discovery proof in police misconduct cases 1997 cumulative supplement



Urban Laszlo Predictive ADMET. Integrated Approaches in Drug Discovery and Development Urban Laszlo Predictive ADMET. Integrated Approaches in Drug Discovery and Development Новинка

Urban Laszlo Predictive ADMET. Integrated Approaches in Drug Discovery and Development

11877.96 руб.
This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.
Harry Cendrowski Cloud Computing and Electronic Discovery Harry Cendrowski Cloud Computing and Electronic Discovery Новинка

Harry Cendrowski Cloud Computing and Electronic Discovery

2870.99 руб.
Explore the frontier of electronic discovery in the cloud Cloud Computing and Electronic Discovery comprehensively covers the quickly-evolving realm of eDiscovery in cloud computing environments, a computing and legal frontier in which the rules and legal precedents are being developed anew seemingly by the day. The book delves into this fascinating and rapidly-developing topic to prepare fraud investigators, legal professionals, forensic accountants, and executives understand the ramifications of storing data with third party providers and how such storage mechanisms relate to the limits of discovery practices. This up-to-date resource also includes a complete discussion of the few existing legal precedents and current cases that are shaping interpretation of discovery laws in the cloud space, a perfect overview for executives storing their companies' data in the cloud and the legal professionals tasked with understanding and interpreting the discovery rules surrounding that data. The book is comprehensive in scope and includes: An overview of current trends in cloud computing, including potential information that should be considered in an investigation that involves data held by a cloud service provider Updates on current and proposed laws governing discovery of information held by a third party cloud service provider Updates on legal cases that address the issues of the Electronic Communication Privacy Act, the Federal law prohibiting release of information by a third party provider Practical guidance on how to consider the availability of cloud data relevant to an investigation, and how to include this data in discovery plans For business, accounting, and legal professionals, Cloud Computing and Electronic Discovery is an invaluable resource for understanding the nuanced development of cloud eDiscovery policies, practices, and law as they continue to unfold and develop.
Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools Новинка

Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools

11418.17 руб.
Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.
Russell Parr L. Intellectual Property. Valuation, Exploitation, and Infringement Damages, 2016 Cumulative Supplement Russell Parr L. Intellectual Property. Valuation, Exploitation, and Infringement Damages, 2016 Cumulative Supplement Новинка

Russell Parr L. Intellectual Property. Valuation, Exploitation, and Infringement Damages, 2016 Cumulative Supplement

14622.12 руб.
Up-to-date, expert guidance and a valuable tool kit for IP valuation Intellectual Property, Valuation, Exploitation, and Infringement Damages provides practical tools and expert clarification for the valuation of intangible assets. This new 2016 Cumulative Supplement contains the latest laws, regulations, and practices surrounding licensing and joint ventures, with practical analytical models that simplify the calculation of royalties and equity splits. As a companion to the comprehensive Intellectual Property, this book provides invaluable guidance toward the investment aspects, business strategies, taxes, and accounting practices involved in intellectual property protection and profit, to help licensing professionals structure optimal arrangements and mitigate risks. Written by leading experts in the intellectual property realm, this guide is a must-have resource for anyone working with intangible assets. Intellectual property is more than a simple profit center; to many owners, it's the cornerstone of their organization, and must be rigorously protected and exploited to the fullest extent. This book provides clear guidance on valuation, which is the foundation of a successful IP strategy. Define the value of intangible assets in real-money terms Examine the business economics of licensing and joint venture strategies Understand the relevant legal, tax, and accounting practices Determine fair royalty rates and equity splits Patents, trademarks, formulas, copyrights, brand names, distribution systems—all fall under the intellectual property umbrella, and each might be the competitive edge upon which a business is built. Intellectual property can cost hundreds of millions of dollars to create, and is often irreplaceable with no substitute or alternative available, making it an organization's most important asset. Protect it properly, and reap every ounce of profit it can produce with the important guidance in Intellectual Property, Valuation, Exploitation, and Infringement Damages, 2016 Cumulative Supplement.
Ian Redpath e-Discovery For Dummies Ian Redpath e-Discovery For Dummies Новинка

Ian Redpath e-Discovery For Dummies

2040.95 руб.
Discover the process of e-discovery and put good practices in place. Electronic information involved in a lawsuit requires a completely different process for management and archiving than paper information. With the recent change to Federal Rules of Civil Procedure making all lawsuits subject to e-discovery as soon as they are filed, it is more important than ever to make sure that good e-discovery practices are in place. e-Discovery For Dummies is an ideal beginner resource for anyone looking to understand the rules and implications of e-discovery policy and procedures. This helpful guide introduces you to all the most important information for incorporating legal, technical, and judicial issues when dealing with the e-discovery process. You'll learn the various risks and best practices for a company that is facing litigation and you'll see how to develop an e-discovery strategy if a company does not already have one in place. E-discovery is the process by which electronically stored information sought, located, secured, preserved, searched, filtered, authenticated, and produced with the intent of using it as evidence Addresses the rules and process of e-discovery and the implications of not having good e-discovery practices in place Explains how to develop an e-discovery strategy if a company does not have one in place e-Discovery For Dummies will help you discover the process and best practices of managing electronic information for lawsuits.
James Speight G. Ethics in the University James Speight G. Ethics in the University Новинка

James Speight G. Ethics in the University

10872.33 руб.
It is the continuous reports of unethical behavior in the form of data manipulation, cheating, plagiarism, and other forms of unacceptable behavior that draw attention to the issues of misconduct. The causes of misconduct are manifold whether it is the need to advance in a chosen discipline or to compete successfully for and obtain research funding. Disappointingly, individuals who are oriented to any form of dishonesty are individuals who had previously displayed little or no consideration for the feelings of others and are therefore more interested in themselves, at the expense of the students, and others recognizing them by any means necessary. This ground-breaking and honest examination of ethics in the university setting is unabashed in its descriptions of misconduct in the academic world. The text is well furbished with numerous citations that point to academic misconduct and the final chapter deals with the means by which misconduct can be mitigated, a strong reminder to everyone in the academic community that above board conduct must be part of our overall message of learning and part of the whole point of education in the first place. A must-have for academics and non-academics alike, this text is the second in a series of books on ethics by James G. Speight, and it is useful to anyone, in any industry, who is interested in ethical behavior and how to navigate the sometimes murky depths of our professional lives.
Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Новинка

Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad

17161.74 руб.
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
Jens-Uwe Peters Polypharmacology in Drug Discovery Jens-Uwe Peters Polypharmacology in Drug Discovery Новинка

Jens-Uwe Peters Polypharmacology in Drug Discovery

10498.58 руб.
An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the «one drug, one target» philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.
Rankovic Zoran Lead Generation Approaches in Drug Discovery Rankovic Zoran Lead Generation Approaches in Drug Discovery Новинка

Rankovic Zoran Lead Generation Approaches in Drug Discovery

9349.1 руб.
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or «virtual» screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Екатерина Талалакина Academic Skills through Cases in American Studies Екатерина Талалакина Academic Skills through Cases in American Studies Новинка

Екатерина Талалакина Academic Skills through Cases in American Studies

181.5 руб.
‘Academic Skills through Cases in American Studies’ is aimed at ESL college students at the Intermediate-high through Advanced levels of language proficiency. It is designed around eight country-specific (U.S.) cases that develop academic skills tested on international exams. The book covers major topics in the areas of academic reading, speaking and writing. Thus, the targeted learning outcome is two-fold: 1) to explore topical issues in American studies and 2) to master key academic skills. The content of the articles in each unit is selected according to the language needs of students majoring in economics, sociology, political science, and the like. The book can be used both as a supplement to a course in American Studies or as a separate curriculum within an academic skills course.
Jie Jack Li Drug Discovery. Practices, Processes, and Perspectives Jie Jack Li Drug Discovery. Practices, Processes, and Perspectives Новинка

Jie Jack Li Drug Discovery. Practices, Processes, and Perspectives

9972.41 руб.
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.
Printio Legends are born in 1997 Printio Legends are born in 1997 Новинка

Printio Legends are born in 1997

1032 руб.
Футболка с полной запечаткой (мужская) — пол: МУЖ, материал: СИНТЕТИКА. Стильный дизайн для любителей гранжа, ретро и брутальности. Легенды рождены в 1997. Лучший подарок на День Рождения неординарным людям.
Miller Seumas Investigative Ethics. Ethics for Police Detectives and Criminal Investigators Miller Seumas Investigative Ethics. Ethics for Police Detectives and Criminal Investigators Новинка

Miller Seumas Investigative Ethics. Ethics for Police Detectives and Criminal Investigators

7506.1 руб.
Investigative Ethics: Ethics for Police Detectives and Criminal Investigators presents applied philosophical analyses of the ethical issues that arise for police detectives and other investigators in contemporary society. Explores ethical issues relating to investigative independence, rights of victims and suspects, use of informants, entrapment, privacy and surveillance, undercover operations, deception, and suspect interviewing Represents the first monograph providing a detailed consideration of ethical issues in police investigations Features authorship by an applied philosopher specializing in police ethics, and a former UK senior police officer Combined authorship ensures the text is anchored in actual police practice as well as providing high quality ethical analysis
Sean Ekins Predictive Approaches in Drug Discovery and Development. Biomarkers and In Vitro / In Vivo Correlations Sean Ekins Predictive Approaches in Drug Discovery and Development. Biomarkers and In Vitro / In Vivo Correlations Новинка

Sean Ekins Predictive Approaches in Drug Discovery and Development. Biomarkers and In Vitro / In Vivo Correlations

11247.23 руб.
Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Benjamin Miller L. Dynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science Benjamin Miller L. Dynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science Новинка

Benjamin Miller L. Dynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science

7889.26 руб.
Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science. Chapters cover: Basic theory Approaches to binding in proteins and nucleic acids Molecular recognition Self-sorting Catalyst discovery Materials discovery Analytical chemistry challenges A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.
Sofia Ahmad Clinical Cases in Orthodontics Sofia Ahmad Clinical Cases in Orthodontics Новинка

Sofia Ahmad Clinical Cases in Orthodontics

7947.76 руб.
Wiley-Blackwell's Clinical Cases series is designed to recognize the centrality of clinical cases to the profession by providing actual cases with an academic backbone. Clinical Cases in Orthodontics applies both theory and practice to real-life orthodontic cases in a clinically relevant format. This unique approach supports the new trend in case-based and problem-based learning, thoroughly covering topics ranging from Class I malocclusions to orthognathic surgery. Highly illustrated in full color, Clinical Cases in Orthodontics' format fosters independent learning and prepares the reader for case-based examinations.
The Whistler The Whistler Новинка

The Whistler

570 руб.
The most corrupt judge in US history. A young investigator with a secret informant. Lacy Stoltz never expected to be in the firing line. Investigating judicial misconduct...
Adrian Furnham All in the Mind. Psychology for the Curious Adrian Furnham All in the Mind. Psychology for the Curious Новинка

Adrian Furnham All in the Mind. Psychology for the Curious

7170.91 руб.
All in the Mind: Psychology for the Curious, Third Edition covers important, topical, and sometimes controversial subjects in the field of Psychology in an engaging alternative or supplement to traditional student textbooks. The third edition of a successful and uniquely readable textbook – includes more than two thirds brand new material, with all retained material thoroughly revised and updated. All in the Mind, 3rd Edition offers a new and engaging way to consider key theories and approaches in psychology; providing an original alternative or supplement to traditional teaching textbooks.
Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future Новинка

Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future

11418.17 руб.
A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both Empirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores: The differing modes of molecular discovery Biological precedents for evolutionary approaches Directed evolutionary methods and related areas Enzyme evolution and design Functional nucleic acid discovery Antibodies and other recognition molecules General aspects of molecular recognition Small molecule discovery approaches Rational molecular design The interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery Searching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspectsof molecular discovery, as well as the thought processes behind experimental approaches. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
Jorgen Nordenstrom The Hunt for the Parathyroids Jorgen Nordenstrom The Hunt for the Parathyroids Новинка

Jorgen Nordenstrom The Hunt for the Parathyroids

2752.32 руб.
The Hunt for the Parathyroid Gland is a part fact, part fiction overview of the discovery of the parathyroid gland by a Swedish scientist in 1880. The discovery of the parathyroid gland in humans in 1880 by an unknown Swedish medical student, Ivar Viktor Sandström, ended a 30 year search for its exact location within the human body, following its discovery in an Indian rhino 30 years before. It is one of the most engaging and remarkable stories in the history of medicine. This book offers a fascinating insight into its discovery. Endocrinologists and ENT health professionals, both in clinical practice and researchers, as well as anyone with an interest in the history of medicine, will find this a fascinating insight into one of the 19th century’s key medical discoveries.
Whitehouse David Molecular and Cellular Therapeutics Whitehouse David Molecular and Cellular Therapeutics Новинка

Whitehouse David Molecular and Cellular Therapeutics

8502.32 руб.
Molecular and Cellular Therapeutics aims to bring together key developments in the areas of molecular diagnostics, therapeutics and drug discovery. The book covers topics including diagnostics, therapeutics, model systems, clinical trials and drug discovery. The developing approaches to molecular and cellular therapies, diagnostics and drug discovery are presented in the context of the pathologies they are devised to treat.
Klara Valko Physicochemical and Biomimetic Properties in Drug Discovery, Enhanced Edition. Chromatographic Techniques for Lead Optimization Klara Valko Physicochemical and Biomimetic Properties in Drug Discovery, Enhanced Edition. Chromatographic Techniques for Lead Optimization Новинка

Klara Valko Physicochemical and Biomimetic Properties in Drug Discovery, Enhanced Edition. Chromatographic Techniques for Lead Optimization

9972.41 руб.
Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measurement data for optimal drug discovery.
Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies Новинка

Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies

16871.56 руб.
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. • Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations • Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts • Covers design criteria, typical profile of current macrocycles, applications, and limitations
Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent Новинка

Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent

11993.49 руб.
Sets the stage for advances in drug discovery using the latest enzyme technology Reviewing new and emerging applications of enzyme technology in drug discovery, this book highlights some of the most promising areas of pharmaceutical and biotechnology research. It covers enzyme assay technology, utilization of enzymology for prodrug design, and the application of enzymes as therapeutic agents. Expert reviews highlight how our latest understanding of enzymology is used to develop new practical applications in drug discovery and design. Filled with case studies, Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents enables readers to better understand the diverse functions of enzymes and master specific applications in drug discovery research. In addition to small molecule drug discovery, the book explores new developments in enzymes as therapeutic agents for genetic disorders. Section A, Enzymes – Essential Workhorses in Pharmaceutical Research, offers support in selecting the best enzyme targets for drug discovery, designing enzyme inhibitors for therapeutic agents, and evaluating selective enzyme inhibitors. Section B, Enzymes – Indispensable Tools for Improving Druggability, sets forth the principles alongside real-world examples of exploiting specific properties of enzymes to design successful prodrugs. Section C, Enzymes – Powerful Weapons for Correcting Nature's Errors, provides new insights on applying enzymes as therapeutic agents or diagnostic tools to treat genetic disorders. Chapters are contributed by leading experts from around the world. Their contributions are based on a thorough review of the current literature as well as their own research. Reviewing our latest understanding of the nature of enzymes and their role in drug discovery, this book is recommended for researchers in pharmaceuticals and biotechnology as well as for researchers in enzymology, biochemistry, molecular biology, and medicinal chemistry.
Laura MacDonald The Police Doctor's Discovery Laura MacDonald The Police Doctor's Discovery Новинка

Laura MacDonald The Police Doctor's Discovery

116.67 руб.
A bad boy turned good?When Dr. Rachel Beresford returns home as a locum GP and police doctor, she's surprised that Nick Kowalski still lives there. Her bad-boy former boyfriend is now a senior police officer, and the powerful connection they one shared flares back to life as if they had never parted!Rachel is determined to avoid Nick's dangerous charms. But as a serious investigation gets underway and a threat is made to Rachel's life, she finds herself seeking safety in his arms – and that their passion is one they can never forget!POLICE SURGEONS Love, life and medicine – on the beat!
Mourad Elloumi Biological Knowledge Discovery Handbook. Preprocessing, Mining and Postprocessing of Biological Data Mourad Elloumi Biological Knowledge Discovery Handbook. Preprocessing, Mining and Postprocessing of Biological Data Новинка

Mourad Elloumi Biological Knowledge Discovery Handbook. Preprocessing, Mining and Postprocessing of Biological Data

14021.69 руб.
The first comprehensive overview of preprocessing, mining, and postprocessing of biological data Molecular biology is undergoing exponential growth in both the volume and complexity of biological data—and knowledge discovery offers the capacity to automate complex search and data analysis tasks. This book presents a vast overview of the most recent developments on techniques and approaches in the field of biological knowledge discovery and data mining (KDD)—providing in-depth fundamental and technical field information on the most important topics encountered. Written by top experts, Biological Knowledge Discovery Handbook: Preprocessing, Mining, and Postprocessing of Biological Data covers the three main phases of knowledge discovery (data preprocessing, data processing—also known as data mining—and data postprocessing) and analyzes both verification systems and discovery systems. BIOLOGICAL DATA PREPROCESSING Part A: Biological Data Management Part B: Biological Data Modeling Part C: Biological Feature Extraction Part D Biological Feature Selection BIOLOGICAL DATA MINING Part E: Regression Analysis of Biological Data Part F Biological Data Clustering Part G: Biological Data Classification Part H: Association Rules Learning from Biological Data Part I: Text Mining and Application to Biological Data Part J: High-Performance Computing for Biological Data Mining Combining sound theory with practical applications in molecular biology, Biological Knowledge Discovery Handbook is ideal for courses in bioinformatics and biological KDD as well as for practitioners and professional researchers in computer science, life science, and mathematics.
Mayr Lorenz M. Label-Free Technologies For Drug Discovery Mayr Lorenz M. Label-Free Technologies For Drug Discovery Новинка

Mayr Lorenz M. Label-Free Technologies For Drug Discovery

13947.02 руб.
Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery. Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis. Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.
Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development Новинка

Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development

10651.85 руб.
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery Новинка

West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery

9885.53 руб.
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Claudia Schiffer Claudia Schiffer Новинка

Claudia Schiffer

6590 руб.
Model. Muse. Global fashion icon. Claudia Schiffer is legendary both in terms of accomplishments and longevity. From her discovery at age seventeen in a Dusseldorf...
Mission IELTS 1. General Training Supplement. Пособие для подготовки к общему модулю. Mission IELTS 1. General Training Supplement. Пособие для подготовки к общему модулю. Новинка

Mission IELTS 1. General Training Supplement. Пособие для подготовки к общему модулю.

1275 руб.
Mission IELTS 1 General Training Supplement aims to help students achieve their potential for success in the IELTS General Training Module. This book can be used either as a stand alone short course for the specific General Training Reading and Writing papers or as part of a comprehensive course of preparation for the whole test in conjunction with the Listening and Speaking units of Mission IELTS 1 Academic. Each unit in the General Training Supplement is thematically linked to one of the Speaking and Listening units in the Mission IELTS 1 thus providing for an integrated and more comprehensive course of General Training Preparation. . .
Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Новинка

Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery

12261.12 руб.
Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover: A general overview of the discipline, from its foundations to contemporary industrial applications Chemoinformatics-based applications Bioinformatics-based applications Data mining methods in clinical development Data mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.
Russell Parr L. Intellectual Property. Valuation, Exploitation, and Infringement Damages 2015 Cumulative Supplement Russell Parr L. Intellectual Property. Valuation, Exploitation, and Infringement Damages 2015 Cumulative Supplement Новинка

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An updated, comprehensive guide to monetizing intellectual property assets Intellectual Property, Valuation, Exploration, and Infringement Damages removes complexity and provides solutions to the challenge of placing a dollar amount on intellectual property. This revised and updated cumulative supplement for 2015 provides insight that reflects the latest regulations and best practices, and the most up to date practical tools for evaluating the investment aspects of licensing and joint venture decisions. The discussion includes procedures for accounting, tax, and legalities, and examines the business economics of strategies involving intellectual property, and analytical models are provided to help you determine reasonable royalty rates for licensing and fair equity splits in joint venture arrangements. With detailed explanations and expert insight into the realities surrounding these assets, you'll have everything you need to exploit your product to the fullest extent. Companies are increasingly looking to their intellectual property as a profit center. Patents, trademarks, formulas, copyrights, and brand names can easily become the cornerstone of a corporation, and its most important asset, all while remaining difficult to quantifiably value. This supplement simplifies the challenge by providing the tools, precedent, and expert advice you need to approach these assets with clarity and understanding. Overcome valuation challenges and avoid common errors Understand the associated legal, tax, and accounting practices Study analytical models for fair licensing and equity splits Review precedent for determining infringement damages Intellectual property can cost hundreds of millions of dollars to create, and is often irreplaceable with no substitute or alternative available. These assets need protection, and companies need recourse in case of infringement. Intellectual Property, Valuation, Exploration, and Infringement Damages clarifies the legal, financial, and investment issues to give you a deeper understanding of how best to handle these valuable assets.
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This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.
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Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
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Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
Amy Truesdale L. Clinical Cases in Pediatric Dentistry Amy Truesdale L. Clinical Cases in Pediatric Dentistry Новинка

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Wiley-Blackwell's «Clinical Cases» series is designed to recognize the centrality of clinical cases to the profession by providing actual cases with an academic backbone. Clinical Cases in Pediatric Dentistry applies both theory and practice to real-life pediatric dentistry cases in a clinically relevant format. This unique approach supports the new trend in case-based and problem-based learning, thoroughly covering topics ranging from infant oral health to complex pulp therapy. Highly illustrated in full color, Clinical Cases in Pediatric Dentistry's format fosters independent learning and prepares the reader for case-based examinations. The book presents actual clinical cases, accompanied by academic commentary, that question and educate the reader about essential topics in pediatric dentistry. Each chapter's progression from common to increasingly challenging clinical cases enables the reader to build their skills, aiding the ability to think critically and independently. Clinical Cases in Pediatric Dentistry's case-based format is particularly useful for pre-doctoral dental students, post-graduate residents and pediatric dentists preparing for Board examinations. The book will also appeal to students and their faculty in pediatric dentistry departments. It will be of interest to practicing pediatric dentists and family dentists as well.
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This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.
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Raimund Mannhold Biomolecular Simulations in Structure-Based Drug Discovery Raimund Mannhold Biomolecular Simulations in Structure-Based Drug Discovery Новинка

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15632.93 руб.
A timely and topical survey of modern simulation tools and their applications in real-life drug discovery, allowing for better and quicker results in structure-based drug design. The first part of this practical guide for industry professionals describes common tools used in the biomolecular simulation of drugs and their targets. A critical analysis of the accuracy of the predictions, the integration of modeling with other experimental data combined with numerous case studies from different therapeutic fields enable users to quickly adopt these new methods for their current projects. The second part then shows how these tools can be applied to drug discovery and development projects. Modeling experts from the pharmaceutical industry and from leading academic institutions present real-life examples for important target classes such as GPCRs, kinases and amyloids as well as for common challenges in structure-based drug discovery. With its inclusion of novel methods and strategies for the modeling of drug-target interactions in the framework of real-life drug discovery and development, this application-oriented reference is tailor-made for medicinal chemists and those working in the pharmaceutical industry.
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BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.
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An updated, comprehensive guide to monetizing intellectual property assets Intellectual Property, Valuation, Exploration, and Infringement Damages removes complexity and provides solutions to the challenge of placing a dollar amount on intellectual property. This revised and updated cumulative supplement for 2015 provides insight that reflects the latest regulations and best practices, and the most up to date practical tools for evaluating the investment aspects of licensing and joint venture decisions. The discussion includes procedures for accounting, tax, and legalities, and examines the business economics of strategies involving intellectual property, and analytical models are provided to help you determine reasonable royalty rates for licensing and fair equity splits in joint venture arrangements. With detailed explanations and expert insight into the realities surrounding these assets, you'll have everything you need to exploit your product to the fullest extent. Companies are increasingly looking to their intellectual property as a profit center. Patents, trademarks, formulas, copyrights, and brand names can easily become the cornerstone of a corporation, and its most important asset, all while remaining difficult to quantifiably value. This supplement simplifies the challenge by providing the tools, precedent, and expert advice you need to approach these assets with clarity and understanding. Overcome valuation challenges and avoid common errors Understand the associated legal, tax, and accounting practices Study analytical models for fair licensing and equity splits Review precedent for determining infringement damages Intellectual property can cost hundreds of millions of dollars to create, and is often irreplaceable with no substitute or alternative available. These assets need protection, and companies need recourse in case of infringement. Intellectual Property, Valuation, Exploration, and Infringement Damages clarifies the legal, financial, and investment issues to give you a deeper understanding of how best to handle these valuable assets.
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