cytometry in Drug Discovery and Development

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This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.
Brendan McCormack Practice Development in Nursing and Healthcare Brendan McCormack Practice Development in Nursing and Healthcare Новинка

Brendan McCormack Practice Development in Nursing and Healthcare

In its first edition, Practice Development in Nursing made an important contribution to understanding practice development and its core components. Now fully updated to take into account the many developments in the field, the second edition continues to fill an important gap in the market for an accessible, practical text on what remains a key issue for all members of the healthcare team globally. Practice Development in Nursing and Healthcare explores the basis of practice development and its aims, implementation and impact on healthcare, to enable readers to be confident in their approaches to practice development. It is aimed at healthcare professionals in a variety of roles (for example clinical practice, education, research and quality improvement) and students, as well as those with a primary practice development role, in order to enable them to effectively and knowledgeably develop practice and the practice of others. Key features: New updated edition of a seminal text in the field, including significant new material Relevance to the entire healthcare team Accessible and practical in style, with case studies, scenarios and examples throughout Edited by and with contributions from experts in the field Fully updated to include the latest research Supported by a strong evidence base
Zhang Honggang Cognitive Communications. Distributed Artificial Intelligence (DAI), Regulatory Policy and Economics, Implementation Zhang Honggang Cognitive Communications. Distributed Artificial Intelligence (DAI), Regulatory Policy and Economics, Implementation Новинка

Zhang Honggang Cognitive Communications. Distributed Artificial Intelligence (DAI), Regulatory Policy and Economics, Implementation

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This book discusses in-depth the concept of distributed artificial intelligence (DAI) and its application to cognitive communications In this book, the authors present an overview of cognitive communications, encompassing both cognitive radio and cognitive networks, and also other application areas such as cognitive acoustics. The book also explains the specific rationale for the integration of different forms of distributed artificial intelligence into cognitive communications, something which is often neglected in many forms of technical contributions available today. Furthermore, the chapters are divided into four disciplines: wireless communications, distributed artificial intelligence, regulatory policy and economics and implementation. The book contains contributions from leading experts (academia and industry) in the field. Key Features: Covers the broader field of cognitive communications as a whole, addressing application to communication systems in general (e.g. cognitive acoustics and Distributed Artificial Intelligence (DAI) Illustrates how different DAI based techniques can be used to self-organise the radio spectrum Explores the regulatory, policy and economic issues of cognitive communications in the context of secondary spectrum access Discusses application and implementation of cognitive communications techniques in different application areas (e.g. Cognitive Femtocell Networks (CFN) Written by experts in the field from both academia and industry Cognitive Communications will be an invaluable guide for research community (PhD students, researchers) in the areas of wireless communications, and development engineers involved in the design and development of mobile, portable and fixed wireless systems., wireless network design engineer. Undergraduate and postgraduate students on elective courses in electronic engineering or computer science, and the research and engineering community will also find this book of interest.
Ola Soderstrom Cities in Relations. Trajectories of Urban Development in Hanoi and Ouagadougou Ola Soderstrom Cities in Relations. Trajectories of Urban Development in Hanoi and Ouagadougou Новинка

Ola Soderstrom Cities in Relations. Trajectories of Urban Development in Hanoi and Ouagadougou

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Cities in Relations advances a novel way of thinking about urban transformation by focusing on transnational relations in the least developed countries. Examines the last 20 years of urban development in Hanoi, Vietnam, and in Ouagadougou, Burkina Faso Considers the ways in which a city’s relationships with other places influences its urban development Provides fresh ideas for comparative urban studies that move beyond discussions of economic and policy factors Offers a clear and concise narrative accompanied by more than 45 photos and maps
Hua-Tay Lin Design, Development, and Applications of Structural Ceramics, Composites, and Nanomaterials Hua-Tay Lin Design, Development, and Applications of Structural Ceramics, Composites, and Nanomaterials Новинка

Hua-Tay Lin Design, Development, and Applications of Structural Ceramics, Composites, and Nanomaterials

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Contains a collection of papers from the below symposia held during the 10th Pacific Rim Conference on Ceramic and Glass Technology (PacRim10), June 2-7, 2013, in Coronado, California 2012: Engineering Ceramics and Ceramic Matrix Composites: Design, Development, and Application Advanced Ceramic Coatings: Processing, Properties, and Application Geopolymers – Low Energy, Environmentally Friendly, Inorganic Polymeric Ceramic Multifunctional Metal Oxide Nanostructures and Heteroarchitectures for Energy and Device Application Advanced Characterization and Modeling of Ceramic Interfaces
Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Новинка

Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery

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Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover: A general overview of the discipline, from its foundations to contemporary industrial applications Chemoinformatics-based applications Bioinformatics-based applications Data mining methods in clinical development Data mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.
Azapagic Adisa Sustainable Development in Practice. Case Studies for Engineers and Scientists Azapagic Adisa Sustainable Development in Practice. Case Studies for Engineers and Scientists Новинка

Azapagic Adisa Sustainable Development in Practice. Case Studies for Engineers and Scientists

13656.41 руб. или Купить в рассрочку!
Sustainable Development in Practice: Case Studies for Engineers and Scientists, Second Edition explores the concept of sustainable development and its implications for science and engineering. It looks at how sustainability criteria can be combined with traditional scientific and engineering considerations to design and operate industrial systems in a more sustainable manner. Taking a life cycle approach to addressing economic, environmental and social issues, the book presents a series of new practical case studies drawn from a range of sectors, including mining, energy, food, buildings, transport, waste, and health. Written in an accessible style, the book opens with a general introduction to the concept of sustainable development and explores its practical implications for technical experts. Recognising that practical application of sustainable development depends on the context, the second part of the book is devoted to case studies. The case studies explore scientific and technical aspects alongside relevant environmental economic and social issues. The key features of this completely revised and updated second edition include: Twelve new chapters, including the case studies on nuclear energy, biofuels, aviation, buildings, urban transport, food, sanitation and health. Six completely revised chapters Coverage of a wide range of sustainability issues in both developed and developing countries Integration of scientific and technical aspects with economic, environmental and social considerations Discussion of policy implications Communication with the non-engaging and non-scientific audience Considered essential reading for all engineers and scientists concerned with sustainable development, Sustainable Development in Practice: Case Studies for Engineers and Scientists, Second Edition also provides key reading and learning materials for undergraduate and postgraduate science and engineering students.
Vikas Mittal Hybrid Nanomaterials. Advances in Energy, Environment, and Polymer Nanocomposites Vikas Mittal Hybrid Nanomaterials. Advances in Energy, Environment, and Polymer Nanocomposites Новинка

Vikas Mittal Hybrid Nanomaterials. Advances in Energy, Environment, and Polymer Nanocomposites

17101.87 руб. или Купить в рассрочку!
A hybrid material is defined as a material composed of an intimate mixture of inorganic components, organic components, or both types of components. In the last few years, a tremendous amount of attention has been given towards the development of materials for efficient energy harvesting; nanostructured hybrid materials have also been gaining significant advances to provide pollutant free drinking water, sensing of environmental pollutants, energy storage and conservation. Separately, intensive work on high performing polymer nanocomposites for applications in the automotive, aerospace and construction industries has been carried out, but the aggregation of many fillers, such as clay, LDH, CNT, graphene, represented a major barrier in their development. Only very recently has this problem been overcome by fabrication and applications of 3D hybrid nanomaterials as nanofillers in a variety of polymers. This book, Hybrid Nanomaterials, examines all the recent developments in the research and specially covers the following subjects: Hybrid nanostructured materials for development of advanced lithium batteries High performing hybrid nanomaterials for supercapacitor applications Nanohybrid materials in the development of solar energy applications Application of hybrid nanomaterials in water purification Advanced nanostructured materials in electromagnetic shielding of radiations Preparation, properties and application of hybrid nanomaterials in sensing of environmental pollutants Development of hybrid fillers/polymer nanocomposites for electronic applications High performance hybrid filler reinforced epoxy nanocomposites State-of-the-art overview of elastomer/hybrid filler nanocomposites
Elisa New New England Beyond Criticism. In Defense of America's First Literature Elisa New New England Beyond Criticism. In Defense of America's First Literature Новинка

Elisa New New England Beyond Criticism. In Defense of America's First Literature

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Timely and beautifully written, New England Beyond Criticism provides a passionate defense of the importance of the literature of New England to the American literary canon, and its impact on the development of spirituality, community, and culture in America. An exploration and defense of the prominence of New England’s literary tradition within the canon of American literature Traces the impact of the literature of New England on the development of spirituality, community, and culture in America Includes in-depth studies of work from authors and poets such as William Bradford, Emily Dickinson, Robert Frost, Henry David Thoreau, Susan Howe, and Marilynne Robinson Examines the place and impression of New England literature in the nation’s intellectual history and the lives of its readers
Ulrich Mueller Handbook of Child Psychology and Developmental Science, Cognitive Processes Ulrich Mueller Handbook of Child Psychology and Developmental Science, Cognitive Processes Новинка

Ulrich Mueller Handbook of Child Psychology and Developmental Science, Cognitive Processes

17481.17 руб. или Купить в рассрочку!
The essential reference for human development theory, updated and reconceptualized The Handbook of Child Psychology and Developmental Science, a four-volume reference, is the field-defining work to which all others are compared. First published in 1946, and now in its Seventh Edition, the Handbook has long been considered the definitive guide to the field of developmental science. Volume 2: Cognitive Processes describes cognitive development as a relational phenomenon that can be studied only as part of a larger whole of the person and context relational system that sustains it. In this volume, specific domains of cognitive development are contextualized with respect to biological processes and sociocultural contexts. Furthermore, key themes and issues (e.g., the importance of symbolic systems and social understanding) are threaded across multiple chapters, although every each chapter is focused on a different domain within cognitive development. Thus, both within and across chapters, the complexity and interconnectivity of cognitive development are well illuminated. Learn about the inextricable intertwining of perceptual development, motor development, emotional development, and brain development Understand the complexity of cognitive development without misleading simplification, reducing cognitive development to its biological substrates, or viewing it as a passive socialization process Discover how each portion of the developmental process contributes to subsequent cognitive development Examine the multiple processes – such as categorizing, reasoning, thinking, decision making and judgment – that comprise cognition The scholarship within this volume and, as well, across the four volumes of this edition, illustrate that developmental science is in the midst of a very exciting period. There is a paradigm shift that involves increasingly greater understanding of how to describe, explain, and optimize the course of human life for diverse individuals living within diverse contexts. This Handbook is the definitive reference for educators, policy-makers, researchers, students, and practitioners in human development, psychology, sociology, anthropology, and neuroscience.
Embroidering Lives: Women's Work and Skill in the Lucknow Embroidery Industry Embroidering Lives: Women's Work and Skill in the Lucknow Embroidery Industry Новинка

Embroidering Lives: Women's Work and Skill in the Lucknow Embroidery Industry

Fusing aesthetic and economic analyses, Embroidering Lives investigates the lives and work of women in the chikan embroidery industry of Lucknow, India. Richly descriptive and accessibly written, the book explores many important issues in women's studies, anthropology, and urban development today - the impact of purdah (seclusion of women) upon women's work and occupational opportunities, the key role of sub-contractors in home-based industry, the need to understand a handicraft from its makers' point of view, and the role of development agencies and programs.
Letizia Brandi Antibiotics. Targets, Mechanisms and Resistance Letizia Brandi Antibiotics. Targets, Mechanisms and Resistance Новинка

Letizia Brandi Antibiotics. Targets, Mechanisms and Resistance

16721.84 руб. или Купить в рассрочку!
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
Innovation in the Pharmaceutical Industry: The Process of Drug Discovery and Development Innovation in the Pharmaceutical Industry: The Process of Drug Discovery and Development Новинка

Innovation in the Pharmaceutical Industry: The Process of Drug Discovery and Development

Book DescriptionInnovation in the Pharmaceutical Industry traces the discovery and development of drugs in Japan and the UK both historically and sociologically. It includes sixteen case studies of major pharmaceutical developments in the twentieth century, encompassing, among others, beta-blockers, beta-stimulants, inhaled steroids and histamine H2-antagonists. The book illustrates that the four stages of drug development - namely compound, application, organizational authorization and market - are interactively shaped by heterogeneous actors and institutions. The book also identifies three different types of pharmaceutical development - paradigmatic innovation, application innovation and modification-based innovation, all with distinguishable features in the drug development process. Finally, several historical, structural and cultural factors influencing the shaping of medicines are revealed by the comparison between British and Japanese drug innovation. Addressing a number of practical implications for the promotion of the pharmaceutical industry, this book will be of enormous interest to students, researchers and academics specializing in science and technology, and the management of technology and innovation. Practitioners, managers, and policy planners within the pharmaceutical industry will also deem this book invaluable.
Tanja Wuestenberg Cellulose and Cellulose Derivatives in the Food Industry. Fundamentals and Applications Tanja Wuestenberg Cellulose and Cellulose Derivatives in the Food Industry. Fundamentals and Applications Новинка

Tanja Wuestenberg Cellulose and Cellulose Derivatives in the Food Industry. Fundamentals and Applications

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Cellulose and its derivatives can be found in many forms in nature and is a valuable material for all manner of applications in industry. This book is authored by an expert with many years of experience as an application engineer at renowned cellulose processing companies in the food industry. All the conventional and latest knowledge available on cellulose and its derivatives is presented. The necessary details are elucidated from a theoretical and practical viewpoint, while retaining the focus on food applications. This book is an essential source of information and includes recommendations and instructions of a general nature to assist readers in the exploration of possible applications of cellulose and its derivatives, as well as providing food for thought for the generation of new ideas for product development. Topics include gelling and rheological properties, synergistic effects with other hydrocolloids, as well as nutritional and legal aspects. The resulting compilation covers all the information and advice needed for the successful development, implementation, and handling of cellulose-containing products.
Michael Maratsos Minnesota Symposium on Child Psychology, Volume 38. Culture and Developmental Systems Michael Maratsos Minnesota Symposium on Child Psychology, Volume 38. Culture and Developmental Systems Новинка

Michael Maratsos Minnesota Symposium on Child Psychology, Volume 38. Culture and Developmental Systems

11020.74 руб. или Купить в рассрочку!
The latest on child psychology and the role of cultural and developmental systems Now in its 38th volume, Minnesota Symposia on Child Psychology: Culture and Developmental Systems contains the collected papers from the most prestigious symposia in the field of child development. Providing scholars, students, and practitioners with access to the work of leading researchers in human development, it outlines how the field has advanced dramatically in recent years—both empirically and conceptually. The updated collection outlines the latest information and research on child psychology, including the cultural neuroscience of the developing brain in childhood, the role of culture and language in the development of color categorization, socioemotional development across cultures, and much more. Find out how much math is 'hard wired,' if at all Explore the development of culture, language, and emotion Discover cultural expressions and the neurobiological underpinnings in mother-infant interactions Examine the cultural organization of young children's everyday learning Written for generalists and specialists alike, Minnesota Symposia on Child Psychology offers the most up-to-date information on the central processes of human development and its implications for school success, as well as other areas.
Natanya Civjan Chemical Biology. Approaches to Drug Discovery and Development to Targeting Disease Natanya Civjan Chemical Biology. Approaches to Drug Discovery and Development to Targeting Disease Новинка

Natanya Civjan Chemical Biology. Approaches to Drug Discovery and Development to Targeting Disease

10633.29 руб. или Купить в рассрочку!
An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.
Qiang Zhang Advanced Hierarchical Nanostructured Materials Qiang Zhang Advanced Hierarchical Nanostructured Materials Новинка

Qiang Zhang Advanced Hierarchical Nanostructured Materials

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An overview of the recent developments and prospects in this highly topical area, covering the synthesis, characterization, properties and applications of hierarchical nanostructured materials. The book concentrates on those materials relevant for research and development in the fields of energy, biomedicine and environmental protection, with a strong focus on 3D materials based on nanocarbons, mesoporous silicates, hydroxides, core-shell particles and helical nanostructures. Thanks to its clear concept and application-oriented approach, this is an essential reference for experienced researchers and newcomers to the field alike.
Nicolas Lesca Environmental Scanning and Sustainable Development Nicolas Lesca Environmental Scanning and Sustainable Development Новинка

Nicolas Lesca Environmental Scanning and Sustainable Development

10788.52 руб. или Купить в рассрочку!
This work is an initial exploration of the relationship between scanning and sustainable development. In ten chapters, the authors examine the application, characteristics and implementation of scanning oriented toward sustainable development. Thus the work offers some answers to the questions “what is sustainable scanning?”, “what new issues does it raise for management practice and management science?”, “what forms can it take?” and “how…?”
James Clackson A Companion to the Latin Language James Clackson A Companion to the Latin Language Новинка

James Clackson A Companion to the Latin Language

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A Companion to the Latin Language presents a collection of original essays from international scholars that track the development and use of the Latin language from its origins to its modern day usage. Brings together contributions from internationally renowned classicists, linguists and Latin language specialists Offers, in a single volume, a detailed account of different literary registers of the Latin language Explores the social and political contexts of Latin Includes new accounts of the Latin language in light of modern linguistic theory Supplemented with illustrations covering the development of the Latin alphabet
Kenneth Kahn B. The PDMA Handbook of New Product Development Kenneth Kahn B. The PDMA Handbook of New Product Development Новинка

Kenneth Kahn B. The PDMA Handbook of New Product Development

10478.06 руб. или Купить в рассрочку!
New Product Development is one of the most important challenges facing organizations today. The Product Development and Management Association (PDMA) Handbook of New Product Development 3rd Edition provides an exceptional review of cutting edge topics for both new and experienced product development leaders. It offers a comprehensive and updated guide to the practices, processes and tools critical to achieving and sustaining new product/service development success in today’s world, delivering valuable information about the fundamentals as well as emerging practices such as venturing, virtual product development and the use of social media in NPD. As the premier global advocate for professionals and organizations working in the fields of new product/service development, PDMA has assembled in the Handbook unique content on the critical aspects of product development success including its 2012 Best Practices Research, Lessons Learned from its Outstanding Corporate Innovator Award Winners and keys to success from organizations with proven innovation track records. The 3rd Edition is an essential reference for anyone with responsibility for product development activities, from novices looking for fundamentals to experts seeking insights on emerging concepts, and is relevant for all functions and all product/service industries.
William Congreve A treatise on the general principles, powers, and facility of application of the Congreve Rocket System, as compared with artillery William Congreve A treatise on the general principles, powers, and facility of application of the Congreve Rocket System, as compared with artillery Новинка

William Congreve A treatise on the general principles, powers, and facility of application of the Congreve Rocket System, as compared with artillery

Полный вариант заголовка: «A treatise on the general principles, powers, and facility of application of the Congreve Rocket System, as compared with artillery : showing the various applications of this weapon, both for sea and land service, and its different uses in the field and in sieges : illustrated by plates of the principal exercises and cases of actual service : with a demonstration of the comparative economy of the system / by Sir W. Congreve».
Triticale Improvement and Production Triticale Improvement and Production Новинка

Triticale Improvement and Production

Triticale, the first successful human-made cereal grain, was deliberately produced in 1875 by crossing wheat with rye. Since then, the evolution of this crop has been the topic of keen interest for many plant scientists. This book presents updated information on various aspects of triticale production, improvement, uses and marketing strategies in the world. It also includes 13 country reports about triticale production and research status. In spite of the recent origin of this new crop and the limited research dedicated to its development, triticale inspires special attraction because of its good performance in stress environments and its diversified uses. Further research and commitment is needed to continue its progress and increase its adaptation to different environments. The present publication is part of this effort.
Marc Maesschalck Reflexive Governance for Research and Innovative Knowledge Marc Maesschalck Reflexive Governance for Research and Innovative Knowledge Новинка

Marc Maesschalck Reflexive Governance for Research and Innovative Knowledge

8740.59 руб. или Купить в рассрочку!
The governance theories that have developed over the past twenty years offer a new framework to consider and examine the collective conditions of a «Responsible Research and Innovation – RRI» linked up with the policy challenges of a society in transition in all its modes of regulation. This book will recall the genesis of the reflexive point of view in the context of the development of the theory of governance. It will then develop the strengths of the model and finally, will show the fruitfulness of its application to the field of the RRI.
Claudio Carini Biomarkers in Drug Development. A Handbook of Practice, Application, and Strategy Claudio Carini Biomarkers in Drug Development. A Handbook of Practice, Application, and Strategy Новинка

Claudio Carini Biomarkers in Drug Development. A Handbook of Practice, Application, and Strategy

15505.33 руб. или Купить в рассрочку!
Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.
Wolfram Jäger Mauerwerk-Kalender 2014. Bemessen, Bewehren, Bestigen Wolfram Jäger Mauerwerk-Kalender 2014. Bemessen, Bewehren, Bestigen Новинка

Wolfram Jäger Mauerwerk-Kalender 2014. Bemessen, Bewehren, Bestigen

In the year of the official introduction of Eurocode 6, the Masonry Yearbook gives useful practical help in its application. Further main themes: reinforced masonry and fixings. In addition, as ever: all new developments requiring approval and building material characteristics.
Kai Chang Fundamentals of Optical Fiber Sensors Kai Chang Fundamentals of Optical Fiber Sensors Новинка

Kai Chang Fundamentals of Optical Fiber Sensors

9272.77 руб. или Купить в рассрочку!
This book describes the latest development in optical fiber devices, and their applications to sensor technology. Optical fiber sensors, an important application of the optical fiber, have experienced fast development, and attracted wide attentions in basic science as well as in practical applications. Sensing is often likened to human sense organs. Optical fiber can not only transport information acquired by sensors at high speed and large volume, but also can play the roles of sensing element itself. Compared with electric and other types of sensors, fiber sensor technology has unique merits. It has advantages over conventional bulky optic sensors, such as combination of sensing and signal transportation, smaller size, and possibility of building distributed systems. Fiber sensor technology has been used in various areas of industry, transportation, communication, security and defense, as well as daily life. Its importance has been growing with the advancement of the technology and the expansion of the scope of its application, a growth this book fully describes.
Sarmento Bruno Chitosan-Based Systems for Biopharmaceuticals. Delivery, Targeting and Polymer Therapeutics Sarmento Bruno Chitosan-Based Systems for Biopharmaceuticals. Delivery, Targeting and Polymer Therapeutics Новинка

Sarmento Bruno Chitosan-Based Systems for Biopharmaceuticals. Delivery, Targeting and Polymer Therapeutics

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Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules – making it a valuable component in the formulation of biopharmaceutical drugs. Chitosan-Based Systems for Biopharmaceuticals provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. The book is divided in four different parts. Part I discusses general aspects of chitosan and its derivatives, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems. Part II deals with the use of chitosan and derivatives in the formulation and delivery of biopharmaceuticals, and focuses on the synergistic effects between chitosan and this particular subset of pharmaceuticals. Part III discusses specific applications of chitosan and its derivatives for biopharmaceutical use. Finally, Part IV presents diverse viewpoints on different issues such as regulatory, manufacturing and toxicological requirements of chitosan and its derivatives related to the development of biopharmaceutical products, as well as their patent status, and clinical application and potential. Topics covered include: chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals physical properties of chitosan and derivatives in sol and gel states absorption promotion properties of chitosan and derivatives biocompatibility and biodegradation of chitosan and derivatives biological and pharmacological activity of chitosan and derivatives biological, chemical and physical compatibility of chitosan and biopharmaceuticals approaches for functional modification or crosslinking of chitosan use of chitosan and derivatives in conventional biopharmaceutical dosage forms manufacture techniques of chitosan-based microparticles and nanoparticles for biopharmaceuticals chitosan and derivatives for biopharmaceutical use: mucoadhesive properties chitosan-based systems for mucosal delivery of biopharmaceuticals chitosan-based delivery systems for mucosal vaccination chitosan-based nanoparticulates for oral delivery of biopharmaceuticals chitosan-based systems for ocular delivery of biopharmaceuticals chemical modification of chitosan for delivery of DNA and siRNA target-specific chitosan-based nanoparticle systems for nucleic acid delivery functional PEGylated chitosan systems for biopharmaceuticals stimuli-sensitive chitosan-based systems for biopharmaceuticals chitosan copolymers for biopharmaceuticals application of chitosan for anti-cancer biopharmaceutical delivery chitosan-based biopharmaceuticals scaffolds in tissue engineering and regenerative medicine wound healing properties of chitosan and its use in wound dressing biopharmaceuticals toxicological properties of chitosan and derivatives for biopharmaceutical applications regulatory status of chitosan and derivatives patentability and intellectual property issues quality control and good manufacturing practice preclinical and clinical use of chitosan and derivatives for biopharmaceuticals Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development.
Karen Wilson Heterogeneous Catalysts for Clean Technology. Spectroscopy, Design, and Monitoring Karen Wilson Heterogeneous Catalysts for Clean Technology. Spectroscopy, Design, and Monitoring Новинка

Karen Wilson Heterogeneous Catalysts for Clean Technology. Spectroscopy, Design, and Monitoring

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Reactive, but not a reactant. Heterogeneous catalysts play an unseen role in many of today's processes and products. With the increasing emphasis on sustainability in both products and processes, this handbook is the first to combine the hot topics of heterogeneous catalysis and clean technology. It focuses on the development of heterogeneous catalysts for use in clean chemical synthesis, dealing with how modern spectroscopic techniques can aid the design of catalysts for use in liquid phase reactions, their application in industrially important chemistries – including selective oxidation, hydrogenation, solid acid- and base-catalyzed processes – as well as the role of process intensification and use of renewable resources in improving the sustainability of chemical processes. With its emphasis on applications, this book is of high interest to those working in the industry.
Evgeniy Goryushkin Databases in DMS of Microsoft Access: methodical handbook on computer science Evgeniy Goryushkin Databases in DMS of Microsoft Access: methodical handbook on computer science Новинка

Evgeniy Goryushkin Databases in DMS of Microsoft Access: methodical handbook on computer science

The educational and methodical manual is a complex set of tasks for the development of databases, as well as a set of tasks for independent work and control questions. There are tasks which are provided for work in the program MS Access, and included in the package of application programs Microsoft Office 2010. The development contains both theoretical and practical parts. This publication is recommended for the teacher for effective formation of both theoretical knowledge and practical skills of students of the international faculty of various specialties. It will be also useful for students who are starting to study this program for the first time and wish to increase and consolidate their level of knowledge and skills in the field of database development.
Thomas Schafer Automatische genetische Analytik Thomas Schafer Automatische genetische Analytik Новинка

Thomas Schafer Automatische genetische Analytik

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The relevance of genetic analysis and the need of its automation have rapidly increased during the last years not only in molecular biology and medicine but particularly in fields outside these 'classical' areas of application. In forensic medicine and criminology, e.g., DNA analysis has become a routine method – and a similar development is just ongoing in fields like anthropology, paleontology, plant and animal breeding, and food production. This book provides a comprehensive and practical overview of the methods – from biological material and analytical processes to the analysis and processing of data – and provides insights into various important applications. Clearly written and nicely illustrated with color figures the book will serve as a useful source of information for a broad spectrum of (potential) users of DNA analysis.
Jiann-Yang Hwang Characterization of Minerals, Metals, and Materials 2014 Jiann-Yang Hwang Characterization of Minerals, Metals, and Materials 2014 Новинка

Jiann-Yang Hwang Characterization of Minerals, Metals, and Materials 2014

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This collection focuses on the characterization of minerals, metals, and materials as well as the application of characterization results on the processing of these materials. Focused sessions within the symposia include those centered on ferrous metals, non-ferrous metals, soft materials, ceramics, clays, composites, and minerals. In addition, sessions will focus exclusively on characterization concerns in the extraction, processing, and environmental application of materials. Finally, method development in characterization will be explored.
Atul Tiwari Reactions and Mechanisms in Thermal Analysis of Advanced Materials Atul Tiwari Reactions and Mechanisms in Thermal Analysis of Advanced Materials Новинка

Atul Tiwari Reactions and Mechanisms in Thermal Analysis of Advanced Materials

17101.87 руб. или Купить в рассрочку!
Strong bonds form stronger materials. For this reason, the investigation on thermal degradation of materials is a significantly important area in research and development activities. The analysis of thermal stability can be used to assess the behavior of materials in the aggressive environmental conditions, which in turn provides valuable information about the service life span of the materiel. Unlike other books published so far that have focused on either the fundamentals of thermal analysis or the degradation pattern of the materials, this book is specifically on the mechanism of degradation of materials. The mechanism of rapturing of chemical bonds as a result of exposure to high-temperature environment is difficult to study and resulting mechanistic pathway hard to establish. Limited information is available on this subject in the published literatures and difficult to excavate. Chapters in this book are contributed by the experts working on thermal degradation and analysis of the wide variety of advanced and traditional materials. Each chapter discusses the material, its possible application, behavior of chemical entities when exposed to high-temperature environment and mode and the mechanistic route of its decomposition. Such information is crucial while selecting the chemical ingredients during the synthesis or development of new materials technology.
Jens Petter Nielsen Applied Bioengineering. Innovations and Future Directions Jens Petter Nielsen Applied Bioengineering. Innovations and Future Directions Новинка

Jens Petter Nielsen Applied Bioengineering. Innovations and Future Directions

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A comprehensive overview of the topic, highlighting recent developments, ongoing research trends and future directions. Experts from Europe, Asia and the US cover five core areas of imminent importance to the food, feed, pharmaceutical and water treatment industries in terms of sustainable and innovative processing and production. In the field of enzyme engineering, they summarize historic developments and provide an overview of molecular enzyme engineering, while also discussing key principles of microbial process engineering, including chapters on process development and control. Further sections deal with animal and plant cell culture engineering. The final section of the book deals with environmental topics and highlights the application of bioengineering principles in waste treatment and the recovery of valuable resources. With its cutting-edge visions, extensive discussions and unique perspectives, this is a ready reference for biotechnologists, bioengineers, bioengineers, biotechnological institutes, and environmental chemists.
Dominique Paret FlexRay and its Applications. Real Time Multiplexed Network Dominique Paret FlexRay and its Applications. Real Time Multiplexed Network Новинка

Dominique Paret FlexRay and its Applications. Real Time Multiplexed Network

2169.35 руб. или Купить в рассрочку!
An authoritative yet highly accessible guide to the design and operation of the FlexRay bus, the latest protocol for automotive network communications A translation of the French edition, originally published in January 2011, this work is the result of numerous training courses that Dominique Paret has given in companies, and it provides detailed explanations of the design and operation of the FlexRay bus. Comprised of five parts the book covers: the FlexRay concept and its communication protocol; the FlexRay physical layer; synchronization and global time and; architecture of a node, components and development aid tools for hardware and software. Provides comprehensive treatment of the FlexRay network, including its implementation through a real automotive application Includes the latest specifications (Version 3) concluded by the FlexRay consortium widely expected to become the industry standard Written by an author with in-depth experience of automotive electronics, including FlexRay, and presenter of specialist training courses to the industry Includes a review of industrial tools to help design and implement a FlexRay based distributor application
Randall Moon T. Wnt Signaling in Development and Disease. Molecular Mechanisms and Biological Functions Randall Moon T. Wnt Signaling in Development and Disease. Molecular Mechanisms and Biological Functions Новинка

Randall Moon T. Wnt Signaling in Development and Disease. Molecular Mechanisms and Biological Functions

13373.72 руб. или Купить в рассрочку!
Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network. • A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field. • Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases • Reviews the complex processes of signal integration and regulation • Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.
Dominique Paret FlexRay and its Applications. Real Time Multiplexed Network Dominique Paret FlexRay and its Applications. Real Time Multiplexed Network Новинка

Dominique Paret FlexRay and its Applications. Real Time Multiplexed Network

An authoritative yet highly accessible guide to the design and operation of the FlexRay bus, the latest protocol for automotive network communications A translation of the French edition, originally published in January 2011, this work is the result of numerous training courses that Dominique Paret has given in companies, and it provides detailed explanations of the design and operation of the FlexRay bus. Comprised of five parts the book covers: the FlexRay concept and its communication protocol; the FlexRay physical layer; synchronization and global time and; architecture of a node, components and development aid tools for hardware and software. Provides comprehensive treatment of the FlexRay network, including its implementation through a real automotive application Includes the latest specifications (Version 3) concluded by the FlexRay consortium widely expected to become the industry standard Written by an author with in-depth experience of automotive electronics, including FlexRay, and presenter of specialist training courses to the industry Includes a review of industrial tools to help design and implement a FlexRay based distributor application
Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development Новинка

Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development

14902.13 руб. или Купить в рассрочку!
A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Kubiak Jacek Z. Xenopus Development Kubiak Jacek Z. Xenopus Development Новинка

Kubiak Jacek Z. Xenopus Development

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Frogs from the genus Xenopus have long been used as model organisms in basic and biomedical research. These frogs have helped unlock key fundamental developmental and cellular processes that have led to important scientific breakthroughs and have had practical application in embryology, cancer research and regenerative medicine. Xenopus Development is a vital resource on the biology and development of these key model organisms, and will be a great tool to researchers using these frogs in various disciplines of biological science. Xenopus Development is divided into four sections, the first three highlight key processes in Xenopus development from embryo to metamophosis. These sections focus on the cellular processes, organogenesis and embryo development. The final section highlights novel techniques and approaches being used in Xenopus research. Providing thorough and detailed coverage, Xenopus Development, will be a timely and welcome volume for those working in cell and molecular biology, genetics, developmental biology and biomedical research. Provides broad overview of the developmental biology of both Xenopus laevis and Xenopus tropicalis Explores cellular to systems development in key biomedical model organisms Timely synthesis of the field of Xenopus biology Highlights key biomedical and basic biological findings unlocked by Xenopus
S. Gupta K. Modern Hydrology and Sustainable Water Development S. Gupta K. Modern Hydrology and Sustainable Water Development Новинка

S. Gupta K. Modern Hydrology and Sustainable Water Development

11250.33 руб. или Купить в рассрочку!
The material of this book will derive its scientific under-pinning from basics of mathematics, physics, chemistry, geology, meteorology, engineering, soil science, and related disciplines and will provide sufficient breadth and depth of understanding in each sub-section of hydrology. It will start with basic concepts: Water, its properties, its movement, modelling and quality The distribution of water in space and time Water resource sustainability Chapters on ‘global change’ and ‘water and ethics’ aim respectively to emphasize the central role of hydrological cycle and its quantitative understanding and monitoring for human well being and to familiarize the readers with complex issues of equity and justice in large scale water resource development process. Modern Hydrology for Sustainable Development is intended not only as a textbook for students in earth and environmental science and civil engineering degree courses, but also as a reference for professionals in fields as diverse as environmental planning, civil engineering, municipal and industrial water supply, irrigation and catchment management.
Brian Wilson Professional SharePoint 2013 Development Brian Wilson Professional SharePoint 2013 Development Новинка

Brian Wilson Professional SharePoint 2013 Development

3233.32 руб. или Купить в рассрочку!
Thorough coverage of development in SharePoint 2013 A team of well-known Microsoft MVPs joins forces in this fully updated resource, providing you with in-depth coverage of development tools in the latest iteration of the immensely popular SharePoint. From building solutions to building custom workflow and content management applications, this book shares field-tested best practices on all aspect of SharePoint 2013 development. Offers a thorough look at Windows Azure and SharePoint 2013 Includes new chapters on Application Life Cycle Management, developing apps in SharePoint, and building PerformancePoint Dashboards in SharePoint Professional SharePoint 2013 Development is an essential SharePoint developer title.
Mrityunjay Singh Design, Development, and Applications of Engineering Ceramics and Composites Mrityunjay Singh Design, Development, and Applications of Engineering Ceramics and Composites Новинка

Mrityunjay Singh Design, Development, and Applications of Engineering Ceramics and Composites

9272.77 руб. или Купить в рассрочку!
This compilation of proceedings covering the latest scientific and technological developments in design, development, and applications of engineering ceramics and composites provides a useful one-stop resource for understanding the most important issues in design, development, and applications of engineering ceramics and composites. Logically organized and carefully selected articles give insight into design, development, and applications of engineering ceramics and composites and incorporates the latest developments related to design, development, and applications of engineering ceramics and composites including developments in engineering ceramics, advanced ceramic coatings, and geopolymers.
Robert A. Copeland Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists Robert A. Copeland Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists Новинка

Robert A. Copeland Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists

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Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.
Clemens Lamberth Bioactive Carboxylic Compound Classes. Pharmaceuticals and Agrochemicals Clemens Lamberth Bioactive Carboxylic Compound Classes. Pharmaceuticals and Agrochemicals Новинка

Clemens Lamberth Bioactive Carboxylic Compound Classes. Pharmaceuticals and Agrochemicals

16341.1 руб. или Купить в рассрочку!
Following the successful and proven concept used in «Bioactive Heterocyclic Compound Classes» by the same editors, this book is the first to present approved pharmaceutical and agrochemical compounds classified by their carboxylic acid functionality in one handy volume. Each of the around 40 chapters describes one or two typical syntheses of a specific compound class and provides concise information on the history of development, mode of action, biological activity and field of application, as well as structure-activity relationships. In addition, similarities and differences between pharmaceuticals and agrochemicals are discussed in the introduction. Written by a team of experts in the field, this is a useful reference for researchers in academia and chemical or pharmaceutical companies working in the field of total synthesis and natural product chemistry, drug development, and crop protection research.
Ю. В. Лысенко Analysis technique and risk assessment of insolvency of machine-building enterprise Ю. В. Лысенко Analysis technique and risk assessment of insolvency of machine-building enterprise Новинка

Ю. В. Лысенко Analysis technique and risk assessment of insolvency of machine-building enterprise

The monograph is devoted to a problem of production and sale of the concentrating and mountain equipment. The economic evaluation of production and sale is opened in the following sequence. The economic essence of the concept «insolvency» of the entity is stated. The reasons of risk of insolvency, its role in diagnostic approaches to solvency analysis of the entity, are called and analysed possibilities of a risk assessment of insolvency of the entity. By means of assessment of a condition the model of the analysis and a risk assessment of insolvency of the entity, an algorithm of its application in the analysis of machine-building enterprise is developed. Assessment of a condition of production and sale is carried out based on huge statistical material on influence of structure and structure of current assets on solvency of machinebuilding enterprise, liquidity of balance and assessment of liquidity and efficiency of cash flows for strengthening and optimization of activities. With use of integration of methods approbation of an analysis technique and a risk assessment of insolvency of machine-building enterprise is carried out and the possibilities of its optimization are considered. In an analysis result, assessment and developed offers the management concept is formulated by liquidity of machine-building enterprise and decrease in risk of insolvency, the principles of its forming and the mechanism of implementation are shown.
Robert Gibbs J. Principles of Urban Retail Planning and Development Robert Gibbs J. Principles of Urban Retail Planning and Development Новинка

Robert Gibbs J. Principles of Urban Retail Planning and Development

…Extraordinary: Gibbs has popped the hood and taken apart the engine of commercial design and development, showing us each individual part and explaining fit, form and function. —Yaromir Steiner, Founder, Chief Executive Officer, Steiner + Associates «…the most comprehensive and expansive book ever written on the subject of Retail Real Estate Development. Gibbs is by far the most prominent advocate for reforming retail planning and development in order to return American cities to economic and physical prominence.» –Stefanos Polyzoides, Moule & Polyzoides Architects & Urbanists The retail environment has evolved rapidly in the past few decades, with the retailing industry and its placement and design of «brick-and-mortar» locations changing with evolving demographics, shopping behavior, transportation options and a desire in recent years for more unique shopping environments. Written by a leading expert, this is a guide to planning for retail development for urban planners, urban designers and architects. It includes an overview of history of retail design, a look at retail and merchandising trends, and principles for current retail developments. Principles of Urban Retail Planning and Development will: Provide insight and techniques necessary for historic downtowns and new urban communities to compete with modern suburban shopping centers. Promote sustainable community building and development by making it more profitable for the shopping center industry to invest in historic cities or to develop walkable urban communities. Includes case studies of recent good examples of retail development
Kang-Zhi Liu Robust Control. Theory and Applications Kang-Zhi Liu Robust Control. Theory and Applications Новинка

Kang-Zhi Liu Robust Control. Theory and Applications

12161.54 руб. или Купить в рассрочку!
Comprehensive and up to date coverage of robust control theory and its application • Presented in a well-planned and logical way • Written by a respected leading author, with extensive experience in robust control • Accompanying website provides solutions manual and other supplementary material
Hugo Kubinyi Predictive Toxicology. From Vision to Reality Hugo Kubinyi Predictive Toxicology. From Vision to Reality Новинка

Hugo Kubinyi Predictive Toxicology. From Vision to Reality

14821.72 руб. или Купить в рассрочку!
Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation methods, novel in vitro systems including those employing stem cells, toxicogenomics and novel biomarkers. In each case, the most promising methods are discussed and compared to classical in vitro and in vivo toxicology assays. Finally, an outlook section discusses such forward-looking topics as immunotoxicology assessment and novel regulatory requirements. With its wealth of methodological knowledge and its critical evaluation of modern approaches, this is a valuable guide for toxicologists working in pharmaceutical development, as well as in safety assessment and the regulation of drugs and chemicals.
Jian Li Characterization of Minerals, Metals, and Materials 2015 Jian Li Characterization of Minerals, Metals, and Materials 2015 Новинка

Jian Li Characterization of Minerals, Metals, and Materials 2015

13757.36 руб. или Купить в рассрочку!
This collection of proceedings focuses on the characterization of minerals, metals, and materials as well as the application of characterization results on the processing of these materials. Papers cover topics such as clays, ceramics, composites, ferrous metals, non-ferrous metals, minerals, electronic materials, magnetic materials, environmental materials, advanced materials, and soft materials. In addition, papers covering materials extraction, materials processing, corrosion, welding, solidification, and method development are included. This book provides a current snapshot of characterization in materials science and its role in validating, informing, and driving current theories in the field of materials science. This proceedings volume will serve the dual purpose of furnishing a broad introduction of the field to novices while simultaneously serving to keep subject matter experts up-to-date.
Military and Technical Cooperation of Russia: Historical Review Military and Technical Cooperation of Russia: Historical Review Новинка

Military and Technical Cooperation of Russia: Historical Review

In the book it is told about the military and technical cooperation of Russia with foreign States during the lot historical period and enough detail in the last century. In its preparation used unique archive documents and materials, many of which are published for the first time.Thanks to its documentary basis the book will be interesting not only to specialists and analysts in the area of international cooperation, but also for a wide circle of readerse interested in the sources and forms of development of the system of military and technical cooperation of Russia with foreign States.The book is designed to become an invaluable source of information for employees of the foreign economic sphere of activity of the statea the military and all those who are interested in the military-political history of Russia.
Ho Law The Psychology of Coaching, Mentoring and Learning Ho Law The Psychology of Coaching, Mentoring and Learning Новинка

Ho Law The Psychology of Coaching, Mentoring and Learning

4109.73 руб. или Купить в рассрочку!
The Psychology of Coaching, Mentoring, and Learning addresses the psychological principles upon which coaching and mentoring is based, and integrates them in a universal framework for the theory and practice of individual and organizational development. The second edition is updated with the latest research, taking into account the increasing importance of positive psychology and its role in coaching and mentoring with an emphasis on strength, growth, and development. Combining high-level theory with practical applications and case studies, this is an invaluable resource for coaches, mentors, trainers, psychologists, executives, managers, and students.
Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines Новинка

Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines

12414.56 руб. или Купить в рассрочку!
This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development. With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.
Kurt Lewin The Conceptual Representation and the Measurement of Psychological Forces Kurt Lewin The Conceptual Representation and the Measurement of Psychological Forces Новинка

Kurt Lewin The Conceptual Representation and the Measurement of Psychological Forces

2013 Reprint of 1938 Edition. Full facsimile of the original edition, not reproduced with Optical Recognition Software. Kurt Lewin (1890-1947) was a German-American psychologist, known as one of the modern pioneers of social, organizational, and applied psychology. Lewin is often recognized as the "founder of social psychology" and was one of the first to study group dynamics and organizational development. Lewin developed the concept of force field analysis, which provides a framework for looking at the factors (forces) that influence a situation, originally social situations. It looks at forces that are either driving movement toward a goal (helping forces) or blocking movement toward a goal (hindering forces). The principle, developed by Kurt Lewin, is a significant contribution to the fields of social science, psychology, social psychology, organizational development, process management, and change management. This book is an early effort to establish the principles of his force field analysis. An attempt is made to describe the position of the concept of force in psychology and to discuss major methods of measuring psychological forces. One of the outstanding properties of force is its directedness. Direction in psychology cannot be defined as physical direction and cannot be determined by Euclidian geometry. A geometry applicable in psychology is that of hodological space. The geometrical properties of this space are described, and examples of its application in...
Serpell Child Development in Africa: Views From Inside. New Directions for Child and Adolescent Development, Number 146 Serpell Child Development in Africa: Views From Inside. New Directions for Child and Adolescent Development, Number 146 Новинка

Serpell Child Development in Africa: Views From Inside. New Directions for Child and Adolescent Development, Number 146

2250.84 руб. или Купить в рассрочку!
In this volume, African scholars engaged in research on the continent reflect on their recent and ongoing empirical studies. They discuss the strengths and limitations of research methods, theories, and interventions designed outside Africa to spur innovative research on the continent. And they explore how insights from African philosophical, theoretical, and empirical work can be combined with exogenous forms of knowledge to generate understanding of the processes of African children’s development in ways that are responsive to local contexts and meaningful for indigenous stakeholders. A new field of African child development research is emerging in African societies, focusing on children as valued and vulnerable members of society and potential civic leaders of the future. Systematic inquiries are now designed to enhance our understanding of how African children think, to discover effective ways of communicating with them, and to inform successful strategies of promoting their health, education, and preparation for adult responsibilities in society. This is the 146th volume in this Jossey-Bass series New Directions for Child and Adolescent Development. Its mission is to provide scientific and scholarly presentations on cutting edge issues and concepts in this subject area. Each volume focuses on a specific new direction or research topic and is edited by experts from that field.
Barry Burd A. Android Application Development All-in-One For Dummies Barry Burd A. Android Application Development All-in-One For Dummies Новинка

Barry Burd A. Android Application Development All-in-One For Dummies

2586.53 руб. или Купить в рассрочку!
Your all-encompassing guide to learning Android app development If you're an aspiring or beginning programmer interested in creating apps for the Android market—which grows in size and downloads every day—this is your comprehensive, one-stop guide. Android Application Development All-in-One For Dummies covers the information you absolutely need to get started developing apps for Android. Inside, you'll quickly get up to speed on Android programming concepts and put your new knowledge to use to manage data, program cool phone features, refine your applications, navigate confidently around the Android native development kit, and add important finishing touches to your apps. Covering the latest features and enhancements to the Android Software Developer's Kit, this friendly, hands-on guide walks you through Android programming basics, shares techniques for developing great Android applications, reviews Android hardware, and much more. All programming examples, including the sample application, are available for download from the book's website Information is carefully organized and presented in an easy-to-follow format 800+ pages of content make this an invaluable resource at an unbeatable price Written by an expert Java educator, Barry Burd, who authors the bestselling Java For Dummies Go from Android newbie to master programmer in no time with the help of Android Application Development All-in-One For Dummies!
William Hughes The Encyclopedia of the Gothic William Hughes The Encyclopedia of the Gothic Новинка

William Hughes The Encyclopedia of the Gothic

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The Encylopedia of the Gothic features a series of newly-commissioned essays from experts in Gothic studies that cover all aspects of the Gothic as it is currently taught and researched, along with the development of the genre and its impact on contemporary culture. Comprises over 200 newly commissioned entries written by a stellar cast of over 130 experts in the field Arranged in A-Z format across two fully cross-referenced volumes Represents the definitive reference guide to all aspects of the Gothic Provides comprehensive coverage of relevant authors, national traditions, critical developments, and notable texts that define, shape, and inform the genre Extends beyond a purely literary analysis to explore Gothic elements of film, music, drama, art, and architecture. Explores the development of the genre and its impact on contemporary culture

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