oxidative stress dna damage in prostate tumours



Doris Abele Oxidative Stress in Aquatic Ecosystems Doris Abele Oxidative Stress in Aquatic Ecosystems Новинка

Doris Abele Oxidative Stress in Aquatic Ecosystems

13946.29 руб.
Reactive oxygen species (ROS) are increasingly appreciated as down-stream effectors of cellular damage and dysfunction under natural and anthropogenic stress scenarios in aquatic systems. This comprehensive volume describes oxidative stress phenomena in different climatic zones and groups of organisms, taking into account specific habitat conditions and how they affect susceptibility to ROS damage. A comprehensive and detailed methods section is included which supplies complete protocols for analyzing ROS production, oxidative damage, and antioxidant systems. Methods are also evaluated with respect to applicability and constraints for different types of research. The authors are all internationally recognized experts in particular fields of oxidative stress research. This comprehensive reference volume is essential for students, researchers, and technicians in the field of ROS research, and also contains information useful for veterinarians, environmental health professionals, and decision makers.
Frederick Villamena A. Molecular Basis of Oxidative Stress. Chemistry, Mechanisms, and Disease Pathogenesis Frederick Villamena A. Molecular Basis of Oxidative Stress. Chemistry, Mechanisms, and Disease Pathogenesis Новинка

Frederick Villamena A. Molecular Basis of Oxidative Stress. Chemistry, Mechanisms, and Disease Pathogenesis

11997.76 руб.
Sets the stage for the development of better diagnostic techniques and therapeutics Featuring contributions from an international team of leading clinicians and biomedical researchers, Molecular Basis of Oxidative Stress reviews the molecular and chemical bases of oxidative stress, describing how oxidative stress can lead to the development of cancer and cardiovascular and neurodegenerative diseases. Moreover, it explains the potential role of free radicals in both the diagnosis and the development of therapeutics to treat disease. Molecular Basis of Oxidative Stress is logically organized, beginning with a comprehensive discussion of the fundamental chemistry of reactive species. Next, the book: Presents new mechanistic insights into how oxidative damage of biomolecules occurs Examines how these oxidative events effect cellular metabolism Investigates the role of oxidative stress in the pathogenesis of cancer, neurodegenerative disease, cardiovascular disease, and cystic fibrosis Explores opportunities to improve the diagnosis of disease and the design of new therapeutic agents Readers will find much novel information, including new radical chemistries and the latest discoveries of how free radicals react with biomolecules. The contributors also present recent findings that help us better understand the initiation of oxidative stress and the mechanisms leading to the pathogenesis of various diseases. Throughout the book, the use of molecular structures helps readers better understand redox chemistry. In addition, plenty of detailed figures illustrate the mechanisms of oxidative stress and disease pathogenesis. Examining everything from the basic chemistry of oxidative stress to the pathogenesis of disease, Molecular Basis of Oxidative Stress will help readers continue to explore the nature of oxidative stress and then use that knowledge to develop new approaches to prevent, detect, and treat a broad range of disease conditions.
Donald Armstrong Oxidative Stress and Antioxidant Protection. The Science of Free Radical Biology and Disease Donald Armstrong Oxidative Stress and Antioxidant Protection. The Science of Free Radical Biology and Disease Новинка

Donald Armstrong Oxidative Stress and Antioxidant Protection. The Science of Free Radical Biology and Disease

11243.68 руб.
Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and< Disease provides an overview of the basic principles of free radical formation. The text delves into free radical formation in molecular biology and its effect on subcellular damage, as well as the role of antioxidant reserves as a protective mechanism. Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.
Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications Новинка

Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications

13121.77 руб.
Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur. The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed. Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways
Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set Новинка

Frans Bruijn J.de Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, 2 Volume Set

41240.57 руб.
Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
Crichton Robert Metal-Based Neurodegeneration. From Molecular Mechanisms to Therapeutic Strategies Crichton Robert Metal-Based Neurodegeneration. From Molecular Mechanisms to Therapeutic Strategies Новинка

Crichton Robert Metal-Based Neurodegeneration. From Molecular Mechanisms to Therapeutic Strategies

15862.82 руб.
Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.
Parvaiz Ahmad Water Stress and Crop Plants. A Sustainable Approach, 2 Volume Set Parvaiz Ahmad Water Stress and Crop Plants. A Sustainable Approach, 2 Volume Set Новинка

Parvaiz Ahmad Water Stress and Crop Plants. A Sustainable Approach, 2 Volume Set

26634.82 руб.
Plants are subjected to a variety of abiotic stresses such as drought, temperature, salinity, air pollution, heavy metals, UV radiations, etc. To survive under these harsh conditions plants are equipped with different resistance mechanisms which vary from species to species. Due to the environmental fluctuations agricultural and horticultural crops are often exposed to different environmental stresses leading to decreased yield and problems in the growth and development of the crops. Drought stress has been found to decrease the yield to an alarming rate of some important crops throughout the globe. During last few decades, lots of physiological and molecular works have been conducted under water stress in crop plants. Water Stress and Crop Plants: A Sustainable Approach presents an up-to-date in-depth coverage of drought and flooding stress in plants, including the types, causes and consequences on plant growth and development. It discusses the physiobiochemical, molecular and omic approaches, and responses of crop plants towards water stress. Topics include nutritional stress, oxidative stress, hormonal regulation, transgenic approaches, mitigation of water stress, approaches to sustainability, and modern tools and techniques to alleviate the water stress on crop yields. This practical book offers pragmatic guidance for scientists and researchers in plant biology, and agribusinesses and biotechnology companies dealing with agronomy and environment, to mitigate the negative effects of stress and improve yield under stress. The broad coverage also makes this a valuable guide enabling students to understand the physiological, biochemical, and molecular mechanisms of environmental stress in plants.
Eugen Stulz DNA in Supramolecular Chemistry and Nanotechnology Eugen Stulz DNA in Supramolecular Chemistry and Nanotechnology Новинка

Eugen Stulz DNA in Supramolecular Chemistry and Nanotechnology

12292.99 руб.
This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Many novel structures have been realized in the past decade, which are now being used to create molecular machines, drug delivery systems, diagnosis platforms or potential electronic devices. The book combines many aspects of DNA nanotechnology, including formation of functional structures based on covalent and non-covalent systems, DNA origami, DNA based switches, DNA machines, and alternative structures and templates. This broad coverage is very appealing since it combines both the synthesis of modified DNA as well as designer concepts to successfully plan and make DNA nanostructures. Contributing authors have provided first a general introduction for the non-specialist reader, followed by a more in-depth analysis and presentation of their topic. In this way the book is attractive and useful for both the non-specialist who would like to have an overview of the topic, as well as the specialist reader who requires more information and inspiration to foster their own research.
Kenneth Karlin D. Progress in Inorganic Chemistry Kenneth Karlin D. Progress in Inorganic Chemistry Новинка

Kenneth Karlin D. Progress in Inorganic Chemistry

13572.09 руб.
This series provides inorganic chemists and materials scientists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 59 continues to report recent advances with a significant, up-to-date selection of contributions by internationally-recognized researchers. The chapters of this volume are devoted to the following topics: • Iron Catalysis in Synthetic Chemistry • A New Paradigm for Photodynamic Therapy Drug Design: Multifunctional, Supramolecular DNA Photomodification Agents Featuring Ru(II)/Os(II) Light Absorbers Coupled to Pt(II) or Rh(III) Bioactive Sites • Selective Binding of Zn2+ Complexes to Non-Canonical Thymine or Uracil in DNA or RNA. • Progress Toward the Electrocatalytic Production of Liquid Fuels from Carbon Dioxide • Monomeric Dinitrosyl Iron Complexes: Synthesis and Reactivity • Interactions of Nitrosoalkanes/arenes, Nitrosamines, Nitrosothiols, and Alkyl Nitrites with Metals • Aminopyridine Iron and Manganese Complexes as Molecular Catalysts for Challenging Oxidative Transformations
Linacre Adrian Wildlife DNA Analysis. Applications in Forensic Science Linacre Adrian Wildlife DNA Analysis. Applications in Forensic Science Новинка

Linacre Adrian Wildlife DNA Analysis. Applications in Forensic Science

12257.29 руб.
DNA typing of non-human DNA is a fast developing area of research and professional practice. The application of DNA typing in wildlife forensic science is one of these prime uses of DNA typing and is gaining increasing profile. The use of DNA profiling in wildlife forensic science falls into two broad areas: species testing and genetic linkage. Species testing answers the question ‘what species is this?’ and genetic linkage answers the question ‘did these two samples come from the same organism or population?’ Wildlife DNA Analysis: Applications in Forensic Science provides an accessible introduction to both of these key areas. Clearly structured throughout, the introduction highlights the different types of crime where these techniques are regularly used. This chapter includes a discussion as to who performs forensic wildlife examinations, the standardisation and validation of methods, and the role of the expert witness in this type of alleged crime. This is followed by a detailed section on the science behind DNA typing including the problems in isolating DNA from trace material and subsequent genetic analysis are also covered. The book then undertakes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons. A comparison of the different markers used in species testing highlights the criteria for a genetic marker. A full set of case histories illustrates the use of the different markers used. The book details the use of genetic markers to link two or more hairs/feather/leaves/needles to the same individual organism and the software used in population assignment. The problems and possibilities in isolating markers, along with the construction of allele databases are discussed in this chapter. The book concludes with evaluation and reporting of genetic evidence in wildlife forensic science illustrated by examples of witness statements. •An accessible introduction to this fast developing area of research within forensic science •Case studies throughout to link theory and practice and to highlight the use of DNA testing in species testing. •Covers both crimes against wildlife and offences where wildlife can provide vital evidence •Assumes only a basic background knowledge of DNA •Includes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons
Mei-yung Leung Stress Management in the Construction Industry Mei-yung Leung Stress Management in the Construction Industry Новинка

Mei-yung Leung Stress Management in the Construction Industry

10497.42 руб.
This systematic review of stress management in construction will help an understanding of the issues and theory as well as offering practical recommendations. addresses the growing concern to make work in construction healthier, safer, and more productive integrates research results, survey statistics and scenario analyses to reveal underlying causes of stress offers recommendations for reducing Stress
Vera Peiffer 20 MINUTES TO MASTER … STRESS MANAGEMENT Vera Peiffer 20 MINUTES TO MASTER … STRESS MANAGEMENT Новинка

Vera Peiffer 20 MINUTES TO MASTER … STRESS MANAGEMENT

152.99 руб.
Stress can damage your personal and professional life, creating anger, a lack of concentration and nervous behaviour. The key to overcoming it isn’t suppressing your stress – it’s understanding it.With this book, you can learn how to identify the symptoms and causes of stress, an how to use that knowledge to rise above it – in just 20 minutes.Everyone experiences stress, but not everyone knows how to deal with it. 20 Minutes to Master Stress Management will show you how to neutralise the stressful forces in your life and develop a positive, purposeful and calm attitude, tailored to your emotional makeup, that you can live with every day.You’ll learn the key facts about identifying stress and overcoming it, including:• The symptoms of stress – both universal and unique to you – and warning signs to watch out for• How to relax in both short and long term, while still achieving your goals• How to avoid damaging thought patterns• How to identify stressful relationships and neutralise them.Previously published as Principles of Stress Management, this ebook brings together classic text from an expert in the field with a new chapter, placed at the end of the book, which condenses all the ideas and techniques into a simple and digestible 20-minute read.20 Minutes to Master Stress Management is your key to feeling calmer, more satisfied and more confident every day.This is part of the 20 Minutes to Master series, five indispensable guides that show you how to transform your life in simple and effective ways. Other titles in the series include 20 Minutes to Master Meditation, 20 Minutes to Master Buddhism, 20 Minutes to Master Your Psychic Potential and 20 Minutes to Master Wicca.
Wei Liu Oxidative Cross-Coupling Reactions Wei Liu Oxidative Cross-Coupling Reactions Новинка

Wei Liu Oxidative Cross-Coupling Reactions

14247.21 руб.
The first handbook on this emerging field provides a comprehensive overview of transition metal-catalyzed coupling reactions in the presence of an oxidant. Following an introduction to the general concept and mechanism of this reaction class, the team of authors presents chapters on C-C cross-coupling reactions using organometallic partners, C-Heteroatom bond forming reactions via oxidative couplings, and C-H couplings via C-H activation. The text also covers such groundbreaking topics as recent achievements in the fields of C-C and C-X bond formation reactions as well as C-H activation involving oxidative couplings. With its novel and concise approach towards important building blocks in organic chemistry and its focus on synthetic applications, this handbook is of great interest to all synthetic chemists in academia and industry alike.
Kevin Murphy D. Modeling and Estimation of Structural Damage Kevin Murphy D. Modeling and Estimation of Structural Damage Новинка

Kevin Murphy D. Modeling and Estimation of Structural Damage

9014.86 руб.
Modelling and Estimation of Damage in Structures is a comprehensiveguide to solving the type of modelling and estimation problems associated with the physics of structural damage. Provides a model-based approach to damage identification Presents an in-depth treatment of probability theory and random processes Covers both theory and algorithms for implementing maximum likelihood and Bayesian estimation approaches Includes experimental examples of all detection and identification approaches Provides a clear means by which acquired data can be used to make decisions regarding maintenance and usage of a structure
Emma Donaldson-Feilder Preventing Stress in Organizations. How to Develop Positive Managers Emma Donaldson-Feilder Preventing Stress in Organizations. How to Develop Positive Managers Новинка

Emma Donaldson-Feilder Preventing Stress in Organizations. How to Develop Positive Managers

9143.62 руб.
Preventing Stress in Organizations:How to Develop Positive Managersoffers an innovative, evidence-based approach to help managers prevent and reduce workplace stress in their staff. Winner of the 2013 BPS Book Award – Practitioner Text category Provides information on the critical skills managers must develop in order to prevent stress in their staff, and the key ongoing behaviours that promote a healthy work environment Shows practitioners in occupational psychology, HR, Health and Safety and related professions how positive management can be integrated into an organization’s existing practices and processes Serves as an essential guide for managers themselves on how to incorporate proven stress management skills into their everyday interactions with team members Balances rigorous research grounding with real-world vignettes, case studies and exercises
Prokar Dasgupta ABC of Prostate Cancer Prokar Dasgupta ABC of Prostate Cancer Новинка

Prokar Dasgupta ABC of Prostate Cancer

3070.4 руб.
Prostate cancer is the most common cancer in men in the UK and US and the second most common worldwide. The ABC of Prostate Cancer provides fully illustrated guidance on the treatment and management of prostate cancer. It covers the biology, anatomy, and pathology of prostate cancer, screening, and active surveillance and monitoring. It presents an assessment of treatment options including prostatectomy, bracytherapy, chemotherapy and immunotherapy, along with modern diagnostic tests and an overview of new approaches to prostate cancer. With an international author team, the ABC of Prostate Cancer is ideal for general practitioners, family physicians, specialist nurses, junior doctors, medical students and others working with prostate cancer patients and their families.
James Segars H. Fibroids James Segars H. Fibroids Новинка

James Segars H. Fibroids

7047.84 руб.
Fibroids are benign growths of the uterus. They are the most common tumours found in women (20-30% of women), usually in later reproductive years. This book covers evidence-based indications for treatment of uterine fibroids in gynecology, the management of fibroids in pregnancy, surgical treatments and outcomes, rare fibroid syndromes, and more.
Manit Arya Focal Therapy in Prostate Cancer Manit Arya Focal Therapy in Prostate Cancer Новинка

Manit Arya Focal Therapy in Prostate Cancer

10718.66 руб.
This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.
Ari Kiev Mastering Trading Stress. Strategies for Maximizing Performance Ari Kiev Mastering Trading Stress. Strategies for Maximizing Performance Новинка

Ari Kiev Mastering Trading Stress. Strategies for Maximizing Performance

3189.81 руб.
In Mastering Trading Stress, author Ari Kiev—a psychiatrist who specializes in stress management and works extensively with traders—offers examples, transcripts of conversations, and personality profiles of real-life traders to illustrate how stress affects their ability to perform at their best. Drawing on his vast experience, Kiev describes a variety of practical techniques that can be used to handle destructive emotions and out-of-control feelings, including his “Most Basic” stress busters, and tells what to do if a breakdown should occur.
Allen Elkin Stress Management For Dummies Allen Elkin Stress Management For Dummies Новинка

Allen Elkin Stress Management For Dummies

1465.86 руб.
Tired of letting stress have a negative impact on your life? Easy. It's impossible to get through life without encountering stress. And unfortunately, most of us learn the incorrect ways to cope with it. Thankfully, Stress Management For Dummies gives you trusted, time-tested guidance on teaching your body and mind to properly cope with stress while keeping your sanity intact. Whether it's love, work, family, or something else that has you in the red zone, this updated edition of Stress Management For Dummies will help you identify the stress triggers in your life and cut them down to size – all without losing your cool. Shows you how to use stress in a positive, motivational way instead of letting it negatively affect your life Teaches you to retrain your body and mind to react positively to stress Helps you overcome common stresses faced in modern life If you want to manage stress and get back to living a normal life, Stress Management For Dummies has you covered.
John Russell A. Neuroendocrinology of Stress John Russell A. Neuroendocrinology of Stress Новинка

John Russell A. Neuroendocrinology of Stress

7683.12 руб.
Exposure to chronic stress has cumulative adverse effects on physical and mental health, considered to be the consequence of chronic exposure to high levels of stress hormones. Consequently, there is extensive research in progress to investigate and better understand how the brain organises neuroendocrine stress responses and how interventions may be able to moderate these responses to improve mental and physical health. Neuroendocrinology of Stress highlights current knowledge of the organisation and physiology of these stress response systems, how the impact of dysregulation of these systems is being investigated, and considers the ways in which contributions to both psychiatric and physical diseases resulting from chronic stress effects can be critically addressed in basic research Written by a team of internationally renowned researchers, each chapter presents a succinct summary of the very latest developments in the field Both print and enhanced e-book versions are available Illustrated in full colour throughout This is the second volume in a new Series «Masterclass in Neuroendocrinology», a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA
Paul Hasegawa M. Plant Abiotic Stress Paul Hasegawa M. Plant Abiotic Stress Новинка

Paul Hasegawa M. Plant Abiotic Stress

15967.37 руб.
A fully revised review of the latest research in molecular basis of plant abiotic stress response and adaptation Abiotic stressors are non-living environmental stressors that can have a negative impact on a plants ability to grow and thrive in a given environment. Stressors can range from temperature stress (both extreme heat and extreme cold) water stress, aridity, salinity among others. This book explores the full gamut of plant abiotic stressors and plants molecular responses and adaptations to adverse environmental conditions. The new edition of Plant Abiotic Stress provides up-to-date coverage of the latest research advances in plant abiotic stress adaptation, with special emphasis on the associated and integrative aspects of physiology, signaling, and molecular-genetics. Since the last edition, major advances in whole genome analysis have revealed previously unknown linkages between genes, genomes, and phenotypes, and new biological and –omics approaches have elucidated previously unknown cellular mechanisms underlying stress tolerance. Chapters are organized by topic, but highlight processes that are integrative among diverse stress responses. As with the first edition, Plant Abiotic Stress will have broad appeal to scientists in fields of applied agriculture, ecology, plant sciences, and biology.
Sophia Kathariou DNA Methods in Food Safety. Molecular Typing of Foodborne and Waterborne Bacterial Pathogens Sophia Kathariou DNA Methods in Food Safety. Molecular Typing of Foodborne and Waterborne Bacterial Pathogens Новинка

Sophia Kathariou DNA Methods in Food Safety. Molecular Typing of Foodborne and Waterborne Bacterial Pathogens

15443.07 руб.
Molecular typing of foodborne pathogens has become an indispensable tool in epidemiological studies. Thanks to these techniques, we now have a better understanding of the distribution and appearance of bacterial foodborne diseases and have a deeper knowledge of the type of food products associated with the major foodborne pathogens. Within the molecular techniques, DNA-based techniques have prospered for more than 40 years and have been incorporated in the first surveillance systems to monitor bacterial foodborne pathogens in the United States and other countries. However, DNA techniques vary widely and many microbiology laboratory personnel working with food and/or water face the dilemma of which method to incorporate. DNA Methods in Food Safety: Molecular Typing of Foodborne and Waterborne Bacterial Pathogens succinctly reviews more than 25 years of data on a variety of DNA typing techniques, summarizing the different mathematical models for analysis and interpretation of results, and detailing their efficacy in typing different foodborne and waterborne bacterial pathogens, such as Campylobacter, Clostridium perfringens, Listeria, Salmonella, among others. Section I describes the different DNA techniques used in the typing of bacterial foodborne pathogens, whilst Section II deals with the application of these techniques to type the most important bacterial foodborne pathogens. In Section II the emphasis is placed on the pathogen, and each chapter describes some of the most appropriate techniques for typing each bacterial pathogen. The techniques presented in this book are the most significant in the study of the molecular epidemiology of bacterial foodborne pathogens to date. It therefore provides a unique reference for students and professionals in the field of microbiology, food and water safety and epidemiology and molecular epidemiology.
Benjamin Bonetti How To Stress Less. Simple ways to stop worrying and take control of your future Benjamin Bonetti How To Stress Less. Simple ways to stop worrying and take control of your future Новинка

Benjamin Bonetti How To Stress Less. Simple ways to stop worrying and take control of your future

1147.69 руб.
Say goodbye to stress for good! It’s a fact – stress kills! Yet, so many of us find ourselves stressed out, day to day. However, if you are feeling anxious, find it hard to relax or perhaps struggle to get rid of that constant mental ache, let celebrated life-coach and mentor Benjamin Bonetti show you how to chill. In his latest title, How To Stress Less, Benjamin shows you how to combat stress by taking action and intentionally rejecting it when it rears its ugly head. How To Stress Less provides you with an easy to follow guide to help you effectively release and manage everyday stress that can seriously affect your health. Benjamin does not promise to wave a magic wand to make your troubles disappear. Rather, he addresses the impact of stress and helps you deal with deep-seated issues surrounding common reasons we find ourselves stressed out in the first place. In this forward thinking stress manual, How To Stress Less offers: Guidance and advice which has helped many of Benjamin’s clients free their lives of stress Practical tips to address the issues that trigger everyday stress as well as tips on how to respond Effective solutions to quit worrying for good and learn to relax
Christian Wittekind TNM Classification of Malignant Tumours Christian Wittekind TNM Classification of Malignant Tumours Новинка

Christian Wittekind TNM Classification of Malignant Tumours

4345.23 руб.
TNM Classification of Malignant Tumours eighth edition provides the latest, internationally agreed-upon standards to describe and categorize cancer stage. Published in affiliation with the Union for International Cancer Control (UICC) Arranged by anatomical region, this authoritative pocket sized guide contains many important updated organ-specific classifications There are new classifications for p16 positive oropharyngeal carcinomas, carcinomas of the thymus, neuroendocrine tumours of the pancreas, and sarcomas To facilitate the collection of stage data for cancer surveillance in low and middle income countries there are new sections on Essential TNM and Paediatric Cancer Stage New colour presentation Erratum TNM Classification of Malignant Tumours, 8th edition is available as an app for iOS and Android. This Wiley app-book is developed by MedHand Mobile Libraries. Improve your performance with relevant, valid material which is accessed quickly and with minimal effort in the palm of your hand using MedHand's patented technology. Click here to buy online or to find out more
Ashutosh Tiwari DNA Engineered Noble Metal Nanoparticles. Fundamentals and State-of-the-Art of Nanobiotechnology Ashutosh Tiwari DNA Engineered Noble Metal Nanoparticles. Fundamentals and State-of-the-Art of Nanobiotechnology Новинка

Ashutosh Tiwari DNA Engineered Noble Metal Nanoparticles. Fundamentals and State-of-the-Art of Nanobiotechnology

16871.56 руб.
There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal nanoparticles/biomolecules conjugates have specific properties and therefore they are attractive materials for nanotechnology in biochemistry and medicine. In this book, the author review work performed dealing with the DNA structure and functionalities, interactions between DNA, noble metal nanoparticles, surface active agents, solvents and other additives. Particular attention is given to how the DNA’s chain length and the DNA conformation affect the interaction and structure of the nanoconjugates and nanostructures that are formed. Also discussed are the recent advances in the preparation, characterization, and applications of noble metal nanoparticles that are conjugated with DNA aptamers and oligomers. The advantages and disadvantages of functionalized nanoparticles through various detection modes are highlighted, including colorimetry, fluorescence, electrochemistry, SPR, and, mass spectrometry for the detection of small molecules and biomolecules. The functionalized noble metal nanoparticles are selective and sensitive for the analytes, showing their great potential in biosensing. Furthermore, this book reviews recent progress in the area of DNA-noble metal nanoparticles based artificial nanostructures, that is, the preparation, collective properties, and applications of various DNA-based nanostructures are also described.
Narendra Tuteja Abiotic Stress Response in Plants Narendra Tuteja Abiotic Stress Response in Plants Новинка

Narendra Tuteja Abiotic Stress Response in Plants

14993.47 руб.
Understanding abiotic stress responses in plants is critical for the development of new varieties of crops, which are better adapted to harsh climate conditions. The new book by the well-known editor team Narendra Tuteja and Sarvajeet Gill provides a comprehensive overview on the molecular basis of plant responses to external stress like drought or heavy metals, to aid in the engineering of stress resistant crops. After a general introduction into the topic, the following sections deal with specific signaling pathways mediating plant stress response. The last part covers translational plant physiology, describing several examples of the development of more stress-resistant crop varieties.
Allan Jamieson A Guide to Forensic DNA Profiling Allan Jamieson A Guide to Forensic DNA Profiling Новинка

Allan Jamieson A Guide to Forensic DNA Profiling

10872.33 руб.
The increasingly arcane world of DNA profiling demands that those needing to understand at least some of it must find a source of reliable and understandable information. Combining material from the successful Wiley Encyclopedia of Forensic Science with newly commissioned and updated material, the Editors have used their own extensive experience in criminal casework across the world to compile an informative guide that will provide knowledge and thought-provoking articles of interest to anyone involved or interested in the use of DNA in the forensic context. Following extensive introductory chapters covering forensic DNA profiling and forensic genetics, this comprehensive volume presents a substantial breadth of material covering: Fundamental material – including sources of DNA, validation, and accreditation Analysis and interpretation – including, extraction, quantification, amplification and interpretation of electropherograms (epgs) Evaluation – including mixtures, low template, and transfer Applications – databases, paternity and kinship, mitochondrial-DNA, wildlife DNA, single-nucleotide polymorphism, phenotyping and familial searching Court – report writing, discovery, cross examination, and current controversies With contributions from leading experts across the whole gamut of forensic science, this volume is intended to be authoritative but not authoritarian, informative but comprehensible, and comprehensive but concise. It will prove to be a valuable addition, and useful resource, for scientists, lawyers, teachers, criminologists, and judges.
Christian Lalanne Mechanical Vibration and Shock Analysis, Fatigue Damage Christian Lalanne Mechanical Vibration and Shock Analysis, Fatigue Damage Новинка

Christian Lalanne Mechanical Vibration and Shock Analysis, Fatigue Damage

15858.99 руб.
Fatigue damage in a system with one degree of freedom is one of the two criteria applied when comparing the severity of vibratory environments. The same criterion is also used for a specification representing the effects produced by the set of vibrations imposed in a real environment. In this volume, which is devoted to the calculation of fatigue damage, Christian Lalanne explores the hypotheses adopted to describe the behavior of material affected by fatigue and the laws of fatigue accumulation. The author also considers the methods for counting response peaks, which are used to establish the histogram when it is not possible to use the probability density of the peaks obtained with a Gaussian signal. The expressions for mean damage and its standard deviation are established and other hypotheses are tested.
Henry Thompson L. The Stress Effect. Why Smart Leaders Make Dumb Decisions--And What to Do About It Henry Thompson L. The Stress Effect. Why Smart Leaders Make Dumb Decisions--And What to Do About It Новинка

Henry Thompson L. The Stress Effect. Why Smart Leaders Make Dumb Decisions--And What to Do About It

1719.4 руб.
Reveals the powerful and undermining effects of stress on good decision making-and what leaders can do about it The ability to make sound and timely decisions is the mark of a good leader. But when leaders with otherwise strong track records suddenly begin making poor decisions-as seen in the recent corporate scandals that rocked the business world-the impact can be widespread. In The Stress Effect, leadership expert Henry L. Thompson argues that stress is often the real culprit behind this leadership failure: when leaders' stress levels become sufficiently elevated-whether in the boardroom or on the front line of a manufacturing process-their ability to effectively use their emotional intelligence and cognitive ability in tandem to make wise decisions is significantly impaired. Until now, experts have argued that increasing your emotional intelligence will help you cope with and manage stress. This book suggests that stress actually blocks access to your emotional intelligence as well as your cognitive ability, two critical components in the decision-making process. This book Shows how stress adversely affects the performance of even the most savvy leaders Reveals the truth about one of the prime factors behind the current failure of leadership Offers a solid prescription for building a «stress resilient system» and arms leaders with best practices for managing specific stressors that take the biggest toll on decision making Is written by an award-winning organizational psychologist and leadership consultant whose clients include a roster of Fortune 500 companies A groundbreaking and insightful resource for leaders, The Stress Effect reopens the dialogue on stress, its effect on decision making, and what to do about it.
Y. Cheng Frank Stress Corrosion Cracking of Pipelines Y. Cheng Frank Stress Corrosion Cracking of Pipelines Новинка

Y. Cheng Frank Stress Corrosion Cracking of Pipelines

10498.58 руб.
Explains why pipeline stress corrosion cracking happens and how it can be prevented Pipelines sit at the heart of the global economy. When they are in good working order, they deliver fuel to meet the ever-growing demand for energy around the world. When they fail due to stress corrosion cracking, they can wreak environmental havoc. This book skillfully explains the fundamental science and engineering of pipeline stress corrosion cracking based on the latest research findings and actual case histories. The author explains how and why pipelines fall prey to stress corrosion cracking and then offers tested and proven strategies for preventing, detecting, and monitoring it in order to prevent pipeline failure. Stress Corrosion Cracking of Pipelines begins with a brief introduction and then explores general principals of stress corrosion cracking, including two detailed case studies of pipeline failure. Next, the author covers: Near-neutral pH stress corrosion cracking of pipelines High pH stress corrosion cracking of pipelines Stress corrosion cracking of pipelines in acidic soil environments Stress corrosion cracking at pipeline welds Stress corrosion cracking of high-strength pipeline steels The final chapter is dedicated to effective management and mitigation of pipeline stress corrosion cracking. Throughout the book, the author develops a number of theoretical models and concepts based on advanced microscopic electrochemical measurements to help readers better understand the occurrence of stress corrosion cracking. By examining all aspects of pipeline stress corrosion cracking—the causes, mechanisms, and management strategies—this book enables engineers to construct better pipelines and then maintain and monitor them to ensure safe, reliable energy supplies for the world.
Kimberly Paffett S. Radiation Biology of Medical Imaging Kimberly Paffett S. Radiation Biology of Medical Imaging Новинка

Kimberly Paffett S. Radiation Biology of Medical Imaging

8019.61 руб.
This book provides a thorough yet concise introduction to quantitative radiobiology and radiation physics, particularly the practical and medical application. Beginning with a discussion of the basic science of radiobiology, the book explains the fast processes that initiate damage in irradiated tissue and the kinetic patterns in which such damage is expressed at the cellular level. The final section is presented in a highly practical handbook style and offers application-based discussions in radiation oncology, fractionated radiotherapy, and protracted radiation among others. The text is also supplemented by a Web site.
Tahira Farooqui Metabolic Syndrome and Neurological Disorders Tahira Farooqui Metabolic Syndrome and Neurological Disorders Новинка

Tahira Farooqui Metabolic Syndrome and Neurological Disorders

15967.37 руб.
Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome – abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension – to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders. Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.
Heidi Hanna Stressaholic. 5 Steps to Transform Your Relationship with Stress Heidi Hanna Stressaholic. 5 Steps to Transform Your Relationship with Stress Новинка

Heidi Hanna Stressaholic. 5 Steps to Transform Your Relationship with Stress

1275.21 руб.
A guidebook for the journey from exhaustion to enlightenment Chronic multitasking and ever-increasing demands on our time and energy have caused a neurochemically-based dependence on sources of stress and stimulation to provide fuel for our chaotic lifestyles. While this may boost performance in the short-term, studies have consistently shown that when stress hormones are elevated over time they create the worst form of internal wear and tear; decreasing productivity, wasting time, and even killing brain cells. As a result, modern society is tired and wired, suffering from physical exhaustion while mentally amped up, and unable to get adequate rest. Stress in and of itself is not bad, and is actually utilized for growth when balanced with adequate recovery. The solution to stress addiction is to build in and prioritize optimal rest and relaxation on a holistic level—body, mind, and spirit—in order to consistently recharge and create a more resilient operating system. Stressaholic shows you how to win the war on stress without limiting progress by creating an optimal performance pulse of stress and recovery for life. Explains the impact of chronic stress on the human operating system; body, mind, and spirit Shows how a simple shift in mindset can dramatically alter physiological responses to stress Reveals simple techniques for altering daily stress patterns to improve natural rhythms, creating a personalized performance pulse With easy to implement tips and real-world examples of people and organizations that have turned stress into sustainable drive, Stressaholic will guide you on your journey from exhaustion to enlightenment!
Simone Шампунь Oxigen+DNA, 200 мл Simone Шампунь Oxigen+DNA, 200 мл Новинка

Simone Шампунь Oxigen+DNA, 200 мл

1515 руб.
Предотвращает выпадение волос.
Varshney Rajeev Translational Genomics for Crop Breeding. Volume 1 - Biotic Stress Varshney Rajeev Translational Genomics for Crop Breeding. Volume 1 - Biotic Stress Новинка

Varshney Rajeev Translational Genomics for Crop Breeding. Volume 1 - Biotic Stress

16318.78 руб.
Genomic Applications for Crop Breeding: Biotic Stress is the first of two volumes looking at the latest advances in genomic applications to crop breeding. This volume focuses on genomic-assisted advances for improving economically important crops against biotic stressors, such as viruses, fungi, nematodes, and bacteria. Looking at key advances in crops such as rice, barley, wheat, and potato amongst others, Genomic Applications for Crop Breeding: Biotic Stress will be an essential reference for crop scientists, geneticists, breeders, industry personnel and advanced students in the field.
Printio Dna tree / древо днк Printio Dna tree / древо днк Новинка

Printio Dna tree / древо днк

900 руб.
Обложка для паспорта — материал: ПОЛИЭСТЕР.
Printio Dna tree / древо днк Printio Dna tree / древо днк Новинка

Printio Dna tree / древо днк

1370 руб.
Лонгслив — цвет: ЧЁРНЫЙ, пол: МУЖ.

кешбака
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Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
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