micropropagation and gene polymorphism of artemisia amygdalina



Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors Новинка

Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors

11701.19 руб.
Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy of Cancer • Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in Gene Therapy • Remaining Obstacles to the Success of Cancer Gene Therapy Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.
Raimo Pohjanvirta The AH Receptor in Biology and Toxicology Raimo Pohjanvirta The AH Receptor in Biology and Toxicology Новинка

Raimo Pohjanvirta The AH Receptor in Biology and Toxicology

13742.51 руб.
This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.
Dittmar Katharina Evolution after Gene Duplication Dittmar Katharina Evolution after Gene Duplication Новинка

Dittmar Katharina Evolution after Gene Duplication

9803.45 руб.
Gene duplication has long been believed to have played a major role in the rise of biological novelty through evolution of new function and gene expression patterns. The first book to examine gene duplication across all levels of biological organization, Evolution after Gene Duplication presents a comprehensive picture of the mechanistic process by which gene duplication may have played a role in generating biodiversity. Key Features: Explores comparative genomics, genome evolution studies and analysis of multi-gene families such as Hox, globins, olfactory receptors and MHC (immune system) A complete post-genome treatment of the topic originally covered by Ohno's 1970 classic, this volume extends coverage to include the fate of associated regulatory pathways Taps the significant increase in multi-gene family data that has resulted from comparative genomics Comprehensive coverage that includes opposing theoretical viewpoints, comparative genomics data, theoretical and empirical evidence and the role of bioinformatics in the study of gene duplication This up-to-date overview of theory and mathematical models along with practical examples is suitable for scientists across various levels of biology as well as instructors and graduate students.
Li Yi Plant Gene Containment Li Yi Plant Gene Containment Новинка

Li Yi Plant Gene Containment

13260.18 руб.
Gene Containment provides a comprehensive look at genetically modified organisms and the strategies and implementation of key methods to gene containment. The book is divided into 5 parts: An Introduction that discusses the need for biotechnology and GMOs, Section 1 looks at the need for gene containment, Part II discusses varying strategies for gene containment, section III explores the assessment of gene containment approaches, and section IV covers the steps involved in implementing gene containment. Gene Containment will provide a thorough and up to date look at gene containment research and the needs for implementing new strategies in this arena.
Hitoshi Iba Evolutionary Computation in Gene Regulatory Network Research Hitoshi Iba Evolutionary Computation in Gene Regulatory Network Research Новинка

Hitoshi Iba Evolutionary Computation in Gene Regulatory Network Research

10572.05 руб.
Introducing a handbook for gene regulatory network research using evolutionary computation, with applications for computer scientists, computational and system biologists This book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC). The book is organized into four parts that deliver materials in a way equally attractive for a reader with training in computation or biology. Each of these sections, authored by well-known researchers and experienced practitioners, provides the relevant materials for the interested readers. The first part of this book contains an introductory background to the field. The second part presents the EC approaches for analysis and reconstruction of GRN from gene expression data. The third part of this book covers the contemporary advancements in the automatic construction of gene regulatory and reaction networks and gives direction and guidelines for future research. Finally, the last part of this book focuses on applications of GRNs with EC in other fields, such as design, engineering and robotics. • Provides a reference for current and future research in gene regulatory networks (GRN) using evolutionary computation (EC) • Covers sub-domains of GRN research using EC, such as expression profile analysis, reverse engineering, GRN evolution, applications • Contains useful contents for courses in gene regulatory networks, systems biology, computational biology, and synthetic biology • Delivers state-of-the-art research in genetic algorithms, genetic programming, and swarm intelligence Evolutionary Computation in Gene Regulatory Network Research is a reference for researchers and professionals in computer science, systems biology, and bioinformatics, as well as upper undergraduate, graduate, and postgraduate students. Hitoshi Iba is a Professor in the Department of Information and Communication Engineering, Graduate School of Information Science and Technology, at the University of Tokyo, Toyko, Japan. He is an Associate Editor of the IEEE Transactions on Evolutionary Computation and the journal of Genetic Programming and Evolvable Machines. Nasimul Noman is a lecturer in the School of Electrical Engineering and Computer Science at the University of Newcastle, NSW, Australia. From 2002 to 2012 he was a faculty member at the University of Dhaka, Bangladesh. Noman is an Editor of the BioMed Research International journal. His research interests include computational biology, synthetic biology, and bioinformatics.
David Koepsell Who Owns You? Science, Innovation, and the Gene Patent Wars David Koepsell Who Owns You? Science, Innovation, and the Gene Patent Wars Новинка

David Koepsell Who Owns You? Science, Innovation, and the Gene Patent Wars

2970.38 руб.
The 2nd Edition of Who Owns You, David Koepsell’s widely acclaimed exploration of the philosophical and legal problems of patenting human genes, is updated to reflect the most recent changes to the cultural and legal climate relating to the practice of gene patenting. Lays bare the theoretical assumptions that underpin the injustice of patents on unmodified genes Makes a unique argument for a commons-by-necessity, explaining how parts of the universe are simply not susceptible to monopoly claims Represents the only work that attempts to first define the nature of the genetic objects involved before any ethical conclusions are reached Provides the most comprehensive accounting of the various lawsuits, legislative changes, and the public debate surrounding AMP v. Myriad, the most significant case regarding gene patents
David Koepsell Who Owns You?. Science, Innovation, and the Gene Patent Wars David Koepsell Who Owns You?. Science, Innovation, and the Gene Patent Wars Новинка

David Koepsell Who Owns You?. Science, Innovation, and the Gene Patent Wars

2789.89 руб.
The 2nd Edition of Who Owns You, David Koepsell’s widely acclaimed exploration of the philosophical and legal problems of patenting human genes, is updated to reflect the most recent changes to the cultural and legal climate relating to the practice of gene patenting. Lays bare the theoretical assumptions that underpin the injustice of patents on unmodified genes Makes a unique argument for a commons-by-necessity, explaining how parts of the universe are simply not susceptible to monopoly claims Represents the only work that attempts to first define the nature of the genetic objects involved before any ethical conclusions are reached Provides the most comprehensive accounting of the various lawsuits, legislative changes, and the public debate surrounding AMP v. Myriad, the most significant case regarding gene patents
Martin Kussmann Nutrigenomics and Proteomics in Health and Disease. Towards a systems-level understanding of gene-diet interactions Martin Kussmann Nutrigenomics and Proteomics in Health and Disease. Towards a systems-level understanding of gene-diet interactions Новинка

Martin Kussmann Nutrigenomics and Proteomics in Health and Disease. Towards a systems-level understanding of gene-diet interactions

15102.93 руб.
Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.
The Extended Phenotype The Extended Phenotype Новинка

The Extended Phenotype

1780 руб.
In The Selfish Gene, Richard Dawkins crystallized the gene's eye view of evolution developed by W.D. Hamilton and others. The book provoked widespread and heated...
Darius Dziuda M. Data Mining for Genomics and Proteomics. Analysis of Gene and Protein Expression Data Darius Dziuda M. Data Mining for Genomics and Proteomics. Analysis of Gene and Protein Expression Data Новинка

Darius Dziuda M. Data Mining for Genomics and Proteomics. Analysis of Gene and Protein Expression Data

8838.78 руб.
Data Mining for Genomics and Proteomics uses pragmatic examples and a complete case study to demonstrate step-by-step how biomedical studies can be used to maximize the chance of extracting new and useful biomedical knowledge from data. It is an excellent resource for students and professionals involved with gene or protein expression data in a variety of settings.
Alister E. McGrath Dawkins' God. From The Selfish Gene to The God Delusion Alister E. McGrath Dawkins' God. From The Selfish Gene to The God Delusion Новинка

Alister E. McGrath Dawkins' God. From The Selfish Gene to The God Delusion

2186.63 руб.
A fully updated new edition of a critically acclaimed examination of the theories and writings of Richard Dawkins by a world-renowned expert on the relation of science and religion Includes in-depth analysis of Dawkins’ landmark treatise The God Delusion (2006), as well as coverage of his later popular works The Magic of Reality (2011) and The Greatest Show on Earth (2011),and a new chapter on Dawkins as a popularizer of science Tackles Dawkins’ hostile and controversial views on religion, and examine the religious implications of his scientific ideas including a comprehensive investigation of the ‘selfish gene’ Written in an accessible and engaging style that will appeal to anyone interested in better understanding the interplay between science and religion
Zhongwei Gu Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery Zhongwei Gu Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery Новинка

Zhongwei Gu Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery

13592.64 руб.
Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.
Nina Fedoroff V. Plant Transposons and Genome Dynamics in Evolution Nina Fedoroff V. Plant Transposons and Genome Dynamics in Evolution Новинка

Nina Fedoroff V. Plant Transposons and Genome Dynamics in Evolution

17118.85 руб.
The transposable genetic elements, or transposons, as they are now known, have had a tumultuous history. Discovered in the mid-20th century by Barbara McClintock, they were initially received with puzzlement. When their genomic abundance began to be apparent, they were categorized as «junk DNA» and acquired the label of parasites. Expanding understanding of gene and genome organization has revealed the profound extent of their impact on both. Plant Transposons and Genome Dynamics in Evolution captures and distills the voluminous research literature on plant transposable elements and seeks to assemble the big picture of how transposons shape gene structure and regulation, as well as how they sculpt genomes in evolution. Individual chapters provide concise overviews of the many flavors of plant transposons and of their roles in gene creation, gene regulation, development, genome evolution, and organismal speciation, as well as of their epigenetic regulation. This volume is essential reading for anyone working in plant genetics, epigenetics, or evolutionary biology.
Martin Schleef Minicircle and Miniplasmid DNA Vectors. The Future of Non-viral and Viral Gene Transfer Martin Schleef Minicircle and Miniplasmid DNA Vectors. The Future of Non-viral and Viral Gene Transfer Новинка

Martin Schleef Minicircle and Miniplasmid DNA Vectors. The Future of Non-viral and Viral Gene Transfer

11327.2 руб.
This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the world's leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.
Rolf Hilfiker Polymorphism in the Pharmaceutical Industry. Solid Form and Drug Development Rolf Hilfiker Polymorphism in the Pharmaceutical Industry. Solid Form and Drug Development Новинка

Rolf Hilfiker Polymorphism in the Pharmaceutical Industry. Solid Form and Drug Development

18423.2 руб.
Polymorphism in the Pharmaceutical Industry – Solid Form and Drug Development highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.
Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster Новинка

Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster

15174.58 руб.
This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. • Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification • Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance • Explains the role of natural products in chemistry and their formation • Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application
Lynne Banks Reid Alice By Accident Lynne Banks Reid Alice By Accident Новинка

Lynne Banks Reid Alice By Accident

120.91 руб.
Nine-year-old Alice must write about herself for a school assignment, and in doing so, she sorts out her feelings about her somewhat prickly single mother, the father she has never met, her flamboyant paternal grandmother and the rest of her sometimes confusing life.Alice doesn’t see how she can write her life story as a class assignment.. How can she fit nine years into a couple of pages? Her pets have died and the only family she has is her mother. Until recently she had a beloved interfering grandmother – Gene – but she’s gone from Alice’s life. Besides, Alice discovered ages ago she was born by accident, and that’s the sort of private thing you don’t write about for school. Alice does the assignment but she thinks it’s boring, until she discovers a need to write about her true life – the exciting, complicated and private of her life. She writes how Gene came along, how she changed Alice’s life, making it richer in experience but also more complicated. She records ongoing quarrels between Gene and her mother which ended with the Big Row and now she can’t see Gene any more.Lynne Reid Banks has written a truly compelling story of a creative child caught in the middle of a difficult but very real and increasingly common situation.
Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set Новинка

Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set

41533.79 руб.
Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
Туфли Gene Gene GE632AWEMIV1 Туфли Gene Gene GE632AWEMIV1 Новинка

Туфли Gene Gene GE632AWEMIV1

1920 руб.
Туфли Gene. Цвет: бежевый. Материал: искусственная кожа.Сезон: Весна-лето 2019. С бесплатной доставкой и примеркой на Lamoda.
Полусапоги Gene Gene GE632AWGBGN8 Полусапоги Gene Gene GE632AWGBGN8 Новинка

Полусапоги Gene Gene GE632AWGBGN8

2740 руб.
Полусапоги Gene. Цвет: черный. Материал: искусственный велюр.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
Дутики Gene Gene GE632AWGBGN2 Дутики Gene Gene GE632AWGBGN2 Новинка

Дутики Gene Gene GE632AWGBGN2

2740 руб.
Дутики Gene. Цвет: черный. Материал: нейлон.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
Дутики Gene Gene GE632AWGBGN4 Дутики Gene Gene GE632AWGBGN4 Новинка

Дутики Gene Gene GE632AWGBGN4

3500 руб.
Дутики Gene. Цвет: коричневый. Материал: текстиль.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
Pierre Delhaes Carbon Based Solids and Materials Pierre Delhaes Carbon Based Solids and Materials Новинка

Pierre Delhaes Carbon Based Solids and Materials

18569.88 руб.
It is well known that solid carbons can be found in various guises with different forms of bulk phases (graphites, diamonds and carbynes) as well as more molecular forms (fullerenes,nanotubes and graphenes) resulting from recent discoveries. The cause of this rich polymorphism is analyzed in the first part of this book (chapters 1-5) with the propensity of carbon atoms for forming different types of homopolar chemical bonds associated with variable coordination numbers. Precursor organic molecules and parent compounds are also described to establish specific links with this rich polymorphism. Then in a second part (chapters 6-10) a comparative review of the main classes of bulk physical properties is presented. This approach emphasizes in particular the electronic behavior of (pi) polyaromatic systems organized in plane and curved atomic sheets. Finally in a third part (chapters 11-15) the surface and interface characteristics are introduced together with the texture and morphology of these multiscale carbon materials. An overview of the main field of applications is related showing the large use and interest for these solids.
Jane Wu Post-Transcriptional Gene Regulation. RNA Processing in Eukaryotes Jane Wu Post-Transcriptional Gene Regulation. RNA Processing in Eukaryotes Новинка

Jane Wu Post-Transcriptional Gene Regulation. RNA Processing in Eukaryotes

2246.87 руб.
Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.
Ботинки Gene Gene GE632AWGBGM2 Ботинки Gene Gene GE632AWGBGM2 Новинка

Ботинки Gene Gene GE632AWGBGM2

3230 руб.
Ботинки Gene. Цвет: черный. Материал: искусственная кожа, искусственный велюр.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
Дутики Gene Gene GE632AWGBGN3 Дутики Gene Gene GE632AWGBGN3 Новинка

Дутики Gene Gene GE632AWGBGN3

2960 руб.
Дутики Gene. Цвет: черный. Материал: текстиль.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
Ботинки Gene Gene GE632AWGBGM4 Ботинки Gene Gene GE632AWGBGM4 Новинка

Ботинки Gene Gene GE632AWGBGM4

3630 руб.
Ботинки Gene. Цвет: розовый. Материал: искусственная кожа.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
Дутики Gene Gene GE632AWGBGN0 Дутики Gene Gene GE632AWGBGN0 Новинка

Дутики Gene Gene GE632AWGBGN0

2910 руб.
Дутики Gene. Цвет: хаки. Материал: искусственная кожа, нейлон.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
Ботинки Gene Gene GE632AWGBGM3 Ботинки Gene Gene GE632AWGBGM3 Новинка

Ботинки Gene Gene GE632AWGBGM3

2910 руб.
Ботинки Gene. Цвет: черный. Материал: искусственная замша, искусственная кожа.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
Сапоги Gene Gene GE632AWGBGM9 Сапоги Gene Gene GE632AWGBGM9 Новинка

Сапоги Gene Gene GE632AWGBGM9

4760 руб.
Сапоги Gene. Цвет: черный. Материал: искусственная кожа.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
Полусапоги Gene Gene GE632AWGBGN7 Полусапоги Gene Gene GE632AWGBGN7 Новинка

Полусапоги Gene Gene GE632AWGBGN7

2490 руб.
Полусапоги Gene. Цвет: черный. Материал: искусственная замша.Сезон: Осень-зима 2019/2020. С бесплатной доставкой и примеркой на Lamoda.
T. A. Brown Gene Cloning and DNA Analysis. An Introduction T. A. Brown Gene Cloning and DNA Analysis. An Introduction Новинка

T. A. Brown Gene Cloning and DNA Analysis. An Introduction

13970.21 руб.
Known world-wide as the standard introductory text to this important and exciting area, the seventh edition of Gene Cloning and DNA Analysis addresses new and growing areas of research whilst retaining the philosophy of the previous editions. Assuming the reader has little prior knowledge of the subject, its importance, the principles of the techniques used and their applications are all carefully laid out, with over 250 clearly presented four-colour illustrations. In addition to a number of informative changes to the text throughout the book, the chapters on DNA sequencing and genome studies have been rewritten to reflect the continuing rapid developments in this area of DNA analysis: In depth description of the next generation sequencing methods and descriptions of their applications in studying genomes and transcriptomes New material on the use of ChiP-seq to locate protein-binding sites Extended coverage of the strategies used to assemble genome sequences Description of how the Neanderthal genome has been sequenced and what that sequence tells us about interbreeding between Neanderthals and Homo sapiens Gene Cloning and DNA Analysis remains an essential introductory text to a wide range of biological sciences students; including genetics and genomics, molecular biology, biochemistry, immunology and applied biology. It is also a perfect introductory text for any professional needing to learn the basics of the subject. All libraries in universities where medical, life and biological sciences are studied and taught should have copies available on their shelves.
The Selfish Gene The Selfish Gene Новинка

The Selfish Gene

1430 руб.
As influential today as when it was first published, The Selfish Gene has become a classic exposition of evolutionary thought. Professor Dawkins articulates a gene's...
Wang Yongjun Gene Discovery for Disease Models Wang Yongjun Gene Discovery for Disease Models Новинка

Wang Yongjun Gene Discovery for Disease Models

12299.53 руб.
This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that “The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decades-old mouse mutants will be understood precisely at the DNA level in the near future.” The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the post-genome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).
Ralph Garcia-Bertrand Genomes, Evolution, and Culture. Past, Present, and Future of Humankind Ralph Garcia-Bertrand Genomes, Evolution, and Culture. Past, Present, and Future of Humankind Новинка

Ralph Garcia-Bertrand Genomes, Evolution, and Culture. Past, Present, and Future of Humankind

7547.89 руб.
This book combines recent information and discoveries in the field of human molecular biology and human molecular evolution. It provides an interdisciplinary approach drawing together data from various diverse disciplines to address both the more classical anthropological content and the current more contemporary molecular focus of courses. Chapters include a history of human evolutionary genetics; the human genome structure and function; population structure and variability; gene and genomic dynamics; culture; health and disease; bioethics; future.
Basel Abu-Jamous Integrative Cluster Analysis in Bioinformatics Basel Abu-Jamous Integrative Cluster Analysis in Bioinformatics Новинка

Basel Abu-Jamous Integrative Cluster Analysis in Bioinformatics

10572.05 руб.
Clustering techniques are increasingly being put to use in the analysis of high-throughput biological datasets. Novel computational techniques to analyse high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. This book details the complete pathway of cluster analysis, from the basics of molecular biology to the generation of biological knowledge. The book also presents the latest clustering methods and clustering validation, thereby offering the reader a comprehensive review of clustering analysis in bioinformatics from the fundamentals through to state-of-the-art techniques and applications. Key Features: Offers a contemporary review of clustering methods and applications in the field of bioinformatics, with particular emphasis on gene expression analysis Provides an excellent introduction to molecular biology with computer scientists and information engineering researchers in mind, laying out the basic biological knowledge behind the application of clustering analysis techniques in bioinformatics Explains the structure and properties of many types of high-throughput datasets commonly found in biological studies Discusses how clustering methods and their possible successors would be used to enhance the pace of biological discoveries in the future Includes a companion website hosting a selected collection of codes and links to publicly available datasets
Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery Новинка

Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery

12083.06 руб.
Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.
Tom Graham Life on Mars: A Fistful of Knuckles Tom Graham Life on Mars: A Fistful of Knuckles Новинка

Tom Graham Life on Mars: A Fistful of Knuckles

79.72 руб.
Time to leap into the Cortina as Sam Tyler and Gene Hunt roar back into action in a brand new installment of Life on Mars.DCI Gene Hunt plunges into the boxing underworld – and this time, the gloves are coming off!The travelling fair has rolled into town, but it has brought with it more than just dodgem cars and candy floss. A young boxer is found brutally murdered, and as Sam Tyler and Gene Hunt delve deeper into the case, it leads them behind the gaudy lights and painted caravans of the fairground, into the shadowy underbelly of bare-knuckle gypsy brawlers and bloody illegal fights.But Sam is coping with more than just police work. He is still being plagued by The Test Card Girl with horrifying visions of the terrible doom that awaits he and Annie. What is this monstrous presence that is pursuing them both? Can Sam find a way of defeating this remorseless evil – or are their fates sealed?Violence, murder, betrayal and revenge. Could this be a case so macho that it will see even the mighty Guv himself on the ropes?
Alessandra Mattei Pharmaceutical Crystals. Science and Engineering Alessandra Mattei Pharmaceutical Crystals. Science and Engineering Новинка

Alessandra Mattei Pharmaceutical Crystals. Science and Engineering

14762.18 руб.
An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.
Erich Grotewold Plant Genes, Genomes and Genetics Erich Grotewold Plant Genes, Genomes and Genetics Новинка

Erich Grotewold Plant Genes, Genomes and Genetics

6036.88 руб.
Plant Genes, Genomes and Genetics provides a comprehensive treatment of all aspects of plant gene expression. Unique in explaining the subject from a plant perspective, it highlights the importance of key processes, many first discovered in plants, that impact how plants develop and interact with the environment. This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications. Written by a highly respected team of specialists in plant biology with extensive experience in teaching at undergraduate and graduate level, this textbook will be invaluable for students and instructors alike. Plant Genes, Genomes and Genetics also includes: • specific examples that highlight when and how plants operate differently from other organisms; • special sections that provide in-depth discussions of particular issues; • end-of-chapter problems to help students recapitulate the main concepts; • rich, full-colour illustrations and diagrams clearly showing important processes in plant gene expression; • a companion website with PowerPoint slides, downloadable figures, and answers to the questions posed in the book. Aimed at upper level undergraduates and graduate students in plant biology, this text is equally suited for advanced agronomy and crop science students inclined to understand molecular aspects of organismal phenomena. It is also an invaluable starting point for professionals entering the field of plant biology.
Rene Fester Kratz Biology Essentials For Dummies Rene Fester Kratz Biology Essentials For Dummies Новинка

Rene Fester Kratz Biology Essentials For Dummies

669.24 руб.
Just the core concepts you need to score high in your biology course Biology Essentials For Dummies focuses on just the core concepts you need to succeed in an introductory biology course. From identifying the structures and functions of plants and animals to grasping the crucial discoveries in evolutionary, reproductive, and ecological biology, this easy-to-follow guide lets you skip the suffering and score high at exam time. Get down to basics – master the fundamentals, from understanding what biologists study to how living things are classified The chemistry of life – find out what you need to know about atoms, elements, molecules, compounds, acids, bases, and more Conquer and divide – discover the ins and outs of asexual and sexual reproduction, including cell division and DNA replication Jump into the gene pool – grasp how proteins make traits happen, and easily understand DNA transcription, RNA processing, translation, and gene regulation Open the book and find: An overview of cells and their substructures Elementary chemistry The key facts about reproduction and DNA The 411 on energy and organisms What you need to know about evolution Coverage of ecosystems and populations Ten great biology discoveries Learn: Core concepts taught in an introductory biology course The structures and functions of plants and animals The key discoveries in evolutionary, reproductive, and ecological biology
Dhammika Amaratunga Exploration and Analysis of DNA Microarray and Other High-Dimensional Data Dhammika Amaratunga Exploration and Analysis of DNA Microarray and Other High-Dimensional Data Новинка

Dhammika Amaratunga Exploration and Analysis of DNA Microarray and Other High-Dimensional Data

9666.45 руб.
Praise for the First Edition “…extremely well written…a comprehensive and up-to-date overview of this important field.” – Journal of Environmental Quality Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition provides comprehensive coverage of recent advancements in microarray data analysis. A cutting-edge guide, the Second Edition demonstrates various methodologies for analyzing data in biomedical research and offers an overview of the modern techniques used in microarray technology to study patterns of gene activity. The new edition answers the need for an efficient outline of all phases of this revolutionary analytical technique, from preprocessing to the analysis stage. Utilizing research and experience from highly-qualified authors in fields of data analysis, Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition features: A new chapter on the interpretation of findings that includes a discussion of signatures and material on gene set analysis, including network analysis New topics of coverage including ABC clustering, biclustering, partial least squares, penalized methods, ensemble methods, and enriched ensemble methods Updated exercises to deepen knowledge of the presented material and provide readers with resources for further study The book is an ideal reference for scientists in biomedical and genomics research fields who analyze DNA microarrays and protein array data, as well as statisticians and bioinformatics practitioners. Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition is also a useful text for graduate-level courses on statistics, computational biology, and bioinformatics.
Mark Johnson H. Developmental Cognitive Neuroscience. An Introduction Mark Johnson H. Developmental Cognitive Neuroscience. An Introduction Новинка

Mark Johnson H. Developmental Cognitive Neuroscience. An Introduction

8680.61 руб.
Developmental Cognitive Neuroscience, 4th Edition, is a revised and updated edition of the landmark text focusing on the development of brain and behaviour during infancy, childhood, and adolescence. Offers a comprehensive introduction to all issues relating to the nature of brain-behaviour relationships and development New or greatly expanded coverage of topics such as epigenetics and gene expression, cell migration and stem cells, sleep and learning/memory, socioeconomic status and development of prefrontal cortex function Includes a new chapter on educational neuroscience, featuring the latest findings on the application of cognitive neuroscience methods in school-age educational contexts Includes a variety of student-friendly features such as chapter-end discussion, practical applications of basic research, and material on recent technological breakthroughs
Elaswarapu Ramnath Genomics. Essential Methods Elaswarapu Ramnath Genomics. Essential Methods Новинка

Elaswarapu Ramnath Genomics. Essential Methods

9803.45 руб.
Genomics research has made significant advances in recent years. In this book, a team of internationally-renowned researchers share the most up-to-date information in a field that has in recent years switched emphasis from gene identification to functional genomics and the characterization of genes and gene products. This volume approaches this complex subject with a broad perspective to supply the reader with a vital overview of genomics and its derivative fields, with a focus on pivotal issues such as data analysis. Expansive and current, this book is a comprehensive research guide that describes both the key new techniques and more established methods. Every chapter discusses the merits and limitations of the various approaches and then provides selected tried-and-tested protocols, as well as a plethora of good practical advice for immediate use at the bench. Key features: Provides a broad introduction to current practices and techniques for lab-based research in genomics Explains clearly and precisely how to carry out selected techniques in addition to background information on the various approaches Chapters are written by a leading international authorities in the field and cover both well-known and new, tried and tested, methods for working in genomics Includes troubleshooting guide and reviews of alternative techniques An essential laboratory manual for students and researchers at all levels
Stuart A. Rice Liquid Polymorphism Stuart A. Rice Liquid Polymorphism Новинка

Stuart A. Rice Liquid Polymorphism

15627.38 руб.
The Advances in Chemical Physics series—the cutting edge of research in chemical physics The Advances in Chemical Physics series provides the chemical physics and physical chemistry fields with a forum for critical, authoritative evaluations of advances in every area of the discipline. Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series presents contributions from internationally renowned chemists and serves as the perfect supplement to any advanced graduate class devoted to the study of chemical physics. This volume explores: Electron Spin Resonance Studies of Supercooled Water Water-like Anomalies of Core-Softened Fluids: Dependence on the Trajectories in (P, ϱ, T) Space Water Proton Environment: A New Water Anomaly at Atomic Scale? Polymorphism and Anomalous Melting in Isotropic Fluids Computer Simulations of Liquid Silica: Water-Like Thermodynamic and Dynamic Anomalies, and the Evidence for Polyamorphism
Luonan Chen Biomolecular Networks. Methods and Applications in Systems Biology Luonan Chen Biomolecular Networks. Methods and Applications in Systems Biology Новинка

Luonan Chen Biomolecular Networks. Methods and Applications in Systems Biology

10119.25 руб.
Alternative techniques and tools for analyzing biomolecular networks With the recent rapid advances in molecular biology, high-throughput experimental methods have resulted in enormous amounts of data that can be used to study biomolecular networks in living organisms. With this development has come recognition of the fact that a complicated living organism cannot be fully understood by merely analyzing individual components. Rather, it is the interactions of components or biomolecular networks that are ultimately responsible for an organism's form and function. This book addresses the important need for a new set of computational tools to reveal essential biological mechanisms from a systems biology approach. Readers will get comprehensive coverage of analyzing biomolecular networks in cellular systems based on available experimental data with an emphasis on the aspects of network, system, integration, and engineering. Each topic is treated in depth with specific biological problems and novel computational methods: GENE NETWORKS—Transcriptional regulation; reconstruction of gene regulatory networks; and inference of transcriptional regulatory networks PROTEIN INTERACTION NETWORKS—Prediction of protein-protein interactions; topological structure of biomolecular networks; alignment of biomolecular networks; and network-based prediction of protein function METABOLIC NETWORKS AND SIGNALING NETWORKS—Analysis, reconstruction, and applications of metabolic networks; modeling and inference of signaling networks; and other topics and new trends In addition to theoretical results and methods, many computational software tools are referenced and available from the authors' Web sites. Biomolecular Networks is an indispensable reference for researchers and graduate students in bioinformatics, computational biology, systems biology, computer science, and applied mathematics.
Manfred Reetz T. Directed Evolution of Selective Enzymes. Catalysts for Organic Chemistry and Biotechnology Manfred Reetz T. Directed Evolution of Selective Enzymes. Catalysts for Organic Chemistry and Biotechnology Новинка

Manfred Reetz T. Directed Evolution of Selective Enzymes. Catalysts for Organic Chemistry and Biotechnology

2171.89 руб.
Authored by one of the world's leading organic chemists, this authoritative reference provides an overview of basic strategies in directed evolution and introduces common gene mutagenesis, screening and selection methods. Throughout the text, emphasis is placed on methodology development to maximize efficiency, reliability and speed of the experiments and to provide guidelines for efficient protein engineering. Professor Reetz highlights the application of directed evolution experiments to address limitations in the field of enzyme selectivity, substrate scope, activity and robustness. He critically reviews recent developments and case studies, takes a look at future applications in the field of organic synthesis, and concludes with lessons learned from previous experiments.
Dale Jeremy W. Molecular Genetics of Bacteria Dale Jeremy W. Molecular Genetics of Bacteria Новинка

Dale Jeremy W. Molecular Genetics of Bacteria

15109.13 руб.
The fifth edition of this highly successful book provides students with an essential introduction to the molecular genetics of bacteria covering the basic concepts and the latest developments. It is comprehensive, easy to use and well structured with clear two-colour diagrams throughout. Specific changes to the new edition include: More detail on sigma factors, anti-sigma factors and anti-anti sigma factors, and the difference in the frequency of sigma factors in bacteria Expand material on integrons as these are becoming increasingly important in antibiotic resistance Enhanced treatment of molecular phylogeny Complete revision and updating of the final chapter on ‘Gene Mapping and Genomics’ Two-colour illustrations throughout. The focus of the book remains firmly on bacteria and will be invaluable to students studying microbiology, biotechnology, molecular biology, biochemistry, genetics and related biomedical sciences.
Korf Bruce R. Human Genetics and Genomics Korf Bruce R. Human Genetics and Genomics Новинка

Korf Bruce R. Human Genetics and Genomics

5462.44 руб.
This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today’s genetics teaching, and includes updated discussion of genetic risk assessment, “single gene” disorders and therapeutics. Key learning features include: Clinical snapshots to help relate science to practice ‘Hot topics’ boxes that focus on the latest developments in testing, assessment and treatment ‘Ethical issues’ boxes to prompt further thought and discussion on the implications of genetic developments ‘Sources of information’ boxes to assist with the practicalities of clinical research and information provision Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: Factsheets on 100 genetic disorders, ideal for study and exam preparation Interactive Multiple Choice Questions (MCQs) with feedback on all answers Links to online resources for further study Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.
Nissim Garti Self-Assembled Supramolecular Architectures. Lyotropic Liquid Crystals Nissim Garti Self-Assembled Supramolecular Architectures. Lyotropic Liquid Crystals Новинка

Nissim Garti Self-Assembled Supramolecular Architectures. Lyotropic Liquid Crystals

12058.36 руб.
This book will describe fundamentals and recent developments in the area of Self-Assembled Supramolecular Architecture and their relevance to the understanding of the functionality of membranes as delivery systems for active ingredients. As the heirarchial architectures determine their performance capabilities, attention will be paid to theoretical and design aspects related to the construction of lyotropic liquid crystals: mesophases such as lamellar, hexagonal, cubic, sponge phase micellosomes. The book will bring to the reader mechanistic aspects, compositional considerations, transition within phases, solubilization capacities, drug entrapment and release mechanisms and transmembrane, transdermal, and other transport phenomena. It will stress the importance of these mesostructures to crystallization and polymorphism of drugs, fats, and nutraceuticals and will discuss regioselectivity of organic and enzymatic reactions that take place at interfaces and within the channels of the mesophase. The book will bring studies on the use of these mesophase as crystallization or particulation media for the formation of nanoparticles and nanocrystals. Chapters will discuss applications in the areas of pharmaceuticals, food, cosmetics, plastics, paper, agro-chemistry and industrial applications.

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Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
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