science a discovery in comics



Jie Jack Li Drug Discovery. Practices, Processes, and Perspectives Jie Jack Li Drug Discovery. Practices, Processes, and Perspectives Новинка

Jie Jack Li Drug Discovery. Practices, Processes, and Perspectives

9973.3 руб.
Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.
Wixom Robert L. Chromatography. A Science of Discovery Wixom Robert L. Chromatography. A Science of Discovery Новинка

Wixom Robert L. Chromatography. A Science of Discovery

9019.88 руб.
Leading researchers discuss the past and present of chromatography More than one hundred years after Mikhail Tswett pioneered adsorption chromatography, his separation technique has developed into an important branch of scientific study. Providing a full portrait of the discipline, Chromatography: A Science of Discovery bridges the gap between early, twentieth-century chromatography and the cutting edge of today’s research. Featuring contributions from more than fifty award-winning chromatographers, Chromatography offers a multifaceted look at the development and maturation of this field into its current state, as well as its importance across various scientific endeavors. The coverage includes: Consideration of chromatography as a unified science rather than just a separation method Key breakthroughs, revolutions, and paradigm shifts in chromatography Profiles of Nobel laureates who used chromatography in their research, and the role it played Recent advances in column technology Chromatography’s contributions to the agricultural, space, biological/medical sciences; pharmaceutical science; and environmental, natural products, and chemical analysis Future trends in chromatography With numerous references and an engaging series of voices, Chromatography: A Science of Discovery offers a diverse look at an essential area of science. It is a unique and invaluable resource for researchers, students, and other interested readers who seek a broader understanding of this field.
Kathleen Susman M. Discovery-Based Learning in the Life Sciences Kathleen Susman M. Discovery-Based Learning in the Life Sciences Новинка

Kathleen Susman M. Discovery-Based Learning in the Life Sciences

4870.68 руб.
For nearly a decade, scientists, educators and policy makers have issued a call to college biology professors to transform undergraduate life sciences education. As a gateway science for many undergraduate students, biology courses are crucial to addressing many of the challenges we face, such as climate change, sustainable food supply and fresh water and emerging public health issues. While canned laboratories and cook-book approaches to college science education do teach students to operate equipment, make accurate measurements and work well with numbers, they do not teach students how to take a scientific approach to an area of interest about the natural world. Science is more than just techniques, measurements and facts; science is critical thinking and interpretation, which are essential to scientific research. Discovery-Based Learning in the Life Sciences presents a different way of organizing and developing biology teaching laboratories, to promote both deep learning and understanding of core concepts, while still teaching the creative process of science. In eight chapters, the text guides undergraduate instructors in creating their own discovery-based experiments. The first chapter introduces the text, delving into the necessity of science education reform. The chapters that follow address pedagogical goals and desired outcomes, incorporating discovery-based laboratory experiences, realistic constraints on such lab experiments, model scenarios, and alternate ways to enhance student understanding. The book concludes with a reflection on four imperatives in life science research– climate, food, energy and health– and how we can use these laboratory experiments to address them. Discovery-Based Learning in the Life Sciences is an invaluable guide for undergraduate instructors in the life sciences aiming to revamp their curriculum, inspire their students and prepare them for careers as educated global citizens.
Benjamin Miller L. Dynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science Benjamin Miller L. Dynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science Новинка

Benjamin Miller L. Dynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science

8008.59 руб.
Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science. Chapters cover: Basic theory Approaches to binding in proteins and nucleic acids Molecular recognition Self-sorting Catalyst discovery Materials discovery Analytical chemistry challenges A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.
Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad Новинка

Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad

17421.31 руб.
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
Mourad Elloumi Biological Knowledge Discovery Handbook. Preprocessing, Mining and Postprocessing of Biological Data Mourad Elloumi Biological Knowledge Discovery Handbook. Preprocessing, Mining and Postprocessing of Biological Data Новинка

Mourad Elloumi Biological Knowledge Discovery Handbook. Preprocessing, Mining and Postprocessing of Biological Data

14022.96 руб.
The first comprehensive overview of preprocessing, mining, and postprocessing of biological data Molecular biology is undergoing exponential growth in both the volume and complexity of biological data—and knowledge discovery offers the capacity to automate complex search and data analysis tasks. This book presents a vast overview of the most recent developments on techniques and approaches in the field of biological knowledge discovery and data mining (KDD)—providing in-depth fundamental and technical field information on the most important topics encountered. Written by top experts, Biological Knowledge Discovery Handbook: Preprocessing, Mining, and Postprocessing of Biological Data covers the three main phases of knowledge discovery (data preprocessing, data processing—also known as data mining—and data postprocessing) and analyzes both verification systems and discovery systems. BIOLOGICAL DATA PREPROCESSING Part A: Biological Data Management Part B: Biological Data Modeling Part C: Biological Feature Extraction Part D Biological Feature Selection BIOLOGICAL DATA MINING Part E: Regression Analysis of Biological Data Part F Biological Data Clustering Part G: Biological Data Classification Part H: Association Rules Learning from Biological Data Part I: Text Mining and Application to Biological Data Part J: High-Performance Computing for Biological Data Mining Combining sound theory with practical applications in molecular biology, Biological Knowledge Discovery Handbook is ideal for courses in bioinformatics and biological KDD as well as for practitioners and professional researchers in computer science, life science, and mathematics.
Rem Word Living science. Naturalist Comics Rem Word Living science. Naturalist Comics Новинка

Rem Word Living science. Naturalist Comics

44 руб.
The speed of light. Perpetual Motion. Time Machine. Antigravity. Communication of similar forms. Teleportation. Sensational experiences on the kitchen table. Classical science. The world is in a new light. It is more expensive than money.
Ian Redpath e-Discovery For Dummies Ian Redpath e-Discovery For Dummies Новинка

Ian Redpath e-Discovery For Dummies

2073.78 руб.
Discover the process of e-discovery and put good practices in place. Electronic information involved in a lawsuit requires a completely different process for management and archiving than paper information. With the recent change to Federal Rules of Civil Procedure making all lawsuits subject to e-discovery as soon as they are filed, it is more important than ever to make sure that good e-discovery practices are in place. e-Discovery For Dummies is an ideal beginner resource for anyone looking to understand the rules and implications of e-discovery policy and procedures. This helpful guide introduces you to all the most important information for incorporating legal, technical, and judicial issues when dealing with the e-discovery process. You'll learn the various risks and best practices for a company that is facing litigation and you'll see how to develop an e-discovery strategy if a company does not already have one in place. E-discovery is the process by which electronically stored information sought, located, secured, preserved, searched, filtered, authenticated, and produced with the intent of using it as evidence Addresses the rules and process of e-discovery and the implications of not having good e-discovery practices in place Explains how to develop an e-discovery strategy if a company does not have one in place e-Discovery For Dummies will help you discover the process and best practices of managing electronic information for lawsuits.
Hirsch Andy Science Comics: Trees: Kings of the Forest Hirsch Andy Science Comics: Trees: Kings of the Forest Новинка

Hirsch Andy Science Comics: Trees: Kings of the Forest

1208 руб.
Every volume of Science Comics offers a complete introduction to a particular topic-dinosaurs, coral reefs, the solar system, volcanoes, bats, flying machines, and many more. These gorgeously illustrated graphic novels offer wildly entertaining views of their subjects. Whether you're a fourth grader doing a natural science unit at school or a thirty-year-old with a secret passion for airplanes, these books are for you! This volume: In Trees we follow an acorn as it learns about its future as Earth's largest, longest-living plant. Starting with the seed's germination, we learn about each stage until the tree's maturation, different types of trees, and the roles trees take on in our ecosystem.
Hirsch Andy Science Comics: Dogs: From Predator to Protector Hirsch Andy Science Comics: Dogs: From Predator to Protector Новинка

Hirsch Andy Science Comics: Dogs: From Predator to Protector

1208 руб.
How well do you know our favorite furry companion? Did they really descend from wolves? What's the difference between a Chihuahua and a Saint Bernard? And just how smart are they? Join one friendly mutt on a journey to discover the secret origin of dogs, how genetics and evolution shape species, and where in the world his favorite ball bounced off to. Every volume of Science Comics offers a complete introduction to a particular topic dinosaurs, coral reefs, the solar system, volcanoes, bats, flying machines, and more. These gorgeously illustrated graphic novels offer wildly entertaining views of their subjects. Whether you're a fourth grader doing a natural science unit at school or a thirty year old with a secret passion for airplanes, these books are for you!
Mark Largent A. A Companion to the History of American Science Mark Largent A. A Companion to the History of American Science Новинка

Mark Largent A. A Companion to the History of American Science

15369.05 руб.
A Companion to the History of American Science offers a collection of essays that give an authoritative overview of the most recent scholarship on the history of American science. Covers topics including astronomy, agriculture, chemistry, eugenics, Big Science, military technology, and more Features contributions by the most accomplished scholars in the field of science history Covers pivotal events in U.S. history that shaped the development of science and science policy such as WWII, the Cold War, and the Women’s Rights movement
Jens-Uwe Peters Polypharmacology in Drug Discovery Jens-Uwe Peters Polypharmacology in Drug Discovery Новинка

Jens-Uwe Peters Polypharmacology in Drug Discovery

10657.38 руб.
An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the «one drug, one target» philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.
Jorgen Nordenstrom The Hunt for the Parathyroids Jorgen Nordenstrom The Hunt for the Parathyroids Новинка

Jorgen Nordenstrom The Hunt for the Parathyroids

2796.59 руб.
The Hunt for the Parathyroid Gland is a part fact, part fiction overview of the discovery of the parathyroid gland by a Swedish scientist in 1880. The discovery of the parathyroid gland in humans in 1880 by an unknown Swedish medical student, Ivar Viktor Sandström, ended a 30 year search for its exact location within the human body, following its discovery in an Indian rhino 30 years before. It is one of the most engaging and remarkable stories in the history of medicine. This book offers a fascinating insight into its discovery. Endocrinologists and ENT health professionals, both in clinical practice and researchers, as well as anyone with an interest in the history of medicine, will find this a fascinating insight into one of the 19th century’s key medical discoveries.
Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools Новинка

Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools

11590.87 руб.
Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.
Urban Laszlo Predictive ADMET. Integrated Approaches in Drug Discovery and Development Urban Laszlo Predictive ADMET. Integrated Approaches in Drug Discovery and Development Новинка

Urban Laszlo Predictive ADMET. Integrated Approaches in Drug Discovery and Development

12057.62 руб.
This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.
Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development Новинка

Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development

10812.96 руб.
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development Новинка

Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development

14935.89 руб.
A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Aaron Meskin The Art of Comics. A Philosophical Approach Aaron Meskin The Art of Comics. A Philosophical Approach Новинка

Aaron Meskin The Art of Comics. A Philosophical Approach

7720.81 руб.
The Art of Comics is the first-ever collection of essays published in English devoted to the philosophical topics raised by comics and graphic novels. In an area of growing philosophical interest, this volume constitutes a great leap forward in the development of this fast expanding field, and makes a powerful contribution to the philosophy of art. The first-ever anthology to address the philosophical issues raised by the art of comics Provides an extensive and thorough introduction to the field, and to comics more generally Responds to the increasing philosophical interest in comic art Includes a preface by the renowned comics author Warren Ellis Many of the chapters are illustrated, and the book carries a stunning cover by the rising young comics star David Heatley
Bernard Lightman A Companion to the History of Science Bernard Lightman A Companion to the History of Science Новинка

Bernard Lightman A Companion to the History of Science

14623.43 руб.
The Wiley Blackwell Companion to the History of Science is a single volume companion that discusses the history of science as it is done today, providing a survey of the debates and issues that dominate current scholarly discussion, with contributions from leading international scholars. Provides a single-volume overview of current scholarship in the history of science edited by one of the leading figures in the field Features forty essays by leading international scholars providing an overview of the key debates and developments in the history of science Reflects the shift towards deeper historical contextualization within the field Helps communicate and integrate perspectives from the history of science with other areas of historical inquiry Includes discussion of non-Western themes which are integrated throughout the chapters Divided into four sections based on key analytic categories that reflect new approaches in the field
Harry Cendrowski Cloud Computing and Electronic Discovery Harry Cendrowski Cloud Computing and Electronic Discovery Новинка

Harry Cendrowski Cloud Computing and Electronic Discovery

2917.17 руб.
Explore the frontier of electronic discovery in the cloud Cloud Computing and Electronic Discovery comprehensively covers the quickly-evolving realm of eDiscovery in cloud computing environments, a computing and legal frontier in which the rules and legal precedents are being developed anew seemingly by the day. The book delves into this fascinating and rapidly-developing topic to prepare fraud investigators, legal professionals, forensic accountants, and executives understand the ramifications of storing data with third party providers and how such storage mechanisms relate to the limits of discovery practices. This up-to-date resource also includes a complete discussion of the few existing legal precedents and current cases that are shaping interpretation of discovery laws in the cloud space, a perfect overview for executives storing their companies' data in the cloud and the legal professionals tasked with understanding and interpreting the discovery rules surrounding that data. The book is comprehensive in scope and includes: An overview of current trends in cloud computing, including potential information that should be considered in an investigation that involves data held by a cloud service provider Updates on current and proposed laws governing discovery of information held by a third party cloud service provider Updates on legal cases that address the issues of the Electronic Communication Privacy Act, the Federal law prohibiting release of information by a third party provider Practical guidance on how to consider the availability of cloud data relevant to an investigation, and how to include this data in discovery plans For business, accounting, and legal professionals, Cloud Computing and Electronic Discovery is an invaluable resource for understanding the nuanced development of cloud eDiscovery policies, practices, and law as they continue to unfold and develop.
Parveen Saini Fundamentals of Conjugated Polymer Blends, Copolymers and Composites. Synthesis, Properties, and Applications Parveen Saini Fundamentals of Conjugated Polymer Blends, Copolymers and Composites. Synthesis, Properties, and Applications Новинка

Parveen Saini Fundamentals of Conjugated Polymer Blends, Copolymers and Composites. Synthesis, Properties, and Applications

18372.85 руб.
Since their discovery in 1977, the evolution of conducting polymers has revolutionized modern science and technology. These polymers enjoy a special status in the area of materials science yet they are not as popular among young readers or common people when compared to other materials like metals, paper, plastics, rubber, textiles, ceramics and composites like concrete. Most importantly, much of the available literature in the form of papers, specific review articles and books is targeted either at advanced readers (scientists/technologists/engineers/senior academicians) or for those who are already familiar with the topic (doctoral/postdoctoral scholars). For a beginner or even school/college students, such compilations are bit difficult to access/digest. In fact, they need proper introduction to the topic of conducting polymers including their discovery, preparation, properties, applications and societal impact, using suitable examples and already known principles/knowledge/phenomenon. Further, active participation of readers in terms of “question & answers”, “fill-in-the-blanks”, “numerical” along with suitable answer key is necessary to maintain the interest and to initiate the “thought process”. The readers also need to know about the drawbacks and any hazards of such materials. Therefore, I believe that a comprehensive source on the science/technology of conducting polymers which maintains a link between grass root fundamentals and state-of-the-art R&D is still missing from the open literature.
Rankovic Zoran Lead Generation Approaches in Drug Discovery Rankovic Zoran Lead Generation Approaches in Drug Discovery Новинка

Rankovic Zoran Lead Generation Approaches in Drug Discovery

9490.51 руб.
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or «virtual» screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Paul Selzer M. Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates Paul Selzer M. Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates Новинка

Paul Selzer M. Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates

2174.26 руб.
Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.
Alecia Spooner M. Environmental Science For Dummies Alecia Spooner M. Environmental Science For Dummies Новинка

Alecia Spooner M. Environmental Science For Dummies

1295.87 руб.
The easy way to score high in Environmental Science Environmental science is a fascinating subject, but some students have a hard time grasping the interrelationships of the natural world and the role that humans play within the environment. Presented in a straightforward format, Environmental Science For Dummies gives you plain-English, easy-to-understand explanations of the concepts and material you'll encounter in your introductory-level course. Here, you get discussions of the earth's natural resources and the problems that arise when resources like air, water, and soil are contaminated by manmade pollutants. Sustainability is also examined, including the latest advancements in recycling and energy production technology. Environmental Science For Dummies is the most accessible book on the market for anyone who needs to get a handle on the topic, whether you're looking to supplement classroom learning or simply interested in learning more about our environment and the problems we face. Presents straightforward information on complex concepts Tracks to a typical introductory level Environmental Science course Serves as an excellent supplement to classroom learning If you're enrolled in an introductory Environmental Science course or studying for the AP Environmental Science exam, this hands-on, friendly guide has you covered.
Malcolm Atkinson The Data Bonanza. Improving Knowledge Discovery in Science, Engineering, and Business Malcolm Atkinson The Data Bonanza. Improving Knowledge Discovery in Science, Engineering, and Business Новинка

Malcolm Atkinson The Data Bonanza. Improving Knowledge Discovery in Science, Engineering, and Business

8548.95 руб.
Complete guidance for mastering the tools and techniques of the digital revolution With the digital revolution opening up tremendous opportunities in many fields, there is a growing need for skilled professionals who can develop data-intensive systems and extract information and knowledge from them. This book frames for the first time a new systematic approach for tackling the challenges of data-intensive computing, providing decision makers and technical experts alike with practical tools for dealing with our exploding data collections. Emphasizing data-intensive thinking and interdisciplinary collaboration, The Data Bonanza: Improving Knowledge Discovery in Science, Engineering, and Business examines the essential components of knowledge discovery, surveys many of the current research efforts worldwide, and points to new areas for innovation. Complete with a wealth of examples and DISPEL-based methods demonstrating how to gain more from data in real-world systems, the book: Outlines the concepts and rationale for implementing data-intensive computing in organizations Covers from the ground up problem-solving strategies for data analysis in a data-rich world Introduces techniques for data-intensive engineering using the Data-Intensive Systems Process Engineering Language DISPEL Features in-depth case studies in customer relations, environmental hazards, seismology, and more Showcases successful applications in areas ranging from astronomy and the humanities to transport engineering Includes sample program snippets throughout the text as well as additional materials on a companion website The Data Bonanza is a must-have guide for information strategists, data analysts, and engineers in business, research, and government, and for anyone wishing to be on the cutting edge of data mining, machine learning, databases, distributed systems, or large-scale computing.
Robert A. Copeland Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists Robert A. Copeland Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists Новинка

Robert A. Copeland Evaluation of Enzyme Inhibitors in Drug Discovery. A Guide for Medicinal Chemists and Pharmacologists

11248.25 руб.
Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.
Friedel Weinert Copernicus, Darwin and Freud. Revolutions in the History and Philosophy of Science Friedel Weinert Copernicus, Darwin and Freud. Revolutions in the History and Philosophy of Science Новинка

Friedel Weinert Copernicus, Darwin and Freud. Revolutions in the History and Philosophy of Science

2174.26 руб.
Using Copernicanism, Darwinism, and Freudianism as examples of scientific traditions, Copernicus, Darwin and Freud takes a philosophical look at these three revolutions in thought to illustrate the connections between science and philosophy. Shows how these revolutions in thought lead to philosophical consequences Provides extended case studies of Copernicanism, Darwinism, and Freudianism Integrates the history of science and the philosophy of science like no other text Covers both the philosophy of natural and social science in one volume
Michael Carroll Clinical Reproductive Science Michael Carroll Clinical Reproductive Science Новинка

Michael Carroll Clinical Reproductive Science

6158.46 руб.
The comprehensive and authoritative guide to clinical reproductive science The field of clinical reproductive science continues to evolve; this important resource offers the basics of reproductive biology as well as the most recent advance in clinical embryology. The author – a noted expert in the field – focuses on the discipline and covers all aspects of this field. The text explores causes of male and female infertility and includes information on patient consultation and assessment, gamete retrieval and preparation, embryo culture, embryo transfer and cryopreservation. Comprehensive in scope, the text contains an introduction to the field of clinical reproductive science and a review of assisted reproductive technology. The author includes information on a wide range of topics such as gonadal development, the regulation of meiotic cell cycle, the biology of sperm and spermatogenesis, in vitro culture, embryo transfer techniques, fundamentals of fertilisation, oocyte activation and much more. This important resource: Offers an accessible guide to the most current research and techniques to the science of clinical reproduction Covers the fundamental elements of reproductive science Includes information on male and the female reproductive basics – everything from sexual differentiation to foetal development and parturition Explores the long-term health of children conceived through IVF Contains the newest developments in assisted reproductive technology Clinical Reproductive Science is a valuable reference written for professionals in academia, research and clinical professionals working in the field of reproductive science, clinical embryology and reproductive medicine.
Tadashi Uragami Science and Technology of Separation Membranes, 2 Volume Set Tadashi Uragami Science and Technology of Separation Membranes, 2 Volume Set Новинка

Tadashi Uragami Science and Technology of Separation Membranes, 2 Volume Set

25121.79 руб.
Offers a comprehensive overview of membrane science and technology from a single source Written by a renowned author with more than 40 years’ experience in membrane science and technology, and polymer science Covers all major current applications of membrane technology in two definitive volumes Includes academic analyses, applications and practical problems for each existing membrane technology Includes novel applications such as membrane reactors, hybrid systems and optical resolution as well as membrane fuel cells
West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery Новинка

West Anthony R. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System. From Biology to Drug Discovery

10035.05 руб.
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Rainer Wesche Physical Properties of High-Temperature Superconductors Rainer Wesche Physical Properties of High-Temperature Superconductors Новинка

Rainer Wesche Physical Properties of High-Temperature Superconductors

12294.1 руб.
A much-needed update on complex high-temperature superconductors, focusing on materials aspects; this timely book coincides with a recent major break-through of the discovery of iron-based superconductors. It provides an overview of materials aspects of high-temperature superconductors, combining introductory aspects, description of new physics, material aspects, and a description of the material properties This title is suitable for researchers in materials science, physics and engineering. Also for technicians interested in the applications of superconductors, e.g. as biomagnets
Claudia Schiffer Claudia Schiffer Новинка

Claudia Schiffer

6590 руб.
Model. Muse. Global fashion icon. Claudia Schiffer is legendary both in terms of accomplishments and longevity. From her discovery at age seventeen in a Dusseldorf...
Dawkins Richard Science in the Soul: Selected Writings of a Passionate Rationalist Dawkins Richard Science in the Soul: Selected Writings of a Passionate Rationalist Новинка

Dawkins Richard Science in the Soul: Selected Writings of a Passionate Rationalist

1223 руб.
Richard Dawkins - author of The Selfish Gene, The Blind Watchmaker, and The God Delusion - is one of science's greatest communicators. This anthology of more than forty pieces is a kaleidoscopic argument for the power and the glory of science. Breathtaking, brilliant and passionate, these essays, journalism, lectures and letters make an unanswerable case for the wonder of scientific discovery and its power to stir the imagination; for the practical necessity of scientific endeavour to society; and for the importance of the scientific way of thinking - particularly in today's `post-truth' world. With an introduction and new commentary by the author, subjects range from evolution and Darwinian natural selection to the role of scientist as prophet, whether science is itself a religion, the probability of alien life in other worlds, and the beauties, cruelties and oddities of earthly life in this one. Alongside the explications, the celebrations and the controversies are wonderfully funny ventures into satire and parody, and moving personal reflections in memory and honour of others. Science in the Soul is a sparkling showcase for Professor Dawkins' rapier wit, the clarity, precision and vigour he brings to an argument, the beauty of his prose, the depth of his feeling and his capacity for joy.
John Gribbin Science: A History in 100 Experiments John Gribbin Science: A History in 100 Experiments Новинка

John Gribbin Science: A History in 100 Experiments

1177.47 руб.
A history of science distilled into 100 notable experiments – epic moments that have fuelled our understanding of Earth and the Universe beyond.The history of science is a fascinating and long one, covering thousands of years of history. The development of scientific experiments involves some of the most enlightened cultures in history, as well as some great scientists, philosophers and theologians. As the Nobel Prize-winning physicist Richard Feynman said, ‘If it disagrees with experiment, it is wrong’, the simplest summary of what science is all about. And science is nothing without experiments.Everything in the scientific world view is based on experiment, including observations of phenomena predicted by theories and hypotheses, such as the bending of light as it goes past the Sun. From the discovery of microscopic worlds to weighing the Earth, from making electricity to the accelerating Universe and gravitational waves, this stunning book by renowned science writers John and Mary Gribbin tells the fascinating history of science through the stories of 100 groundbreaking experiments.
Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines Новинка

Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines

12442.68 руб.
This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development. With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.
Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Новинка

Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery

12446.57 руб.
Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover: A general overview of the discipline, from its foundations to contemporary industrial applications Chemoinformatics-based applications Bioinformatics-based applications Data mining methods in clinical development Data mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.
Nair K. M. Advances in Electroceramic Materials II Nair K. M. Advances in Electroceramic Materials II Новинка

Nair K. M. Advances in Electroceramic Materials II

11902.04 руб.
During the past decades, understanding of the science and technology powering electronic materials has played a major role in satisfying social needs by developing electronic devices for automotive, telecommunications, military, and medical applications. This volume contains a collection of selected papers from the international symposia on Advanced Dielectric Materials and Electronic Devices and Ferroelectrics and Multiferroics presented during the Material Science and Technology conference held in Pittsburgh in October 2009. It is a one-stop resource for academics on the most important issues in advances in electroceramic materials.
Westrup Hugh DK Workbook. Science Kindergarten Westrup Hugh DK Workbook. Science Kindergarten Новинка

Westrup Hugh DK Workbook. Science Kindergarten

699 руб.
Perfect for children ages 5 and 6, DK Workbooks: Science: Kindergarten contains exercises on changes in the weather, comparing objects, animal and plant life cycles, and other fundamentals of science. Help your child move to the head of the class! DK Workbooks: Science is an innovative series of workbooks aligned to school curriculum that helps make learning easy and fun. Each title is packed with exercises and activities to strengthen knowledge from the science lessons taught in school. Developed in consultation with curriculum experts, these science workbooks reinforce learning and understanding of key concepts such as force and motion, materials, and ecosystems. A parents' section contains answers, tips, and guidance to provide support, and a certificate of achievement will reinforce confidence in kids by rewarding their accomplishments. Supports the Common Core State Standards.
Tsaioun Katya ADMET for Medicinal Chemists. A Practical Guide Tsaioun Katya ADMET for Medicinal Chemists. A Practical Guide Новинка

Tsaioun Katya ADMET for Medicinal Chemists. A Practical Guide

11902.04 руб.
This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.
Bryson Bill Seeing Further: The Story of Science and the Royal Bryson Bill Seeing Further: The Story of Science and the Royal Новинка

Bryson Bill Seeing Further: The Story of Science and the Royal

1078 руб.
Edited and introduced by Bill Bryson, with contributions from Richard Dawkins, Margaret Atwood, Richard Holmes, Martin Rees, Richard Fortey, Steve Jones, James Gleick and Neal Stephenson amongst others, this beautiful, lavishly illustrated book tells the story of science and the Royal Society, from 1660 to the present. Since its inception in 1660, the Royal Society has pioneered scientific discovery and exploration. The oldest scientific academy in existence, its backbone is its Fellowship of the most eminent scientists in history including Charles Darwin, Isaac Newton and Albert Einstein. Today, its Fellows are the most influential men and women in science, many of whom have contributed to this ground-breaking volume alongside some of the world's most celebrated novelists, essayists and historians. This book celebrates the Royal Society's vast achievements in its illustrious past as well as its huge contribution to the development of modern science. With unrestricted access to the Society's archives and photographs, Seeing Further shows that the history of scientific endeavour and discovery is a continuous thread running through the history of the world and of society - and is one that continues to shape the world we live in today.
Pam Walker The Science Teacher's Activity-A-Day, Grades 5-10. Over 180 Reproducible Pages of Quick, Fun Projects that Illustrate Basic Concepts Pam Walker The Science Teacher's Activity-A-Day, Grades 5-10. Over 180 Reproducible Pages of Quick, Fun Projects that Illustrate Basic Concepts Новинка

Pam Walker The Science Teacher's Activity-A-Day, Grades 5-10. Over 180 Reproducible Pages of Quick, Fun Projects that Illustrate Basic Concepts

1422.93 руб.
A hands-on and fun-filled resource for teaching science to middle and high school students New in the 5-Minute Fundamentals Series, The Science Teacher's Activity-A-Day, Grades 6-12, includes 180 easy, five-minute hook or sponge activities to capture learners' attention and introduce lessons. Divided into three units, Physical Science, Life Science, and Earth and Space Science; the activities cover topics based on the National Science Education Standards. All the book's activities can be done with materials that are inexpensive and easy to find Includes quick and fun «sponge» activities that are designed to engage students All the activities take about 5 minutes to complete The Science Teacher's Activity-a-Day is an ideal resource for middle and high school science teachers.
Blann Andrew Blood Science. Principles and Pathology Blann Andrew Blood Science. Principles and Pathology Новинка

Blann Andrew Blood Science. Principles and Pathology

13691.23 руб.
Blood Science is a relatively new discipline which merges biochemistry, haematology, immunology, transfusion science and genetics. This bringing together of traditional disciplines requires a corresponding change in education and training for healthcare scientists and Blood Science: Principles and Pathology is written in response to this emerging need. An introduction to the subject and an overview of the techniques used in blood science are followed by a series of chapters based on groups of analytes investigated in blood – red blood cells, white blood cells and platelets, followed by the constituents of plasma, including waste products, electrolytes, glucose, lipids, enzymes, hormones, nutrients, drugs, poisons and others. Each chapter is supported by learning objectives, summaries and further information, and a focus is given to chapter specific case studies with interpretation to demonstrate how laboratory data in conjunction with clinical details is utilised when investigating patients with actual or suspected disease. Finally, a separate chapter offers more detailed case reports that integrate the different aspects of blood science. Undergraduate students taking blood science modules as part of their BSc programmes in Biomedical and Healthcare Sciences will appreciate the level of integration between clinical biochemistry and haematology. In addition, this book will provide suitable initial reading for those students embarking on blood science modules on MSc programmes and will be of value to new graduates entering the profession and starting their career in blood science departments by supplementing practice-based training with the required theoretical underpinning. This book is approved by the Institute of Biomedical Science and written by its expert writers, many of whom work on the Institute’s advisory panels.
Jacek Lipkowski Nanopatterned and Nanoparticle-Modified Electrodes Jacek Lipkowski Nanopatterned and Nanoparticle-Modified Electrodes Новинка

Jacek Lipkowski Nanopatterned and Nanoparticle-Modified Electrodes

13872.84 руб.
Volume XVII in the «Advances in Electrochemical Science and Engineering» series, this monograph covers progress in this rapidly developing field with a particular emphasis on important applications, including spectroscopy, medicinal chemistry and analytical chemistry. As such it covers nanopatterned and nanoparticle-modified electrodes for analytical detection, surface spectroscopy, electrocatalysis and a fundamental understanding of the relation between the electrode structure and its function. Written by a group of international experts, this is a valuable resource for researchers working in such fields as electrochemistry, materials science, spectroscopy, analytical and medicinal chemistry.
Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future Новинка

Ian Dunn S. Searching for Molecular Solutions. Empirical Discovery and Its Future

11590.87 руб.
A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both Empirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores: The differing modes of molecular discovery Biological precedents for evolutionary approaches Directed evolutionary methods and related areas Enzyme evolution and design Functional nucleic acid discovery Antibodies and other recognition molecules General aspects of molecular recognition Small molecule discovery approaches Rational molecular design The interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery Searching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspectsof molecular discovery, as well as the thought processes behind experimental approaches. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
Westrup Hugh, Pranikoff Kara DK. Workbook. Science. Pre-K Westrup Hugh, Pranikoff Kara DK. Workbook. Science. Pre-K Новинка

Westrup Hugh, Pranikoff Kara DK. Workbook. Science. Pre-K

699 руб.
Focusing on the very basic principles of science including the five senses, weather, seasons, animal babies, and more, DK Workbooks: Science: Pre-K will help preschoolers learn and understand first science concepts. Help your child move to the head of the class! DK Workbooks: Science is an innovative series of workbooks aligned to school curriculum that helps make learning easy and fun. Each title is packed with exercises and activities to strengthen knowledge from the science lessons taught in school. Developed in consultation with curriculum experts, these science workbooks reinforce learning and understanding of key concepts such as force and motion, materials, and ecosystems. A parents' section contains answers, tips, and guidance to provide support, and a certificate of achievement will reinforce confidence in kids by rewarding their accomplishments. Supports the Common Core State Standards.
Mike Lee S. Mass Spectrometry Handbook Mike Lee S. Mass Spectrometry Handbook Новинка

Mike Lee S. Mass Spectrometry Handbook

17110.15 руб.
Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.
D. Davies Huw Vaccinology. Principles and Practice D. Davies Huw Vaccinology. Principles and Practice Новинка

D. Davies Huw Vaccinology. Principles and Practice

14769.28 руб.
Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.
Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies Новинка

Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies

16873.08 руб.
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. • Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations • Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts • Covers design criteria, typical profile of current macrocycles, applications, and limitations
Thomas Michaud Innovation, Between Science and Science Fiction Thomas Michaud Innovation, Between Science and Science Fiction Новинка

Thomas Michaud Innovation, Between Science and Science Fiction

9373.54 руб.
Fantasy and science fiction are both involved in the process of innovation in techno-scientific societies. Long regarded as a hindrance to rationality, and to science, science fiction has become the object of praise in recent decades. Innovative organizations use science fiction to stimulate the creativity of their teams, and more and more entrepreneurs are using its influence to develop innovation. Scientific practice relies in part on an imaginary dimension. The mapping of the technical imagination of science fiction has become an important strategic issue, as has its patentability. The conquest of space, the construction of cyberspace and virtual reality, biotechnologies and nanotechnologies are all at the center of futuristic fictions that participate in scientific speeches and discoveries.
Litwin Virginia Flow Cytometry in Drug Discovery and Development Litwin Virginia Flow Cytometry in Drug Discovery and Development Новинка

Litwin Virginia Flow Cytometry in Drug Discovery and Development

10812.96 руб.
This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.
Jon Agar Science in the 20th Century and Beyond Jon Agar Science in the 20th Century and Beyond Новинка

Jon Agar Science in the 20th Century and Beyond

5182.83 руб.
A compelling history of science from 1900 to the present day, this is the first book to survey modern developments in science during a century of unprecedented change, conflict and uncertainty. The scope is global. Science's claim to access universal truths about the natural world made it an irresistible resource for industrial empires, ideological programs, and environmental campaigners during this period. Science has been at the heart of twentieth century history – from Einstein's new physics to the Manhattan Project, from eugenics to the Human Genome Project, or from the wonders of penicillin to the promises of biotechnology. For some science would only thrive if autonomous and kept separate from the political world, while for others science was the best guide to a planned and better future. Science was both a routine, if essential, part of an orderly society, and the disruptive source of bewildering transformation. Jon Agar draws on a wave of recent scholarship that explores science from interdisciplinary perspectives to offer a readable synthesis that will be ideal for anyone curious about the profound place of science in the modern world.
Tatsuki Ohji Advances in Materials Science for Environmental and Energy Technologies VI Tatsuki Ohji Advances in Materials Science for Environmental and Energy Technologies VI Новинка

Tatsuki Ohji Advances in Materials Science for Environmental and Energy Technologies VI

16873.08 руб.
An excellent one-volume resource for understanding the most important current issues in the research and advances in materials science for environmental and energy technologies This proceedings volume contains a collection of 20 papers from the 2016 Materials Science and Technology (MS&T'16) meeting held in Salt Lake City, UT, from October 24-27 of that year. These conference symposia provided a forum for scientists, engineers, and technologists to discuss and exchange state-of-the-art ideas, information, and technology on advanced methods and approaches for processing, synthesis, characterization, and applications of ceramics, glasses, and composites. Topics covered include: the 8th International Symposium on Green and Sustainable Technologies for Materials Manufacturing Processing; Materials Issues in Nuclear Waste Management in the 21st Century; Construction and Building Materials for a Better Environment; Materials for Nuclear Applications and Extreme Environments; Nanotechnology for Energy, Healthcare, and Industry; and Materials for Processes for CO2 Capture, Conversion and Sequestration. Logically organized and carefully selected articles give insight into advances in materials science for environmental and energy technologies. Incorporates the latest developments related to advances in materials science for environmental and energy technologies Advances in Materials Science for Environmental and Energy Technologies VI: Ceramic Transactions Volume 262 is ideal for academics in mechanical and chemical engineering, materials and or ceramics, chemistry departments and for those working in government laboratories.
Dawkins R. Science in the Soul Dawkins R. Science in the Soul Новинка

Dawkins R. Science in the Soul

742 руб.
Richard Dawkins - author of The Selfish Gene, The Blind Watchmaker, and The God Delusion - is one of science's greatest communicators. This anthology of more than forty pieces is a kaleidoscopic argument for the power and the glory of science. Breathtaking, brilliant and passionate, these essays, journalism, lectures and letters make an unanswerable case for the wonder of scientific discovery and its power to stir the imagination; for the practical necessity of scientific endeavour to society; and for the importance of the scientific way of thinking – particularly in today’s ‘post-truth’ world. With an introduction and new commentary by the author, subjects range from evolution and Darwinian natural selection to the role of scientist as prophet, whether science is itself a religion, the probability of alien life in other worlds, and the beauties, cruelties and oddities of earthly life in this one. Alongside the explications, the celebrations and the controversies are wonderfully funny ventures into satire and parody, and moving personal reflections in memory and honour of others. Science in the Soul is a sparkling showcase for Professor Dawkins' rapier wit, the clarity, precision and vigour he brings to an argument, the beauty of his prose, the depth of his feeling and his capacity for joy.
Joerg Lahann Click Chemistry for Biotechnology and Materials Science Joerg Lahann Click Chemistry for Biotechnology and Materials Science Новинка

Joerg Lahann Click Chemistry for Biotechnology and Materials Science

14022.96 руб.
Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions.
Joerg Lahann Click Chemistry for Biotechnology and Materials Science Joerg Lahann Click Chemistry for Biotechnology and Materials Science Новинка

Joerg Lahann Click Chemistry for Biotechnology and Materials Science

14546.93 руб.
Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions.
Law Barry A. Technology of Cheesemaking Law Barry A. Technology of Cheesemaking Новинка

Law Barry A. Technology of Cheesemaking

19599.46 руб.
Now in a fully-revised new edition, this book covers the science and technology underlying cheesemaking, as practised today in the manufacture of hard, semi-soft and soft cheeses. Emphasis is placed on the technology, and the science and technology are integrated throughout. Authors also cover research developments likely to have a commercial impact on cheesemaking in the foreseeable future within the areas of molecular genetics, advanced sensor / measurement science, chemometrics, enzymology and flavour chemistry. In order to reflect new issues and challenges that have emerged since publication of the first book, the new chapters are included on milk handling prior to cheesemaking; packaging; and major advances in the control of the end user properties of cheese using key manufacturing parameters and variables. The volume has been structured to flow through the discrete stages of cheese manufacture in the order in which they are executed in cheese plants – from milk process science, through curd process science, to cheese ripening science and quality assessment. Overall, the volume provides process technologists, product development specialists, ingredients suppliers, research and development scientists and quality assurance personnel with a complete reference to cheese technology, set against the background of its physical, chemical and biological scientific base.
Huang Xianhai Case Studies in Modern Drug Discovery and Development Huang Xianhai Case Studies in Modern Drug Discovery and Development Новинка

Huang Xianhai Case Studies in Modern Drug Discovery and Development

11668.66 руб.
Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining: All phases of drug discovery and development from initial idea to commercialization Some of today's most important and life-saving medications Drugs designed for different therapeutic areas such as cardiovascular disease, infection, inflammation, cancer, metabolic syndrome, and allergies Examples of prodrugs and inhaled drugs Reasons why certain drugs failed to advance to market despite major research investments Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies. Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects.
Lin Xiao Bioinspired Materials Science and Engineering Lin Xiao Bioinspired Materials Science and Engineering Новинка

Lin Xiao Bioinspired Materials Science and Engineering

12641.05 руб.
An authoritative introduction to the science and engineering of bioinspired materials Bioinspired Materials Science and Engineering offers a comprehensive view of the science and engineering of bioinspired materials and includes a discussion of biofabrication approaches and applications of bioinspired materials as they are fed back to nature in the guise of biomaterials. The authors also review some biological compounds and shows how they can be useful in the engineering of bioinspired materials. With contributions from noted experts in the field, this comprehensive resource considers biofabrication, biomacromolecules, and biomaterials. The authors illustrate the bioinspiration process from materials design and conception to application of bioinspired materials. In addition, the text presents the multidisciplinary aspect of the concept, and contains a typical example of how knowledge is acquired from nature, and how in turn this information contributes to biological sciences, with an accent on biomedical applications. This important resource: Offers an introduction to the science and engineering principles for the development of bioinspired materials Includes a summary of recent developments on biotemplated formation of inorganic materials using natural templates Illustrates the fabrication of 3D-tumor invasion models and their potential application in drug assessments Explores electroactive hydrogels based on natural polymers Contains information on turning mechanical properties of protein hydrogels for biomedical applications Written for chemists, biologists, physicists, and engineers, Bioinspired Materials Science and Engineering contains an indispensible resource for an understanding of bioinspired materials science and engineering.

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Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.
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