identification of new genes involved in meiosis via a genetic screen



Wang Yongjun Gene Discovery for Disease Models Wang Yongjun Gene Discovery for Disease Models Новинка

Wang Yongjun Gene Discovery for Disease Models

11724.7 руб.
This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that “The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decades-old mouse mutants will be understood precisely at the DNA level in the near future.” The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the post-genome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).
Mark Stoneking An Introduction to Molecular Anthropology Mark Stoneking An Introduction to Molecular Anthropology Новинка

Mark Stoneking An Introduction to Molecular Anthropology

9744.05 руб.
Molecular anthropology uses molecular genetic methods to address questions and issues of anthropological interest. More specifically, molecular anthropology is concerned with genetic evidence concerning human origins, migrations, and population relationships, including related topics such as the role of recent natural selection in human population differentiation, or the impact of particular social systems on patterns of human genetic variation. Organized into three major sections, An Introduction to Molecular Anthropology first covers the basics of genetics – what genes are, what they do, and how they do it – as well as how genes behave in populations and how evolution influences them. The following section provides an overview of the different kinds of genetic variation in humans, and how this variation is analyzed and used to make evolutionary inferences. The third section concludes with a presentation of the current state of genetic evidence for human origins, the spread of humans around the world, the role of selection and adaptation in human evolution, and the impact of culture on human genetic variation. A final, concluding chapter discusses various aspects of molecular anthropology in the genomics era, including personal ancestry testing and personal genomics. An Introduction to Molecular Anthropology is an invaluable resource for students studying human evolution, biological anthropology, or molecular anthropology, as well as a reference for anthropologists and anyone else interested in the genetic history of humans.
Lionel Larue The Colors of Mice. A Model Genetic Network Lionel Larue The Colors of Mice. A Model Genetic Network Новинка

Lionel Larue The Colors of Mice. A Model Genetic Network

14842.65 руб.
Serving the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma and more, this new book showcases a blend of new technologies and new insights in the field of pigmantary genetics of mice, with comparative information on other animals. Graduate students can learn here the terminology and scope of the field, and animal fanciers can discover the genetics behind common color variants of mammals. The book is hailed for being written by four of the premier scientists in the field. These authors aim to present the molecular /cellular work in the context of phenotype and the interacting functions of genes that direct the development and function of one biological system. For other researchers, the depth of genetic knowledge on the pigmantary system makes it a valuable model for the study of other systems.
Joseph Heitman Evolution of Virulence in Eukaryotic Microbes Joseph Heitman Evolution of Virulence in Eukaryotic Microbes Новинка

Joseph Heitman Evolution of Virulence in Eukaryotic Microbes

12368.4 руб.
A unique and timely review of the emergence of eukaryotic virulence in fungi, oomycetes, and protozoa, as they affect both animals and plants Evolution of Virulence in Eukaryotic Microbes addresses new developments in defining the molecular basis of virulence in eukaryotic pathogens. By examining how pathogenic determinants have evolved in concert with their hosts, often overcoming innate and adaptive immune mechanisms, the book takes a fresh look at the selective processes that have shaped their evolution. Introductory chapters ground the reader in principal evolutionary themes such as phylogenetics and genetic exchange, building a basis of knowledge for later chapters covering advances in genetic tools, how pathogens exchange genetic material in nature, and the common themes of evolutionary adaptation that lead to disease in different hosts. With the goal of linking the research findings of the many disparate scientific communities in the field, the book: Assembles for the first time a collection of chapters on the diversity of eukaryotic microorganisms and the influence of evolutionary forces on the origins and emergence of their virulent attributes Highlights examples from three important, divergent groups of eukaryotic microorganisms that cause disease in animals and plants: oomycetes, protozoan parasites, and fungi Covers how the development of genetic tools has fostered the identification and functional analyses of virulence determinants Addresses how pathogens exchange genetic material in nature via classical or modified meiotic processes, horizontal gene transfer, and sexual cycles including those that are cryptic or even unisexual Provides a broad framework for formulating future studies by illustrating themes common to different pathogenic microbes Evolution of Virulence in Eukaryotic Microbes is an ideal book for microbiologists, evolutionary biologists and medical professionals, as well as graduate students, postdoctoral fellows, and faculty members working on the evolution of pathogens.
Keen Patricia L. Antimicrobial Resistance in the Environment Keen Patricia L. Antimicrobial Resistance in the Environment Новинка

Keen Patricia L. Antimicrobial Resistance in the Environment

11874.13 руб.
Examines effects of the environmental distribution of antimicrobial resistance genes on human health and the ecosystem Resistance genes are everywhere in nature—in pathogens, commensals, and environmental microorganisms. This contributed work shows how the environment plays a pivotal role in the development of antimicrobial resistance traits in bacteria and the distribution of resistant microbial species, resistant genetic material, and antibiotic compounds. Readers will discover the impact of the distribution in the environment of antimicrobial resistance genes and antibiotics on both the ecosystem and human and animal health. Antimicrobial Resistance in the Environment is divided into four parts: Part I, Sources, including ecological and clinical consequences of antibiotic resistance by environmental microbes Part II, Fate, including strategies to assess and minimize the biological risk of antibiotic resistance in the environment Part III, Antimicrobial Substances and Resistance, including antibiotics in the aquatic environment Part IV, Effects and Risks, including the effect of antimicrobials used for non-human purposes on human health Recognizing the intricate links among overlapping complex systems, this book examines antimicrobial resistance using a comprehensive ecosystem approach. Moreover, the book's multidisciplinary framework applies principles of microbiology, environmental toxicology, and chemistry to assess the human and ecological risks associated with exposure to antibiotics or antibiotic resistance genes that are environmental contaminants. Each chapter has been written by one or more leading researchers in such fields as microbiology, environmental science, ecology, and toxicology. Comprehensive reference lists at the end of all chapters serve as a gateway to the primary research in the field. Presenting and analyzing the latest findings in a field of growing importance to human and environmental health, this text offers readers new insights into the role of the environment in antimicrobial resistance development, the dissemination of antimicrobial resistant genetic elements, and the transport of antibiotic resistance genes and antibiotics.
Nicholas Plant From Genes to Genomes. Concepts and Applications of DNA Technology Nicholas Plant From Genes to Genomes. Concepts and Applications of DNA Technology Новинка

Nicholas Plant From Genes to Genomes. Concepts and Applications of DNA Technology

12368.4 руб.
The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.
Matt Ridley Nature via Nurture: Genes, experience and what makes us human Matt Ridley Nature via Nurture: Genes, experience and what makes us human Новинка

Matt Ridley Nature via Nurture: Genes, experience and what makes us human

474.5 руб.
Acclaimed author Matt Ridley's thrilling follow-up to his bestseller Genome. Armed with the extraordinary new discoveries about our genes, Ridley turns his attention to the nature versus nurture debate to bring the first popular account of the roots of human behaviour.What makes us who we are?In February 2001 it was announced that the genome contains not 100,000 genes as originally expected but only 30,000. This startling revision led some scientists to conclude that there are simply not enough human genes to account for all the different ways people behave: we must be made by nurture, not nature.Matt Ridley argues that the emerging truth is far more interesting than this myth. Nurture depends on genes, too, and genes need nurture. Genes not only predetermine the broad structure of the brain; they also absorb formative experiences, react to social cues and even run memory. They are consequences as well as causes of the will.Published fifty years after the discovery of the double helix of DNA, Nature via Nurture chronicles a new revolution in our understanding of genes. Ridley recounts the hundred years' war between the partisans of nature and nurture to explain how this paradoxical creature, the human being, can be simultaneously free-willed and motivated by instinct and culture. Nature via Nurture is an enthralling, up-to-the-minute account of how genes build brains to absorb experience.Note that it has not been possible to include the same picture content that appeared in the original print version.
Robin Bennett L. The Practical Guide to the Genetic Family History Robin Bennett L. The Practical Guide to the Genetic Family History Новинка

Robin Bennett L. The Practical Guide to the Genetic Family History

5823.39 руб.
Helps you develop and assess pedigrees to make diagnoses, evaluate risk, and counsel patients The Second Edition of The Practical Guide to the Genetic Family History not only shows how to take a medical-family history and record a pedigree, but also explains why each bit of information gathered is important. It provides essential support in diagnosing conditions with a genetic component. Moreover, it aids in recommending genetic testing, referring patients for genetic counseling, determining patterns of inheritance, calculating risk of disease, making decisions for medical management and surveillance, and informing and educating patients. Based on the author's twenty-five years as a genetic counselor, the book also helps readers deal with the psychological, social, cultural, and ethical problems that arise in gathering a medical-family history and sharing findings with patients. Featuring a new Foreword by Arno Motulsky, widely recognized as the founder of medical genetics, and completely updated to reflect the most recent findings in genetic medicine, this Second Edition presents the latest information and methods for preparing and assessing a pedigree, including: Value and utility of a thorough medical-family history Directed questions to ask when developing a medical-family history for specific disease conditions Use of pedigrees to identify individuals with an increased susceptibility to cancer Verification of family medical information Special considerations when adoptions or gamete donors are involved Ethical issues that may arise in recording a pedigree Throughout the book, clinical examples based on hypothetical families illustrate key concepts, helping readers understand how real issues present themselves and how they can be resolved. This book will enable all healthcare providers, including physicians, nurses, medical social workers, and physician assistants, as well as genetic counselors, to take full advantage of the pedigree as a primary tool for making a genetic risk assessment and providing counseling for patients and their families.
John Harwood L. Lipids. Biochemistry, Biotechnology and Health John Harwood L. Lipids. Biochemistry, Biotechnology and Health Новинка

John Harwood L. Lipids. Biochemistry, Biotechnology and Health

8243.7 руб.
For the 6th Edition of this highly regarded textbook devoted to lipids, the title has been modified from Lipid Biochemistry to Lipids to acknowledge the coming together of biological and medical sciences, the increasingly blurred boundaries between them and the growing importance of lipids in diverse aspects of science and technology. The principal aims of this new edition – to inform students and researchers about lipids, to assist teachers and encourage further research – have not changed since previous editions. Significant advances in lipid science have demanded yet another extensive rewriting for this edition, with the addition of two new authors, to cover new knowledge of genes coding for proteins involved in lipid metabolism, the many lipids involved in cell signalling, the roles of lipids in health and disease and new developments in biotechnology in support of agriculture and industry. An introductory chapter summarizes the types of lipids covered and their identification and provides a guide to the contents. Chapters contain boxes illustrating special topics, key point summaries and suggested further reading. Lipids: Sixth Edition provides a huge wealth of information for upper-level students of biological and clinical sciences, food science and nutrition, and for professionals working in academic and industrial research. Libraries in all universities and research establishments where biological, medical and food and nutritional sciences are studied and taught should have copies of this excellent and comprehensive new edition on their shelves.
Andy Beaumont Biotechnology and Genetics in Fisheries and Aquaculture Andy Beaumont Biotechnology and Genetics in Fisheries and Aquaculture Новинка

Andy Beaumont Biotechnology and Genetics in Fisheries and Aquaculture

13193.62 руб.
Following the extremely well-received structure of the first edition, this carefully revised and updated new edition now includes much new information of vital importance to those working and researching in the fisheries and aquaculture industries. Commencing with chapters covering genetic variation and how it can be measured, the authors then look at genetic structure in natural populations, followed by a new chapter covering genetics in relation to population size and conservation issues. Genetic variation of traits and triploids and the manipulation of ploidy are fully covered, and another new chapter is included, entitled 'From Genetics to Genomics'. The book concludes with a chapter covering the impact of genetic engineering in aquaculture. With the inclusion of a wealth of up-to-date information, new text and figures and the inclusion of a third author, Pierre Boudry, the second edition of Biotechnology and Genetics in Fisheries and Aquaculture provides an excellent text and reference of great value and use to upper level students and professionals working across fish biology, aquatic sciences, fisheries, aquaculture, genetics and biotechnology. Libraries in all universities and research establishments where biological sciences, fisheries and aquaculture are studied and taught should have several copies of this excellent new edition on their shelves. Completely updated, revised and expanded new edition Subject area of ever increasing importance Expanded authorship Commercially useful information for fish breeders
Rebecca Bellone Equine Color Genetics Rebecca Bellone Equine Color Genetics Новинка

Rebecca Bellone Equine Color Genetics

8247.26 руб.
Equine Color Genetics, Fourth Edition presents a detailed examination of the color variation in horses and donkeys and the genetic mechanisms that produce color variations. Thoroughly covers the basic colors in horses, including bay, chestnut, black, and brown Details the genetic basis of the colors built from the basic coat color, including dilutions and white patterning Provides an explanation of genetic mechanisms that determine coat color Presents a thorough revision and update, including new advances in molecular genetics, biochemistry, molecular mechanisms, genetic loci, coat colors before domestication, and more Offers a new introduction describing the principles of genetics and genomics research to help outline how knowledge is discovered and to assist the reader in understanding concepts covered in the book
Samuel Webster Embryology at a Glance Samuel Webster Embryology at a Glance Новинка

Samuel Webster Embryology at a Glance

2765.92 руб.
Highly Commended in Obstetrics and gynaecology in the 2017 BMA Medical Book Awards Embryology at a Glance is a highly illustrated and innovative introduction to key embryological concepts, with concise, memorable descriptions of major embryological developments. This new edition covers the basic principles of human development, from mitosis and meiosis, before exploring the primary formation of each body system, including the development of the musculoskeletal, circulatory, digestive, reproductive, and nervous systems during the foetal and neonatal periods. Key features include: New chapters on cell signalling genes, stem cells, and antenatal screening for common congenital and genetic defects Full colour photographs and illustrations Links to clinical practice highlighted throughout Timelines of each developmental stage MCQs and EMQs for revision and review A companion website at www.ataglanceseries.com/embryology featuring 15 brand new animations, and podcasts to help clearly explain the processes that occur during development. An additional instructor resource contains an image bank of all the figures from the book to aid teaching this fascinating area Embryology at a Glance provides the perfect alternative to the overwhelming detail seen in conventional embryology texts. It provides just the right level of detail on embryology and congenital abnormalities for all medical students and health professionals to develop a thorough understanding of human development and its implications for clinical practice.
Korf Bruce R. Medical Genetics at a Glance Korf Bruce R. Medical Genetics at a Glance Новинка

Korf Bruce R. Medical Genetics at a Glance

3214.71 руб.
Medical Genetics at a Glance covers the core scientific principles necessary for an understanding of medical genetics and its clinical applications, while also considering the social implications of genetic disorders. This third edition has been fully updated to include the latest developments in the field, covering the most common genetic anomalies, their diagnosis and management, in clear, concise and revision-friendly sections to complement any health science course. Medical Genetics at a Glance now has a completely revised structure, to make its content even more accessible. Other features include: • Three new chapters on Gene Identification, The Biology of Cancer, and Genomic Approaches to Cancer • A much extended treatment of Biochemical Genetics • A completely revised chapter on The Cell Cycle, explaining principles of biochemistry and genetics which are fundamental to understanding cancer causation • Two new chapters on Cardiac Developmental Pathology • An extended Case Studies section Providing a broad understanding of one of the most rapidly progressing topics in medicine, Medical Genetics at a Glance is perfect for students of medicine, molecular biology, genetics and genetic counselling, and is a previous winner of a BMA Award.
David Koepsell Who Owns You?. Science, Innovation, and the Gene Patent Wars David Koepsell Who Owns You?. Science, Innovation, and the Gene Patent Wars Новинка

David Koepsell Who Owns You?. Science, Innovation, and the Gene Patent Wars

2770.19 руб.
The 2nd Edition of Who Owns You, David Koepsell’s widely acclaimed exploration of the philosophical and legal problems of patenting human genes, is updated to reflect the most recent changes to the cultural and legal climate relating to the practice of gene patenting. Lays bare the theoretical assumptions that underpin the injustice of patents on unmodified genes Makes a unique argument for a commons-by-necessity, explaining how parts of the universe are simply not susceptible to monopoly claims Represents the only work that attempts to first define the nature of the genetic objects involved before any ethical conclusions are reached Provides the most comprehensive accounting of the various lawsuits, legislative changes, and the public debate surrounding AMP v. Myriad, the most significant case regarding gene patents
David Koepsell Who Owns You? Science, Innovation, and the Gene Patent Wars David Koepsell Who Owns You? Science, Innovation, and the Gene Patent Wars Новинка

David Koepsell Who Owns You? Science, Innovation, and the Gene Patent Wars

2828.88 руб.
The 2nd Edition of Who Owns You, David Koepsell’s widely acclaimed exploration of the philosophical and legal problems of patenting human genes, is updated to reflect the most recent changes to the cultural and legal climate relating to the practice of gene patenting. Lays bare the theoretical assumptions that underpin the injustice of patents on unmodified genes Makes a unique argument for a commons-by-necessity, explaining how parts of the universe are simply not susceptible to monopoly claims Represents the only work that attempts to first define the nature of the genetic objects involved before any ethical conclusions are reached Provides the most comprehensive accounting of the various lawsuits, legislative changes, and the public debate surrounding AMP v. Myriad, the most significant case regarding gene patents
Montgomery Stuart A. Treatment-Resistant Depression Montgomery Stuart A. Treatment-Resistant Depression Новинка

Montgomery Stuart A. Treatment-Resistant Depression

4134.3 руб.
Successful management of patients with treatment-resistant depression is going to require a thorough understanding of the biological basis for both the depression and its failure to respond to standard treatments. This book clearly and succinctly summarizes the latest scientific research and its applications in clinical practice. A first step is a clear definition of what constitutes treatment-resistant depression so that clinical trials and other studies are using common criteria, enabling comparison and meta-analysis of their outcomes. The opening chapter reviews definitions and predictors of originating from different fields and discusses their usefulness in clinical practice and clinical research. The next chapter proposes a new definition, adapting terminology from medicine. Biological classification requires identification of genetic risk factors: with gene variants accounting for 50% of the variance in the clinical outcomes of antidepressant treatments this is clearly a fruitful area of research. Chapter 3 describes several genes already associated with treatment-resistant depression and, while further work is needed to translate findings into clinical recommendations, predicts that genetic prediction of TRD could became a widespread clinical reality within a few years. Most patients with TRD will be treated pharmacologically and three chapters review the latest evidence for pharmacological best practice, including switching strategies for antidepressants, the role of antipsychotics and augmentation strategies to complement lithium. There are two major alternatives to pharmacotherapy: neuromodulation and psychotherapy. The brain intervention chapter summarizes clinical research and experience with electroconvulsive therapy, transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy. The final chapter reviews the literature pertaining to the effectiveness of various forms of psychotherapy in patients who have not responded to antidepressant pharmacotherapy, revealing that patients who have not responded to one or two trials of antidepressant medication have a 30%-50% chance of responding to a focused psychotherapy. It proposes indications for psychotherapy in TRD and summarizes general therapeutic principles.
Reid Alistair G. The Genetic Basis of Haematological Cancers Reid Alistair G. The Genetic Basis of Haematological Cancers Новинка

Reid Alistair G. The Genetic Basis of Haematological Cancers

11268.58 руб.
Written by a team of international experts, this book provides an authoritative overview and practical guide to the molecular biology and genetic basis of haematologic cancers including leukemia. Focusing on the importance of cytogenetics and related assays, both as diagnostic tools and as a basis for translational research, this is an invaluable guide for basic and clinical researchers with an interest in medical genetics and haemato-oncology. The Genetic Basis of Haematological Cancers reviews the etiology and significance of genetic and epigenetic defects that occur in malignancies of the haematopoietic system. Some of these chromosomal and molecular aberrations are well established and already embedded in clinical management, while many others have only recently come to light as a result of advances in genomic technology and functional investigation. The book includes seven chapters written by clinical and academic leaders in the field, organised according to haematological malignancy sub-type. Each chapter includes a background on disease pathology and the genetic abnormalities most commonly associated with the condition. Authors present in-depth discussions outlining the biological significance of these lesions in pathogenesis and progression, and their use in diagnosis and monitoring response to therapy. The current or potential role of specific abnormalities as novel therapeutic targets is also discussed. There is also a full colour section containing original FISH, microarrays and immunostaining images.
Peter Blythe Attention, Balance and Coordination. The A.B.C. of Learning Success Peter Blythe Attention, Balance and Coordination. The A.B.C. of Learning Success Новинка

Peter Blythe Attention, Balance and Coordination. The A.B.C. of Learning Success

4353.77 руб.
An updated edition of the definitive handbook on the physical basis for learning for professionals involved in education and child development, written by the respected author of acclaimed titles in the field. A comprehensive overview of the relationship between neuromotor maturity and physical development on learning outcomes and behaviour in childhood and later life Explores why early reflexes are important, their functions in early development, their effects on learning and behavior if retained, and the possible effects on other aspects of development Brings together a specialist body of knowledge and makes it accessible to anyone involved in treating the symptoms of specific learning difficulties and emotional problems. Includes new information on the role of the vestibular system in anxiety and agoraphobia, a new chapter of case studies, and an Epilogue placing the INPP Method in a broader scientific context
Allanson Judith E. Management of Genetic Syndromes Allanson Judith E. Management of Genetic Syndromes Новинка

Allanson Judith E. Management of Genetic Syndromes

18771.01 руб.
The American Journal of Medical Genetics heralded the first edition of Management of Genetic Syndromes as an «unparalleled collection of knowledge.» Since the first edition's publication, advances have been made in diagnosis, understanding, and treatment of genetic syndromes, resulting in the potential for a higher quality of life for individuals affected. Management of Genetic Syndromes, Second Edition incorporates all the most recent developments in knowledge about and management of the most common genetic syndromes seen in children and adults. Expanded to cover twenty-five new syndromes, this comprehensive new edition also features thorough updates of chapters from the first edition. Edited by two of the field's most highly esteemed experts, each chapter is written by an expert with extensive direct professional experience with that disorder and includes detailed coverage of: Incidence Etiology and pathogenesis Natural history Diagnostic criteria and diagnostic testing, including photographs of distinctive physical findings Differential diagnosis Evaluation Management throughout life References and resources, including family support organizations Written to be clear and accessible to medical generalists and specialists, as well as allied health and education professionals and families, Management of Genetic Syndromes, Second Edition provides a unique and up-to-date resource for this rapidly developing field.
Varghese John BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease Varghese John BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease Новинка

Varghese John BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease

9808.9 руб.
BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.
Rodney J. Y. Ho Biotechnology and Biopharmaceuticals. Transforming Proteins and Genes into Drugs Rodney J. Y. Ho Biotechnology and Biopharmaceuticals. Transforming Proteins and Genes into Drugs Новинка

Rodney J. Y. Ho Biotechnology and Biopharmaceuticals. Transforming Proteins and Genes into Drugs

12257.29 руб.
Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.
Erich Grotewold Plant Genes, Genomes and Genetics Erich Grotewold Plant Genes, Genomes and Genetics Новинка

Erich Grotewold Plant Genes, Genomes and Genetics

5994.26 руб.
Plant Genes, Genomes and Genetics provides a comprehensive treatment of all aspects of plant gene expression. Unique in explaining the subject from a plant perspective, it highlights the importance of key processes, many first discovered in plants, that impact how plants develop and interact with the environment. This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications. Written by a highly respected team of specialists in plant biology with extensive experience in teaching at undergraduate and graduate level, this textbook will be invaluable for students and instructors alike. Plant Genes, Genomes and Genetics also includes: • specific examples that highlight when and how plants operate differently from other organisms; • special sections that provide in-depth discussions of particular issues; • end-of-chapter problems to help students recapitulate the main concepts; • rich, full-colour illustrations and diagrams clearly showing important processes in plant gene expression; • a companion website with PowerPoint slides, downloadable figures, and answers to the questions posed in the book. Aimed at upper level undergraduates and graduate students in plant biology, this text is equally suited for advanced agronomy and crop science students inclined to understand molecular aspects of organismal phenomena. It is also an invaluable starting point for professionals entering the field of plant biology.
Rodney Ho J.Y. Biotechnology and Biopharmaceuticals. Transforming Proteins and Genes into Drugs Rodney Ho J.Y. Biotechnology and Biopharmaceuticals. Transforming Proteins and Genes into Drugs Новинка

Rodney Ho J.Y. Biotechnology and Biopharmaceuticals. Transforming Proteins and Genes into Drugs

11993.49 руб.
Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.
Rajamani Doraiswami Identification of Physical Systems. Applications to Condition Monitoring, Fault Diagnosis, Soft Sensor and Controller Design Rajamani Doraiswami Identification of Physical Systems. Applications to Condition Monitoring, Fault Diagnosis, Soft Sensor and Controller Design Новинка

Rajamani Doraiswami Identification of Physical Systems. Applications to Condition Monitoring, Fault Diagnosis, Soft Sensor and Controller Design

10497.42 руб.
Identification of a physical system deals with the problem of identifying its mathematical model using the measured input and output data. As the physical system is generally complex, nonlinear, and its input–output data is corrupted noise, there are fundamental theoretical and practical issues that need to be considered. Identification of Physical Systems addresses this need, presenting a systematic, unified approach to the problem of physical system identification and its practical applications. Starting with a least-squares method, the authors develop various schemes to address the issues of accuracy, variation in the operating regimes, closed loop, and interconnected subsystems. Also presented is a non-parametric signal or data-based scheme to identify a means to provide a quick macroscopic picture of the system to complement the precise microscopic picture given by the parametric model-based scheme. Finally, a sequential integration of totally different schemes, such as non-parametric, Kalman filter, and parametric model, is developed to meet the speed and accuracy requirement of mission-critical systems. Key features: Provides a clear understanding of theoretical and practical issues in identification and its applications, enabling the reader to grasp a clear understanding of the theory and apply it to practical problems Offers a self-contained guide by including the background necessary to understand this interdisciplinary subject Includes case studies for the application of identification on physical laboratory scale systems, as well as number of illustrative examples throughout the book Identification of Physical Systems is a comprehensive reference for researchers and practitioners working in this field and is also a useful source of information for graduate students in electrical, computer, biomedical, chemical, and mechanical engineering.
Aubrey Milunsky Genetic Disorders and the Fetus. Diagnosis, Prevention, and Treatment Aubrey Milunsky Genetic Disorders and the Fetus. Diagnosis, Prevention, and Treatment Новинка

Aubrey Milunsky Genetic Disorders and the Fetus. Diagnosis, Prevention, and Treatment

18741.83 руб.
Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment, Seventh Edition is the eagerly awaited new edition of the discipline-leading text that has been at the forefront of diagnosis, prevention, and treatment of fetal genetic disorders for over 36 years. The seventh edition continues the long-established tradition of excellence that has become synonymous with this text. The book builds on the foundations of preconception and prenatal genetic counseling and the original pillars of prenatal diagnosis while also providing authoritative coverage of exciting developments in non-invasive genetic testing and rapidly developing molecular techniques, including microarray analysis and next generation sequencing, that are revolutionizing the field. Chapters are once again authored by internationally recognized authorities in the field of prenatal diagnosis. The editors have added three entirely new chapters to this edition to complement the complete revision of existing content. The three new chapters focus on non-invasive prenatal screening, placental genetics, and the psychology of prenatal and perinatal grief. The broad-ranging coverage and international scope will ensure that the new edition maintains its role as the major repository for information on all aspects of prenatal diagnosis. The editors have brought together an invaluable collection of evidence-based facts bolstered by knowledge and decades of experience in the field. Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment, 7th Edition is a timely update to this world-leading text.
Jack Higgins East of Desolation Jack Higgins East of Desolation Новинка

Jack Higgins East of Desolation

306.63 руб.
Classic adventure from the undisputed master of action and adrenalin-pumping suspense.When a plane crashes in the icy Greenland desert with no passengers on board, and no means of identification, Joe Martin is hired to fly to the scene of the crash by the insurance company involved and the beautiful widow of the dead pilot. But the routine mission spirals into hair-raising suspense when a priceless batch of emeralds are added to the mystery, and suddenly Joe finds himself in mortal danger.
А. Е. Mikusheva Survey on statistical inferences in weakly-identified instrumental variable models А. Е. Mikusheva Survey on statistical inferences in weakly-identified instrumental variable models Новинка

А. Е. Mikusheva Survey on statistical inferences in weakly-identified instrumental variable models

79.9 руб.
This paper provides a brief review of the current state of knowledge on the topic of weakly-identified instrumental variable regression. We describe the essence of the problem of weak identification, possible methods for detecting it in applied work as well as methods robust to weak identification. Special attention is devoted to the question of hypothesis testing in the presence of weak identification.
Kevin Murphy D. Modeling and Estimation of Structural Damage Kevin Murphy D. Modeling and Estimation of Structural Damage Новинка

Kevin Murphy D. Modeling and Estimation of Structural Damage

9014.86 руб.
Modelling and Estimation of Damage in Structures is a comprehensiveguide to solving the type of modelling and estimation problems associated with the physics of structural damage. Provides a model-based approach to damage identification Presents an in-depth treatment of probability theory and random processes Covers both theory and algorithms for implementing maximum likelihood and Bayesian estimation approaches Includes experimental examples of all detection and identification approaches Provides a clear means by which acquired data can be used to make decisions regarding maintenance and usage of a structure
Linacre Adrian Wildlife DNA Analysis. Applications in Forensic Science Linacre Adrian Wildlife DNA Analysis. Applications in Forensic Science Новинка

Linacre Adrian Wildlife DNA Analysis. Applications in Forensic Science

12257.29 руб.
DNA typing of non-human DNA is a fast developing area of research and professional practice. The application of DNA typing in wildlife forensic science is one of these prime uses of DNA typing and is gaining increasing profile. The use of DNA profiling in wildlife forensic science falls into two broad areas: species testing and genetic linkage. Species testing answers the question ‘what species is this?’ and genetic linkage answers the question ‘did these two samples come from the same organism or population?’ Wildlife DNA Analysis: Applications in Forensic Science provides an accessible introduction to both of these key areas. Clearly structured throughout, the introduction highlights the different types of crime where these techniques are regularly used. This chapter includes a discussion as to who performs forensic wildlife examinations, the standardisation and validation of methods, and the role of the expert witness in this type of alleged crime. This is followed by a detailed section on the science behind DNA typing including the problems in isolating DNA from trace material and subsequent genetic analysis are also covered. The book then undertakes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons. A comparison of the different markers used in species testing highlights the criteria for a genetic marker. A full set of case histories illustrates the use of the different markers used. The book details the use of genetic markers to link two or more hairs/feather/leaves/needles to the same individual organism and the software used in population assignment. The problems and possibilities in isolating markers, along with the construction of allele databases are discussed in this chapter. The book concludes with evaluation and reporting of genetic evidence in wildlife forensic science illustrated by examples of witness statements. •An accessible introduction to this fast developing area of research within forensic science •Case studies throughout to link theory and practice and to highlight the use of DNA testing in species testing. •Covers both crimes against wildlife and offences where wildlife can provide vital evidence •Assumes only a basic background knowledge of DNA •Includes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons
Schoukens Johan System Identification. A Frequency Domain Approach Schoukens Johan System Identification. A Frequency Domain Approach Новинка

Schoukens Johan System Identification. A Frequency Domain Approach

12720.91 руб.
System identification is a general term used to describe mathematical tools and algorithms that build dynamical models from measured data. Used for prediction, control, physical interpretation, and the designing of any electrical systems, they are vital in the fields of electrical, mechanical, civil, and chemical engineering. Focusing mainly on frequency domain techniques, System Identification: A Frequency Domain Approach, Second Edition also studies in detail the similarities and differences with the classical time domain approach. It high??lights many of the important steps in the identification process, points out the possible pitfalls to the reader, and illustrates the powerful tools that are available. Readers of this Second Editon will benefit from: MATLAB software support for identifying multivariable systems that is freely available at the website http://booksupport.wiley.com State-of-the-art system identification methods for both time and frequency domain data New chapters on non-parametric and parametric transfer function modeling using (non-)period excitations Numerous examples and figures that facilitate the learning process A simple writing style that allows the reader to learn more about the theo??retical aspects of the proofs and algorithms Unlike other books in this field, System Identification, Second Edition is ideal for practicing engineers, scientists, researchers, and both master's and PhD students in electrical, mechanical, civil, and chemical engineering.
Singer Peter A Companion to Bioethics Singer Peter A Companion to Bioethics Новинка

Singer Peter A Companion to Bioethics

18387.85 руб.
This second edition of A Companion to Bioethics, fully revised and updated to reflect the current issues and developments in the field, covers all the material that the reader needs to thoroughly grasp the ideas and debates involved in bioethics. Thematically organized around an unparalleled range of issues, including discussion of the moral status of embryos and fetuses, new genetics, life and death, resource allocation, organ donations, AIDS, human and animal experimentation, health care, and teaching Now includes new essays on currently controversial topics such as cloning and genetic enhancement Topics are clearly and compellingly presented by internationally renowned bioethicists A detailed index allows the reader to find terms and topics not listed in the titles of the essays themselves
Elaswarapu Ramnath Genomics. Essential Methods Elaswarapu Ramnath Genomics. Essential Methods Новинка

Elaswarapu Ramnath Genomics. Essential Methods

9345.27 руб.
Genomics research has made significant advances in recent years. In this book, a team of internationally-renowned researchers share the most up-to-date information in a field that has in recent years switched emphasis from gene identification to functional genomics and the characterization of genes and gene products. This volume approaches this complex subject with a broad perspective to supply the reader with a vital overview of genomics and its derivative fields, with a focus on pivotal issues such as data analysis. Expansive and current, this book is a comprehensive research guide that describes both the key new techniques and more established methods. Every chapter discusses the merits and limitations of the various approaches and then provides selected tried-and-tested protocols, as well as a plethora of good practical advice for immediate use at the bench. Key features: Provides a broad introduction to current practices and techniques for lab-based research in genomics Explains clearly and precisely how to carry out selected techniques in addition to background information on the various approaches Chapters are written by a leading international authorities in the field and cover both well-known and new, tried and tested, methods for working in genomics Includes troubleshooting guide and reviews of alternative techniques An essential laboratory manual for students and researchers at all levels
David Warnock W. Identification of Pathogenic Fungi David Warnock W. Identification of Pathogenic Fungi Новинка

David Warnock W. Identification of Pathogenic Fungi

13193.62 руб.
Since the first edition of Identification of Pathogenic Fungi, there has been incredible progress in the diagnosis, treatment and prevention of fungal diseases: new methods of diagnosis have been introduced, and new antifungal agents have been licensed for use. However, these developments have been offset by the emergence of resistance to several classes of drugs, and an increase in infections caused by fungi with innate resistance to one or more classes. Identification of Pathogenic Fungi, Second Edition, assists in the identification of over 100 of the most significant organisms of medical importance. Each chapter is arranged so that the descriptions for similar organisms may be found on adjacent pages. Differential diagnosis details are given for each organism on the basis of both colonial appearance and microscopic characteristics for the organisms described. In this fully updated second edition, a new chapter on the identification of fungi in histopathological sections and smears has been added, while colour illustrations of cultures and microscopic structures have been included, and high quality, four colour digital images are incorporated throughout.
Adrian Baranchuk Clinical Arrhythmology Adrian Baranchuk Clinical Arrhythmology Новинка

Adrian Baranchuk Clinical Arrhythmology

12190.55 руб.
The second edition of Clinical Arrhythmology provides a fresh, clear, and authoritative overview that will guide readers from a solid understanding of the mechanisms behind cardiac arrhythmias – which is fundamental to their identification – to diagnosis via electrocardiograms and other tools, to specific management options for each of the arrhythmias that cardiologists and other clinicians will encounter in clinical practice. Organized in a clear, intuitive manner; introducing the reader to an understanding of the anatomical and electrophysiological bases of arrhythmias, then to a comprehensive review of how to diagnose the full range of rhythmic abnormalities, and then to a discussion of specific clinical syndromes in which arrhythmias play a part Highly illustrated chapters ensure key concepts are simpler to understand Detailed appendices provide quick reference values for diagnostic and therapeutic techniques, and pharmacotherapeutic agents, and Recommendations
William Goodwin An Introduction to Forensic Genetics William Goodwin An Introduction to Forensic Genetics Новинка

William Goodwin An Introduction to Forensic Genetics

12368.4 руб.
This is a completely revised edition of a comprehensive and popular introduction to the fast moving area of Forensic Genetics. The text begins with key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Now illustrated in full colour throughout, this accessible textbook includes numerous references to relevant casework. With information on the full process of DNA evidence from collection at the scene of a crime to presentation in a legal context this book provides a complete overview of the field. Key Features: Greater in-depth coverage of kinship problems now covered in two separate chapters: one dealing with relationships between living individuals and the other covering identification of human remains. New chapter on non-human forensic genetics, including identification of bacteria and viruses, animals and plants. Self assessment questions to aid student understanding throughout the text. Now with full colour illustrations throughout New companion website Accessible introduction to forensic genetics, from the collection of evidence to the presentation of evidence in a legal context. Included in the Forensic Science Society 'Essentials in Forensic Science' book series. This edition is to be included in the Forensic Science Society 'Essentials of Forensic Science' book series aimed at advanced level undergraduates and new practitioners to the field.
Lee Mike S. Mass Spectrometry in Drug Metabolism and Disposition. Basic Principles and Applications Lee Mike S. Mass Spectrometry in Drug Metabolism and Disposition. Basic Principles and Applications Новинка

Lee Mike S. Mass Spectrometry in Drug Metabolism and Disposition. Basic Principles and Applications

12720.91 руб.
This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
Thomas Bulkowski N. Encyclopedia of Candlestick Charts Thomas Bulkowski N. Encyclopedia of Candlestick Charts Новинка

Thomas Bulkowski N. Encyclopedia of Candlestick Charts

12644.28 руб.
Following in the footsteps of author Thomas Bulkowski’s bestselling Encyclopedia of Chart Patterns—and structured in the same way—this easy-to-read and -use resource takes an in-depth look at 103 candlestick formations, from identification guidelines and statistical analysis of their behavior to detailed trading tactics. Encyclopedia of Candlestick Charts also includes chapters that contain important discoveries and statistical summaries, as well as a glossary of relevant terms and a visual index to make candlestick identification easy.
Flanagan Dawn P. Essentials of Specific Learning Disability Identification Flanagan Dawn P. Essentials of Specific Learning Disability Identification Новинка

Flanagan Dawn P. Essentials of Specific Learning Disability Identification

3831.6 руб.
Complete coverage on how SLD manifests in academic performance Expert advice on theory- and research-based approaches to SLD identification Conveniently formatted for rapid reference Quickly acquire the knowledge and skills you need to accurately identify specific learning disabilities Essentials of Specific Learning Disability Identification provides a brief overview examining the definitions and classification systems of—and methods for—identification of specific learning disabilities (SLDs). Focusing on descriptive efforts of the manifestations of SLDs in the academically critical areas of reading, writing, math, oral expression, and listening comprehension, this book features contributions by leading experts in the field, including Virginia Berninger, Steven Feifer, Jack Fletcher, Nancy Mather, Jack Naglieri, and more. Like all the volumes in the Essentials of Psychological Assessment series, each concise chapter features numerous callout boxes highlighting key concepts, bulleted points, and extensive illustrative material, as well as test questions that help you gauge and reinforce your grasp of the information covered. With multiple perspectives spanning several different theoretical orientations and offering various approaches to SLD identification that can be put into practice right away—from RTI methods to cognitive strengths and weaknesses approaches—this book offers important content for professionals who work with children and youth at risk for learning disabilities. With a Foreword by Cecil Reynolds, Essentials of Specific Learning Disability Identification presents rich and up-to-date information on models and methods of SLD identification.
Bo Peng Forward-Time Population Genetics Simulations. Methods, Implementation, and Applications Bo Peng Forward-Time Population Genetics Simulations. Methods, Implementation, and Applications Новинка

Bo Peng Forward-Time Population Genetics Simulations. Methods, Implementation, and Applications

8322.67 руб.
The only book available in the area of forward-time population genetics simulations—applicable to both biomedical and evolutionary studies The rapid increase of the power of personal computers has led to the use of serious forward-time simulation programs in genetic studies. Forward-Time Population Genetics Simulations presents both new and commonly used methods, and introduces simuPOP, a powerful and flexible new program that can be used to simulate arbitrary evolutionary processes with unique features like customized chromosome types, arbitrary nonrandom mating schemes, virtual subpopulations, information fields, and Python operators. The book begins with an overview of important concepts and models, then goes on to show how simuPOP can simulate a number of standard population genetics models—with the goal of demonstrating the impact of genetic factors such as mutation, selection, and recombination on standard Wright-Fisher models. The rest of the book is devoted to applications of forward-time simulations in various research topics. Forward-Time Population Genetics Simulations includes: An overview of currently available forward-time simulation methods, their advantages, and shortcomings An overview and evaluation of currently available software A simuPOP tutorial Applications in population genetics Applications in genetic epidemiology, statistical genetics, and mapping complex human diseases The only book of its kind in the field today, Forward-Time Population Genetics Simulations will appeal to researchers and students of population and statistical genetics.
Marino Xanthos Functional Fillers for Plastics Marino Xanthos Functional Fillers for Plastics Новинка

Marino Xanthos Functional Fillers for Plastics

20000.95 руб.
A comprehensive and up-to-date overview of the major mineral and organic fillers for plastics, their production, structure and properties, as well as their applications in terms of primary and secondary functions. Edited and co-authored by Professor Marino Xanthos with contributions by international experts from industry and academia, this book presents methods of mixing/incorporation technologies, surface treatments and modifications for enhanced functionality, an analysis of parameters affecting filler performance and a presentation of current and emerging applications. Additionally, the novel classification according to modification of specific polymer properties rather than filler chemical composition provides a better understanding of the relationships between processing, structure and properties of products containing functional fillers and the identification of new markets and applications. For engineers, scientists and technologists involved in the important sector of polymer composites.
Gil Alterovitz Automation in Proteomics and Genomics. An Engineering Case-Based Approach Gil Alterovitz Automation in Proteomics and Genomics. An Engineering Case-Based Approach Новинка

Gil Alterovitz Automation in Proteomics and Genomics. An Engineering Case-Based Approach

13197.18 руб.
In the last decade DNA sequencing costs have decreased over a magnitude, largely because of increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics & Genomics: An Engineering Case-Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics covered include: molecular biology fundamentals: from ‘blueprint’ (DNA) to ‘task list’ (RNA) to ‘molecular machine’ (protein); proteomics methods and technologies; modelling protein networks and interactions analysis via automation: DNA sequencing; microarrays and other parallelization technologies; protein characterization and identification; protein interaction and gene regulatory networks design via automation: DNA synthesis; RNA by design; building protein libraries; synthetic networks integration: multiple modalities; computational and experimental methods; trends in automation for genomics and proteomics new enabling technologies and future applications Automation in Proteomics & Genomics: An Engineering Case-Based Approach is an essential guide to the current capabilities and challenges of high-throughput analysis of genes and proteins for bioinformaticians, engineers, chemists, and biologists interested in developing a cross-discipline problem-solving based approach to systems biology.
Lorenzo Ressel Normal Cell Morphology in Canine and Feline Cytology. An Identification Guide Lorenzo Ressel Normal Cell Morphology in Canine and Feline Cytology. An Identification Guide Новинка

Lorenzo Ressel Normal Cell Morphology in Canine and Feline Cytology. An Identification Guide

3749.08 руб.
A concise and practical visual guide to normal cell identification for all those dealing with cytology in the dog and cat. Normal Cell Morphology in Canine and Feline Cytology: An Identification Guide takes a uniquely visual approach to normal cell identification in dogs and cats. Single-page presentations offer vivid snapshots of particular cell types, with high quality microphotographs matched with annotated schematic diagrams and accompanying explanatory text. Providing a vital understanding of what normal cells look like, this text is ideal for all those in small animal veterinary practice examining cytology samples. The book begins with a concise, yet comprehensive introduction to the principles of morphological identification, followed by a description of the distribution of cells and where different cell types can be sampled from in the various tissues and organs. The main part of the book is devoted to describing each cell type and its characteristics. Cytoarchitectures, observed non-cellular material and general pathological changes are also described. Offers a unique alphabetically organised visual guide to each cell type, covering cells from every type of organ and system Features an abundance of full-colour microphotographs accompanied by beautifully rendered schematic diagrams, making cell identification quick and easy Includes a visual index for ultimate ease of navigation at the microscope Normal Cell Morphology in Canine and Feline Cytology is a must-have text for veterinary students and an indispensable bench manual for small animal veterinary practitioners.
Jules Janick Plant Breeding Reviews, Volume 37 Jules Janick Plant Breeding Reviews, Volume 37 Новинка

Jules Janick Plant Breeding Reviews, Volume 37

18928.1 руб.
Plant Breeding Reviews presents state-of-the-art reviews on plant genetics and the breeding of all types of crops by both traditional means and molecular methods. Many of the crops widely grown today stem from a very narrow genetic base; understanding and preserving crop genetic resources is vital to the security of food systems worldwide. The emphasis of the series is on methodology, a fundamental understanding of crop genetics, and applications to major crops. It is a serial title that appears in the form of one or two volumes per year.
Jules Janick Plant Breeding Reviews, Volume 36 Jules Janick Plant Breeding Reviews, Volume 36 Новинка

Jules Janick Plant Breeding Reviews, Volume 36

18928.1 руб.
Plant Breeding Reviews presents state-of-the-art reviews on plant genetics and the breeding of all types of crops by both traditional means and molecular methods. Many of the crops widely grown today stem from a very narrow genetic base; understanding and preserving crop genetic resources is vital to the security of food systems worldwide. The emphasis of the series is on methodology, a fundamental understanding of crop genetics, and applications to major crops. It is a serial title that appears in the form of one or two volumes per year.
Jules Janick Plant Breeding Reviews, Volume 38 Jules Janick Plant Breeding Reviews, Volume 38 Новинка

Jules Janick Plant Breeding Reviews, Volume 38

16871.56 руб.
Plant Breeding Reviews presents state-of-the-art reviews on plant genetics and the breeding of all types of crops by both traditional means and molecular methods. Many of the crops widely grown today stem from a very narrow genetic base; understanding and preserving crop genetic resources is vital to the security of food systems worldwide. The emphasis of the series is on methodology, a fundamental understanding of crop genetics, and applications to major crops. It is a serial title that appears in the form of one or two volumes per year.
Jules Janick Plant Breeding Reviews, Volume 39 Jules Janick Plant Breeding Reviews, Volume 39 Новинка

Jules Janick Plant Breeding Reviews, Volume 39

16871.56 руб.
Plant Breeding Reviews presents state-of-the-art reviews on plant genetics and the breeding of all types of crops by both traditional means and molecular methods. Many of the crops widely grown today stem from a very narrow genetic base; understanding and preserving crop genetic resources is vital to the security of food systems worldwide. The emphasis of the series is on methodology, a fundamental understanding of crop genetics, and applications to major crops. It is a serial title that appears in the form of one or two volumes per year.
Christophe Lecoutre Constraint Networks. Targeting Simplicity for Techniques and Algorithms Christophe Lecoutre Constraint Networks. Targeting Simplicity for Techniques and Algorithms Новинка

Christophe Lecoutre Constraint Networks. Targeting Simplicity for Techniques and Algorithms

22836.34 руб.
A major challenge in constraint programming is to develop efficient generic approaches to solve instances of the constraint satisfaction problem (CSP). With this aim in mind, this book provides an accessible synthesis of the author's research and work in this area, divided into four main topics: representation, inference, search, and learning. The results obtained and reproduced in this book have a wide applicability, regardless of the nature of the problem or the constraints involved, making it an extremely user-friendly resource for those involved in this field.
Dante Cicchetti Developmental Psychopathology, Risk, Resilience, and Intervention Dante Cicchetti Developmental Psychopathology, Risk, Resilience, and Intervention Новинка

Dante Cicchetti Developmental Psychopathology, Risk, Resilience, and Intervention

18746.1 руб.
Examine the latest research merging nature and nurture in pathological development Developmental Psychopathology is a four-volume compendium of the most complete and current research on every aspect of the field. Volume Four: Genes and Environment focuses on the interplay between nature and nurture throughout the life stages, and the ways in which a child's environment can influence his or her physical and mental health as an adult. The discussion explores relationships with family, friends, and the community; environmental factors like poverty, violence, and social support; the development of coping mechanisms, and more, including the impact of these factors on physical brain development. This new third edition has been fully updated to incorporate the latest advances, and to better reflect the increasingly multilevel and interdisciplinary nature of the field and the growing importance of translational research. The relevance of classification in a developmental context is also addressed, including DSM-5 criteria and definitions. Advances in developmental psychopathology are occurring increasingly quickly as expanding theoretical and empirical work brings about dramatic gains in the multiple domains of child and adult development. This book brings you up to date on the latest developments surrounding genetics and environmental influence, including their intersection in experience-dependent brain development. Understand the impact of childhood adversity on adulthood health Gauge the effects of violence, poverty, interparental conflict, and more Learn how peer, family, and community relationships drive development Examine developments in prevention science and future research priorities Developmental psychopathology is necessarily interdisciplinary, as development arises from a dynamic interplay between psychological, genetic, social, cognitive, emotional, and cultural factors. Developmental Psychopathology Volume Four: Genes and Environment brings this diverse research together to give you a cohesive picture of the state of knowledge in the field.
Gawley Robert E. Stereochemical Aspects of Organolithium Compounds Gawley Robert E. Stereochemical Aspects of Organolithium Compounds Новинка

Gawley Robert E. Stereochemical Aspects of Organolithium Compounds

14253.55 руб.
Topics in Stereochemistry, previously edited by «the father of stereochemistry» Ernest L. Eliel, is a longstanding, successful series covering the most important advances in the field. The much-anticipated Volume 26 on stereochemical aspects of organolithium compounds includes chapters on the following topics: * Asymmetric Deprotonations Using Chiral Lithium Amide Bases * Self-Regeneration of Stereocenters (SRS) via Stereolabile Axially Chiral Intermediates * Overview of Carbanion Dynamics and Electrophilic Substitutions in Chiral Organolithium Compounds * Oxiranyllithiums as Chiral Synthons for Asymmetric Synthesis * Test on the Configurational Stability/Lability of Organolithium Compounds * Mechanism and Stereochemical Features in Asymmetric Deprotonation Using RLi/(-)-Sparteine Bases * Dynamic Resolutions of Chiral Organolithiums Volume 26 of Topics in Stereochemistry marks the end of an era, while developing a bridge to the next generation. A new generation in publishing, parallel to a new generation in Stereochemistry mandated a new venue and modus operandi for Topics. Zurich, the home of Werner and Wislicenus, has a unique heritage in Stereochemistry. Fortunately, the Wiley family's publishing partnerships include Verlag Helvetica Chimica Acta, a house with a reputation for superior quality in publishing. Indeed, within the pages of its namesake periodical, Helvetica Chimica Acta, one finds many of the seminal research works of stereochemistry's giants. As such, a transfer of editorial operations to Zurich and a collaboration bringing Topics as a series closer to periodical status provides a growth platform for the future.
Saheer Gharbia E. MALDI-TOF and Tandem MS for Clinical Microbiology Saheer Gharbia E. MALDI-TOF and Tandem MS for Clinical Microbiology Новинка

Saheer Gharbia E. MALDI-TOF and Tandem MS for Clinical Microbiology

11997.76 руб.
This book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade. This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss: Challenges of Identifying Mycobacterium to the Species level Identification of Bacteroides and Other Clinically Relevant Anaerobes Identification of Species in Mixed Microbial Populations Detection of Resistance Mechanisms Proteomics as a biomarker discovery and validation platform Determination of Antimicrobial Resistance using Tandem Mass Spectrometry
Sally Aitken N. Conservation and the Genetics of Populations Sally Aitken N. Conservation and the Genetics of Populations Новинка

Sally Aitken N. Conservation and the Genetics of Populations

13193.62 руб.
Loss of biodiversity is among the greatest problems facing the world today. Conservation and the Genetics of Populations gives a comprehensive overview of the essential background, concepts, and tools needed to understand how genetic information can be used to conserve species threatened with extinction, and to manage species of ecological or commercial importance. New molecular techniques, statistical methods, and computer programs, genetic principles, and methods are becoming increasingly useful in the conservation of biological diversity. Using a balance of data and theory, coupled with basic and applied research examples, this book examines genetic and phenotypic variation in natural populations, the principles and mechanisms of evolutionary change, the interpretation of genetic data from natural populations, and how these can be applied to conservation. The book includes examples from plants, animals, and microbes in wild and captive populations. This second edition contains new chapters on Climate Change and Exploited Populations as well as new sections on genomics, genetic monitoring, emerging diseases, metagenomics, and more. One-third of the references in this edition were published after the first edition. Each of the 22 chapters and the statistical appendix have a Guest Box written by an expert in that particular topic (including James Crow, Louis Bernatchez, Loren Rieseberg, Rick Shine, and Lisette Waits). This book is essential for advanced undergraduate and graduate students of conservation genetics, natural resource management, and conservation biology, as well as professional conservation biologists working for wildlife and habitat management agencies. Additional resources for this book can be found at: www.wiley.com/go/allendorf/populations.
Sarah Wamala The Handbook of Global Health Policy Sarah Wamala The Handbook of Global Health Policy Новинка

Sarah Wamala The Handbook of Global Health Policy

15067.45 руб.
The Handbook of Global Health Policy provides a definitive source of the key areas in the field. It examines the ethical and practical dimensions of new and current policy models and their effect on the future development of global health and policy. Maps out key debates and policy structures involved in all areas of global health policy Isolates and examines new policy initiatives in global health policy Provides an examination of these initiatives that captures both the ethical/critical as well as practical/empirical dimensions involved with global health policy, global health policy formation and its implications Confronts the theoretical and practical questions of ‘who gets what and why’ and ‘how, when and where?’ Captures the views of a wide array of scholars and practitioners, including from low- and middle-income countries, to ensure an inclusive view of current policy debates
David Sigee C. Freshwater Algae. Identification, Enumeration and Use as Bioindicators David Sigee C. Freshwater Algae. Identification, Enumeration and Use as Bioindicators Новинка

David Sigee C. Freshwater Algae. Identification, Enumeration and Use as Bioindicators

8548.18 руб.
This is the second edition of Freshwater Algae; the popular guide to temperate freshwater algae. This book uniquely combines practical information on sampling and experimental techniques with an explanation of basic algal taxonomy plus a key to identify the more frequently-occurring organisms. Fully revised, it describes major bioindicator species in relation to key environmental parameters and their implications for aquatic management. This second edition includes: the same clear writing style as the first edition to provide an easily accessible source of information on algae within standing and flowing waters, and the problems they may cause the identification of 250 algae using a key based on readily observable morphological features that can be readily observed under a conventional light microscope up-to-date information on the molecular determination of taxonomic status, analytical microtechniques and the potential role of computer analysis in algal biology upgrades to numerous line drawings to include more detail and extra species information, full colour photographs of live algae – including many new images from the USA and China Bridging the gap between simple identification texts and highly specialised research volumes, this book is used both as a comprehensive introduction to the subject and as a laboratory manual. The new edition will be invaluable to aquatic biologists for algal identification, and for all practitioners and researchers working within aquatic microbiology in industry and academia.
Arben Merkoci Biosensing Using Nanomaterials Arben Merkoci Biosensing Using Nanomaterials Новинка

Arben Merkoci Biosensing Using Nanomaterials

14943.24 руб.
An interdisciplinary approach to one of the hottest topics in nanotechnology and nanoscience Biosensing Using Nanomaterials introduces novel concepts in the area of bioanalysis based on nanomaterials, opening new opportunities for basic research and new tools for real bioanalytical applications. In fifteen chapters, readers are introduced to the most successful nanomaterials used so far in biosensing, including carbon nanotubes, nanoparticles, and nanochannels. Each chapter provides a theoretical overview of the topic, a discussion of the published data relating to the bioanalytical system, and a selected list of references for further investigation. The result is a book that provides a comprehensive forum of interest to scientists, engineers, researchers, manufacturers, teachers, and students. Biosensing Using Nanomaterials is an important resource for a broad audience involved in the research, teaching, learning, and practice of integrating nanomaterials into biosensing systems for clinical, environmental, and industrial applications.
Dorothy Gennard Forensic Entomology. An Introduction Dorothy Gennard Forensic Entomology. An Introduction Новинка

Dorothy Gennard Forensic Entomology. An Introduction

2139.84 руб.
Forensic Entomology provides undergraduates with a concise introduction to the subject. The book is written with the clarity necessary for students starting out in entomology yet authoritative enough to prove useful for more experienced researchers. Worked examples of the necessary mathematics, including how to use excel to process data, coupled with lab protocols and self-assessment questions make the book an essential starting point in the subject. Assuming little prior knowledge of either biology or entomology the book provides information on identification, life cycles and ecology of insects presented in a forensic context. Information is conveyed in an accessible style with practical tasks and suggestions for further reading included in each chapter. Fully revised and updated to include new research in the field New chapter on aquatic forensic entomology New pictorial key to aid identification of species contributed by Dr. Krzysztof Szpila, Nicolaus Copernicus University, Poland Further coverage of civil applications of forensic entomology Practical tasks and further reading included to aid understanding Colour plate section and improved illustrations throughout to assist in the identification of insects associated with the corpse Approaches the topic from the dual perspectives of basic entomology and its forensic applications Covers the contributions to forensic investigations of both flies and beetles Provides information on culturing insects collected from crime scenes Guides students through the processes of writing entomological court reports and presenting in court alongside the scientific topics Extended coverage of PMI calculations, role of professional associations for forensic entomologists and sampling at the crime scene New sections to discuss the identification of traces of explosives found in larvae, puparia and pupae and DNA sampling from insects
Zajac Anne M. Veterinary Clinical Parasitology Zajac Anne M. Veterinary Clinical Parasitology Новинка

Zajac Anne M. Veterinary Clinical Parasitology

6053.29 руб.
Veterinary Clinical Parasitology, Eighth Edition, prepared under the auspices of the American Association of Veterinary Parasitologists (AAVP), emphasizes the morphologic identification of both internal and external parasites of domestic animals. Focusing on the tests and information most relevant to daily practice, the book describes accurate, cost-effective techniques for diagnosing parasitic infections in animals. Including clear, easy-to-find information on the distribution, life cycle, and importance of each parasite, Veterinary Clinical Parasitology offers more than 450 images to aid with diagnosis. The Eighth Edition includes a new chapter on immunologic and molecular diagnosis, increased coverage of ticks and new sections on identification of microfilariae and larvae in diagnostic samples. The new edition also features expanded information on quantitative egg counts, detection of anthelmintic resistance and identification of ruminant strongylid larvae. Additional improvements include many new images throughout the book, revised taxonomic information, a new layout featuring tabs by section to improve user-friendliness, and a companion website offering the images from the book in PowerPoint at www.wiley.com/go/zajac. Veterinary Clinical Parasitology is a highly practical benchside reference invaluable to clinicians, technicians, and students.
Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts Новинка

Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts

11997.76 руб.
Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug–drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.
Paris Goodyear-Brown Handbook of Child Sexual Abuse. Identification, Assessment, and Treatment Paris Goodyear-Brown Handbook of Child Sexual Abuse. Identification, Assessment, and Treatment Новинка

Paris Goodyear-Brown Handbook of Child Sexual Abuse. Identification, Assessment, and Treatment

6513.72 руб.
A comprehensive guide to the identification, assessment, and treatment of child sexual abuse The field of child sexual abuse has experienced an explosion of research, literature, and enhanced treatment methods over the last thirty years. Representing the latest refinements of thought in this field, Handbook of Child Sexual Abuse: Identification, Assessment, and Treatment combines the most current research with a wealth of clinical experience. The contributing authors, many of whom are pioneers in their respective specialties, include researchers and clinicians, forensic interviewers and law enforcement professionals, caseworkers and victim advocates, all of whom do the work of helping children who have been sexually victimized. Offering a snapshot of the state of the field as it stands today, Handbook of Child Sexual Abuse explores a variety of issues related to child sexual abuse, from identification, assessment, and treatment methods to models for implementation and prevention, including: The impact of sexual abuse on the developing brain The potential implications of early sexual victimization Navigating the complexities of multidisciplinary teams Forensic interviewing and clinical assessment Treatment options for children who have traumagenic symptoms as a response to their sexual victimization Treating children with sexual behavior problems and adolescents who engage in illegal sexual behavior Secondary trauma and vicarious traumatization Cultural considerations and prevention efforts Edited by a leader in the field of child therapy, this important reference equips helping professionals on the front lines in the battle against child sexual abuse—not merely with state-of-the-art knowledge—but also with a renewed vision for the importance of their role in the shaping of our culture and the healing of victimized children.
Cagnoni Stefano Genetic and Evolutionary Computation. Medical Applications Cagnoni Stefano Genetic and Evolutionary Computation. Medical Applications Новинка

Cagnoni Stefano Genetic and Evolutionary Computation. Medical Applications

11494.8 руб.
Genetic and Evolutionary Computation: Medical Applications provides an overview of the range of GEC techniques being applied to medicine and healthcare in a context that is relevant not only for existing GEC practitioners but also those from other disciplines, particularly health professionals. There is rapidly increasing interest in applying evolutionary computation to problems in medicine, but to date no text that introduces evolutionary computation in a medical context. By explaining the basic introductory theory, typical application areas and detailed implementation in one coherent volume, this book will appeal to a wide audience from software developers to medical scientists. Centred around a set of nine case studies on the application of GEC to different areas of medicine, the book offers an overview of applications of GEC to medicine, describes applications in which GEC is used to analyse medical images and data sets, derive advanced models, and suggest diagnoses and treatments, finally providing hints about possible future advancements of genetic and evolutionary computation in medicine. Explores the rapidly growing area of genetic and evolutionary computation in context of its viable and exciting payoffs in the field of medical applications. Explains the underlying theory, typical applications and detailed implementation. Includes general sections about the applications of GEC to medicine and their expected future developments, as well as specific sections on applications of GEC to medical imaging, analysis of medical data sets, advanced modelling, diagnosis and treatment. Features a wide range of tables, illustrations diagrams and photographs.
Soumyajit Mukherjee Ductile Shear Zones. From Micro- to Macro-scales Soumyajit Mukherjee Ductile Shear Zones. From Micro- to Macro-scales Новинка

Soumyajit Mukherjee Ductile Shear Zones. From Micro- to Macro-scales

11268.58 руб.
The elucidation of the mechanisms and kinematics of shear zone deformation, at both local and regional scales, is the subject of a great deal of interest to scientists in the hydrocarbon industry, in seismology, and in structural geology more generally. This book comprises a collection of five theoretical and twelve regional contributions to the subject from a number of leading researchers in the field, with particular emphasis on work carried out in the Indian subcontinent. The book will be invaluable to advances students and researchers involved in the kinematics of shear.

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DNA typing of non-human DNA is a fast developing area of research and professional practice. The application of DNA typing in wildlife forensic science is one of these prime uses of DNA typing and is gaining increasing profile. The use of DNA profiling in wildlife forensic science falls into two broad areas: species testing and genetic linkage. Species testing answers the question ‘what species is this?’ and genetic linkage answers the question ‘did these two samples come from the same organism or population?’ Wildlife DNA Analysis: Applications in Forensic Science provides an accessible introduction to both of these key areas. Clearly structured throughout, the introduction highlights the different types of crime where these techniques are regularly used. This chapter includes a discussion as to who performs forensic wildlife examinations, the standardisation and validation of methods, and the role of the expert witness in this type of alleged crime. This is followed by a detailed section on the science behind DNA typing including the problems in isolating DNA from trace material and subsequent genetic analysis are also covered. The book then undertakes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons. A comparison of the different markers used in species testing highlights the criteria for a genetic marker. A full set of case histories illustrates the use of the different markers used. The book details the use of genetic markers to link two or more hairs/feather/leaves/needles to the same individual organism and the software used in population assignment. The problems and possibilities in isolating markers, along with the construction of allele databases are discussed in this chapter. The book concludes with evaluation and reporting of genetic evidence in wildlife forensic science illustrated by examples of witness statements. •An accessible introduction to this fast developing area of research within forensic science •Case studies throughout to link theory and practice and to highlight the use of DNA testing in species testing. •Covers both crimes against wildlife and offences where wildlife can provide vital evidence •Assumes only a basic background knowledge of DNA •Includes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons
Продажа identification of new genes involved in meiosis via a genetic screen лучших цены всего мира
Посредством этого сайта магазина - каталога товаров мы очень легко осуществляем продажу identification of new genes involved in meiosis via a genetic screen у одного из интернет-магазинов проверенных фирм. Определитесь с вашими предпочтениями один интернет-магазин, с лучшей ценой продукта. Прочитав рекомендации по продаже identification of new genes involved in meiosis via a genetic screen легко охарактеризовать производителя как превосходную и доступную фирму.