mihich antibiotics chemotherapy – design of canc er chemotherapy– exper clin approaches



Crump Kenneth Cancer Chemotherapy for the Veterinary Health Team Crump Kenneth Cancer Chemotherapy for the Veterinary Health Team Новинка

Crump Kenneth Cancer Chemotherapy for the Veterinary Health Team

4511.23 руб.
Cancer Chemotherapy for the Veterinary Health Team is a clinically relevant and practical manual designed as a guide for the safe and effective administration of cancer chemotherapy. Coverage includes patient assessment, chemotherapy equipment, drug preparation, safety considerations, handling, administration, waste disposal, and management of chemotherapy side effects. An alphabetical listing of common chemotherapy agents offers information on their uses, indications, and toxicities, as well as administration guidelines for methods, routes, and speeds. With background information for effectively communicating with clients, including coverage of veterinary cancer surgery and radiation therapy, the book provides specific strategies that address the challenging emotional issues surrounding the diagnosis and treatment of cancer in pets. With particular insight into the technician's role, Cancer Chemotherapy for the Veterinary Health Team is a must-have reference for any practice offering chemotherapy.
Rafik Samuel Antibiotics Manual. A Guide to commonly used antimicrobials Rafik Samuel Antibiotics Manual. A Guide to commonly used antimicrobials Новинка

Rafik Samuel Antibiotics Manual. A Guide to commonly used antimicrobials

6659.3 руб.
A comprehensive compendium of all commonly used antibiotics, including indications, side effects, dosage information, and drug/food interactions Antibiotics Manual: A Guide to Commonly Used Antimicrobials, Second Edition is a unique, user-friendly guide made for all who prescribe antibiotics. It’s the only book available that takes a 100% drug-listed approach to 200 of the most common antibiotics prescribed to patients each day. Presented in full color, it’s also a convenient reference for every clinician to consult once the decision to use a particular antibiotic has been reached. This edition of Antibiotics Manual includes newer antibiotics that have been released since the publication of the First Edition and updates prescribing information for the older antibiotics. This all-new Second Edition: Has a color-coded interior design which provides quick and easy point of care access for the user Includes 200 of the most commonly prescribed antibiotics, listed by both brand and generic names Features important recently-released antibiotics such as ceftaroline, tedizolid, and bedaquiline Antibiotics Manual: A Guide to Commonly Used Antimicrobials, Second Edition is a welcome book for physicians in all specialties of medicine who prescribe antibiotics. It is also a handy tool for pharmacists, nurses, nurse practitioners, and physician assistants who want more information on the drugs they administer.
Felix Kratz Drug Delivery in Oncology. From Basic Research to Cancer Therapy, 3 Volume Set Felix Kratz Drug Delivery in Oncology. From Basic Research to Cancer Therapy, 3 Volume Set Новинка

Felix Kratz Drug Delivery in Oncology. From Basic Research to Cancer Therapy, 3 Volume Set

47993.23 руб.
In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.
Daniel Simon Co-design Approaches to Dependable Networked Control Systems Daniel Simon Co-design Approaches to Dependable Networked Control Systems Новинка

Daniel Simon Co-design Approaches to Dependable Networked Control Systems

12373.78 руб.
This book describes co-design approaches, and establishes the links between the QoC (Quality of Control) and QoS (Quality of Service) of the network and computing resources. The methods and tools described in this book take into account, at design level, various parameters and properties that must be satisfied by systems controlled through a network. Among the important network properties examined are the QoC, the dependability of the system, and the feasibility of the real-time scheduling of tasks and messages. Correct exploitation of these approaches allows for efficient design, diagnosis, and implementation of the NCS. This book will be of great interest to researchers and advanced students in automatic control, real-time computing, and networking domains, and to engineers tasked with development of NCS, as well as those working in related network design and engineering fields.
Средство чистящее Clin Мультиблеск универсальное 500мл Средство чистящее Clin Мультиблеск универсальное 500мл Новинка

Средство чистящее Clin Мультиблеск универсальное 500мл

219 руб.
Универсальные чистящие средства Clin Средство чистящее Clin Мультиблеск универсальное 500мл
Letizia Brandi Antibiotics. Targets, Mechanisms and Resistance Letizia Brandi Antibiotics. Targets, Mechanisms and Resistance Новинка

Letizia Brandi Antibiotics. Targets, Mechanisms and Resistance

16498.14 руб.
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
Prokar Dasgupta ABC of Prostate Cancer Prokar Dasgupta ABC of Prostate Cancer Новинка

Prokar Dasgupta ABC of Prostate Cancer

3070.68 руб.
Prostate cancer is the most common cancer in men in the UK and US and the second most common worldwide. The ABC of Prostate Cancer provides fully illustrated guidance on the treatment and management of prostate cancer. It covers the biology, anatomy, and pathology of prostate cancer, screening, and active surveillance and monitoring. It presents an assessment of treatment options including prostatectomy, bracytherapy, chemotherapy and immunotherapy, along with modern diagnostic tests and an overview of new approaches to prostate cancer. With an international author team, the ABC of Prostate Cancer is ideal for general practitioners, family physicians, specialist nurses, junior doctors, medical students and others working with prostate cancer patients and their families.
Ola Skold Antibiotics and Antibiotic Resistance Ola Skold Antibiotics and Antibiotic Resistance Новинка

Ola Skold Antibiotics and Antibiotic Resistance

4507.99 руб.
This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future scientists recognize the problem antibiotics resistance poses for medicinal and drug-related fields, and perhaps trigger more research and discoveries to fight antibiotic resistant strains. Current overviews of the topic are included, along with specific discussions on the individual mechanisms (betalactams, glycopeptides, aminoglycosides, etc) used in various antibacterial agents and explanations of how resistances to those develop. Methods for counteracting resistance development in bacteria are discussed as well.
Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future Новинка

Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future

11590.87 руб.
A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both Empirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores: The differing modes of molecular discovery Biological precedents for evolutionary approaches Directed evolutionary methods and related areas Enzyme evolution and design Functional nucleic acid discovery Antibodies and other recognition molecules General aspects of molecular recognition Small molecule discovery approaches Rational molecular design The interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery Searching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspectsof molecular discovery, as well as the thought processes behind experimental approaches. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
Printio Le tour du monde en un clin d'oeil Printio Le tour du monde en un clin d'oeil Новинка

Printio Le tour du monde en un clin d'oeil

1450 руб.
Подушка 60х40 с полной запечаткой — тип наволочки: НАВОЛОЧКА ЗАШИТА. Le Tour du Monde en un Clin d'Oeil 1876. Уникальная карта мира на которой обозначено Свободное море
Rachel Airley Cancer Chemotherapy. Basic Science to the Clinic Rachel Airley Cancer Chemotherapy. Basic Science to the Clinic Новинка

Rachel Airley Cancer Chemotherapy. Basic Science to the Clinic

14620.83 руб.
This textbook is a clear and accessible introduction to the scientific and clinical aspects of the creation, development and administration of drugs or drug regimens used in the treatment of cancer. Unique in its approach, this book enables the student to gain an understanding of the pathological, physiological and molecular processes governing malignancy, whilst also introducing the role of health professionals and scientists in the research and treatment of cancer. The book consolidates all the essential information necessary for a full understanding of cancer chemotherapy, providing an informative, inexpensive and up-to-date coverage of the subject aimed at an undergraduate level readership. Key Features: Incorporates numerous diagrams, tables and illustrations to aid understanding. Examines key pharmacological and pharmaceutical issues such as dosing, toxicity and preparation of anti-cancer drugs. Includes a key chapter of practice essay questions to ease revision. Comprehensive coverage of drugs currently in pre-clinical and clinical development. An indispensable text for undergraduate students studying pharmacy and medicine as well as those doing courses such as molecular biology, biomedical sciences and pharmacology which cover aspects of oncology.
нож д/нарезки соломки TESCOMA Presto Exper пластик/нерж.сталь нож д/нарезки соломки TESCOMA Presto Exper пластик/нерж.сталь Новинка

нож д/нарезки соломки TESCOMA Presto Exper пластик/нерж.сталь

249 руб.
Presto Exper для нарезки соломки Материал лезвия: нержавеющая стальМатериал ручки: пластик
Printio Le tour du monde en un clin d'oeil 1876 Printio Le tour du monde en un clin d'oeil 1876 Новинка

Printio Le tour du monde en un clin d'oeil 1876

4350 руб.
Плед флисовый 130х170 см. Le Tour du Monde en un Clin d'Oeil 1876. Уникальная карта мира на которой обозначено Свободное море
S. Fanning Concise Review of Veterinary Microbiology S. Fanning Concise Review of Veterinary Microbiology Новинка

S. Fanning Concise Review of Veterinary Microbiology

3748.7 руб.
Updated to reflect the latest developments in the field, Concise Review of Veterinary Microbiology, 2nd Edition, presents essential information on veterinary microbiology for students and those requiring a refresher on key topics relating to microbial diseases in animals. Morphological, cultural and other descriptive features of pathogenic microorganisms are described, together with their habitats and aetiological roles in disease production in animals and, where appropriate, in the human population. Key features: • There are five sections covering bacteriology, mycology, virology, biosecurity and other aspects of infectious diseases • Provides concise, yet comprehensive information on pathogenic microorganisms of importance in veterinary medicine, the diseases which they cause, their diagnosis and control • The 79 short chapters in this book include 13 new chapters on antibacterial resistance, structure and function of the immune system, antifungal chemotherapy, antiviral chemotherapy, principles of biosecurity and a number of topics related to the control and prevention of infectious diseases • This latest edition uses updated nomenclature and includes detailed diagrams now in full colour, and comprehensive tables
Christos Kassapoglou Modeling the Effect of Damage in Composite Structures. Simplified Approaches Christos Kassapoglou Modeling the Effect of Damage in Composite Structures. Simplified Approaches Новинка

Christos Kassapoglou Modeling the Effect of Damage in Composite Structures. Simplified Approaches

8998.6 руб.
Comprehensively covers new and existing methods for the design and analysis of composites structures with damage present Provides efficient and accurate approaches for analysing structures with holes and impact damage Introduces a new methodology for fatigue analysis of composites Provides design guidelines, and step by step descriptions of how to apply the methods, along with evaluation of their accuracy and applicability Includes problems and exercises Accompanied by a website hosting lecture slides and solutions
Gottfried Unden Host - Pathogen Interaction. Microbial Metabolism, Pathogenicity and Antiinfectives Gottfried Unden Host - Pathogen Interaction. Microbial Metabolism, Pathogenicity and Antiinfectives Новинка

Gottfried Unden Host - Pathogen Interaction. Microbial Metabolism, Pathogenicity and Antiinfectives

15372.6 руб.
In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.
Cathy Eng Colorectal Cancer. Diagnosis and Clinical Management Cathy Eng Colorectal Cancer. Diagnosis and Clinical Management Новинка

Cathy Eng Colorectal Cancer. Diagnosis and Clinical Management

9599.07 руб.
Colorectal Cancer: Diagnosis and Clinical Management provides colorectal surgeons, gastroenterologists and oncologists with an authoritative, practical guide to best practice in the diagnosis and clinical management of colorectal cancer. Covering all forms of treatment including surgery, chemotherapy and radiotherapy, it examines the various new and emerging therapies, new strategies for screening and prevention, as well as the latest guidance on the most challenging and controversial aspects of managing colorectal cancer. The authors present important information on: Controversies in adjuvant chemotherapy Long versus short course radiotherapy Minimally invasive surgery and robotics Radical colonic resection Each chapter contains key points, tips and tricks and clinical case studies to aid rapid browsing and knowledge of the basic principles, while self-assessment questions allow readers to test their clinical knowledge. With leading international surgeons, gastroenterologists and oncologists combining to offer their considerable wealth of expertise and knowledge, Colorectal Cancer is a well-balanced, indispensable resource for all those involved in colorectal cancer management.
CLIN-K Повседневные брюки CLIN-K Повседневные брюки Новинка

CLIN-K Повседневные брюки

1650 руб.
плотная ткань, логотип, двухцветный узор, низкая талия, обтягивающая модель, брюки-бананы, молния и пуговицы, множество карманов, стрейч, брюки чинос
Brian Wood J.B. Building Care Brian Wood J.B. Building Care Новинка

Brian Wood J.B. Building Care

5211.35 руб.
Building care encompasses everything from maintenance of a building to energy conservation and range of approaches, including the effects on design. A range of approaches to looking after buildings and their users is covered in this book. The rationale and conditions that support them (e.g. PPM – preventative planned maintenance; JIT – just in time) are explained, together with the commercial and environmental imperatives driving new approaches to building care.
Nicolas Larrieu Rapid Prototyping Software for Avionics Systems. Model-oriented Approaches for Complex Systems Certification Nicolas Larrieu Rapid Prototyping Software for Avionics Systems. Model-oriented Approaches for Complex Systems Certification Новинка

Nicolas Larrieu Rapid Prototyping Software for Avionics Systems. Model-oriented Approaches for Complex Systems Certification

7345.15 руб.
The design, implementation and validation of avionics and aeronautical systems have become extremely complex tasks due to the increase of functionalities that are deployed in current avionics systems and the need to be able certify them before putting them into production. This book proposes a methodology to enable the rapid prototyping of such a system by considering from the start the certification aspects of the solution produced. This method takes advantage of the model-based design approaches as well as the use of formal methods for the validation of these systems. Furthermore, the use of automatic software code generation tools using models makes it possible to reduce the development phase as well as the final solution testing. This book presents, firstly, an overview of the model-based design approaches such as those used in the field of aeronautical software engineering. Secondly, an original methodology that is perfectly adapted to the field of aeronautical embedded systems is introduced. Finally, the authors illustrate the use of this method using a case study for the design, implementation and testing of a new generation aeronautical router.
Gisbert Schneider De novo Molecular Design Gisbert Schneider De novo Molecular Design Новинка

Gisbert Schneider De novo Molecular Design

15747.54 руб.
Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development, the approaches are equally applicable for chemical probes and diagnostics, pesticides, and any other molecule designed to interact with a biological system. Numerous images and screenshots illustrate the many examples and method descriptions. With its broad and balanced coverage, this will be the firststop resource not only for medicinal chemists, biochemists and biotechnologists, but equally for bioinformaticians and molecular designers for many years to come. From the content: * Reaction-driven de novo design * Adaptive methods in molecular design * Design of ligands against multitarget profiles * Free energy methods in ligand design * Fragment-based de novo design * Automated design of focused and target family-oriented compound libraries * Molecular de novo design by nature-inspired computing * 3D QSAR approaches to de novo drug design * Bioisosteres in de novo design * De novo design of peptides, proteins and nucleic acid structures, including RNA aptamers and many more.
средство д/стекол CLIN Лимон спрей 0,5л средство д/стекол CLIN Лимон спрей 0,5л Новинка

средство д/стекол CLIN Лимон спрей 0,5л

218 руб.
ЛимонОбъем: 0,5 лФорма выпуска: спрей
Nicolae-Doru Stanescu Classical and Modern Approaches in the Theory of Mechanisms Nicolae-Doru Stanescu Classical and Modern Approaches in the Theory of Mechanisms Новинка

Nicolae-Doru Stanescu Classical and Modern Approaches in the Theory of Mechanisms

8964.45 руб.
Classical and Modern Approaches in the Theory of Mechanisms is a study of mechanisms in the broadest sense, covering the theoretical background of mechanisms, their structures and components, the planar and spatial analysis of mechanisms, motion transmission, and technical approaches to kinematics, mechanical systems, and machine dynamics. In addition to classical approaches, the book presents two new methods: the analytic-assisted method using Turbo Pascal calculation programs, and the graphic-assisted method, outlining the steps required for the development of graphic constructions using AutoCAD; the applications of these methods are illustrated with examples. Aimed at students of mechanical engineering, and engineers designing and developing mechanisms in their own fields, this book provides a useful overview of classical theories, and modern approaches to the practical and creative application of mechanisms, in seeking solutions to increasingly complex problems.
Buchwald Peter Retrometabolic Drug Design and Targeting Buchwald Peter Retrometabolic Drug Design and Targeting Новинка

Buchwald Peter Retrometabolic Drug Design and Targeting

12835.53 руб.
Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
Jack Martin The Wiley Handbook of Theoretical and Philosophical Psychology. Methods, Approaches, and New Directions for Social Sciences Jack Martin The Wiley Handbook of Theoretical and Philosophical Psychology. Methods, Approaches, and New Directions for Social Sciences Новинка

Jack Martin The Wiley Handbook of Theoretical and Philosophical Psychology. Methods, Approaches, and New Directions for Social Sciences

14623.43 руб.
The Wiley Handbook of Theoretical and Philosophical Psychology presents a comprehensive exploration of the wide range of methodological approaches utilized in the contemporary field of theoretical and philosophical psychology. The Wiley Handbook of Theoretical and Philosophical Psychology presents a comprehensive exploration of the wide range of methodological approaches utilized in the contemporary field of theoretical and philosophical psychology. Gathers together for the first time all the approaches and methods that define scholarly practice in theoretical and philosophical psychology Chapters explore various philosophical and conceptual approaches, historical approaches, narrative approaches to the nature of human conduct, mixed-method studies of psychology and psychological inquiry, and various theoretical bases of contemporary psychotherapeutic practices Features contributions from ten Past Presidents of the Society of Theoretical and Philosophical Psychology, along with several Past Presidents of other relevant societies
Литагент HarperCollins USD Natural Alternatives to Antibiotics: How you can Supercharge Your Immune System and Fight Infection Литагент HarperCollins USD Natural Alternatives to Antibiotics: How you can Supercharge Your Immune System and Fight Infection Новинка

Литагент HarperCollins USD Natural Alternatives to Antibiotics: How you can Supercharge Your Immune System and Fight Infection

389.75 руб.
We now know that antibiotics are not the simple solution we once thought. But how can we stay well without them? This book shows how to keep your immune system in peak condition – and stay healthy without antibiotics.Antibiotics have been one of the most succesful inventions of modern medicine – saving many millions of lives around the world. But antibiotics aren’t the trouble free pill for all ills we once thought.Over exposure to antibiotics through over prescription and also from the food chain – means our immune systems are often ‘lazy’.• Antibiotic resistant superbugs mean we need healthier immune systems than ever before.When our immune system is naturally healthy, infections and bugs should hardly ever be a problem. Natural Alternatives to Antibiotics explains the natural therapies herbal medicines you can take to:• strengthen your immune system naturally so you that minor infections don’t become problems.• fight infections without antiobiotics.• make sure your children have well developed immune systems.
Alison Leary Lung Cancer. A Multidisciplinary Approach Alison Leary Lung Cancer. A Multidisciplinary Approach Новинка

Alison Leary Lung Cancer. A Multidisciplinary Approach

2174.26 руб.
Lung Cancer: A Multidisciplinary Approach provides clinicians with a comprehensive text that can be used when caring for patients with lung cancer throughout the entire patient journey. This edited collection explores the aetiology of lung cancer; mesothelioma; the range of available treatments, including chemotherapy and radiotherapy; surgical care; supportive and end-of-life care; quality-of-life issues; and the role of the nurse within the multidisciplinary team. A comprehensive, evidence-based guide to lung cancer Illustrative case studies used throughout Contributions from respected healthcare professionals in the field Interprofessional in focus Lung Cancer: A Multidisciplinary Approach is an essential resource for all nurses and healthcare professionals working with cancer patients.
Ingvar Eidhammer Computational and Statistical Methods for Protein Quantification by Mass Spectrometry Ingvar Eidhammer Computational and Statistical Methods for Protein Quantification by Mass Spectrometry Новинка

Ingvar Eidhammer Computational and Statistical Methods for Protein Quantification by Mass Spectrometry

8020.33 руб.
The definitive introduction to data analysis in quantitative proteomics This book provides all the necessary knowledge about mass spectrometry based proteomics methods and computational and statistical approaches to pursue the planning, design and analysis of quantitative proteomics experiments. The author’s carefully constructed approach allows readers to easily make the transition into the field of quantitative proteomics. Through detailed descriptions of wet-lab methods, computational approaches and statistical tools, this book covers the full scope of a quantitative experiment, allowing readers to acquire new knowledge as well as acting as a useful reference work for more advanced readers. Computational and Statistical Methods for Protein Quantification by Mass Spectrometry: Introduces the use of mass spectrometry in protein quantification and how the bioinformatics challenges in this field can be solved using statistical methods and various software programs. Is illustrated by a large number of figures and examples as well as numerous exercises. Provides both clear and rigorous descriptions of methods and approaches. Is thoroughly indexed and cross-referenced, combining the strengths of a text book with the utility of a reference work. Features detailed discussions of both wet-lab approaches and statistical and computational methods. With clear and thorough descriptions of the various methods and approaches, this book is accessible to biologists, informaticians, and statisticians alike and is aimed at readers across the academic spectrum, from advanced undergraduate students to post doctorates entering the field.
Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches Новинка

Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches

9594.8 руб.
A practical guide for health professionals and trainers, offering evidence-based low arousal approaches to defusing and managing aggressive behaviours in a variety of health care settings. Provides both an academic background and practical advice on how to manage and minimize confrontation Illustrates low arousal approaches and offers clear advice on physical restraint and the reduction of these methods Describes the evidence base for recommended approaches Includes a wide range of valuable case examples from a variety of care settings
Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches Новинка

Andrew McDonnell A. Managing Aggressive Behaviour in Care Settings. Understanding and Applying Low Arousal Approaches

9953.37 руб.
A practical guide for health professionals and trainers, offering evidence-based low arousal approaches to defusing and managing aggressive behaviours in a variety of health care settings. Provides both an academic background and practical advice on how to manage and minimize confrontation Illustrates low arousal approaches and offers clear advice on physical restraint and the reduction of these methods Describes the evidence base for recommended approaches Includes a wide range of valuable case examples from a variety of care settings
Rankovic Zoran Lead Generation Approaches in Drug Discovery Rankovic Zoran Lead Generation Approaches in Drug Discovery Новинка

Rankovic Zoran Lead Generation Approaches in Drug Discovery

9490.51 руб.
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or «virtual» screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Terri Peters Design for Health. Sustainable Approaches to Therapeutic Architecture Terri Peters Design for Health. Sustainable Approaches to Therapeutic Architecture Новинка

Terri Peters Design for Health. Sustainable Approaches to Therapeutic Architecture

2995.97 руб.
Design for Health: Sustainable Approaches to Therapeutic Architecture Guest-Edited by Terri Peters This issue of AD seeks out innovative and varied sustainable architectural responses to designing for health, such as: integrating sensory gardens and landscapes into the care environment; specifying local materials and passive technologies; and reinvigorating aging postwar facilities. Contributors include: Anne-Marie Adams, Sean Ahlquist, Giuseppe Boscherini, Robin Guenther, Charles Jencks, Richard Mazuch, Stephen Verderber, Featured architects: 100% Interior, Arup, C.F. Møller, Lyons, MASS Design Group, Mongomery Sisam Architects, Penoyre & Prasad
Jonathan Passmore The Wiley Blackwell Handbook of the Psychology of Positivity and Strengths-Based Approaches at Work Jonathan Passmore The Wiley Blackwell Handbook of the Psychology of Positivity and Strengths-Based Approaches at Work Новинка

Jonathan Passmore The Wiley Blackwell Handbook of the Psychology of Positivity and Strengths-Based Approaches at Work

12294.1 руб.
A state-of-the-art psychological perspective on positivity and strengths-based approaches at work This handbook makes a unique contribution to organizational psychology and HRM by providing comprehensive international coverage of the contemporary field of positivity and strengths-based approaches at work. It provides critical reviews of key topics such as resilience, wellbeing, hope, motivation, flow, authenticity, positive leadership and engagement, drawing on the work of leading thinkers including Kim Cameron, Shane Lopez, Peter Clough and Robert Biswas-Diener.
Kefei Li Durability Design of Concrete Structures. Phenomena, Modeling, and Practice Kefei Li Durability Design of Concrete Structures. Phenomena, Modeling, and Practice Новинка

Kefei Li Durability Design of Concrete Structures. Phenomena, Modeling, and Practice

10124.13 руб.
Comprehensive coverage of durability of concrete at both material and structural levels, with design related issues Links two active fields in materials science and structural engineering: the durability processes of concrete materials and design methods of concrete structures Facilitates communication between the two communities, helping to implement life-cycle concepts into future design methods of concrete structures Presents state-of-the-art information on the deterioration mechanism and performance evolution of structural concrete under environmental actions and the design methods for durability of concrete structures Provides efficient support and practical tools for life-cycle oriented structural design which has been widely recognized as a new generation of design philosophy for engineering structures The author has long experience working with the topic and the materials presented have been part of the author's current teaching course of Durability and Assessment of Engineering Structures for graduate students at Tsinghua University The design methods and approaches for durability of concrete structures are developed from newly finished high level research projects and have been employed as recommended provisions in design code including Chinese Code and Eurocode 2
Frederick Harris Antimicrobial Peptides Frederick Harris Antimicrobial Peptides Новинка

Frederick Harris Antimicrobial Peptides

12748.01 руб.
In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers. The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.
Alison Leary Lung Cancer. A Multidisciplinary Approach Alison Leary Lung Cancer. A Multidisciplinary Approach Новинка

Alison Leary Lung Cancer. A Multidisciplinary Approach

4123.65 руб.
Lung Cancer: A Multidisciplinary Approach provides clinicians with a comprehensive text that can be used when caring for patients with lung cancer throughout the entire patient journey. This edited collection explores the aetiology of lung cancer; mesothelioma; the range of available treatments, including chemotherapy and radiotherapy; surgical care; supportive and end-of-life care; quality-of-life issues; and the role of the nurse within the multidisciplinary team. A comprehensive, evidence-based guide to lung cancer Illustrative case studies used throughout Contributions from respected healthcare professionals in the field Interprofessional in focus Lung Cancer: A Multidisciplinary Approach is an essential resource for all nurses and healthcare professionals working with cancer patients.
KlingStubbins Sustainable Design of Research Laboratories. Planning, Design, and Operation KlingStubbins Sustainable Design of Research Laboratories. Planning, Design, and Operation Новинка

KlingStubbins Sustainable Design of Research Laboratories. Planning, Design, and Operation

7390.15 руб.
Architecture, Sustainable Design A comprehensive book on the sustainable design of research laboratories Today's research laboratories are complex and difficult building types to design, and making them sustainable adds more obstacles. Written by members of the well-known firm KlingStubbins, under the guidance of its Directors of Laboratory Planning, Engineering, and Sustainability, Sustainable Design of Research Laboratories represents a multidisciplinary approach to addressing these challenges. With the needs of architects, engineers, construction professionals, and facility owners in mind, this book provides a road map for sustainable planning, design, construction, and operations. The book is valuable both to experienced laboratory designers seeking guidance on sustainable strategies, as well as professionals versed in sustainable design who want insight into laboratory applications. With content rich in guidance on performance strategies, even the most technically oriented reader will find valuable lessons inside. This book: Focuses on the links between best sustainable practices and the specific needs of research laboratories Provides a number of case studies of the best contemporary sustainably designed labs, with a focus on architecture and engineering Explores the challenges in applying rating systems, including LEED, to laboratory buildings Examines unique considerations of sustainable approaches in leased and renovated laboratories Includes contributions by experts on approaches to integrated design, site design, programming, and commissioning This important book shows how theoretical ideas can be applied to real-life laboratory projects to create healthier and more efficient research environments.
Keen Patricia L. Antimicrobial Resistance in the Environment Keen Patricia L. Antimicrobial Resistance in the Environment Новинка

Keen Patricia L. Antimicrobial Resistance in the Environment

12053.73 руб.
Examines effects of the environmental distribution of antimicrobial resistance genes on human health and the ecosystem Resistance genes are everywhere in nature—in pathogens, commensals, and environmental microorganisms. This contributed work shows how the environment plays a pivotal role in the development of antimicrobial resistance traits in bacteria and the distribution of resistant microbial species, resistant genetic material, and antibiotic compounds. Readers will discover the impact of the distribution in the environment of antimicrobial resistance genes and antibiotics on both the ecosystem and human and animal health. Antimicrobial Resistance in the Environment is divided into four parts: Part I, Sources, including ecological and clinical consequences of antibiotic resistance by environmental microbes Part II, Fate, including strategies to assess and minimize the biological risk of antibiotic resistance in the environment Part III, Antimicrobial Substances and Resistance, including antibiotics in the aquatic environment Part IV, Effects and Risks, including the effect of antimicrobials used for non-human purposes on human health Recognizing the intricate links among overlapping complex systems, this book examines antimicrobial resistance using a comprehensive ecosystem approach. Moreover, the book's multidisciplinary framework applies principles of microbiology, environmental toxicology, and chemistry to assess the human and ecological risks associated with exposure to antibiotics or antibiotic resistance genes that are environmental contaminants. Each chapter has been written by one or more leading researchers in such fields as microbiology, environmental science, ecology, and toxicology. Comprehensive reference lists at the end of all chapters serve as a gateway to the primary research in the field. Presenting and analyzing the latest findings in a field of growing importance to human and environmental health, this text offers readers new insights into the role of the environment in antimicrobial resistance development, the dissemination of antimicrobial resistant genetic elements, and the transport of antibiotic resistance genes and antibiotics.
Jean Salencon Yield Design Jean Salencon Yield Design Новинка

Jean Salencon Yield Design

8790.39 руб.
Since the middle of the 20th Century yield design approaches have been identified with the lower and upper bound theorem of limit analysis theory – a theory associated with perfect plasticity. This theory is very restrictive regarding the applicability of yield design approaches, which have been used for centuries for the stability of civil engineering structures. This book presents a theory of yield design within the original “equilibrium/resistance” framework rather than referring to the theories of plasticity or limit analysis; expressing the compatibility between the equilibrium of the considered structure and the resistance of its constituent material through simple mathematical arguments of duality and convex analysis results in a general formulation, which encompasses the many aspects of its implementation to various stability analysis problems. After a historic outline and an introductory example, the general theory is developed for the three-dimensional continuum model in a versatile form based upon simple arguments from the mathematical theory of convexity. It is then straightforwardly transposed to the one-dimensional curvilinear continuum, for the yield design analysis of beams, and the two-dimensional continuum model of plates and thin slabs subjected to bending. Field and laboratory observations of the collapse of mechanical systems are presented along with the defining concept of the multi-parameter loading mode. The compatibility of equilibrium and resistance is first expressed in its primal form, on the basis of the equilibrium equations and the strength domain of the material defined by a convex strength criterion along with the dual approach in the field of potentially safe loads, as is the highlighting of the role implicitly played by the theory of yield design as the fundamental basis of the implementation of the ultimate limit state design (ULSD) philosophy with the explicit introduction of resistance parameters. Contents 1. Origins and Topicality of a Concept. 2. An Introductory Example of the Yield Design Approach. 3. The Continuum Mechanics Framework. 4. Primal Approach of the Theory of Yield Design. 5. Dual Approach of the Theory of Yield Design. 6. Kinematic Exterior Approach. 7. Ultimate Limit State Design from the Theory of Yield Design. 8. Optimality and Probability Approaches of Yield Design. 9. Yield Design of Structures. 10. Yield Design of Plates: the Model. 11. Yield Design of Plates Subjected to Pure Bending. About the Authors Jean Salençon is Emeritus Professor at École polytechnique and École des ponts et chaussées, ParisTech, France. Since 2009 he has been a member of the Administrative Board of CNRS (Paris, France). He has received many awards including the Légion d’Honneur (Commander), Ordre National du Mérite (Officer) and Palmes Académiques (Commander). His research interests include structure analysis, soil mechanics and continuum mechanics.
Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery Новинка

Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery

17247.31 руб.
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art «omics» technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.
J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria Новинка

J. Hardwick Marie The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria

14623.43 руб.
This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders
Camilo Olaya Social Systems Engineering. The Design of Complexity Camilo Olaya Social Systems Engineering. The Design of Complexity Новинка

Camilo Olaya Social Systems Engineering. The Design of Complexity

7498.83 руб.
Uniquely reflects an engineering view to social systems in a wide variety of contexts of application Social Systems Engineering: The Design of Complexity brings together a wide variety of application approaches to social systems from an engineering viewpoint. The book defines a social system as any complex system formed by human beings. Focus is given to the importance of systems intervention design for specific and singular settings, the possibilities of engineering thinking and methods, the use of computational models in particular contexts, and the development of portfolios of solutions. Furthermore, this book considers both technical, human and social perspectives, which are crucial to solving complex problems. Social Systems Engineering: The Design of Complexity provides modelling examples to explore the design aspect of social systems. Various applications are explored in a variety of areas, such as urban systems, health care systems, socio-economic systems, and environmental systems. It covers important topics such as organizational design, modelling and intervention in socio-economic systems, participatory and/or community-based modelling, application of systems engineering tools to social problems, applications of computational behavioral modeling, computational modelling and management of complexity, and more. Highlights an engineering view to social systems (as opposed to a “scientific” view) that stresses the importance of systems intervention design for specific and singular settings Divulges works where the design, re-design, and transformation of social systems constitute the main aim, and where joint considerations of both technical and social perspectives are deemed important in solving social problems Features an array of applied cases that illustrate the application of social systems engineering in different domains Social Systems Engineering: The Design of Complexity is an excellent text for academics and graduate students in engineering and social science—specifically, economists, political scientists, anthropologists, and management scientists with an interest in finding systematic ways to intervene and improve social systems.
Harris Nic Greatest Invention of All Time Harris Nic Greatest Invention of All Time Новинка

Harris Nic Greatest Invention of All Time

915 руб.
Determining the greatest invention of all time invites the greatest debate. From the internet to antibiotics, this reader explores our most significant contributions to education, technology, medicine, and transportation.
Eva Murray #MakeoverMonday. Improving How We Visualize and Analyze Data, One Chart at a Time Eva Murray #MakeoverMonday. Improving How We Visualize and Analyze Data, One Chart at a Time Новинка

Eva Murray #MakeoverMonday. Improving How We Visualize and Analyze Data, One Chart at a Time

3107.75 руб.
Explore different perspectives and approaches to create more effective visualizations #MakeoverMonday offers inspiration and a giant dose of perspective for those who communicate data. Originally a small project in the data visualization community, #MakeoverMonday features a weekly chart or graph and a dataset that community members reimagine in order to make it more effective. The results have been astounding; hundreds of people have contributed thousands of makeovers, perfectly illustrating the highly variable nature of data visualization. Different takes on the same data showed a wide variation of theme, focus, content, and design, with side-by-side comparisons throwing more- and less-effective techniques into sharp relief. This book is an extension of that project, featuring a variety of makeovers that showcase various approaches to data communication and a focus on the analytical, design and storytelling skills that have been developed through #MakeoverMonday. Paging through the makeovers ignites immediate inspiration for your own work, provides insight into different perspectives, and highlights the techniques that truly make an impact. Explore the many approaches to visual data communication Think beyond the data and consider audience, stakeholders, and message Design your graphs to be intuitive and more communicative Assess the impact of layout, color, font, chart type, and other design choices Creating visual representation of complex datasets is tricky. There’s the mandate to include all relevant data in a clean, readable format that best illustrates what the data is saying—but there is also the designer’s impetus to showcase a command of the complexity and create multidimensional visualizations that “look cool.” #MakeoverMonday shows you the many ways to walk the line between simple reporting and design artistry to create exactly the visualization the situation requires.
Jan Awrejcewicz Asymptotic Methods in the Theory of Plates with Mixed Boundary Conditions Jan Awrejcewicz Asymptotic Methods in the Theory of Plates with Mixed Boundary Conditions Новинка

Jan Awrejcewicz Asymptotic Methods in the Theory of Plates with Mixed Boundary Conditions

11623.19 руб.
Asymptotic Methods in the Theory of Plates with Mixed Boundary Conditions comprehensively covers the theoretical background of asymptotic approaches and their use in solving mechanical engineering-oriented problems of structural members, primarily plates (statics and dynamics) with mixed boundary conditions. The first part of this book introduces the theory and application of asymptotic methods and includes a series of approaches that have been omitted or not rigorously treated in the existing literature. These lesser known approaches include the method of summation and construction of the asymptotically equivalent functions, methods of small and large delta, and the homotopy perturbations method. The second part of the book contains original results devoted to the solution of the mixed problems of the theory of plates, including statics, dynamics and stability of the studied objects. In addition, the applicability of the approaches presented to other related linear or nonlinear problems is addressed. Key features: • Includes analytical solving of mixed boundary value problems • Introduces modern asymptotic and summation procedures • Presents asymptotic approaches for nonlinear dynamics of rods, beams and plates • Covers statics, dynamics and stability of plates with mixed boundary conditions • Explains links between the Adomian and homotopy perturbation approaches Asymptotic Methods in the Theory of Plates with Mixed Boundary Conditions is a comprehensive reference for researchers and practitioners working in the field of Mechanics of Solids and Mechanical Engineering, and is also a valuable resource for graduate and postgraduate students from Civil and Mechanical Engineering.
Murugan Ramalingam Biomimetics. Advancing Nanobiomaterials and Tissue Engineering Murugan Ramalingam Biomimetics. Advancing Nanobiomaterials and Tissue Engineering Новинка

Murugan Ramalingam Biomimetics. Advancing Nanobiomaterials and Tissue Engineering

15518.45 руб.
This book compiles all aspects of biomimetics from fundamental principles to current technological advances and their future trends in the development of nanoscale biomaterials and tissue engineering. The scope of this book is principally confined to biologically-inspired design of materials and systems for the development of next generation nanobiomaterials and tissue engineering. The book addresses the state-of-the-art of research progress in the applications of the principles, processes, and techniques of biomimetics. The prospective outcomes of current advancements and challenges in biomimetic approaches are also presented.
Gregoris Simos CBT For Anxiety Disorders. A Practitioner Book Gregoris Simos CBT For Anxiety Disorders. A Practitioner Book Новинка

Gregoris Simos CBT For Anxiety Disorders. A Practitioner Book

8469.98 руб.
CBT for Anxiety Disorders presents a comprehensive overview of the latest anxiety disorder-specific treatment techniques contributed by the foremost experts in various CBT approaches. Summarizes the state-of-the-art CBT approaches for each of the DSM anxiety disorders Represents a one-stop tool for researchers, clinicians, and students on CBT for anxiety disorders Features world leading CBT authors who provide an up to date description of their respective treatment approaches in a succinct, and clinician-tailored, fashion
Janet Moyer Lennox The Landscape Lighting Book Janet Moyer Lennox The Landscape Lighting Book Новинка

Janet Moyer Lennox The Landscape Lighting Book

10124.13 руб.
This richly illustrated, up-to-date guide offers practical coverage of all aspects of lighting design. Written by an award-winning, internationally known lighting designer, it covers lighting practices, materials, and their design applications and offers guidelines for preparing lighting drawings, control and transfer charts, symbol lists, and other technical specifications. This edition provides a new focus on the use of LEDs, as well as new and expanded coverage of renderings, Mesopic Vision, and the latest controls approaches and systems.
Tobias Jeffrey S. Cancer and its Management Tobias Jeffrey S. Cancer and its Management Новинка

Tobias Jeffrey S. Cancer and its Management

8008.59 руб.
Now in its sixth edition, this highly-regarded book is designed as an introductory text on the principles of diagnosis, staging and treatment of tumours. The new edition: Includes up-to-date information on the most recent techniques and therapies available Emphasises the importance of multidisciplinary teamwork in the care of cancer patients Highlights frequent dilemmas and difficulties encountered during cancer management Features the important contributions of a new author Professor Daniel Hochhauser Contains a brand-new two-colour design As with previous editions, the first part of the book is devoted to the mechanisms of tumour development and cancer treatment. This is followed by a systematic account of the current management of individual major cancers. For each tumour there are details of the pathology, mode of spread, clinical presentation, staging and treatment with radiotherapy and chemotherapy. This accessible and practical resource will be invaluable to trainees in oncology, palliative care and general medicine, as well as specialist nurses, general practitioners, medical students, and professions allied to medicine. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.
CLIN-K Повседневные брюки CLIN-K Повседневные брюки Новинка

CLIN-K Повседневные брюки

1750 руб.
плотная ткань, вышивка, логотип, одноцветное изделие, низкая талия, обтягивающая модель, брюки-бананы, молния и пуговицы, множество карманов, стрейч, модель 5 карманов
Heinz-Bernhard Kraatz Kinomics. Approaches and Applications Heinz-Bernhard Kraatz Kinomics. Approaches and Applications Новинка

Heinz-Bernhard Kraatz Kinomics. Approaches and Applications

10245.08 руб.
Authored by the world's leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field. Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown. The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.
Christian Derix Empathic Space. The Computation of Human-Centric Architecture Christian Derix Empathic Space. The Computation of Human-Centric Architecture Новинка

Christian Derix Empathic Space. The Computation of Human-Centric Architecture

2995.97 руб.
In recent years, questions of space have gained renewed momentum in architecture and urban design, as adaptation, densification and sustainable regeneration have become an increasing priority. While most computing-based design tends to emphasise the formal aspects of architecture, overlooking space and its users, the ‘original’ computational design approaches first spearheaded in the UK in the 1960s and 1970s tended to be focused on behavioural and occupational patterns. Over the last decade, a new generation of design research has emerged that has started to implement and validate previous investigations into spatial computation, aiming to understand how to design spatial configurations based on user experiences. This revives an interest in the experiential that was first explored in the early 20th century by German and Nordic organic architects, who invented design methods that correlated cognitive responses of buildings' occupants to spatial structure. The current revival of human-centric design, however, represents the first design approach that synthesises spatial design and algorithmic techniques with organic design thinking, which could also be regarded as a return to the ‘first principles' of architectural design. Contributors include: Paul Coates, Christian Derix, Olafur Eliasson, Lucy Helme, Bill Hillier, Åsmund Izaki, Prarthana Jagannath, Dan Montello, Juhani Pallasmaa, Philip Steadman and Guy Theraulaz. Featured Architects/Designers: Jussi Ängeslevä (Art+Com), Stan Allen, Aedas|R&D, Markus Braach (Kaisersrot), Hermann Hertzberger, Kazuhiro Kojima (Cat), Pablo Miranda and Rafi Segal.
Nancy Blossom The Handbook of Interior Design Nancy Blossom The Handbook of Interior Design Новинка

Nancy Blossom The Handbook of Interior Design

14623.43 руб.
The Handbook of Interior Design explores ways of thinking that inform the discipline of interior design. It challenges readers to consider the connections within theory, research, and practice and the critical underpinnings that have shaped interior design. Offers a theory of interior design by moving beyond a descriptive approach to the discipline to a 'why and how' study of interiors Provides a full overview of the most current Interior Design research and scholarly thought from around the world Explores examples of research designs and methodological approaches that are applicable to interior design upper division and graduate education courses Brings together an international team of contributors, including well established scholars alongside emerging voices in the field – reflecting mature and emergent ideas, research, and philosophies in the field Exemplifies where interior design sits in its maturation as a discipline and profession through inclusion of diverse authors, topics, and ideas
Francisco Azuaje Bioinformatics and Biomarker Discovery. Omic Data Analysis for Personalized Medicine Francisco Azuaje Bioinformatics and Biomarker Discovery. Omic Data Analysis for Personalized Medicine Новинка

Francisco Azuaje Bioinformatics and Biomarker Discovery. Omic Data Analysis for Personalized Medicine

13220.59 руб.
This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems. The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of «omic» data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications. Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of «omic» data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery Covers the main range of data sources currently used for biomarker discovery Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies Discusses systems biology approaches and applications Includes expert chapter commentaries to further discuss relevance of techniques, summarize biological/clinical implications and provide alternative interpretations

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Since the middle of the 20th Century yield design approaches have been identified with the lower and upper bound theorem of limit analysis theory – a theory associated with perfect plasticity. This theory is very restrictive regarding the applicability of yield design approaches, which have been used for centuries for the stability of civil engineering structures. This book presents a theory of yield design within the original “equilibrium/resistance” framework rather than referring to the theories of plasticity or limit analysis; expressing the compatibility between the equilibrium of the considered structure and the resistance of its constituent material through simple mathematical arguments of duality and convex analysis results in a general formulation, which encompasses the many aspects of its implementation to various stability analysis problems. After a historic outline and an introductory example, the general theory is developed for the three-dimensional continuum model in a versatile form based upon simple arguments from the mathematical theory of convexity. It is then straightforwardly transposed to the one-dimensional curvilinear continuum, for the yield design analysis of beams, and the two-dimensional continuum model of plates and thin slabs subjected to bending. Field and laboratory observations of the collapse of mechanical systems are presented along with the defining concept of the multi-parameter loading mode. The compatibility of equilibrium and resistance is first expressed in its primal form, on the basis of the equilibrium equations and the strength domain of the material defined by a convex strength criterion along with the dual approach in the field of potentially safe loads, as is the highlighting of the role implicitly played by the theory of yield design as the fundamental basis of the implementation of the ultimate limit state design (ULSD) philosophy with the explicit introduction of resistance parameters. Contents 1. Origins and Topicality of a Concept. 2. An Introductory Example of the Yield Design Approach. 3. The Continuum Mechanics Framework. 4. Primal Approach of the Theory of Yield Design. 5. Dual Approach of the Theory of Yield Design. 6. Kinematic Exterior Approach. 7. Ultimate Limit State Design from the Theory of Yield Design. 8. Optimality and Probability Approaches of Yield Design. 9. Yield Design of Structures. 10. Yield Design of Plates: the Model. 11. Yield Design of Plates Subjected to Pure Bending. About the Authors Jean Salençon is Emeritus Professor at École polytechnique and École des ponts et chaussées, ParisTech, France. Since 2009 he has been a member of the Administrative Board of CNRS (Paris, France). He has received many awards including the Légion d’Honneur (Commander), Ordre National du Mérite (Officer) and Palmes Académiques (Commander). His research interests include structure analysis, soil mechanics and continuum mechanics.
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