handbook of forensic drug analysis



Lawrence Kobilinsky Forensic Chemistry Handbook Lawrence Kobilinsky Forensic Chemistry Handbook Новинка

Lawrence Kobilinsky Forensic Chemistry Handbook

10498.58 руб.
A concise, robust introduction to the various topics covered by the discipline of forensic chemistry The Forensic Chemistry Handbook focuses on topics in each of the major chemistry-related areas of forensic science. With chapter authors that span the forensic chemistry field, this book exposes readers to the state of the art on subjects such as serology (including blood, semen, and saliva), DNA/molecular biology, explosives and ballistics, toxicology, pharmacology, instrumental analysis, arson investigation, and various other types of chemical residue analysis. In addition, the Forensic Chemistry Handbook: Covers forensic chemistry in a clear, concise, and authoritative way Brings together in one volume the key topics in forensics where chemistry plays an important role, such as blood analysis, drug analysis, urine analysis, and DNA analysis Explains how to use analytical instruments to analyze crime scene evidence Contains numerous charts, illustrations, graphs, and tables to give quick access to pertinent information Media focus on high-profile trials like those of Scott Peterson or Kobe Bryant have peaked a growing interest in the fascinating subject of forensic chemistry. For those readers who want to understand the mechanisms of reactions used in laboratories to piece together crime scenes—and to fully grasp the chemistry behind it—this book is a must-have.
Julie Roberts Forensic Ecology Handbook. From Crime Scene to Court Julie Roberts Forensic Ecology Handbook. From Crime Scene to Court Новинка

Julie Roberts Forensic Ecology Handbook. From Crime Scene to Court

7419.19 руб.
The analysis of plants, insects, soil and other particulates from scenes of crime can be vital in proving or excluding contact between a suspect and a scene, targeting search areas, and establishing a time and place of death. Forensic Ecology: A Practitioner’s Guide provides a complete handbook covering all aspects of forensic ecology. Bringing together the forensic applications of anthropology, archaeology, entomology, palynology and sedimentology in one volume, this book provides an essential resource for practitioners in the field of forensic science, whether crime scene investigators, forensic science students or academics involved in the recovery and analysis of evidence from crime scenes. Forensic Ecology: A Practitioner’s Guide includes information not only on the search, location, recovery and analysis of evidence, but includes sampling strategies for diatom analysis, pollen and soils samples and entomology and provides guides for good practice. Each chapter provides background information on each discipline and is structured according to pre-scene attendance (what questions should the scientist ask when receiving a call? What sort of preparation is required?), scene attendance (including protocols at the scene, sampling strategies, recording), scientific examination of analysis of the evidence up to the stages and guidelines for witness statement and presenting evidence in court. The book is written by specialists in all fields with a wealth of experience who are current forensic practitioners around the world. It provides an essential and accessible resource for students, academics, forensic practitioners and police officers everywhere.
Shihning Chou Assessments in Forensic Practice. A Handbook Shihning Chou Assessments in Forensic Practice. A Handbook Новинка

Shihning Chou Assessments in Forensic Practice. A Handbook

9744.05 руб.
Assessments in Forensic Practice: A Handbook provides practical guidance in the assessment of the most frequently encountered offender subgroups found within the criminal justice system. Topics include: criminal justice assessments offenders with mental disorders family violence policy and practice
Jay Siegel Forensic Chemistry. Fundamentals and Applications Jay Siegel Forensic Chemistry. Fundamentals and Applications Новинка

Jay Siegel Forensic Chemistry. Fundamentals and Applications

6658.7 руб.
Forensic Chemistry: Fundamentals and Applications presents a new approach to the study of applications of chemistry to forensic science. It is edited by one of the leading forensic scientists with each chapter written by international experts specializing in their respective fields, and presents the applications of chemistry, especially analytical chemistry, to various topics that make up the forensic scientists toolkit. This comprehensive, textbook includes in-depth coverage of the major topics in forensic chemistry including: illicit drugs, fibers, fire and explosive residues, soils, glass and paints, the chemistry of fingerprint recovery on porous surfaces, the chemistry of firearms analysis, as well as two chapters on the key tools of forensic science, microscopy and chemometrics. Each topic is explored at an advanced college level, with an emphasis, throughout the text, on the use of chemical tools in evidence analysis. Forensic Chemistry: Fundamentals and Applications is essential reading for advanced students of forensic science and analytical chemistry, as well as forensic science practitioners, researchers and faculty, and anyone who wants to learn about the fascinating subject of forensic chemistry in some depth. This book is published as part of the AAFS series ‘Forensic Science in Focus’.
Burkhard Madea Handbook of Forensic Medicine Burkhard Madea Handbook of Forensic Medicine Новинка

Burkhard Madea Handbook of Forensic Medicine

30289.28 руб.
Forensic Medicine encompasses all areas in which medicine and law interact. This book covers diverse aspects of forensic medicine including forensic pathology, traumatology and violent death, sudden and unexpected death, clinical forensic medicine, toxicology, traffic medicine, identification, haemogenetics and medical law. A knowledge of all these subdisciplines is necessary in order to solve routine as well as more unusual cases. Taking a comprehensive approach the book m.oves beyond a focus on forensic pathology to include clinical forensic medicine and forensic toxicology. All aspects of forensic medicine are covered to meet the specialist needs of daily casework. Aspects of routine analysis and quality control are addressed in each chapter. The book provides coverage of the latest developments in forensic molecular biology, forensic toxicology, molecular pathology and immunohistochemistry. A must-have reference for every specialist in the field this book is set to become the bench-mark for the international forensic medical community.
Craig Adam Essential Mathematics and Statistics for Forensic Science Craig Adam Essential Mathematics and Statistics for Forensic Science Новинка

Craig Adam Essential Mathematics and Statistics for Forensic Science

12640.45 руб.
This text is an accessible, student-friendly introduction to the wide range of mathematical and statistical tools needed by the forensic scientist in the analysis, interpretation and presentation of experimental measurements. From a basis of high school mathematics, the book develops essential quantitative analysis techniques within the context of a broad range of forensic applications. This clearly structured text focuses on developing core mathematical skills together with an understanding of the calculations associated with the analysis of experimental work, including an emphasis on the use of graphs and the evaluation of uncertainties. Through a broad study of probability and statistics, the reader is led ultimately to the use of Bayesian approaches to the evaluation of evidence within the court. In every section, forensic applications such as ballistics trajectories, post-mortem cooling, aspects of forensic pharmacokinetics, the matching of glass evidence, the formation of bloodstains and the interpretation of DNA profiles are discussed and examples of calculations are worked through. In every chapter there are numerous self-assessment problems to aid student learning. Its broad scope and forensically focused coverage make this book an essential text for students embarking on any degree course in forensic science or forensic analysis, as well as an invaluable reference for post-graduate students and forensic professionals. Key features: Offers a unique mix of mathematics and statistics topics, specifically tailored to a forensic science undergraduate degree. All topics illustrated with examples from the forensic science discipline. Written in an accessible, student-friendly way to engage interest and enhance learning and confidence. Assumes only a basic high-school level prior mathematical knowledge.
Colin Aitken Statistical Analysis in Forensic Science. Evidential Values of Multivariate Physicochemical Data Colin Aitken Statistical Analysis in Forensic Science. Evidential Values of Multivariate Physicochemical Data Новинка

Colin Aitken Statistical Analysis in Forensic Science. Evidential Values of Multivariate Physicochemical Data

8019.61 руб.
A practical guide for determining the evidential value of physicochemical data Microtraces of various materials (e.g. glass, paint, fibres, and petroleum products) are routinely subjected to physicochemical examination by forensic experts, whose role is to evaluate such physicochemical data in the context of the prosecution and defence propositions. Such examinations return various kinds of information, including quantitative data. From the forensic point of view, the most suitable way to evaluate evidence is the likelihood ratio. This book provides a collection of recent approaches to the determination of likelihood ratios and describes suitable software, with documentation and examples of their use in practice. The statistical computing and graphics software environment R, pre-computed Bayesian networks using Hugin Researcher and a new package, calcuLatoR, for the computation of likelihood ratios are all explored. Statistical Analysis in Forensic Science will provide an invaluable practical guide for forensic experts and practitioners, forensic statisticians, analytical chemists, and chemometricians. Key features include: Description of the physicochemical analysis of forensic trace evidence. Detailed description of likelihood ratio models for determining the evidential value of multivariate physicochemical data. Detailed description of methods, such as empirical cross-entropy plots, for assessing the performance of likelihood ratio-based methods for evidence evaluation. Routines written using the open-source R software, as well as Hugin Researcher and calcuLatoR. Practical examples and recommendations for the use of all these methods in practice.
Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient Новинка

Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient

13121.77 руб.
Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
Mitchell Damon Forensic CBT. A Handbook for Clinical Practice Mitchell Damon Forensic CBT. A Handbook for Clinical Practice Новинка

Mitchell Damon Forensic CBT. A Handbook for Clinical Practice

10188.22 руб.
Forensic CBT: A Handbook for Clinical Practice is an edited collection that represents the first authoritative resource on the utilization of CBT strategies and techniques for offender clients. Features contributions from leaders of the major schools of CBT on the treatment of antisocial personality patterns as well as anger, interpersonal violence, substance abuse, and sexual aggression Addresses modified CBT approaches for female, juvenile, and culturally diverse forensic populations Covers emerging areas of forensic practices, including the integration of motivational interviewing and strength-based approaches Includes an assortment of worksheets, handouts, and exercises for practitioners to use with their clients
Robert Sadoff L. Handbook of Forensic Assessment. Psychological and Psychiatric Perspectives Robert Sadoff L. Handbook of Forensic Assessment. Psychological and Psychiatric Perspectives Новинка

Robert Sadoff L. Handbook of Forensic Assessment. Psychological and Psychiatric Perspectives

8247.97 руб.
The first handbook to explore forensic assessment from psychiatric and psychological perspectives «The editors have assembled a magnificent collaboration between psychiatrists and psychologists to bring forth critical knowledge and insight to the core competency of forensic assessment. This handbook is essential reading and a comprehensive resource for both newly minted and seasoned forensic practitioners.» —Robert I. Simon, MD, Director, Program in Psychiatry and Law, Georgetown University School of Medicine «This long-awaited resource blows the dust off traditional standards, shakes the cobwebs out of our old ways of thinking, and shows the practical steps in producing work that will make sense to juries and withstand the most skillful cross-examination. . . . [T]here is no better resource.» —Kenneth S. Pope, PhD, ABPP, Diplomate in Clinical Psychology; coauthor, Ethics in Psychotherapy and Counseling, Fourth Edition «From preparation to collection to interpretation to communication of the results, this excellent, comprehensive treasure shows how to conduct forensic assessments. Each splendid evidence-based chapter is presented from the collaboration between psychologists and psychiatrists. It is a must-have resource for forensic experts as well as general practitioners or anyone wishing to understand standard of care in forensic assessment.» —Melba Vasquez, PhD, ABPP, 2011 American Psychological Association President The practitioner-oriented coverage in the Handbook of Forensic Assessment examines: The current state of psychology and psychiatry—including requisite clinical competencies, ethical guidelines, and considerations of multidisciplinary collaboration Various approaches to assessments in criminal and civil matters The principles of effective preparation, data collection, and interpretation, as well as communication for each special situation Topics including competence to stand trial, sexual offender evaluations, addictions, child abuse, and education Overarching practice issues, such as practice development, retention, compensation, consultation, and forensic treatment Includes sample reports that demonstrate the integrative potential of both psychology and psychiatry Incorporating a wealth of current and multidisciplinary research, the Handbook of Forensic Assessment is destined to become every mental health professional's most valuable one-stop reference for their forensic work.
Michael Corey J. Coupled Bioluminescent Assays. Methods, Evaluations, and Applications Michael Corey J. Coupled Bioluminescent Assays. Methods, Evaluations, and Applications Новинка

Michael Corey J. Coupled Bioluminescent Assays. Methods, Evaluations, and Applications

12261.12 руб.
This book highlights the applications of coupled bioluminescence assay techniques to real-world problems in drug discovery, environmental and chemical analysis, and biodefense. It separates theoretical aspects from the applied sections in a clear and readable way. Coupled Bioluminescent Assays, explains the uses of CB technologies across drug discovery to analyze toxicity, drug receptors, and enzymes. It covers applications in environmental analysis and biodefense, including cytotoxicity, fertilizer and explosives analysis, and nerve agent and pesticide detection. This is the premier reference on coupled bioluminescent assays for chemists, biochemists, and molecular biologists.
Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling Новинка

Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling

11247.23 руб.
Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.
Franco Taroni Bayesian Networks for Probabilistic Inference and Decision Analysis in Forensic Science Franco Taroni Bayesian Networks for Probabilistic Inference and Decision Analysis in Forensic Science Новинка

Franco Taroni Bayesian Networks for Probabilistic Inference and Decision Analysis in Forensic Science

7798.37 руб.
"This book should have a place on the bookshelf of every forensic scientist who cares about the science of evidence interpretation" Dr. Ian Evett, Principal Forensic Services Ltd, London, UK Continuing developments in science and technology mean that the amounts of information forensic scientists are able to provide for criminal investigations is ever increasing. The commensurate increase in complexity creates difficulties for scientists and lawyers with regard to evaluation and interpretation, notably with respect to issues of inference and decision. Probability theory, implemented through graphical methods, and specifically Bayesian networks, provides powerful methods to deal with this complexity. Extensions of these methods to elements of decision theory provide further support and assistance to the judicial system. Bayesian Networks for Probabilistic Inference and Decision Analysis in Forensic Science provides a unique and comprehensive introduction to the use of Bayesian decision networks for the evaluation and interpretation of scientific findings in forensic science, and for the support of decision-makers in their scientific and legal tasks. • Includes self-contained introductions to probability and decision theory. • Develops the characteristics of Bayesian networks, object-oriented Bayesian networks and their extension to decision models. • Features implementation of the methodology with reference to commercial and academically available software. • Presents standard networks and their extensions that can be easily implemented and that can assist in the reader’s own analysis of real cases. • Provides a technique for structuring problems and organizing data based on methods and principles of scientific reasoning. • Contains a method for the construction of coherent and defensible arguments for the analysis and evaluation of scientific findings and for decisions based on them. • Is written in a lucid style, suitable for forensic scientists and lawyers with minimal mathematical background. • Includes a foreword by Ian Evett. The clear and accessible style of this second edition makes this book ideal for all forensic scientists, applied statisticians and graduate students wishing to evaluate forensic findings from the perspective of probability and decision analysis. It will also appeal to lawyers and other scientists and professionals interested in the evaluation and interpretation of forensic findings, including decision making based on scientific information.
Alan Gunn Essential Forensic Biology Alan Gunn Essential Forensic Biology Новинка

Alan Gunn Essential Forensic Biology

5977.3 руб.
A completely revised and updated edition that teaches the essentials of forensic biology, with increased coverage of molecular biological techniques and new information on wildlife forensics, wound analysis and the potential of microbiomes as forensic indicators This fully revised and updated introduction to forensic biology carefully guides the reader through the science of biology in legal investigations. Full-colour throughout, including many new images, it offers an accessible overview to the essentials of the subject, providing balanced coverage of the range of organisms used as evidence in forensic investigations, such as invertebrates, vertebrates, plants and microbes. The book provides an accessible overview of the decay process and discusses the role of forensic indicators like human fluids and tissues, including bloodstain pattern analysis, hair, teeth, bones and wounds. It also examines the study of forensic biology in cases of suspicious death. This third edition of Essential Forensic Biology expands its coverage of molecular techniques throughout, offering additional material on bioterrorism and wildlife forensics. The new chapter titled ‘Wildlife Forensics’ looks at welfare legislation, CITES and the use of forensic techniques to investigate criminal activity such as wildlife trafficking and dog fighting. The use of DNA and RNA for the identification of individuals and their personal characteristics is now covered as well, along with a discussion of the ethical issues associated with the maintenance of DNA databases. Fully revised and updated third edition of the successful student-friendly introduction to the essentials of Forensic Biology Covers a wide variety of legal investigations such as homicide, suspicious death, neglect, real and fraudulent claims for the sale of goods unfit for purpose, the illegal trade in protected species of plants and animals and bioterrorism Discusses the use of a wide variety of biological material for forensic evidence Supported by a website that includes numerous photographs, interactive MCQs, self-assessment quizzes and a series of questions and topics for further study to enhance student understanding Includes a range of important, key case studies in which the difficulties of evaluating biological evidence are highlighted Essential Forensic Biology, Third Edition is an excellent guide for undergraduates studying forensic science and forensic biology.
Barbara Stuart H. Forensic Analytical Techniques Barbara Stuart H. Forensic Analytical Techniques Новинка

Barbara Stuart H. Forensic Analytical Techniques

14247.21 руб.
The book will be an open learning / distance learning text in the Analytical Techniques for the Sciences (AnTS) covering analytical techniques used in forensic science. No prior knowledge of the analytical techniques will be required by the reader. An introductory chapter will provide an overview of the science of the materials used as forensic evidence. Each of the following chapters will describe the techniques used in forensic analysis. The theory, instrumentation and sampling techniques will be explained and examples of the application of each technique to particular forensic samples will be provided. The reader will be able to assess their understanding with the use of regular self assessment questions and discussion questions throughout the book. The user of the book will be able to apply their understanding to the application of specific techniques to particular analyses encountered in their professional life.
Sara Castiglioni Illicit Drugs in the Environment. Occurrence, Analysis, and Fate using Mass Spectrometry Sara Castiglioni Illicit Drugs in the Environment. Occurrence, Analysis, and Fate using Mass Spectrometry Новинка

Sara Castiglioni Illicit Drugs in the Environment. Occurrence, Analysis, and Fate using Mass Spectrometry

7720.11 руб.
Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis. This landmark reference discusses the analytical techniques used to detect illicit drugs in wastewater and surface water, details how to estimate the levels of contaminants in the environment, and explores the behavior, fate, and toxic effects of this new class of contaminants, now a ubiquitous presence in wastewater and surface water. The book details how an estimate of illicit drug consumption in a given population can be developed from an analysis of the residues of illicit drugs in wastewater. An important resource for analytical chemists, environmental researchers, forensic scientists, biologists, and toxicologists.
Yiyang Dong Direct Analysis in Real Time Mass Spectrometry. Principles and Practices of DART-MS Yiyang Dong Direct Analysis in Real Time Mass Spectrometry. Principles and Practices of DART-MS Новинка

Yiyang Dong Direct Analysis in Real Time Mass Spectrometry. Principles and Practices of DART-MS

11997.76 руб.
DART-MS is a relatively new, but very fast evolving technology. Due to its versatility, it addresses fields of crucial importance to people and community, e.g. food or agricultural, forensic, industrial, environmental, medicinal and clinical analysis.
Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics Новинка

Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics

10192.06 руб.
Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.
Kevin Browne D. Assessment and Treatment of Sexual Offenders with Intellectual Disabilities. A Handbook Kevin Browne D. Assessment and Treatment of Sexual Offenders with Intellectual Disabilities. A Handbook Новинка

Kevin Browne D. Assessment and Treatment of Sexual Offenders with Intellectual Disabilities. A Handbook

11468.48 руб.
A practical handbook for practitioners that covers the assessment, treatment and management of sexual offenders with intellectual disabilities – an area of growing interest within clinical forensic psychology. New for the Wiley Series in Forensic Clinical Psychology: a practical handbook that covers the assessment, treatment and management of sexual offenders with intellectual disabilities Summarises the research literature on the characteristics and prevalence of sexual offenders with intellectual disabilities Discusses risk assessment and innovations in treatment and management Includes contributors world-renowned in the field of assessment and treatment of sexual offenders with intellectual disabilities such as Tony Ward, Glynis Murphy, and Douglas Boer
Nicholas Marquez-Grant Taphonomy of Human Remains. Forensic Analysis of the Dead and the Depositional Environment Nicholas Marquez-Grant Taphonomy of Human Remains. Forensic Analysis of the Dead and the Depositional Environment Новинка

Nicholas Marquez-Grant Taphonomy of Human Remains. Forensic Analysis of the Dead and the Depositional Environment

9748.31 руб.
A truly interdisciplinary approach to this core subject within Forensic Science Combines essential theory with practical crime scene work Includes case studies Applicable to all time periods so has relevance for conventional archaeology, prehistory and anthropology Combines points of view from both established practitioners and young researchers to ensure relevance
Mike Lee S. Mass Spectrometry Handbook Mike Lee S. Mass Spectrometry Handbook Новинка

Mike Lee S. Mass Spectrometry Handbook

16855.21 руб.
Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.
Alexandra Georgakopoulou The Handbook of Narrative Analysis Alexandra Georgakopoulou The Handbook of Narrative Analysis Новинка

Alexandra Georgakopoulou The Handbook of Narrative Analysis

14622.12 руб.
Featuring contributions from leading scholars in the field, The Handbook of Narrative Analysis is the first comprehensive collection of sociolinguistic scholarship on narrative analysis to be published. Organized thematically to provide an accessible guide for how to engage with narrative without prescribing a rigid analytic framework Represents established modes of narrative analysis juxtaposed with innovative new methods for conducting narrative research Includes coverage of the latest advances in narrative analysis, from work on social media to small stories research Introduces and exemplifies a practice-based approach to narrative analysis that separates narrative from text so as to broaden the field beyond the printed page
Jussi Meriluoto Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis Jussi Meriluoto Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis Новинка

Jussi Meriluoto Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis

14341.82 руб.
A valuable handbook containing reviews, practical methods and standard operating procedures. A valuable and practical working handbook containing introductory and specialist content that tackles a major and growing field of environmental, microbiological and ecotoxicological monitoring and analysis Includes introductory reviews, practical analytical chapters and a comprehensive listing of almost thirty Standard Operating Procedures (SOPs) For use in the laboratory, in academic and government institutions and industrial settings
Wolfram Meier-Augenstein Stable Isotope Forensics. Methods and Forensic Applications of Stable Isotope Analysis Wolfram Meier-Augenstein Stable Isotope Forensics. Methods and Forensic Applications of Stable Isotope Analysis Новинка

Wolfram Meier-Augenstein Stable Isotope Forensics. Methods and Forensic Applications of Stable Isotope Analysis

11247.23 руб.
The number-one guide, internationally, to all aspects of forensic isotope analysis, thoroughly updated and revised and featuring many new case studies This edition of the internationally acclaimed guide to forensic stable isotope analysis uses real-world examples to bridge discussions of the basic science, instrumentation and analytical techniques underlying forensic isotope profiling and its various technical applications. Case studies describe an array of applications, many of which were developed by the author himself. They include cases in which isotope profiling was used in murder, and drugs-related crime investigations, as well as for pharmaceutical and food authenticity control studies. Updated with coverage of exciting advances occurring in the field since the publication of the 1st edition, this 2nd edition explores innovative new techniques and applications in forensic isotope profiling, as well as key findings from original research. More than a simple update, though, this edition has been significantly revised in order to address serious problems that can arise from non-comparable and unfit-for-purpose stable isotope data. To that end, Part II has been virtually rewritten with greater emphasis now being placed on important quality control issues in stable isotope analysis in general and forensic stable isotope analysis in particular. Written in a highly accessible style that will appeal to practitioners, researchers and students alike Illustrates the many strengths and potential pitfalls of forensic stable isotope analysis Uses recent case examples to bridge underlying principles with technical applications Presents hands-on applications that let experienced researchers and forensic practitioners match problems with success stories Includes new chapters devoted to aspects of quality control and quality assurance, including scale normalisation, the identical treatment principle, hydrogen exchange and accreditation Stable Isotope Forensics, 2nd Edition is an important professional resource for forensic scientists, law enforcement officials, public prosecutors, defence attorneys, forensic anthropologists and others for whom isotope profiling has become an indispensable tool of the trade. It is also an excellent introduction to the field for senior undergraduate and graduate forensic science students. «All students of forensic criminology, and all law enforcement officers responsible for the investigation of serious crime , will want to study this book. Wolfram highlights the value, and future potential, of Stable Isotope Forensics as an emerging powerful tool in the investigation of crime.» —Roy McComb, Deputy Director, Specialist Investigations, National Crime Agency (NCA), UK “A single author text in these days is rare and the value of this book lies in the dedication and experience of the author which is evident in the clarity of prose, the honest illustration of evidence and the realistic practical application of the subject – it makes this a text of genuine scientific value.” – Prof Dame Sue Black, PhD, DBE, OBE, FRSE, Leverhulme Research Centre for Forensic Science, University of Dundee, UK
Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action Новинка

Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action

13487.23 руб.
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.
Paul Selzer M. Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates Paul Selzer M. Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates Новинка

Paul Selzer M. Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates

2139.84 руб.
Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.
Bernard Robertson Interpreting Evidence. Evaluating Forensic Science in the Courtroom Bernard Robertson Interpreting Evidence. Evaluating Forensic Science in the Courtroom Новинка

Bernard Robertson Interpreting Evidence. Evaluating Forensic Science in the Courtroom

10497.42 руб.
This book explains the correct logical approach to analysis of forensic scientific evidence. The focus is on general methods of analysis applicable to all forms of evidence. It starts by explaining the general principles and then applies them to issues in DNA and other important forms of scientific evidence as examples. Like the first edition, the book analyses real legal cases and judgments rather than hypothetical examples and shows how the problems perceived in those cases would have been solved by a correct logical approach. The book is written to be understood both by forensic scientists preparing their evidence and by lawyers and judges who have to deal with it. The analysis is tied back both to basic scientific principles and to the principles of the law of evidence. This book will also be essential reading for law students taking evidence or forensic science papers and science students studying the application of their scientific specialisation to forensic questions.
Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines Новинка

Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines

12257.29 руб.
This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development. With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.
Karl Kropf The Handbook of Urban Morphology Karl Kropf The Handbook of Urban Morphology Новинка

Karl Kropf The Handbook of Urban Morphology

5998.52 руб.
Conceived as a practical manual of morphological analysis, The Handbook of Urban Morphology focuses on the form, structure and evolution of human settlements – from villages to metropolitan regions. It is the first book in any language focused on specific, up-to-date ‘how-to’ guidance , with clear summaries of the central concepts, step-by-step instructions for carrying out the analysis, case studies illustrating specific applications and discussion of theoretical underpinnings tied to evidence from the field. Ideal for students as well as professionals and academics dealing with the built environment.
Amitava Dasgupta Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring. A Comprehensive Guide Amitava Dasgupta Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring. A Comprehensive Guide Новинка

Amitava Dasgupta Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring. A Comprehensive Guide

10498.58 руб.
The tools for detecting false positives, false negatives, and interference in interactions when testing and monitoring therapeutic drug use For physicians monitoring a patient's progress, efficacy of treatment is often linked to a patient's response to medication. Determining whether a patient is taking the prescribed amount, the drug or dosage is effective, or the prescribed medication is interacting with other drugs can be determined through drug testing. Written as a guide for toxicologists, chemists, and health professionals involved in patient care, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring provides an up-to-date introduction to the tests and methodologies used in a toxicology lab as well as the sources of testing error that can lead to false positives, false negatives, and unreliable conclusions of drug abuse or under use. Covering a host of common therapeutic drugs as well as specific types of interference in immunoassays used in drug testing, the book details a number of possible testing scenarios and problems as well as solutions: False positive results in immunoassays for drugs in abuse testing Interferences in immunoassays used for monitoring anticonvulsants, tricyclic antidepressants, and digoxin False positive alcohol tests using breath analyzers and automated analyzers When a toxicology report is negative in a suspected overdose patient: the world of designer drugs Effects of drug-herb interactions on therapeutic drug monitoring Pharmacogenomics and the general principles of genetic analysis Approaches for eliminating interference/discordant specimen in therapeutic drug monitoring and drugs in abuse testing What to do in case there is no readily available method for testing Complete with easy-to-read tables and flowcharts, this book helps toxicologists, clinical chemists, clinical pathologists, and forensic pathologists develop accurate, unbiased drug monitoring and toxicology reports. Health care professionals involved in patient care, especially of critically ill patients, will find this guide indispensable in making sure lab tests are reliable enough to provide high-quality care. An indispensable handbook to the entire suite of toxicology lab tests, as well as all the possible sources of testing error, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring offers clear remedies for eliminating and preventing testing error.
Douglas Ubelaker H. The Global Practice of Forensic Science Douglas Ubelaker H. The Global Practice of Forensic Science Новинка

Douglas Ubelaker H. The Global Practice of Forensic Science

10043.55 руб.
The Global Practice of Forensic Science presents histories, issues, patterns, and diversity in the applications of international forensic science. Written by 64 experienced and internationally recognized forensic scientists, the volume documents the practice of forensic science in 28 countries from Africa, the Americas, Asia, Australia and Europe. Each country’s chapter explores factors of political history, academic linkages, the influence of individual cases, facility development, types of cases examined, integration within forensic science, recruitment, training, funding, certification, accreditation, quality control, technology, disaster preparedness, legal issues, research and future directions. Aimed at all scholars interested in international forensic science, the volume provides detail on the diverse fields within forensic science and their applications around the world.
Walter Korfmacher A. Mass Spectrometry for Drug Discovery and Drug Development Walter Korfmacher A. Mass Spectrometry for Drug Discovery and Drug Development Новинка

Walter Korfmacher A. Mass Spectrometry for Drug Discovery and Drug Development

9897.71 руб.
Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC–high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.
Ala Nassar F. Drug Metabolism Handbook. Concepts and Applications Ala Nassar F. Drug Metabolism Handbook. Concepts and Applications Новинка

Ala Nassar F. Drug Metabolism Handbook. Concepts and Applications

17161.74 руб.
A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.
Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry Новинка

Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry

18851.47 руб.
The book «Drug Selectivity – An Evolving Concept in Medicinal Chemistry» provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Douglas Ubelaker H. Forensic Science. Current Issues, Future Directions Douglas Ubelaker H. Forensic Science. Current Issues, Future Directions Новинка

Douglas Ubelaker H. Forensic Science. Current Issues, Future Directions

10718.66 руб.
Co-published with the American Academy of Forensic Sciences, Forensic Science presents comprehensive international discussion of key issues and future directions within the forensic sciences. Written by accomplished and respected specialists in approximately eleven distinct areas of the forensic sciences, the volume will examine central issues within each discipline, provide perspective on current debate and explore current and proposed research initiatives. It will also provide the forensically involved international community with current in-depth perspective on the key issues in the contemporary practice of the forensic sciences.
Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery Новинка

Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery

17245.76 руб.
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art «omics» technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.
Craig Adam Forensic Evidence in Court. Evaluation and Scientific Opinion Craig Adam Forensic Evidence in Court. Evaluation and Scientific Opinion Новинка

Craig Adam Forensic Evidence in Court. Evaluation and Scientific Opinion

5624.33 руб.
The interpretation and evaluation of scientific evidence and its presentation in a court of law is central both to the role of the forensic scientist as an expert witness and to the interests of justice. This book aims to provide a thorough and detailed discussion of the principles and practice of evidence interpretation and evaluation by using real cases by way of illustration. The presentation is appropriate for students of forensic science or related disciplines at advanced undergraduate and master's level or for practitioners engaged in continuing professional development activity. The book is structured in three sections. The first sets the scene by describing and debating the issues around the admissibility and reliability of scientific evidence presented to the court. In the second section, the principles underpinning interpretation and evaluation are explained, including discussion of those formal statistical methods founded on Bayesian inference. The following chapters present perspectives on the evaluation and presentation of evidence in the context of a single type or class of scientific evidence, from DNA to the analysis of documents. For each, the science underpinning the analysis and interpretation of the forensic materials is explained, followed by the presentation of cases which illustrate the variety of approaches that have been taken in providing expert scientific opinion.
Kun Cheng Advanced Drug Delivery Kun Cheng Advanced Drug Delivery Новинка

Kun Cheng Advanced Drug Delivery

9672.91 руб.
Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.
Jie Jack Li Innovative Drug Synthesis Jie Jack Li Innovative Drug Synthesis Новинка

Jie Jack Li Innovative Drug Synthesis

9372.7 руб.
This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery
Casciano Daniel A. Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology Casciano Daniel A. Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology Новинка

Casciano Daniel A. Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology

19004.74 руб.
The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.
Jane Taylor Forensic Odontology. Principles and Practice Jane Taylor Forensic Odontology. Principles and Practice Новинка

Jane Taylor Forensic Odontology. Principles and Practice

10244.16 руб.
Forensic odontology refers to the science and practice of dentistry which may be applied to help solve litigation in both criminal and civil cases. It is a specialist branch of dentistry that assists the legal system in the handling, analysis and interpretation of dental evidence. Forensic Odontology: Principles and Practice pulls together the very latest research findings and advice on best practice and essential skills, including aspects of forensic science that provide a well-rounded educational experience for the reader. Chapters provide coverage of anatomy and morphology, mortuary techniques, physical anthropology, applied forensic sciences, child and elder abuse, and facial approximation. The text introduces the various topics and discusses underpinning philosophies without being an exhaustive historical treatise. Appropriate case studies are used to highlight issues, and references to current research are provided to stimulate further reading and research. Written by experienced practitioners in the field, this informative introductory text is invaluable to graduate and undergraduate students, as well as experienced dentists, wishing to gain experience or pursue a career in forensic odontology. This text will be a welcome addition to the forensic odontological libraries of all practicing forensic odontologists.
Eric Johnson R. Handbook of Decision Analysis Eric Johnson R. Handbook of Decision Analysis Новинка

Eric Johnson R. Handbook of Decision Analysis

12372.67 руб.
A ONE-OF-A-KIND GUIDE TO THE BEST PRACTICES IN DECISION ANALYSIS Decision analysis provides powerful tools for addressing complex decisions that involve uncertainty and multiple objectives, yet most training materials on the subject overlook the soft skills that are essential for success in the field. This unique resource fills this gap in the decision analysis literature and features both soft personal/interpersonal skills and the hard technical skills involving mathematics and modeling. Readers will learn how to identify and overcome the numerous challenges of decision making, choose the appropriate decision process, lead and manage teams, and create value for their organization. Performing modeling analysis, assessing risk, and implementing decisions are also addressed throughout. Additional features include: Key insights gleaned from decision analysis applications and behavioral decision analysis research Integrated coverage of the techniques of single- and multiple-objective decision analysis Multiple qualitative and quantitative techniques presented for each key decision analysis task Three substantive real-world case studies illustrating diverse strategies for dealing with the challenges of decision making Extensive references for mathematical proofs and advanced topics The Handbook of Decision Analysis is an essential reference for academics and practitioners in various fields including business, operations research, engineering, and science. The book also serves as a supplement for courses at the upper-undergraduate and graduate levels.
Shilin Chen Handbook of Chemical and Biological Plant Analytical Methods, 3 Volume Set Shilin Chen Handbook of Chemical and Biological Plant Analytical Methods, 3 Volume Set Новинка

Shilin Chen Handbook of Chemical and Biological Plant Analytical Methods, 3 Volume Set

53612.53 руб.
Plants and plant-derived compounds and drugs are becoming more and more popular with increasing numbers of scientists researching plant analysis. The quality control of herbal drugs is also becoming essential to avoid severe health problems, and in the future many more new drugs will be developed from plant sources. This three-volume Handbook, featuring 47 detailed review articles, is unique as it deals with chemical and biological methodologies for plant analysis. It presents the most important and most accurate methods which are available for plant analysis. This comprehensive work is divided into six sections as follows: Sample preparation and identification – discussing plant selection and collection, followed by extraction and sample preparation methodologies. Extraction and sample preparation methodologies Instrumentation for chemical analysis – several instrumentations for chemical plant analysis are presented with an emphasis on hyphenated techniques, e.g. the coupling between HPLC and mass spectroscometry, and HPLC with NMR. Strategies for selective classes of compounds – coverage of the most interesting classes of compounds such as polysaccharides, saponins, cardiotonic glycosides, alkaloids, terpenoids, lipids, volatile compounds and polyphenols ( flavonoids, xanthones, coumarins, naphthoquinones, anthraquinones, proanthocyanidins, etc.). Biological Analysis – includes phenotyping, DNA barcoding techniques, transcriptome analysis , microarray, metabolomics and proteomics. Drugs from Plants – covers the screening of plant extracts and strategies for the quick discovery of novel bioactive natural products. Safety assessment of herbal drugs is highly dependent on outstanding chromatographic and spectroscopic methods which are also featured here. This Handbook introduces to scientists involved in plant studies the current knowledge of methodologies in various fields of chemically- and biochemically-related topics in plant research. The content from this Handbook will publish online within the Encyclopedia of Analytical Chemistry via Wiley Online Library: http://www.wileyonlinelibrary.com/ref/eac Benefit from the introductory offer, valid until 30 November 2014! Introductory price: £425.00 / $695.00 / €550.00 List price thereafter: £495.00 / $795.00 / €640.00
MACKILLOP JAMES The Wiley-Blackwell Handbook of Addiction Psychopharmacology MACKILLOP JAMES The Wiley-Blackwell Handbook of Addiction Psychopharmacology Новинка

MACKILLOP JAMES The Wiley-Blackwell Handbook of Addiction Psychopharmacology

4594.09 руб.
The Wiley-Blackwell Handbook of Addiction Psychopharmacology presents a comprehensive guide to contemporary research approaches to the study of drug addiction in adults. With a focus on empirically relevant research methods and nuanced methodologies, it provides practical tools to enable strong psychopharmacological practices. Contributions from experts in diverse domains offer reviews of the most current experimental methodologies, make recommendations for ‘best-practices', and identify future directions for the field. Topics covered include core methods for assessing drug effects, distal and proximal determinants of drug use, and insights from cognitive neuroscience. Compiled by a team of widely-published researchers in substance addiction, the Wiley-Blackwell Handbook of Addiction Psychopharmacology is an authoritative, state-of-the-art collection of modern research approaches for the scientific study of drug addiction. Its multidisciplinary approach makes it a comprehensive and invaluable resource for all those in this field
David Baldwin The Forensic Examination and Interpretation of Tool Marks David Baldwin The Forensic Examination and Interpretation of Tool Marks Новинка

David Baldwin The Forensic Examination and Interpretation of Tool Marks

11993.49 руб.
The Forensic Examination and Interpretation of Tool Marks brings together key techniques and developments in the field of tool marks in forensic science and explains clearly how tool mark analysis can be used within forensic investigation. The purpose of this book is to bring together as much of this information as possible in an accessible manner. The book deals with all aspects of tool mark evidence from crime scene to courtroom. The examination of a wide variety of different tool marks are discussed, including those made by specific tools such as saws and in complex materials such as bone. The general principles and techniques used in tool mark examinations can also be applied to some other closely related fields. Therefore, sections on the examination of manufacturing marks, including those on plastic film items, and physical fit comparisons are also included. The book will be of interest to a wide range of people and not just to tool mark examiners and people studying forensic science. It will be of use to crime scene examiners, officers investigating crimes where tool marks are found and members of the legal professions. Brings together key techniques and developments within the field of tool mark investigation. Includes material on examining tool marks at the crime scene and in the laboratory, interpretation and evaluation issues and how tool mark evidence should be presented in court. Covers specialized tool mark examinations, manufacturing marks, including those on plastic film items, and physical fits. Includes a large range of illustrations and photographs. Invaluable reference for practicing forensic scientists, students of forensic sciences, members of the legal professions and crime scene investigators, enabling them to recognise the importance of tool marks within an investigation. An extremely valuable resource in the on-going debate regarding the evidential value of tool marks in court. Part of the ‘Essentials in Forensic Science’ book series.
Francesco Clementi General and Molecular Pharmacology. Principles of Drug Action Francesco Clementi General and Molecular Pharmacology. Principles of Drug Action Новинка

Francesco Clementi General and Molecular Pharmacology. Principles of Drug Action

11247.23 руб.
With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, all figures and tables from the book, and Power Point slides
Пиголкин Юрий Иванович, Дубровин Иван Александрович Forensic Medicine. Textbook Пиголкин Юрий Иванович, Дубровин Иван Александрович Forensic Medicine. Textbook Новинка

Пиголкин Юрий Иванович, Дубровин Иван Александрович Forensic Medicine. Textbook

4288 руб.
The textbook outlines the main provisions of forensic medicine in accordance with the syllabus for the course of Forensic medicine at higher professional education establishments, and an innovative modular educational program. The textbook captures the current achievements of forensic medicine in areas of forensic traumatology, tanatology and person’s identification. All information is presented in the form of a system of interconnected modules, with consideration to the Bologna Declaration, latest updates in legislation and new regulations on determining the severity of harm to human health. The textbook can provide invaluable assistance to students in obtaining theoretical knowledge and mastering practical skills for further work in the field of forensic medicine.
Mayr Lorenz M. Label-Free Technologies For Drug Discovery Mayr Lorenz M. Label-Free Technologies For Drug Discovery Новинка

Mayr Lorenz M. Label-Free Technologies For Drug Discovery

13947.02 руб.
Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery. Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis. Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.
Allan Jamieson A Guide to Forensic DNA Profiling Allan Jamieson A Guide to Forensic DNA Profiling Новинка

Allan Jamieson A Guide to Forensic DNA Profiling

10872.33 руб.
The increasingly arcane world of DNA profiling demands that those needing to understand at least some of it must find a source of reliable and understandable information. Combining material from the successful Wiley Encyclopedia of Forensic Science with newly commissioned and updated material, the Editors have used their own extensive experience in criminal casework across the world to compile an informative guide that will provide knowledge and thought-provoking articles of interest to anyone involved or interested in the use of DNA in the forensic context. Following extensive introductory chapters covering forensic DNA profiling and forensic genetics, this comprehensive volume presents a substantial breadth of material covering: Fundamental material – including sources of DNA, validation, and accreditation Analysis and interpretation – including, extraction, quantification, amplification and interpretation of electropherograms (epgs) Evaluation – including mixtures, low template, and transfer Applications – databases, paternity and kinship, mitochondrial-DNA, wildlife DNA, single-nucleotide polymorphism, phenotyping and familial searching Court – report writing, discovery, cross examination, and current controversies With contributions from leading experts across the whole gamut of forensic science, this volume is intended to be authoritative but not authoritarian, informative but comprehensible, and comprehensive but concise. It will prove to be a valuable addition, and useful resource, for scientists, lawyers, teachers, criminologists, and judges.
Franco Taroni Data Analysis in Forensic Science. A Bayesian Decision Perspective Franco Taroni Data Analysis in Forensic Science. A Bayesian Decision Perspective Новинка

Franco Taroni Data Analysis in Forensic Science. A Bayesian Decision Perspective

8243.7 руб.
This is the first text to examine the use of statistical methods in forensic science and bayesian statistics in combination. The book is split into two parts: Part One concentrates on the philosophies of statistical inference. Chapter One examines the differences between the frequentist, the likelihood and the Bayesian perspectives, before Chapter Two explores the Bayesian decision-theoretic perspective further, and looks at the benefits it carries. Part Two then introduces the reader to the practical aspects involved: the application, interpretation, summary and presentation of data analyses are all examined from a Bayesian decision-theoretic perspective. A wide range of statistical methods, essential in the analysis of forensic scientific data is explored. These include the comparison of allele proportions in populations, the comparison of means, the choice of sampling size, and the discrimination of items of evidence of unknown origin into predefined populations. Throughout this practical appraisal there are a wide variety of examples taken from the routine work of forensic scientists. These applications are demonstrated in the ever-more popular R language. The reader is taken through these applied examples in a step-by-step approach, discussing the methods at each stage.
Behnam Davani Pharmaceutical Analysis for Small Molecules Behnam Davani Pharmaceutical Analysis for Small Molecules Новинка

Behnam Davani Pharmaceutical Analysis for Small Molecules

9372.7 руб.
A comprehensive introduction for scientists engaged in new drug development, analysis, and approvals Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates—especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors—into its ranks. However, because of their limited background in pharmaceutical analysis most of those new recruits find making the transition from academia to industry very difficult. Designed to assist both recent graduates, as well as experienced chemists or scientists with limited regulatory, compendial or pharmaceutical analysis background, make that transition, Pharmaceutical Analysis for Small Molecules is a concise, yet comprehensive introduction to the drug development process and analysis of chemically synthesized, small molecule drugs. It features contributions by distinguished experts in the field, including editor and author, Dr. Behnam Davani, an analytical chemist with decades of technical management and teaching experience in compendial, regulatory, and industry. This book provides an introduction to pharmaceutical analysis for small molecules (non-biologics) using commonly used techniques for drug characterization and performance tests. The driving force for industry to perform pharmaceutical analyses is submission of such data and supporting documents to regulatory bodies for drug approval in order to market their products. In addition, related required supporting studies including good laboratory/documentation practices including analytical instrument qualification are highlighted in this book. Topics covered include: Drug Approval Process and Regulatory Requirements (private standards) Pharmacopeias and Compendial Approval Process (public standards) Common methods in pharmaceutical analysis (typically compendial) Common Calculations for assays and impurities and other specific tests Analytical Method Validation, Verification, Transfer Specifications including how to handle out of specification (OOS) and out of trend (OOT) Impurities including organic, inorganic, residual solvents and elemental impurities Good Documentation Practices for regulatory environment Management of Analytical Laboratories Analytical Instrument Qualifications including IQ, OQ, PQ and VQ Due to global nature of pharmaceutical industry, other topics on both regulatory (ICH) and Compendial harmonization are also highlighted. Pharmaceutical Analysis for Small Molecules is a valuable working resource for scientists directly or indirectly involved with the drug development process, including analytical chemists, pharmaceutical scientists, pharmacists, and quality control/quality assurance professionals. It also is an excellent text/reference for graduate students in analytical chemistry, pharmacy, pharmaceutical and regulatory sciences.
Deborah Tannen The Handbook of Discourse Analysis Deborah Tannen The Handbook of Discourse Analysis Новинка

Deborah Tannen The Handbook of Discourse Analysis

29618.43 руб.
The second edition of the highly successful Handbook of Discourse Analysis has been expanded and thoroughly updated to reflect the very latest research to have developed since the original publication, including new theoretical paradigms and discourse-analytic models, in an authoritative two-volume set. Twenty new chapters highlight emerging trends and the latest areas of research Contributions reflect the range, depth, and richness of current research in the field Chapters are written by internationally-recognized leaders in their respective fields, constituting a Who’s Who of Discourse Analysis A vital resource for scholars and students in discourse studies as well as for researchers in related fields who seek authoritative overviews of discourse analytic issues, theories, and methods
Miguel de la Guardia Handbook of Green Analytical Chemistry Miguel de la Guardia Handbook of Green Analytical Chemistry Новинка

Miguel de la Guardia Handbook of Green Analytical Chemistry

15096.5 руб.
The emerging field of green analytical chemistry is concerned with the development of analytical procedures that minimize consumption of hazardous reagents and solvents, and maximize safety for operators and the environment. In recent years there have been significant developments in methodological and technological tools to prevent and reduce the deleterious effects of analytical activities; key strategies include recycling, replacement, reduction and detoxification of reagents and solvents. The Handbook of Green Analytical Chemistry provides a comprehensive overview of the present state and recent developments in green chemical analysis. A series of detailed chapters, written by international specialists in the field, discuss the fundamental principles of green analytical chemistry and present a catalogue of tools for developing environmentally friendly analytical techniques. Topics covered include: Concepts: Fundamental principles, education, laboratory experiments and publication in green analytical chemistry. The Analytical Process: Green sampling techniques and sample preparation, direct analysis of samples, green methods for capillary electrophoresis, chromatography, atomic spectroscopy, solid phase molecular spectroscopy, derivative molecular spectroscopy and electroanalytical methods. Strategies: Energy saving, automation, miniaturization and photocatalytic treatment of laboratory wastes. Fields of Application: Green bioanalytical chemistry, biodiagnostics, environmental analysis and industrial analysis. This advanced handbook is a practical resource for experienced analytical chemists who are interested in implementing green approaches in their work.
Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Новинка

Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad

17161.74 руб.
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts Новинка

Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts

11997.76 руб.
Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug–drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.
Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Новинка

Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

11247.23 руб.
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
Samprit Chatterjee Handbook of Regression Analysis Samprit Chatterjee Handbook of Regression Analysis Новинка

Samprit Chatterjee Handbook of Regression Analysis

10272.62 руб.
A Comprehensive Account for Data Analysts of the Methods and Applications of Regression Analysis. Written by two established experts in the field, the purpose of the Handbook of Regression Analysis is to provide a practical, one-stop reference on regression analysis. The focus is on the tools that both practitioners and researchers use in real life. It is intended to be a comprehensive collection of the theory, methods, and applications of regression methods, but it has been deliberately written at an accessible level. The handbook provides a quick and convenient reference or “refresher” on ideas and methods that are useful for the effective analysis of data and its resulting interpretations. Students can use the book as an introduction to and/or summary of key concepts in regression and related course work (including linear, binary logistic, multinomial logistic, count, and nonlinear regression models). Theory underlying the methodology is presented when it advances conceptual understanding and is always supplemented by hands-on examples. References are supplied for readers wanting more detailed material on the topics discussed in the book. R code and data for all of the analyses described in the book are available via an author-maintained website. «I enjoyed the presentation of the Handbook, and I would be happy to recommend this nice handy book as a reference to my students. The clarity of the writing and proper choices of examples allows the presentations ofmany statisticalmethods shine. The quality of the examples at the end of each chapter is a strength. They entail explanations of the resulting R outputs and successfully guide readers to interpret them.» American Statistician
Johnson Douglas S. Modern Drug Synthesis Johnson Douglas S. Modern Drug Synthesis Новинка

Johnson Douglas S. Modern Drug Synthesis

10192.06 руб.
Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.
Linacre Adrian Wildlife DNA Analysis. Applications in Forensic Science Linacre Adrian Wildlife DNA Analysis. Applications in Forensic Science Новинка

Linacre Adrian Wildlife DNA Analysis. Applications in Forensic Science

12257.29 руб.
DNA typing of non-human DNA is a fast developing area of research and professional practice. The application of DNA typing in wildlife forensic science is one of these prime uses of DNA typing and is gaining increasing profile. The use of DNA profiling in wildlife forensic science falls into two broad areas: species testing and genetic linkage. Species testing answers the question ‘what species is this?’ and genetic linkage answers the question ‘did these two samples come from the same organism or population?’ Wildlife DNA Analysis: Applications in Forensic Science provides an accessible introduction to both of these key areas. Clearly structured throughout, the introduction highlights the different types of crime where these techniques are regularly used. This chapter includes a discussion as to who performs forensic wildlife examinations, the standardisation and validation of methods, and the role of the expert witness in this type of alleged crime. This is followed by a detailed section on the science behind DNA typing including the problems in isolating DNA from trace material and subsequent genetic analysis are also covered. The book then undertakes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons. A comparison of the different markers used in species testing highlights the criteria for a genetic marker. A full set of case histories illustrates the use of the different markers used. The book details the use of genetic markers to link two or more hairs/feather/leaves/needles to the same individual organism and the software used in population assignment. The problems and possibilities in isolating markers, along with the construction of allele databases are discussed in this chapter. The book concludes with evaluation and reporting of genetic evidence in wildlife forensic science illustrated by examples of witness statements. •An accessible introduction to this fast developing area of research within forensic science •Case studies throughout to link theory and practice and to highlight the use of DNA testing in species testing. •Covers both crimes against wildlife and offences where wildlife can provide vital evidence •Assumes only a basic background knowledge of DNA •Includes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons

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The number-one guide, internationally, to all aspects of forensic isotope analysis, thoroughly updated and revised and featuring many new case studies This edition of the internationally acclaimed guide to forensic stable isotope analysis uses real-world examples to bridge discussions of the basic science, instrumentation and analytical techniques underlying forensic isotope profiling and its various technical applications. Case studies describe an array of applications, many of which were developed by the author himself. They include cases in which isotope profiling was used in murder, and drugs-related crime investigations, as well as for pharmaceutical and food authenticity control studies. Updated with coverage of exciting advances occurring in the field since the publication of the 1st edition, this 2nd edition explores innovative new techniques and applications in forensic isotope profiling, as well as key findings from original research. More than a simple update, though, this edition has been significantly revised in order to address serious problems that can arise from non-comparable and unfit-for-purpose stable isotope data. To that end, Part II has been virtually rewritten with greater emphasis now being placed on important quality control issues in stable isotope analysis in general and forensic stable isotope analysis in particular. Written in a highly accessible style that will appeal to practitioners, researchers and students alike Illustrates the many strengths and potential pitfalls of forensic stable isotope analysis Uses recent case examples to bridge underlying principles with technical applications Presents hands-on applications that let experienced researchers and forensic practitioners match problems with success stories Includes new chapters devoted to aspects of quality control and quality assurance, including scale normalisation, the identical treatment principle, hydrogen exchange and accreditation Stable Isotope Forensics, 2nd Edition is an important professional resource for forensic scientists, law enforcement officials, public prosecutors, defence attorneys, forensic anthropologists and others for whom isotope profiling has become an indispensable tool of the trade. It is also an excellent introduction to the field for senior undergraduate and graduate forensic science students. «All students of forensic criminology, and all law enforcement officers responsible for the investigation of serious crime , will want to study this book. Wolfram highlights the value, and future potential, of Stable Isotope Forensics as an emerging powerful tool in the investigation of crime.» —Roy McComb, Deputy Director, Specialist Investigations, National Crime Agency (NCA), UK “A single author text in these days is rare and the value of this book lies in the dedication and experience of the author which is evident in the clarity of prose, the honest illustration of evidence and the realistic practical application of the subject – it makes this a text of genuine scientific value.” – Prof Dame Sue Black, PhD, DBE, OBE, FRSE, Leverhulme Research Centre for Forensic Science, University of Dundee, UK
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