methods in enzymology volume 48 enzyme structure part f



Methods in Enzymology: Volume 48: Enzyme Structure: Part F Methods in Enzymology: Volume 48: Enzyme Structure: Part F Новинка

Methods in Enzymology: Volume 48: Enzyme Structure: Part F

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Methods in Enzymology: Volume 61: Enzyme Structure: Part H Methods in Enzymology: Volume 61: Enzyme Structure: Part H Новинка

Methods in Enzymology: Volume 61: Enzyme Structure: Part H

The critically acclaimed laboratory standard, METHODS IN ENZYMOLOGY, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Enzyme Structure: Part L: Volume 131: Enzyme Structure: Part L Enzyme Structure: Part L: Volume 131: Enzyme Structure: Part L Новинка

Enzyme Structure: Part L: Volume 131: Enzyme Structure: Part L

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Methods in Enzymology: Volume 49: Enzyme Structure: Part G Methods in Enzymology: Volume 49: Enzyme Structure: Part G Новинка

Methods in Enzymology: Volume 49: Enzyme Structure: Part G

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Methods in Enzymology, Volume 130: Enzyme Structure, Part K Methods in Enzymology, Volume 130: Enzyme Structure, Part K Новинка

Methods in Enzymology, Volume 130: Enzyme Structure, Part K

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Methods in Enzymology: Volume 112: Drug and Enzyme Targeting: Part A Methods in Enzymology: Volume 112: Drug and Enzyme Targeting: Part A Новинка

Methods in Enzymology: Volume 112: Drug and Enzyme Targeting: Part A

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Methods in Enzymology: Volume 104: Enzyme Purification and Related Techniques: Part C Methods in Enzymology: Volume 104: Enzyme Purification and Related Techniques: Part C Новинка

Methods in Enzymology: Volume 104: Enzyme Purification and Related Techniques: Part C

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Methods in Enzymology: Volume 111: Steroids and Isoprenoids: Part B Methods in Enzymology: Volume 111: Steroids and Isoprenoids: Part B Новинка

Methods in Enzymology: Volume 111: Steroids and Isoprenoids: Part B

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Methods in Enzymology: Volume 115: Diffraction Methods for Biological Macromolecules: Part B Methods in Enzymology: Volume 115: Diffraction Methods for Biological Macromolecules: Part B Новинка

Methods in Enzymology: Volume 115: Diffraction Methods for Biological Macromolecules: Part B

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Methods in Enzymology: Volume 1 Methods in Enzymology: Volume 1 Новинка

Methods in Enzymology: Volume 1

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Methods in Enzymology: Volume 141: Cellular Regulators: Part B: Calcium and Lipids Methods in Enzymology: Volume 141: Cellular Regulators: Part B: Calcium and Lipids Новинка

Methods in Enzymology: Volume 141: Cellular Regulators: Part B: Calcium and Lipids

The critically acclaimed laboratory standard, METHODS IN ENZYMOLOGY, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Hans Bisswanger Practical Enzymology Hans Bisswanger Practical Enzymology Новинка

Hans Bisswanger Practical Enzymology

The second edition of the perfect companion for practical course work in enzymology. Now with an improved selection of enzymatic assays based on key metabolic reactions, this book provides the detailed background to the enzymatic reaction and the enzyme per se. Particular emphasis is placed on troubleshooting with the described methods, and, in addition, the new four-color layout throughout features detailed protocols highlighted for easy recognition. www.wiley-vch.de/home/enzymology: A companion website provides animations for all figures together with supplementary material, for deeper understanding of the partially abstract matter.
Robert A. Copeland Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists Robert A. Copeland Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists Новинка

Robert A. Copeland Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists

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Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.
Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent Новинка

Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent

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Sets the stage for advances in drug discovery using the latest enzyme technology Reviewing new and emerging applications of enzyme technology in drug discovery, this book highlights some of the most promising areas of pharmaceutical and biotechnology research. It covers enzyme assay technology, utilization of enzymology for prodrug design, and the application of enzymes as therapeutic agents. Expert reviews highlight how our latest understanding of enzymology is used to develop new practical applications in drug discovery and design. Filled with case studies, Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents enables readers to better understand the diverse functions of enzymes and master specific applications in drug discovery research. In addition to small molecule drug discovery, the book explores new developments in enzymes as therapeutic agents for genetic disorders. Section A, Enzymes – Essential Workhorses in Pharmaceutical Research, offers support in selecting the best enzyme targets for drug discovery, designing enzyme inhibitors for therapeutic agents, and evaluating selective enzyme inhibitors. Section B, Enzymes – Indispensable Tools for Improving Druggability, sets forth the principles alongside real-world examples of exploiting specific properties of enzymes to design successful prodrugs. Section C, Enzymes – Powerful Weapons for Correcting Nature's Errors, provides new insights on applying enzymes as therapeutic agents or diagnostic tools to treat genetic disorders. Chapters are contributed by leading experts from around the world. Their contributions are based on a thorough review of the current literature as well as their own research. Reviewing our latest understanding of the nature of enzymes and their role in drug discovery, this book is recommended for researchers in pharmaceuticals and biotechnology as well as for researchers in enzymology, biochemistry, molecular biology, and medicinal chemistry.
Hans Bisswanger Enzyme Kinetics. Principles and Methods Hans Bisswanger Enzyme Kinetics. Principles and Methods Новинка

Hans Bisswanger Enzyme Kinetics. Principles and Methods

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Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.
Michael Dolg Computational Methods in Lanthanide and Actinide Chemistry Michael Dolg Computational Methods in Lanthanide and Actinide Chemistry Новинка

Michael Dolg Computational Methods in Lanthanide and Actinide Chemistry

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The f-elements and their compounds often possess an unusually complex electronic structure, governed by the high number of electronic states arising from open f-shells as well as large relativistic and electron correlation effects. A correct theoretical description of these elements poses the highest challenges to theory. Computational Methods in Lanthanide and Actinide Chemistry summarizes state-of-the-art electronic structure methods applicable for quantum chemical calculations of lanthanide and actinide systems and presents a broad overview of their most recent applications to atoms, molecules and solids. The book contains sixteen chapters, written by leading experts in method development as well as in theoretical investigations of f-element systems. Topics covered include: Relativistic configuration interaction calculations for lanthanide and actinide anions Study of actinides by relativistic coupled cluster methods Relativistic all-electron approaches to the study of f- element chemistry Relativistic pseudopotentials and their applications Gaussian basis sets for lanthanide and actinide elements Applied computational actinide chemistry This book will serve as a comprehensive reference work for quantum chemists and computational chemists, both those already working in, and those planning to enter the field of quantum chemistry for f-elements. Experimentalists will also find important information concerning the capabilities of modern quantum chemical methods to assist in the interpretation or even to predict the outcome of their experiments.
Lloyd Wolfinbarger, Jr. Enzyme Regulation in Metabolic Pathways Lloyd Wolfinbarger, Jr. Enzyme Regulation in Metabolic Pathways Новинка

Lloyd Wolfinbarger, Jr. Enzyme Regulation in Metabolic Pathways

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Enzyme Regulation in Metabolic Pathways shows the reader how to understand the roles of enzymes and their kinetic constants in intermediary metabolism. It provides a means of correlating data obtained in experimental studies to multiple possible mechanisms through which some enzyme may catalyze the conversion of a substrate to a product. Although not the most appropriate means of determining some potential kinetic mechanism, quasi-equilibrium assumptions are used throughout the book, keeping the rate equation derivations simple. Actual metabolic pathways with known (presumed) positive and negative regulation events are linked to these potential kinetic mechanisms using both rate equation derivations and data plots illustrating how the rate equation derivations can be used to explain the data plots. This book will be a valuable reference for students in biological sciences and biochemistry majors required to take a core course in enzymology.
Dermot O'Hare Structure from Diffraction Methods. Inorganic Materials Series Dermot O'Hare Structure from Diffraction Methods. Inorganic Materials Series Новинка

Dermot O'Hare Structure from Diffraction Methods. Inorganic Materials Series

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Inorganic materials show a diverse range of important properties that are desirable for many contemporary, real-world applications. Good examples include recyclable battery cathode materials for energy storage and transport, porous solids for capture and storage of gases and molecular complexes for use in electronic devices. An understanding of the function of these materials is necessary in order to optimise their behaviour for real applications, hence the importance of 'structure–property relationships'. The chapters presented in this volume deal with recent advances in the characterisation of crystalline materials. They include some familiar diffraction methods, thoroughly updated with modern advances. Also included are techniques that can now probe details of the three-dimensional arrangements of atoms in nanocrystalline solids, allowing aspects of disorder to be studied. Small-angle scattering, a technique that is often overlooked, can probe both ordered and disordered structures of materials at longer length scales than those probed by powder diffraction methods. Addressing both physical principals and recent advances in their applications, Structure from Diffraction Methods covers: Powder Diffraction X-Ray and Neutron Single-Crystal Diffraction PDF Analysis of Nanoparticles Electron Crystallography Small-Angle Scattering Ideal as a complementary reference work to other volumes in the series (Local Structural Characterisation and Multi Length-Scale Characterisation), or as an examination of the specific characterisation techniques in their own right, Structure from Diffraction Methods is a valuable addition to the Inorganic Materials Series.
Hanrahan Grady Chemometric Methods in Capillary Electrophoresis Hanrahan Grady Chemometric Methods in Capillary Electrophoresis Новинка

Hanrahan Grady Chemometric Methods in Capillary Electrophoresis

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Use chemometric techniques to develop optimum separation conditions for capillary electrophoreses For all its advantages, capillary electrophoresis (CE) also carries significant disadvantages for the researcher. Offering a unique blend of information from authors active in a variety of developments of chemometrics in CE, Chemometric Methods in Capillary Electrophoresis presents modern chemometric methods as an alternative to help alleviate the problems commonly encountered during routine analysis and method development. Focusing on current chemometric methods utilized in CE endeavours by research-active experts in the field, the book begins with a thorough introduction to CE and chemometric-related concepts and the need for modern chemometric methods in CE. Part 1 discusses differing types of screening designs and response surface methodology¿in an¿application based format Part 2 includes vital discussion on various exploratory data analysis, prediction, and classification techniques utilized in CE-related studies Part 3 provides practical information on modelling quantitative structure relationships Part 4 explores transformation techniques, in particular fundamental studies and applications of cross-correlation and Hadamard Transform Electrophoresis Showing how chemometric methods are applied in a wide array of applications including biological, medical, pharmaceutical, food, forensic, and environmental science, Chemometric Methods in Capillary Electrophoresis is not only highly significant to capillary electrophoresis-based endeavours, but instructive for investigators active in other areas of separation science who could benefit from its informative content.
Robert Scott A. Computational Inorganic and Bioinorganic Chemistry Robert Scott A. Computational Inorganic and Bioinorganic Chemistry Новинка

Robert Scott A. Computational Inorganic and Bioinorganic Chemistry

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Over the past several decades there have been major advances in our ability to computationally evaluate the electronic structure of inorganic molecules, particularly transition metal systems. This advancement is due to the Moore’s Law increase in computing power as well as the impact of density functional theory (DFT) and its implementation in commercial and freeware programs for quantum chemical calculations. Improved pure and hybrid density functionals are allowing DFT calculations with accuracy comparable to high-level Hartree-Fock treatments, and the results of these calculations can now be evaluated by experiment. When calculations are correlated to, and supported by, experimental data they can provide fundamental insight into electronic structure and its contributions to physical properties and chemical reactivity. This interplay continues to expand and contributes to both improved value of experimental results and improved accuracy of computational predictions. The purpose of this EIC Book is to provide state-of-the-art presentations of quantum mechanical and related methods and their applications, written by many of the leaders in the field. Part 1 of this volume focuses on methods, their background and implementation, and their use in describing bonding properties, energies, transition states and spectroscopic features. Part 2 focuses on applications in bioinorganic chemistry and Part 3 discusses inorganic chemistry, where electronic structure calculations have already had a major impact. This addition to the EIC Book series is of significant value to both experimentalists and theoreticians, and we anticipate that it will stimulate both further development of the methodology and its applications in the many interdisciplinary fields that comprise modern inorganic and bioinorganic chemistry. This volume is also available as part of Encyclopedia of Inorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007 to 2010, representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. Find out more.
Kenneth Lipkowitz B. Reviews in Computational Chemistry Kenneth Lipkowitz B. Reviews in Computational Chemistry Новинка

Kenneth Lipkowitz B. Reviews in Computational Chemistry

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The Reviews in Computational Chemistry series brings together leading authorities in the field to teach the newcomer and update the expert on topics centered on molecular modeling, such as computer-assisted molecular design (CAMD), quantum chemistry, molecular mechanics and dynamics, and quantitative structure-activity relationships (QSAR). This volume, like those prior to it, features chapters by experts in various fields of computational chemistry. Topics in Volume 29 include: Noncovalent Interactions in Density-Functional Theory Long-Range Inter-Particle Interactions: Insights from Molecular Quantum Electrodynamics (QED) Theory Efficient Transition-State Modeling using Molecular Mechanics Force Fields for the Everyday Chemist Machine Learning in Materials Science: Recent Progress and Emerging Applications Discovering New Materials via a priori Crystal Structure Prediction Introduction to Maximally Localized Wannier Functions Methods for a Rapid and Automated Description of Proteins: Protein Structure, Protein Similarity, and Protein Folding
Maria Vineeta Delaunay Tetrahedralization and its dual Voronoi Diagrams Maria Vineeta Delaunay Tetrahedralization and its dual Voronoi Diagrams Новинка

Maria Vineeta Delaunay Tetrahedralization and its dual Voronoi Diagrams

Master's Thesis from the year 2014 in the subject Computer Science - Applied, grade: B+, Bournemouth University, course: Msc Computer Animation and Visual Effects, language: English, abstract: The Delaunay tetrahedralization (DT) is one of the most popular and common methods used for solving problems related to meshes. It is either used for generating a mesh or for breaking it up, as Voronoi diagrams, dual of the DT, is a commonly used process for that. The main task of this project is to implement a robust Delaunay Tetrahedralization structure, with a set of points generated from sampling a given 3D Mesh.Points within the volume of the mesh can be obtained by several methods. We present two such methods and discuss the result obtained. These points serve as vertices for the tetrahedrons that are a part of the combinatorial structure DT.3D Delaunay Tetrahedralization is not as optimal as 2D Delaunay triangulations. Implementing them gives rise to several degeneracies, which are quite difficult to handle. In this project, we have implemented a simple Incremental Insertion Algorithm based on the paper presented by Ledoux (2007), inorder to construct the DT structure. Correctness of the structure is given utmost importance rather than its speed.
Yuri Bazilevs Computational Fluid-Structure Interaction. Methods and Applications Yuri Bazilevs Computational Fluid-Structure Interaction. Methods and Applications Новинка

Yuri Bazilevs Computational Fluid-Structure Interaction. Methods and Applications

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Computational Fluid-Structure Interaction: Methods and Applications takes the reader from the fundamentals of computational fluid and solid mechanics to the state-of-the-art in computational FSI methods, special FSI techniques, and solution of real-world problems. Leading experts in the field present the material using a unique approach that combines advanced methods, special techniques, and challenging applications. This book begins with the differential equations governing the fluid and solid mechanics, coupling conditions at the fluid–solid interface, and the basics of the finite element method. It continues with the ALE and space–time FSI methods, spatial discretization and time integration strategies for the coupled FSI equations, solution techniques for the fully-discretized coupled equations, and advanced FSI and space–time methods. It ends with special FSI techniques targeting cardiovascular FSI, parachute FSI, and wind-turbine aerodynamics and FSI. Key features: First book to address the state-of-the-art in computational FSI Combines the fundamentals of computational fluid and solid mechanics, the state-of-the-art in FSI methods, and special FSI techniques targeting challenging classes of real-world problems Covers modern computational mechanics techniques, including stabilized, variational multiscale, and space–time methods, isogeometric analysis, and advanced FSI coupling methods Is in full color, with diagrams illustrating the fundamental concepts and advanced methods and with insightful visualization illustrating the complexities of the problems that can be solved with the FSI methods covered in the book. Authors are award winning, leading global experts in computational FSI, who are known for solving some of the most challenging FSI problems Computational Fluid-Structure Interaction: Methods and Applications is a comprehensive reference for researchers and practicing engineers who would like to advance their existing knowledge on these subjects. It is also an ideal text for graduate and senior-level undergraduate courses in computational fluid mechanics and computational FSI.
Klaus Buchholz Biocatalysts and Enzyme Technology Klaus Buchholz Biocatalysts and Enzyme Technology Новинка

Klaus Buchholz Biocatalysts and Enzyme Technology

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This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.
Eric Toone J. Advances in Enzymology and Related Areas of Molecular Biology Eric Toone J. Advances in Enzymology and Related Areas of Molecular Biology Новинка

Eric Toone J. Advances in Enzymology and Related Areas of Molecular Biology

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This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes.
Matthias Froeck Methodische Arbeiten zur Entwicklung verbesserter Enzymaktivitatsbestimmungen von Xylanasen und Glucanasen in komplexen Proben (Futtermitteln und Digesta) Matthias Froeck Methodische Arbeiten zur Entwicklung verbesserter Enzymaktivitatsbestimmungen von Xylanasen und Glucanasen in komplexen Proben (Futtermitteln und Digesta) Новинка

Matthias Froeck Methodische Arbeiten zur Entwicklung verbesserter Enzymaktivitatsbestimmungen von Xylanasen und Glucanasen in komplexen Proben (Futtermitteln und Digesta)

Inhaltsangabe:Problemstellung: In der Tiernährung werden verschiedene Enzyme eingesetzt, um bei landwirtschaftlichen Nutztieren antinutritive Effekte pflanzlicher Futtermittel zu beseitigen und die Futterverwertung zu verbessern. Nichtstärkepolysaccaride abbauende Enzyme unterstützen die Verdauungskapazität körpereigener Enzyme, indem viskositätsbildende Futterkomponenten für die das Tier keine eigenen Enzyme besitzt, partitiell hydrolysiert werden, und durch körpereigene Enzyme verdauliche Nahrungsbestandteile auf Grund einer Solubilisierung von Zellwandkomponenten dem enzymatischen Abbau besser zugänglich gemacht werden. So senken Xylanasen und ß-Glucanasen die Viskosität des Nahrungsbreis im Verdauungstrakt und fördern dadurch die Verdaulichkeit der Hauptnährstoffe z.B., bei Broilern. Kommerzielle Nichtstärkepolysaccharide spaltende Enzyme werden meist durch Fermentationsprozesse mit Pilzen hergestellt. Der Einschluss NSP-spaltender Enzyme in die EU-Futterzusatzstoffdirektive hat folgende Forderung an die Enzymanaltytik gestellt: da die Enzyme in den Beschreibungen der Futtermittel als Zusatzstoffe deklariert werden müssen, verlangen die zuständigen Behörden eine Testmethode zur Enzymaktivitätsbestimmung im Futtermittel, damit die beigemengten Enzyme tatsächlich den Konzentrationen entsprechen, die in Produktspezifikation angegeben sind. Das geltende Futtermittelrecht fasst alle Wirkstoffe unter dem Begriff Futterzusatzstoffe zusammen. Juristisch gelten für Enzyme in Futte...
Advances in Latent Variable Mixture Models (PB) Advances in Latent Variable Mixture Models (PB) Новинка

Advances in Latent Variable Mixture Models (PB)

The current volume, Advances in Latent Variable Mixture Models, contains chapters by all of the speakers who participated in the 2006 CILVR conference, providing not just a snapshot of the event, but more importantly chronicling the state of the art in latent variable mixture model research. The volume starts with an overview chapter by the CILVR conference keynote speaker, Bengt Muthén, offering a "lay of the land" for latent variable mixture models before the volume moves to more specific constellations of topics. Part I, Multilevel and Longitudinal Systems, deals with mixtures for data that are hierarchical in nature either due to the data's sampling structure or to the repetition of measures (of varied types) over time. Part II, Models for Assessment and Diagnosis, addresses scenarios for making judgments about individuals' state of knowledge or development, and about the instruments used for making such judgments. Finally, Part III, Challenges in Model Evaluation, focuses on some of the methodological issues associated with the selection of models most accurately representing the processes and populations under investigation. It should be stated that this volume is not intended to be a first exposure to latent variable methods. Readers lacking such foundational knowledge are encouraged to consult primary and/or secondary didactic resources in order to get the most from the chapters in this volume. Once armed with that basic understanding of latent variabl...
Kumar Pradeep Purification of Alcohol Dehydrogenase from Yeast Cells Kumar Pradeep Purification of Alcohol Dehydrogenase from Yeast Cells Новинка

Kumar Pradeep Purification of Alcohol Dehydrogenase from Yeast Cells

Proteins and enzymes have a vast scope of applications in several aspects of our life like in detergents, leather, paper and pulp, textile, cosmetic, healthcare and food processing industries, for clinical and diagnostics research. Due to the wide uses of proteins and enzymes interest in the industrial production of such useful enzymes has grown up in recent years. Today the focus is on developing efficient purification methods for proteins which can meet the increasing industrial needs. A number of separation and purification strategies have been developed for these purposes including non chromatographic methods and also some modern methods including chromatographic techniques. This work aims to develop such an efficient method for the purification of biochemically important enzyme, Alcohol Dehydrogenase from yeast cells. Three phase partitioning is a useful affinity based non chromatographic method to purify proteins and enzyme which is applied to purify the enzyme ADH. This book will be proved useful for researchers, students, individuals and anyone working in the area of protein purification.
Robert Scott A. Applications of Physical Methods to Inorganic and Bioinorganic Chemistry Robert Scott A. Applications of Physical Methods to Inorganic and Bioinorganic Chemistry Новинка

Robert Scott A. Applications of Physical Methods to Inorganic and Bioinorganic Chemistry

20168.13 руб. или Купить в рассрочку!
Modern spectroscopic and instrumental techniques are essential to the practice of inorganic and bioinorganic chemistry. This first volume in the new Wiley Encyclopedia of Inorganic Chemistry Methods and Applications Series provides a consistent and comprehensive description of the practical applicability of a large number of techniques to modern problems in inorganic and bioinorganic chemistry. The outcome is a text that provides invaluable guidance and advice for inorganic and bioinorganic chemists to select appropriate techniques, whilst acting as a source to the understanding of these methods. This volume is also available as part of Encyclopedia of Inorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007 to 2010, representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. Find out more.
Jeffrey Reimers R. Computational Methods for Large Systems. Electronic Structure Approaches for Biotechnology and Nanotechnology Jeffrey Reimers R. Computational Methods for Large Systems. Electronic Structure Approaches for Biotechnology and Nanotechnology Новинка

Jeffrey Reimers R. Computational Methods for Large Systems. Electronic Structure Approaches for Biotechnology and Nanotechnology

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While its results normally complement the information obtained by chemical experiments, computer computations can in some cases predict unobserved chemical phenomena Electronic-Structure Computational Methods for Large Systems gives readers a simple description of modern electronic-structure techniques. It shows what techniques are pertinent for particular problems in biotechnology and nanotechnology and provides a balanced treatment of topics that teach strengths and weaknesses, appropriate and inappropriate methods. It’s a book that will enhance the your calculating confidence and improve your ability to predict new effects and solve new problems.
Lorena Wilson Problem Solving in Enzyme Biocatalysis Lorena Wilson Problem Solving in Enzyme Biocatalysis Новинка

Lorena Wilson Problem Solving in Enzyme Biocatalysis

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Enzyme biocatalysis is a fast-growing area in process biotechnology that has expanded from the traditional fields of foods, detergents, and leather applications to more sophisticated uses in the pharmaceutical and fine-chemicals sectors and environmental management. Conventional applications of industrial enzymes are expected to grow, with major opportunities in the detergent and animal feed sectors, and new uses in biofuel production and human and animal therapy. In order to design more efficient enzyme reactors and evaluate performance properly, sound mathematical expressions must be developed which consider enzyme kinetics, material balances, and eventual mass transfer limitations. With a focus on problem solving, each chapter provides abridged coverage of the subject, followed by a number of solved problems illustrating resolution procedures and the main concepts underlying them, plus supplementary questions and answers. Based on more than 50 years of teaching experience, Problem Solving in Enzyme Biocatalysis is a unique reference for students of chemical and biochemical engineering, as well as biochemists and chemists dealing with bioprocesses. Contains: Enzyme properties and applications; enzyme kinetics; enzyme reactor design and operation 146 worked problems and solutions in enzyme biocatalysis.
Ulle Endriss Trends in Computational Social Choice Ulle Endriss Trends in Computational Social Choice Новинка

Ulle Endriss Trends in Computational Social Choice

Computational social choice is concerned with the design and analysis of methods for collective decision making. It is a research area that is located at the interface of Computer Science and Economics. This volume reports on a number of recent research trends in computational social choice. It has three parts. The first part presents novel scenarios in which methods for collective decision making are required. The second part introduces novel techniques for the analysis of such methods. The third part, finally, discusses a range of innovative applications enabled by recent research in computational social choice.
Helmut Clemens Neutrons and Synchrotron Radiation in Engineering Materials Science. From Fundamentals to Applications Helmut Clemens Neutrons and Synchrotron Radiation in Engineering Materials Science. From Fundamentals to Applications Новинка

Helmut Clemens Neutrons and Synchrotron Radiation in Engineering Materials Science. From Fundamentals to Applications

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Retaining its proven concept, the second edition of this ready reference specifically addresses the need of materials engineers for reliable, detailed information on modern material characterization methods. As such, it provides a systematic overview of the increasingly important field of characterization of engineering materials with the help of neutrons and synchrotron radiation. The first part introduces readers to the fundamentals of structure-property relationships in materials and the radiation sources suitable for materials characterization. The second part then focuses on such characterization techniques as diffraction and scattering methods, as well as direct imaging and tomography. The third part presents new and emerging methods of materials characterization in the field of 3D characterization techniques like three-dimensional X-ray diffraction microscopy. The fourth and final part is a collection of examples that demonstrate the application of the methods introduced in the first parts to problems in materials science. With thoroughly revised and updated chapters and now containing about 20% new material, this is the must-have, in-depth resource on this highly relevant topic.
Raimund Mannhold Biomolecular Simulations in Structure-Based Drug Discovery Raimund Mannhold Biomolecular Simulations in Structure-Based Drug Discovery Новинка

Raimund Mannhold Biomolecular Simulations in Structure-Based Drug Discovery

15380.44 руб. или Купить в рассрочку!
A timely and topical survey of modern simulation tools and their applications in real-life drug discovery, allowing for better and quicker results in structure-based drug design. The first part of this practical guide for industry professionals describes common tools used in the biomolecular simulation of drugs and their targets. A critical analysis of the accuracy of the predictions, the integration of modeling with other experimental data combined with numerous case studies from different therapeutic fields enable users to quickly adopt these new methods for their current projects. The second part then shows how these tools can be applied to drug discovery and development projects. Modeling experts from the pharmaceutical industry and from leading academic institutions present real-life examples for important target classes such as GPCRs, kinases and amyloids as well as for common challenges in structure-based drug discovery. With its inclusion of novel methods and strategies for the modeling of drug-target interactions in the framework of real-life drug discovery and development, this application-oriented reference is tailor-made for medicinal chemists and those working in the pharmaceutical industry.
Dermot O'Hare Multi Length-Scale Characterisation. Inorganic Materials Series Dermot O'Hare Multi Length-Scale Characterisation. Inorganic Materials Series Новинка

Dermot O'Hare Multi Length-Scale Characterisation. Inorganic Materials Series

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This volume examines important experimental techniques needed to characterise inorganic materials in order to elucidate their properties for practical application. Addressing methods that examine the structures and properties of materials over length scales ranging from local atomic order to long-range order on the meso- and macro-scopic scales, Multi Length-Scale Characterisation contains five detailed chapters: Measurement of Bulk Magnetic Properties Thermal Methods Atomic Force Microscopy Gas Sorption in the Analysis of Nanoporous Solids Dynamic Light Scattering Ideal as a complementary reference work to other volumes in the series (Local Structural Characterisation and Structure from Diffraction Methods) or as an examination of the specific characterisation techniques in their own right, Multi Length-Scale Characterisation is a valuable addition to the Inorganic Materials Series.
Md. Safiur Rahman Mahdi, A.B.M. Zunaid Haque, S.M. Al Mamun Protein Secondary Structure Prediction Md. Safiur Rahman Mahdi, A.B.M. Zunaid Haque, S.M. Al Mamun Protein Secondary Structure Prediction Новинка

Md. Safiur Rahman Mahdi, A.B.M. Zunaid Haque, S.M. Al Mamun Protein Secondary Structure Prediction

Protein secondary structure prediction is a very hot topic in bioinformatics. Predicting protein secondary structure means to find out the portions that contain Helix and Sheet in protein sequence. There are several methods for predicting protein secondary structure. The methods like Genetic Algorithm, Hidden Markov Model and different kinds of Neural Networks are there. Genetic Algorithm mostly deals with protein tertiary structure and sequence alignment, for Hidden Markov Model the accuracy is not good and Neural Network is the most successful for predicting protein secondary structure. So, we used the method named "Feed Forward Neural Network" and implemented it with JOONE (Java Object Oriented Neural Engine) editor. At first we have classified the 20 protein according to their structure, size and hydrophobic manner. Then we have modeled a new architecture in feed forward network and used those classified proteins as input. Our achieved accuracy of helix prediction is 71% and sheet prediction is 65%. The result shows the improvement over previous works done in this regard. We hope that our work will be a future directive in this arena.
Sustainability and Collaboration in Supply Chain Management Sustainability and Collaboration in Supply Chain Management Новинка

Sustainability and Collaboration in Supply Chain Management

As the customer is demanding more sustainable and affordable products, the supply chains have to find innovative ways to fulfill this need. In this context, collaboration as well as optimization methods are becoming even more evident to enhance supply chain structure to an efficient and sustainable approach. While collaboration and optimization increase complexity and susceptibility, risk management needs to be applied concurrently.This volume, edited by Wolfgang Kersten, Thorsten Blecker and Christian Ringle, provides valuable insights into:- Sustainability in Logistics- Sustainability and collaboration practices- Supply chain risk management- Optimization methods in supply chain management.This volume addresses timely and relevant topics. Both researchers and practitioners are addressed and can obtain background information from current distributions by international authors presenting a state of the art research overview.
Hisashi Yamamoto Molecular Technology. Life Innovation Hisashi Yamamoto Molecular Technology. Life Innovation Новинка

Hisashi Yamamoto Molecular Technology. Life Innovation

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Edited by foremost leaders in chemical research together with a number of distinguished international authors, Volume 2 presents the most important and promising recent chemical developments in life sciences, neatly summarized in one book. Interdisciplinary and application-oriented, this ready reference focuses on methods and processes with a high practical aspect, covering new trends in drug delivery, in-vivo analysis, structure formation and much more. Of great interest to chemists and life scientists in academia and industry.
Yuliang Zhao Toxicology of Nanomaterials Yuliang Zhao Toxicology of Nanomaterials Новинка

Yuliang Zhao Toxicology of Nanomaterials

14140.42 руб. или Купить в рассрочку!
This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.
Benson David J. Arbitrary Lagrangian Eulerian and Fluid-Structure Interaction. Numerical Simulation Benson David J. Arbitrary Lagrangian Eulerian and Fluid-Structure Interaction. Numerical Simulation Новинка

Benson David J. Arbitrary Lagrangian Eulerian and Fluid-Structure Interaction. Numerical Simulation

11309.15 руб. или Купить в рассрочку!
This book provides the fundamental basics for solving fluid structure interaction problems, and describes different algorithms and numerical methods used to solve problems where fluid and structure can be weakly or strongly coupled. These approaches are illustrated with examples arising from industrial or academic applications. Each of these approaches has its own performance and limitations. Given the book’s comprehensive coverage, engineers, graduate students and researchers involved in the simulation of practical fluid structure interaction problems will find this book extremely useful.
Qiuliang Wang Practical Design of Magnetostatic Structure Using Numerical Simulation Qiuliang Wang Practical Design of Magnetostatic Structure Using Numerical Simulation Новинка

Qiuliang Wang Practical Design of Magnetostatic Structure Using Numerical Simulation

11162.94 руб. или Купить в рассрочку!
Magnets are widely used in industry, medical, scientific instruments, and electrical equipment. They are the basic tools for scientific research and electromagnetic devices. Numerical methods for the magnetic field analysis combined with mathematical optimization from practical applications of the magnets have been widely studied in recent years. It is necessary for professional researchers, engineers, and students to study these numerical methods for the complex magnet structure design instead of using traditional «trial-and-error» methods. Those working in this field will find this book useful as a reference to help reduce costs and obtain good magnetic field quality. Presents a clear introduction to magnet technology, followed by basic theories, numerical analysis, and practical applications Emphasizes the latest developments in magnet design, including MRI systems Provides comprehensive numerical techniques that provide solutions to practical problems Introduces the latest computation techniques for optimizing and characterizing the magnetostatic structure design Well organized and adaptable by researchers, engineers, lecturers, and students Appendix available on the Wiley Companion Website As a comprehensive treatment of the topic, Practical Design of Magnetostatic Structure Using Numerical Simulation is ideal for researchers in the field of magnets and their applications, materials scientists, structural engineers, and graduate students in electrical engineering. The book will also better equip mechanical engineers and aerospace engineers.
Operations Research. Methods, Models, and Applications Operations Research. Methods, Models, and Applications Новинка

Operations Research. Methods, Models, and Applications

Drawn from a conference honoring Gerald L. Thompson, the pioneer of operations research, this volume brings together some of the latest writings of major figures in the field. The volume is divided into four parts: the first part reviews the career and significance of Thompson, the second concentrates on linear and nonlinear optimization, the third looks at network and integer programming, and the fourth provides examples of applications-oriented research in manufacturing. This volume will be an invaluable resource for all scholars and researchers involved in theory and methodology in operations research and management science.
William Maddock Bayliss The Nature of Enzyme Action, Volume 3 William Maddock Bayliss The Nature of Enzyme Action, Volume 3 Новинка

William Maddock Bayliss The Nature of Enzyme Action, Volume 3

Эта книга — репринт оригинального издания, созданный на основе электронной копии высокого разрешения, которую очистили и обработали вручную, сохранив структуру и орфографию оригинального издания. Редкие, забытые и малоизвестные книги, изданные с петровских времен до наших дней, вновь доступны в виде печатных книг.
Norbert Mitzel Structural Methods in Molecular Inorganic Chemistry Norbert Mitzel Structural Methods in Molecular Inorganic Chemistry Новинка

Norbert Mitzel Structural Methods in Molecular Inorganic Chemistry

14213.85 руб. или Купить в рассрочку!
Determining the structure of molecules is a fundamental skill that all chemists must learn. Structural Methods in Molecular Inorganic Chemistry is designed to help readers interpret experimental data, understand the material published in modern journals of inorganic chemistry, and make decisions about what techniques will be the most useful in solving particular structural problems. Following a general introduction to the tools and concepts in structural chemistry, the following topics are covered in detail: • computational chemistry • nuclear magnetic resonance spectroscopy • electron paramagnetic resonance spectroscopy • Mössbauer spectroscopy • rotational spectra and rotational structure • vibrational spectroscopy • electronic characterization techniques • diffraction methods • mass spectrometry The final chapter presents a series of case histories, illustrating how chemists have applied a broad range of structural techniques to interpret and understand chemical systems. Throughout the textbook a strong connection is made between theoretical topics and the real world of practicing chemists. Each chapter concludes with problems and discussion questions, and a supporting website contains additional advanced material. Structural Methods in Molecular Inorganic Chemistry is an extensive update and sequel to the successful textbook Structural Methods in Inorganic Chemistry by Ebsworth, Rankin and Cradock. It is essential reading for all advanced students of chemistry, and a handy reference source for the professional chemist.
Artem Oganov R. Modern Methods of Crystal Structure Prediction Artem Oganov R. Modern Methods of Crystal Structure Prediction Новинка

Artem Oganov R. Modern Methods of Crystal Structure Prediction

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Gathering leading specialists in the field of structure prediction, this book provides a unique view of this complex and rapidly developing field, reflecting the numerous viewpoints of the different authors. A summary of the major achievements over the last few years and of the challenges still remaining makes this monograph very timely.
Hugo Kubinyi Protein-Ligand Interactions Hugo Kubinyi Protein-Ligand Interactions Новинка

Hugo Kubinyi Protein-Ligand Interactions

14586.66 руб. или Купить в рассрочку!
Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental methods (calorimetry, surface plasmon resonance, NMR) used in generating interaction data. The second half of the book is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.
T. D. H. Bugg Introduction to Enzyme and Coenzyme Chemistry T. D. H. Bugg Introduction to Enzyme and Coenzyme Chemistry Новинка

T. D. H. Bugg Introduction to Enzyme and Coenzyme Chemistry

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Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.
Eric Toone J. Advances in Enzymology and Related Areas of Molecular Biology Eric Toone J. Advances in Enzymology and Related Areas of Molecular Biology Новинка

Eric Toone J. Advances in Enzymology and Related Areas of Molecular Biology

10932.18 руб. или Купить в рассрочку!
This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Новинка

Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad

16884.56 руб. или Купить в рассрочку!
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
Wolfgang Wiedermann Statistics and Causality. Methods for Applied Empirical Research Wolfgang Wiedermann Statistics and Causality. Methods for Applied Empirical Research Новинка

Wolfgang Wiedermann Statistics and Causality. Methods for Applied Empirical Research

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A one-of-a-kind guide to identifying and dealing with modern statistical developments in causality Written by a group of well-known experts, Statistics and Causality: Methods for Applied Empirical Research focuses on the most up-to-date developments in statistical methods in respect to causality. Illustrating the properties of statistical methods to theories of causality, the book features a summary of the latest developments in methods for statistical analysis of causality hypotheses. The book is divided into five accessible and independent parts. The first part introduces the foundations of causal structures and discusses issues associated with standard mechanistic and difference-making theories of causality. The second part features novel generalizations of methods designed to make statements concerning the direction of effects. The third part illustrates advances in Granger-causality testing and related issues. The fourth part focuses on counterfactual approaches and propensity score analysis. Finally, the fifth part presents designs for causal inference with an overview of the research designs commonly used in epidemiology. Statistics and Causality: Methods for Applied Empirical Research also includes: New statistical methodologies and approaches to causal analysis in the context of the continuing development of philosophical theories End-of-chapter bibliographies that provide references for further discussions and additional research topics Discussions on the use and applicability of software when appropriate Statistics and Causality: Methods for Applied Empirical Research is an ideal reference for practicing statisticians, applied mathematicians, psychologists, sociologists, logicians, medical professionals, epidemiologists, and educators who want to learn more about new methodologies in causal analysis. The book is also an excellent textbook for graduate-level courses in causality and qualitative logic.
Feminist Interpretation of the Hebrew Bible in Retrospect. III. Methods Feminist Interpretation of the Hebrew Bible in Retrospect. III. Methods Новинка

Feminist Interpretation of the Hebrew Bible in Retrospect. III. Methods

This is the third of a set of three volumes reviewing the progress of feminist Hebrew Bible scholarship over the last forty years. In this third volume, eighteen contributors focus on the wide range of exegetical methods as they have been productively employed in feminist biblical interpretations. More specifically, each essay investigates how feminist Hebrew Bible exegetes have worked with exegetical methods. Each essay surveys the method under consideration as it has emerged in academic discourse generally and in biblical studies in particular. Each essay also explains how feminist uses of the various exegetical methods have been deeply embedded within the theological, cultural, and even political expectations and assumptions of readers of the Bible. This volume asks readers to come to terms with the following question: What are the best methods for feminist exegesis in the light of past and present socio-political, theological, or hermeneutical developments in reading the Bible? After all, feminist theorists have come to recognize that methods are always already situated within powerful epistemological and methodological structures that have their roots in vast arrays of historical, political, economic, social, and religious factors. This volume encourages feminist debate on these complex issues that stand at the heart of biblical exegesis.
Antti Poso Beton-Kalender 2014. Schwerpunkte: Unterirdisches Bauen - Grundbau - Eurocode 7 Antti Poso Beton-Kalender 2014. Schwerpunkte: Unterirdisches Bauen - Grundbau - Eurocode 7 Новинка

Antti Poso Beton-Kalender 2014. Schwerpunkte: Unterirdisches Bauen - Grundbau - Eurocode 7

5592.06 руб. или Купить в рассрочку!
Underground construction and foundations are very complex and expensive today, particularly in inner cities. In order to provide a quick overview of the interfaces and the necessary dialogue among qualified engineers in modern design and construction, the entire range of disciplines and specialisations involved are described. The latest types of foundations and construction methods in general building are extensively described. Particular attention is paid to the highly non-linear and complex holistic behavior of the system ground-structure and the interaction between the verification of serviceability of the foundation and the limit state of load-bearing capacity in the structure above. Excavations are required for almost all construction projects, from pipe laying to extensive building projects between existing buildings. The essential calculation methods and construction processes are explained here, updated from EAB 2012.
N. Balakrishnan Methods and Applications of Statistics in Clinical Trials, Volume 2. Planning, Analysis, and Inferential Methods N. Balakrishnan Methods and Applications of Statistics in Clinical Trials, Volume 2. Planning, Analysis, and Inferential Methods Новинка

N. Balakrishnan Methods and Applications of Statistics in Clinical Trials, Volume 2. Planning, Analysis, and Inferential Methods

14954.52 руб. или Купить в рассрочку!
Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features: • Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems • Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index • Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials
Robert Schunk W. Modeling the Ionosphere-Thermosphere, Volume 201 Robert Schunk W. Modeling the Ionosphere-Thermosphere, Volume 201 Новинка

Robert Schunk W. Modeling the Ionosphere-Thermosphere, Volume 201

Published by the American Geophysical Union as part of the Geophysical Monograph Series, Volume 201. Modeling the Ionosphere-Thermosphere System brings together for the first time a detailed description of the physics of the IT system in conjunction with numerical techniques to solve the complex system of equations that describe the system, as well as issues of current interest. Volume highlights include discussions of: Physics of the ionosphere and thermosphere IT system, and the numerical methods to solve the basic equations of the IT system The physics and numerical methods to determine the global electrodynamics of the IT system The response of the IT system to forcings from below (i.e., the lower atmosphere) and from above (i.e., the magnetosphere) The physics and numerical methods to model ionospheric irregularities Data assimilation techniques, comparison of model results to data, climate variability studies, and applications to space weather Providing a clear description of the physics of this system in several tutorial-like articles, Modeling the Ionosphere-Thermosphere System is of value to the upper atmosphere science community in general. Chapters describing details of the numerical methods used to solve the equations that describe the IT system make the volume useful to both active researchers in the field and students.
MBR BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант MBR BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант Новинка

MBR BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант

Высокотехнологичный препарат на основе альфа- и бета-гидроксикислот в комбинации с высокотехнологичными ферментами, идентичными ферментам кожи. Способствует удалению ороговевших клеток и стимулирует обновление кожи.
MBR BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант MBR BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант Новинка

MBR BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант BIOCHANGE BETA-ENZYME EXFOLIATOR Эксфолиант

Высокотехнологичный препарат на основе альфа- и бета-гидроксикислот в комбинации с высокотехнологичными ферментами, идентичными ферментам кожи. Способствует удалению ороговевших клеток и стимулирует обновление кожи.
Michael B. Smith Compendium of Organic Synthetic Methods Michael B. Smith Compendium of Organic Synthetic Methods Новинка

Michael B. Smith Compendium of Organic Synthetic Methods

14400.32 руб. или Купить в рассрочку!
The Compendium of Organic Synthetic Methods series facilitates the working chemist's search for the most useful functional group transformations in organic chemistry. Drawn from an exhaustive survey of the literature, Compendium of Organic Synthetic Methods, Volume 12 contains both functional group transformations and carbon-carbon bond-forming reactions. Author Michael Smith adheres to stringent criteria for listing reactions, including real synthetic utility and reagents that are either readily available or easily prepared and handled in the laboratory. A clear organizational scheme-chemical transformations classified first by reacting functional group of starting material, then by functional group formed-allows for quick reference and information retrieval. Compendium of Organic Synthetic Methods, Volume 12 provides an unparalleled source of information on the methods, reactions, and transformations in contemporary organic chemistry for the working chemist and student alike.
Sandra Gemma Structure-based Design of Drugs and Other Bioactive Molecules. Tools and Strategies Sandra Gemma Structure-based Design of Drugs and Other Bioactive Molecules. Tools and Strategies Новинка

Sandra Gemma Structure-based Design of Drugs and Other Bioactive Molecules. Tools and Strategies

10269.76 руб. или Купить в рассрочку!
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present «best practice» methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
CFR 7, Parts 900 to 999, Agriculture, January 01, 2017 (Volume 8 of 15) CFR 7, Parts 900 to 999, Agriculture, January 01, 2017 (Volume 8 of 15) Новинка

CFR 7, Parts 900 to 999, Agriculture, January 01, 2017 (Volume 8 of 15)

Code of Federal Regulations Title 7, Volume 8, January 1, 2017 contains regulations governing Agriculture and may also be referenced as:- Code of Federal Regulations Title 7, Volume 8, January 1, 2017- CFR Title 7- CFR 7, Agriculture- CFR 7, Parts 900 to 999, AgricultureThis volume contains Parts 900 to 999:- Part 900; GENERAL REGULATIONS- Part 905; ORANGES, GRAPEFRUIT, TANGERINES, AND PUMMELOS GROWN IN FLORIDA- Part 906; ORANGES AND GRAPEFRUIT GROWN IN LOWER RIO GRANDE VALLEY IN TEXAS- Part 915; AVOCADOS GROWN IN SOUTH FLORIDA- Part 917; FRESH PEARS AND PEACHES GROWN IN CALIFORNIA- Part 920; KIWIFRUIT GROWN IN CALIFORNIA- Part 922; APRICOTS GROWN IN DESIGNATED COUNTIES IN WASHINGTON- Part 923; SWEET CHERRIES GROWN IN DESIGNATED COUNTIES IN WASHINGTON- Part 925; GRAPES GROWN IN A DESIGNATED AREA OF SOUTHEASTERN CALIFORNIA- Part 926; DATA COLLECTION, REPORTING AND RECORDKEEPING REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER- Part 927; PEARS GROWN IN OREGON AND WASHINGTON- Part 929; CRANBERRIES GROWN IN STATES OF MASSACHUSETTS, RHODE ISLAND, CONNECTICUT, NEW JERSEY, WISCONSIN, MICHIGAN, MINNESOTA, OREGON, WASHINGTON, AND LONG ISLAND IN THE STATE OF NEW YORK- Part 930; TART CHERRIES GROWN IN THE STATES OF MICHIGAN, NEW YORK, PENNSYLVANIA, OREGON, UTAH, WASHINGTON, AND WISCONSIN- Part 932; OLIVES GROWN IN CALIFORNIA- Part 944; FRUITS; IMPORT REGULATIONS- Part 945; IRISH POTATOES GROWN IN CERTAIN DESIGNATED COUNTIES IN IDAHO, AND MALHEUR COUNTY...
Whittall John Practical Methods for Biocatalysis and Biotransformations 2 Whittall John Practical Methods for Biocatalysis and Biotransformations 2 Новинка

Whittall John Practical Methods for Biocatalysis and Biotransformations 2

12817.03 руб. или Купить в рассрочку!
Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities. Practical Methods for Biocatalysis and Biotransformations 2 is a «how-to» guide that focuses on the practical applications of enzymes and strains of microorganisms that are readily obtained or derived from culture collections. The sources of starting materials and reagents, hints, tips and safety advice (where appropriate) are given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology are given and relevant references to the primary literature are cited. This second volume – which can be used on its own or in combination with the first volume – concentrates on new applications and new enzyme families reported since the first volume. Contents include: introduction to recent developments and future needs in biocatalysts and synthetic biology in industry reductive amination enoate reductases for reduction of electron deficient alkenes industrial carbonyl reduction regio- and stereo- selective hydroxylation oxidation of alcohols selective oxidation industrial hydrolases and related enzymes transferases for alkylation, glycosylation and phosphorylation C-C bond formation and decarboxylation halogenation/dehalogenation/heteroatom oxidation tandem and sequential multi-enzymatic syntheses Practical Methods for Biocatalysis and Biotransformations 2 is an essential collection of biocatalytic methods for chemical synthesis which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.

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Over the past several decades there have been major advances in our ability to computationally evaluate the electronic structure of inorganic molecules, particularly transition metal systems. This advancement is due to the Moore’s Law increase in computing power as well as the impact of density functional theory (DFT) and its implementation in commercial and freeware programs for quantum chemical calculations. Improved pure and hybrid density functionals are allowing DFT calculations with accuracy comparable to high-level Hartree-Fock treatments, and the results of these calculations can now be evaluated by experiment. When calculations are correlated to, and supported by, experimental data they can provide fundamental insight into electronic structure and its contributions to physical properties and chemical reactivity. This interplay continues to expand and contributes to both improved value of experimental results and improved accuracy of computational predictions. The purpose of this EIC Book is to provide state-of-the-art presentations of quantum mechanical and related methods and their applications, written by many of the leaders in the field. Part 1 of this volume focuses on methods, their background and implementation, and their use in describing bonding properties, energies, transition states and spectroscopic features. Part 2 focuses on applications in bioinorganic chemistry and Part 3 discusses inorganic chemistry, where electronic structure calculations have already had a major impact. This addition to the EIC Book series is of significant value to both experimentalists and theoreticians, and we anticipate that it will stimulate both further development of the methodology and its applications in the many interdisciplinary fields that comprise modern inorganic and bioinorganic chemistry. This volume is also available as part of Encyclopedia of Inorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007 to 2010, representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. Find out more.
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