neuroprotective agents and cerebral ischaemia40



Rosaleen Anderson Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications Rosaleen Anderson Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications Новинка

Rosaleen Anderson Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

13646.79 руб.
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes – sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis – β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
Tahira Farooqui Neuroprotective Effects of Phytochemicals in Neurological Disorders Tahira Farooqui Neuroprotective Effects of Phytochemicals in Neurological Disorders Новинка

Tahira Farooqui Neuroprotective Effects of Phytochemicals in Neurological Disorders

14993.47 руб.
Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.
Cao Jiannong Mobile Agents in Networking and Distributed Computing Cao Jiannong Mobile Agents in Networking and Distributed Computing Новинка

Cao Jiannong Mobile Agents in Networking and Distributed Computing

6816.42 руб.
The book focuses on mobile agents, which are computer programs that can autonomously migrate between network sites. This text introduces the concepts and principles of mobile agents, provides an overview of mobile agent technology, and focuses on applications in networking and distributed computing.
E. V. Shevchenko Pediatric stroke. Revascularization and reconstructive surgery in children with cerebrovascular disease E. V. Shevchenko Pediatric stroke. Revascularization and reconstructive surgery in children with cerebrovascular disease Новинка

E. V. Shevchenko Pediatric stroke. Revascularization and reconstructive surgery in children with cerebrovascular disease

490 руб.
This book is about pediatric stroke. The book represents the main literary information about the etiology, pathogenesis, clinical manifestations of pediatric stroke, methods of examination and tactics of conservative and surgical treatment cerebral ischemia in children and surgical treatment of acute and chronic cerebral ischemia in children.
Sophie Levitt Treatment of Cerebral Palsy and Motor Delay Sophie Levitt Treatment of Cerebral Palsy and Motor Delay Новинка

Sophie Levitt Treatment of Cerebral Palsy and Motor Delay

4597.28 руб.
Treatment of Cerebral Palsy and Motor Delay is a highly practical, easy-to-read resource for all paediatric practitioners and students working with the developmental abilities and difficulties of children, providing a thorough overview of cerebral palsy and its treatment. The sixth edition has been thoroughly revised and updated to integrate the latest evidence-base on motor control and motor learning, whilst still retaining Sophie Levitt's eclectic, holistic and functional approach. It includes greater detail on paediatric occupational therapy, classification systems, the latest systematic reviews of research, as well as an expanded chapter on adolescents and adults with cerebral palsy. The chapter on equipment has also been increased so as to be of further relevance to occupational therapists. Supported by clear diagrams and photographs, as well as summaries to consolidate learning, it outlines therapeutic approaches and suggests treatment and management options, providing a wealth of practical information. The book promotes positive relationships between therapists, people with cerebral palsy and their families.
Klee Klee Новинка

Klee

1160 руб.
With meticulous theories and many thousands of paintings, drawings, and watercolors, Paul Klee (1879-1940) is considered one of the most cerebral and prolific leaders of...
Sophie Levitt Treatment of Cerebral Palsy and Motor Delay Sophie Levitt Treatment of Cerebral Palsy and Motor Delay Новинка

Sophie Levitt Treatment of Cerebral Palsy and Motor Delay

5976.66 руб.
Treatment of Cerebral Palsy and Motor Delay is first and foremost a practical book, a distillation of Sophie Levitt’s considerable experience in treating those affected by cerebral palsy. This fifth edition outlines therapeutic approaches and suggests treatment and management options, providing a wealth of practical information, supported by clear diagrams and photographs, on assessment, management and treatment. The book emphasises an eclectic, holistic approach, and integrates current ideas on motor control and motor learning in a further development of Levitt’s Collaborative Learning Approach. This new edition provides greater commentary on evidence-based practice, as well as practical, updated information on the use of botulinum toxin, orthopaedic surgery and the therapist's role following these procedures. The book is aimed primarily at practitioners and students concerned with the developmental abilities and difficulties of children, particularly physiotherapists and occupational therapists working in paediatrics. Doctors and other healthcare professionals will also find useful insights in the book. Parents, families and also teachers of people with cerebral palsy can learn more about therapy by consulting the book together with their therapist. Written by an international authority in the field Extensively revised, updated and well referenced Emphasises an eclectic, functional and holistic approach Highly illustrated Promotes positive relationships between therapists, people with cerebral palsy and their families From the Foreword: «I greatly welcome the fifth edition of this book which brings together the management of cerebral palsies into a comprehensive but readable form… This book is in my view an essential part of both a therapist’s and doctor’s basic understanding of the subject… This book remains essential for those managing children with disability.» —Brian Neville, Professor of Childhood Epilepsy, Professor of Paediatric Neurology, University College London, Institute of Child Health/Great Ormond Street Hospital for Children NHS Trust.
Gravanis Achille G. Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis Gravanis Achille G. Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis Новинка

Gravanis Achille G. Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

16012.26 руб.
As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.
Andre Richardt CBRN Protection. Managing the Threat of Chemical, Biological, Radioactive and Nuclear Weapons Andre Richardt CBRN Protection. Managing the Threat of Chemical, Biological, Radioactive and Nuclear Weapons Новинка

Andre Richardt CBRN Protection. Managing the Threat of Chemical, Biological, Radioactive and Nuclear Weapons

7798.37 руб.
Originating in the armed forces of the early 20th century, weapons based on chemical, biological or nuclear agents have become an everpresent threat that has not vanished after the end of the cold war. Since the technology to produce these agents is nowadays available to many countries and organizations, including those with terrorist aims, civil authorities across the world need to prepare against incidents involving these agents and train their personnel accordingly. As an introductory text on NBC CBRN weapons and agents, this book leads the reader from the scientific basics to the current threats and strategies to prepare against them. After an introductory part on the history of NBC CBRN weapons and their international control, the three classes of nuclear/radiological, biological, and chemical weapons are introduced, focusing on agents and delivery vehicles. Current methods for the rapid detection of NBC CBRN agents are introduced, and the principles of physical protection of humans and structures are explained. The final parts addresses more general issues of risk management, preparedness and response management, as the set of tools that authorities and civil services will be needed in a future CBRN scenario as well as the likely future scenarios that authorities and civil services will be faced with in the coming years. This book is a must-have for Health Officers, Public Health Agencies, and Military Authorities.
Goutam Brahmachari Neuroprotective Natural Products. Clinical Aspects and Mode of Action Goutam Brahmachari Neuroprotective Natural Products. Clinical Aspects and Mode of Action Новинка

Goutam Brahmachari Neuroprotective Natural Products. Clinical Aspects and Mode of Action

13871.59 руб.
Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.
Stephen Wiviott D. Antiplatelet Therapy In Ischemic Heart Disease Stephen Wiviott D. Antiplatelet Therapy In Ischemic Heart Disease Новинка

Stephen Wiviott D. Antiplatelet Therapy In Ischemic Heart Disease

12257.29 руб.
This book in the new American Heart Association Clinical Series, explores and explains state-of-the-art use of antiplatelet agents and draws on the expertise of global leaders in antiplatelet therapy. Skillfully organized for fast reference, the book is divided into five parts: Concepts in Platelet Physiology, Function, and Measurement Pharmacology of Oral Antiplatelet Agents Pharmacology of Intravenous Antiplatelet Agents Clinical Use of Antiplatelet Agents in Cardiovascular Disease Special Circumstances. Each chapter in the clinical section contains an overview of guidelines, plus specifics on medical and interventional uses. Clinical cardiologists, platelet biologists, and a wide range of practicing and prospective clinicians in allied fields will find this text an exceptional source of current information.
Gary Tucker S. Food Preservation and Biodeterioration Gary Tucker S. Food Preservation and Biodeterioration Новинка

Gary Tucker S. Food Preservation and Biodeterioration

15746.13 руб.
Biodeterioration is the breakdown of food by agents of microbiological origin, either directly or indirectly from products of their metabolism. Preservation on the other hand is the process by which food materials are maintained in their original condition or as close to this as possible. This second edition of Food Preservation and Biodeterioration is fully updated and reorganised throughout. It discusses how the agents of food biodeterioration operate and how the commercial methods available to counteract these agents are applied to produce safe and wholesome foods. With this book, readers will discover traditional methods as well as major advances in preservation technology. Both microbiological and chemical pathways are analysed. This topic being important to all producers of food, the readership spans food scientists across industry and academia, particularly those involved with safety and quality.
Printio Agents of chaos Printio Agents of chaos Новинка

Printio Agents of chaos

1112 руб.
Футболка с полной запечаткой для мальчиков.
Printio Agents of chaos Printio Agents of chaos Новинка

Printio Agents of chaos

1112 руб.
Футболка с полной запечаткой для девочек.
Lothar Helm The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging Lothar Helm The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging Новинка

Lothar Helm The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

17021.67 руб.
Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: «…attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique…»—Journal of the American Chemical Society «…well balanced in its scope and attention to detail…a valuable addition to the library of MR scientists…»—NMR in Biomedicine
Mohamed Abou-Donia Mammalian Toxicology Mohamed Abou-Donia Mammalian Toxicology Новинка

Mohamed Abou-Donia Mammalian Toxicology

10123.22 руб.
Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.
Shayne Cox Gad Development of Therapeutic Agents Handbook Shayne Cox Gad Development of Therapeutic Agents Handbook Новинка

Shayne Cox Gad Development of Therapeutic Agents Handbook

21456.96 руб.
A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.
Tim Storr Ligand Design in Medicinal Inorganic Chemistry Tim Storr Ligand Design in Medicinal Inorganic Chemistry Новинка

Tim Storr Ligand Design in Medicinal Inorganic Chemistry

14622.12 руб.
Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.
Printio Agents of chaos Printio Agents of chaos Новинка

Printio Agents of chaos

1112 руб.
Футболка с полной запечаткой (мужская) — пол: МУЖ, материал: СИНТЕТИКА.
Printio Agents of chaos Printio Agents of chaos Новинка

Printio Agents of chaos

1112 руб.
Футболка с полной запечаткой (женская) — пол: ЖЕН, материал: СИНТЕТИКА.
Игра для приставки Sony PS4 Agents of Mayhem ИЗДАНИЕ ПЕРВОГО ДНЯ Игра для приставки Sony PS4 Agents of Mayhem ИЗДАНИЕ ПЕРВОГО ДНЯ Новинка

Игра для приставки Sony PS4 Agents of Mayhem ИЗДАНИЕ ПЕРВОГО ДНЯ

1599 руб.
Платформа: PS4 Жанр: экшн Возраст: 18 Страна-производитель: Австрия
Patrick Butaye Detection of Highly Dangerous Pathogens. Microarray Methods for BSL 3 and BSL 4 Agents Patrick Butaye Detection of Highly Dangerous Pathogens. Microarray Methods for BSL 3 and BSL 4 Agents Новинка

Patrick Butaye Detection of Highly Dangerous Pathogens. Microarray Methods for BSL 3 and BSL 4 Agents

7869.51 руб.
Written by leading experts in the field as part of an interdisciplinary pan-European research program funded by the EU, the results provided in this booklet provide a unique and comprehensive overview of how microarray technology can be used in safely tracking the most highly dangerous pathogens. A must-have for public health agencies focused on bioterrorism as well as all laboratories working with BSL3 and/or BSL 4 agents.
Ron Waksman Antiplatelet Therapy in Cardiovascular Disease Ron Waksman Antiplatelet Therapy in Cardiovascular Disease Новинка

Ron Waksman Antiplatelet Therapy in Cardiovascular Disease

7720.11 руб.
Edited by a team of the world’s leading interventional cardiologists and educators, this new book is created with an eye to giving the reader a solid, practical, and clinically focused understanding of this important class of drugs, from basic science to a clear-headed discussion of complex topics such as combination therapies, drug-to-drug interactions, and resistance to antiplatelet agents. This important new book: Begins with a concise but thorough discussion of platelet biology and pathophysiology so that readers understand how antiplatelet agents work and why they produce such a varied range of complications, from minor GI upset to potentially life-threatening conditions such as neutropenia, a critical shortage of white blood cells. Thoroughly covers platelet function testing, including novel techniques. Clarifies current best practice regarding the use of antiplatelet agents in both chronic and acute cardiovascular disease. Reviews all types of antiplatelet agents – from aspirin to recently approved drugs – including indications, clinical outcomes, and side effects. Written by an international “who’s who” of experts in the field, Antiplatelet Therapy in Cardiovascular Disease also includes an entire section covering the use of antiplatelet drugs in PCIs, including percutaneous valve repair, which makes this text particularly essential to interventional cardiologists.
Брелок POP! Keychain Agents of Shield: Ghostrider Брелок POP! Keychain Agents of Shield: Ghostrider Новинка

Брелок POP! Keychain Agents of Shield: Ghostrider

690 руб.
Брелок Agents of Shield: Ghostrider с персонажем комиксов!
Verbrugge Rineke Teamwork in Multi-Agent Systems. A Formal Approach Verbrugge Rineke Teamwork in Multi-Agent Systems. A Formal Approach Новинка

Verbrugge Rineke Teamwork in Multi-Agent Systems. A Formal Approach

8659.42 руб.
What makes teamwork tick? Cooperation matters, in daily life and in complex applications. After all, many tasks need more than a single agent to be effectively performed. Therefore, teamwork rules! Teams are social groups of agents dedicated to the fulfilment of particular persistent tasks. In modern multiagent environments, heterogeneous teams often consist of autonomous software agents, various types of robots and human beings. Teamwork in Multi-agent Systems: A Formal Approach explains teamwork rules in terms of agents' attitudes and their complex interplay. It provides the first comprehensive logical theory, TeamLog, underpinning teamwork in dynamic environments. The authors justify design choices by showing TeamLog in action. The book guides the reader through a fascinating discussion of issues essential for teamwork to be successful: What is teamwork, and how can a logical view of it help in designing teams of agents? What is the role of agents' awareness in an uncertain, dynamic environment? How does collective intention constitute a team? How are plan-based collective commitments related to team action? How can one tune collective commitment to the team's organizational structure and its communication abilities? What are the methodological underpinnings for teamwork in a dynamic environment? How does a team and its attitudes adjust to changing circumstances? How do collective intentions and collective commitments arise through dialogue? What is the computational complexity of TeamLog? How can one make TeamLog efficient in applications? This book is an invaluable resource for researchers and graduate students in computer science and artificial intelligence as well as for developers of multi-agent systems. Students and researchers in organizational science, in particular those investigating teamwork, will also find this book insightful. Since the authors made an effort to introduce TeamLog as a conceptual model of teamwork, understanding most of the book requires solely a basic logical background.
Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent Новинка

Wu-Kuang Yeh Enzyme Technologies. Pluripotent Players in Discovering Therapeutic Agent

11993.49 руб.
Sets the stage for advances in drug discovery using the latest enzyme technology Reviewing new and emerging applications of enzyme technology in drug discovery, this book highlights some of the most promising areas of pharmaceutical and biotechnology research. It covers enzyme assay technology, utilization of enzymology for prodrug design, and the application of enzymes as therapeutic agents. Expert reviews highlight how our latest understanding of enzymology is used to develop new practical applications in drug discovery and design. Filled with case studies, Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents enables readers to better understand the diverse functions of enzymes and master specific applications in drug discovery research. In addition to small molecule drug discovery, the book explores new developments in enzymes as therapeutic agents for genetic disorders. Section A, Enzymes – Essential Workhorses in Pharmaceutical Research, offers support in selecting the best enzyme targets for drug discovery, designing enzyme inhibitors for therapeutic agents, and evaluating selective enzyme inhibitors. Section B, Enzymes – Indispensable Tools for Improving Druggability, sets forth the principles alongside real-world examples of exploiting specific properties of enzymes to design successful prodrugs. Section C, Enzymes – Powerful Weapons for Correcting Nature's Errors, provides new insights on applying enzymes as therapeutic agents or diagnostic tools to treat genetic disorders. Chapters are contributed by leading experts from around the world. Their contributions are based on a thorough review of the current literature as well as their own research. Reviewing our latest understanding of the nature of enzymes and their role in drug discovery, this book is recommended for researchers in pharmaceuticals and biotechnology as well as for researchers in enzymology, biochemistry, molecular biology, and medicinal chemistry.
Thomas DeRosa F. Advances in Polymer Chemistry and Methods Reported in Recent US Patents Thomas DeRosa F. Advances in Polymer Chemistry and Methods Reported in Recent US Patents Новинка

Thomas DeRosa F. Advances in Polymer Chemistry and Methods Reported in Recent US Patents

13487.23 руб.
The objective of this book is to convey to academic and industrial researchers and students advances in synthetic and characterization methods in 9 selected areas of polymer chemistry reported in 2007-2008 US Patents. It reviews the impact of newer bulk anionic, cationic, and free radical polymerization methods within selected industrial applications. Bulk and surface crosslinking agents using selected bi- and tri-functional reagents, photochemical methods, or free radical agents are also reviewed. Finally, there is a separate section on cationic and cationic ring opening polymerization reactions describing di- and tri-heterocyclic monomers and their use in medical devices.
Patrick Butaye BSL3 and BSL4 Agents. Proteomics, Glycomics and Antigenicity Patrick Butaye BSL3 and BSL4 Agents. Proteomics, Glycomics and Antigenicity Новинка

Patrick Butaye BSL3 and BSL4 Agents. Proteomics, Glycomics and Antigenicity

12744.02 руб.
Unique coverage of proteomic and glycomic approaches to better distinguish highly dangerous pathogens, as well as using these to explore novel treatment and prevention options. The editors and authors are either part of a specialized European network initiated to develop fast and reliable detection and therapy options, or are associated with the core military research complex of the United States. With its description of the methods, their advantages and limitations, as well as the principle outcomes, this is a must-have resource for all professionals dealing with BSL3 and/or BSL 4 agents.
Akunin Boris The Diamond Chariot Akunin Boris The Diamond Chariot Новинка

Akunin Boris The Diamond Chariot

1918 руб.
A stunning and epic finale to the series, pitting Fandorin against both Ninjas and terrorists on the Trans-Siberian Express! The first of the interlinked plotlines is set in Russia during the Russo-Japanese War in 1905. Fandorin is charged with protecting the Trans-Siberian Railway from Japanese sabotage in a pacy adventure filled with double agents and ticking bombs. Then we travel back to the Japan of the late 1870s. This is the story of Fandorin's arrival and life in Yokohama, his first meeting with Masa and the martial arts education that came in so handy later. He investigates the death of a Russian ship-captain, fights for a woman, exposes double-agents in the Japanese police, fights against, and then with the ninjas, and becomes embroiled in a shocking finale that interweaves the two stories and ties up the series as a whole.
Jan Lotvall Advances in Combination Therapy for Asthma and COPD Jan Lotvall Advances in Combination Therapy for Asthma and COPD Новинка

Jan Lotvall Advances in Combination Therapy for Asthma and COPD

11414.34 руб.
Aimed at specialists in respiratory medicine, this new book comprehensively reviews the variety of agents currently available for treatment of asthma, COPD, and other airway diseases and covers practical guidelines as well as challenges and complications in their use. Advances in Combination Therapy for Asthma and COPD is the first book to address the complexity of multi-agent therapy and deal with management issues in an integrated fashion. A review of currently available agents and their applications, as well as new therapies soon to become available are outlined. Advantages of combined therapies and additional considerations that arise from multi-agent programs are highlighted.
Chris Brogan Trust Agents. Using the Web to Build Influence, Improve Reputation, and Earn Trust Chris Brogan Trust Agents. Using the Web to Build Influence, Improve Reputation, and Earn Trust Новинка

Chris Brogan Trust Agents. Using the Web to Build Influence, Improve Reputation, and Earn Trust

1080.74 руб.
The New York Times and Wall Street Journal bestseller-now in a new, updated paperback edition Today's online influencers are Web natives who trade in trust, reputation, and relationships, using social media to accrue the influence that builds up or brings down businesses online. In Trust Agents, two social media veterans show you how to tap into the power of social networks to build your brand's influence, reputation, and, of course, profits. In this revised paperback version, learn how businesses are using the latest online social tools to build networks of influence and how you can use those networks to positively impact your business. Combining high-level theory and practical actions, this guide delivers actionable steps and case studies that show how social media can positively impact your business. New edition features specific first moves for entering social media for small businesses, educators, travel and hospitality enterprises, nonprofit organizations, and corporations Authors both have a major presence on the social Web as well as years of online marketing and new media experience If you want your business to succeed, don't sit on the sidelines while new markets and channels grow. Instead, use the Web to build trust with your consumers using Trust Agents.
Maximilian Gaynesford de Agents and Their Actions Maximilian Gaynesford de Agents and Their Actions Новинка

Maximilian Gaynesford de Agents and Their Actions

2752.32 руб.
Reflecting a recent flourishing of creative thinking in the field, Agents and Their Actions presents seven newly commissioned essays by leading international philosophers that highlight the most recent debates in the philosophy of action Features seven internationally significant authors, including new work by two of philosophy's ‘super stars’, John McDowell and Joseph Raz Presents the first clear indication of how John McDowell is extending his path-breaking work on intentionality and perceptual experience towards an account of action and agency Covers all the major interconnections between action-agency and central areas of Philosophy: Metaphysics, Epistemology, History of Philosophy, Ethics, Logic, Philosophy of Language Provides a snapshot of current debate on the subject, which is fresh, enlightening, and fruitful
Joseph Caruso A. Analysis of Chemical Warfare Degradation Products Joseph Caruso A. Analysis of Chemical Warfare Degradation Products Новинка

Joseph Caruso A. Analysis of Chemical Warfare Degradation Products

7569.3 руб.
This book describes nerve agents and vesicants, their decomposition and their degradation products' chemistry as well as their toxicity including a list of detection techniques of nerve agents and their degradation products. This book will present their history, toxicity, comparison between different sample preparation methods, separation techniques, and detection methods all together in a short, easy to read book, tied together by a single group doing the writing and the editing to assure smooth transition from chapter to chapter, with sufficient Tables and literature references for the reader who looks to further detail.The text will illustrate the pluses and minuses of the various techniques with sufficient references for the reader to obtain extensive detail.
Dries Van Noten 51-100 Dries Van Noten 51-100 Новинка

Dries Van Noten 51-100

9420 руб.
Dries Van Noten is a master artist and fabric is his medium. - www.barneys.com. One of fashion's most cerebral designers. New York Times. Dries...
Bruce Kaplan Immunotherapy in Transplantation. Principles and Practice Bruce Kaplan Immunotherapy in Transplantation. Principles and Practice Новинка

Bruce Kaplan Immunotherapy in Transplantation. Principles and Practice

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This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the efficacy of each for specific diseases.
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Covering fundamentals and new developments in phytotherapy, this book combines pharmaceutical sciences and chemistry with clinical issues. • Helps readers better understand phytotherapy and learn the fundamentals of and how to analyze phytotherapeutic agents • Discusses phytotherapy in modern medicine, chemoprevention of disease, and alternatives to western medicines for specific diseases • Chapters summarizes the uses and applications of phytomedicines, by type like Chinese, Greco-Arab, Indian, European, and Ayurvedic • Includes international regulatory perspectives and discusses emerging regulations for various established and emerging markets
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Stabilisers, thickeners and gelling agents are extracted from a variety of natural raw materials and incorporated into foods to give the structure, flow, stability and eating qualities desired by consumers. These additives include traditional materials such as starch, a thickener obtained from many land plants; gelatine, an animal by-product giving characteristic melt-in-the-mouth gels; and cellulose, the most abundant structuring polymer in land plants. Seed gums and other materials derived from sea plants extend the range of polymers. Recently-approved additives include the microbial polysaccharides of xanthan, gellan and pullulan. This book is a highly practical guide to the use of polymers in food technology to stabilise, thicken and gel foods, resulting in consistent, high quality products. The information is designed to be easy to read and assimilate. New students will find chapters presented in a standard format, enabling key points to be located quickly. Those with more experience will be able to compare and contrast different materials and gain a greater understanding of the interactions that take place during food production. This concise, modern review of hydrocolloid developments will be a valuable teaching resource and reference text for all academic and practical workers involved in hydrocolloids in particular, and food development and production in general.
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Emerging Infectious Diseases offers an introduction to emerging and reemerging infectious disease, focusing on significant illnesses found in various regions of the world. Many of these diseases strike tropical regions or developing countries with particular virulence, others are found in temperate or developed areas, and still other microbes and infections are more indiscriminate. This volume includes information on the underlying mechanisms of microbial emergence, the technology used to detect them, and the strategies available to contain them. The author describes the diseases and their causative agents that are major factors in the health of populations the world over. The book contains up-to-date selections from infectious disease journals as well as information from the Centers for Disease Control and Prevention, the World Health Organization, MedLine Plus, and the American Society for Microbiology. Perfect for students or those new to the field, the book contains Summary Overviews (thumbnail sketches of the basic information about the microbe and the associated disease under examination), Review Questions (testing students' knowledge of the material), and Topics for Further Discussion (encouraging a wider conversation on the implications of the disease and challenging students to think creatively to develop new solutions). This important volume provides broad coverage of a variety of emerging infectious diseases, of which most are directly important to health practitioners in the United States.

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Treatment of Cerebral Palsy and Motor Delay is first and foremost a practical book, a distillation of Sophie Levitt’s considerable experience in treating those affected by cerebral palsy. This fifth edition outlines therapeutic approaches and suggests treatment and management options, providing a wealth of practical information, supported by clear diagrams and photographs, on assessment, management and treatment. The book emphasises an eclectic, holistic approach, and integrates current ideas on motor control and motor learning in a further development of Levitt’s Collaborative Learning Approach. This new edition provides greater commentary on evidence-based practice, as well as practical, updated information on the use of botulinum toxin, orthopaedic surgery and the therapist's role following these procedures. The book is aimed primarily at practitioners and students concerned with the developmental abilities and difficulties of children, particularly physiotherapists and occupational therapists working in paediatrics. Doctors and other healthcare professionals will also find useful insights in the book. Parents, families and also teachers of people with cerebral palsy can learn more about therapy by consulting the book together with their therapist. Written by an international authority in the field Extensively revised, updated and well referenced Emphasises an eclectic, functional and holistic approach Highly illustrated Promotes positive relationships between therapists, people with cerebral palsy and their families From the Foreword: «I greatly welcome the fifth edition of this book which brings together the management of cerebral palsies into a comprehensive but readable form… This book is in my view an essential part of both a therapist’s and doctor’s basic understanding of the subject… This book remains essential for those managing children with disability.» —Brian Neville, Professor of Childhood Epilepsy, Professor of Paediatric Neurology, University College London, Institute of Child Health/Great Ormond Street Hospital for Children NHS Trust.
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