self emulsifying drug delivery systems



Priyank B. Patel and Mukesh R. Patel Development of Self Microemulsifying Drug Delivery System Priyank B. Patel and Mukesh R. Patel Development of Self Microemulsifying Drug Delivery System Новинка

Priyank B. Patel and Mukesh R. Patel Development of Self Microemulsifying Drug Delivery System

4419 руб.
Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate. . In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drug compounds. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self microemulsifying drug delivery systems (SMEDDS).
Rebecca Bader A. Engineering Polymer Systems for Improved Drug Delivery Rebecca Bader A. Engineering Polymer Systems for Improved Drug Delivery Новинка

Rebecca Bader A. Engineering Polymer Systems for Improved Drug Delivery

10303.08 руб.
Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.
Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery Новинка

Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery

12395.59 руб.
Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.
Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action Новинка

Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action

13994.75 руб.
Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.
Kun Cheng Advanced Drug Delivery Kun Cheng Advanced Drug Delivery Новинка

Kun Cheng Advanced Drug Delivery

9993.65 руб.
Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.
Yoon Yeo Nanoparticulate Drug Delivery Systems. Strategies, Technologies, and Applications Yoon Yeo Nanoparticulate Drug Delivery Systems. Strategies, Technologies, and Applications Новинка

Yoon Yeo Nanoparticulate Drug Delivery Systems. Strategies, Technologies, and Applications

12395.59 руб.
Frank discussions of opportunities and challenges point the way to new, more effective drug delivery systems Interest in nanomedicine has grown tremendously, fueled by the expectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agents to human tissues and organs. The field, however, has faced several challenges attempting to translate novel ideas into clinical benefits. With contributions from an international team of leading nanomedicine researchers, this book provides a practical assessment of the possibilities and the challenges of modern nanomedicine that will enable the development of clinically effective nanoparticulate drug delivery products and systems. Nanoparticulate Drug Delivery Systems focuses on the rationales and preclinical evaluation of new nanoparticulate drug carriers that have yet to be thoroughly reviewed in the literature. The first chapter sets the stage with a general overview of targeted nanomedicine. The book then explores new and promising nanoparticulate drug delivery systems, including: Lipid nanoparticles for the delivery of nucleic acids Multifunctional dendritic nanocarriers Polymer drug nanoconjugates Next, the book presents new opportunities and challenges for nanoparticulate drug delivery systems, including: Clearance of nanoparticles during circulation Drug delivery strategies for combatting multiple drug resistance Toxicological assessment of nanomedicine Chapters offer state-of-the-technology reviews with extensive references to facilitate further investigation. Moreover, each chapter concludes with an expert assessment of remaining challenges, pointing the way to solutions and new avenues of research. With its frank discussions of opportunities and challenges, Nanoparticulate Drug Delivery Systems sets a solid foundation for new research leading to the discovery and development of better nanomedicines.
Pathak Yashwant Antibody-Mediated Drug Delivery Systems. Concepts, Technology, and Applications Pathak Yashwant Antibody-Mediated Drug Delivery Systems. Concepts, Technology, and Applications Новинка

Pathak Yashwant Antibody-Mediated Drug Delivery Systems. Concepts, Technology, and Applications

13116.1 руб.
This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.
Shantanu Bandyopadhyay,Bhupinder Singh and O.P. Katare Formulation of Self Nano-Emulsifying Systems of Ezetimibe Shantanu Bandyopadhyay,Bhupinder Singh and O.P. Katare Formulation of Self Nano-Emulsifying Systems of Ezetimibe Новинка

Shantanu Bandyopadhyay,Bhupinder Singh and O.P. Katare Formulation of Self Nano-Emulsifying Systems of Ezetimibe

4983 руб.
Oral route is preferred for the treatment of various diseases/disorders. However, the oral bioavailability of nearly 40% of newly discovered molecules is diminished due to various physicochemical and physiological barriers. The reasons of low and variable oral bioavailability include, high lipophilicity, restricted permeability, first pass metabolism in the gut and liver and efflux transporter systems. These problems, in turn, lead to high intra- and inter-subject variability and lack of dose proportionality. To overcome these drawbacks, various formulation strategies have been adopted. However, the focus has recently shifted to lipid-based formulations owing to their ability to improve the oral bioavailability of poorly water soluble drug compounds. In this regard, self-emulsifying drug delivery systems (SEDDS), particularly nano-based systems, have been able to surmount the above mentioned problems. SEDDS are the recent technological innovations which are physically more stable and easier to manufacture with the globule size ranging between 10 to 1000 nm. Not only this, SEDDS are able to modulate the drug absorption leading ultimately to enhance oral bioavailability.
Dionysios Douroumis Drug Delivery Strategies for Poorly Water-Soluble Drugs Dionysios Douroumis Drug Delivery Strategies for Poorly Water-Soluble Drugs Новинка

Dionysios Douroumis Drug Delivery Strategies for Poorly Water-Soluble Drugs

15261.31 руб.
Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.
Rishad R. Jivani and Chhagan N. Patel Gastroretentive Drug Delivery systems of Baclofen Rishad R. Jivani and Chhagan N. Patel Gastroretentive Drug Delivery systems of Baclofen Новинка

Rishad R. Jivani and Chhagan N. Patel Gastroretentive Drug Delivery systems of Baclofen

6190 руб.
Over the past three decades, the pursuit and exploration of devices designed to be retained in the upper part of the gastrointestinal (GI) tract has advanced consistently in terms of technology and diversity, encompassing a variety of systems and devices such as floating systems, raft systems, expanding systems, swelling systems, bioadhesive systems and low-density systems. Gastric retention will provide advantages such as the delivery of drugs with narrow absorption windows in the small intestinal region.This book consists of detail aspect of gastroretentive drug delivery systems. Authors had design and developed various gastroretentive formulations of narrow absorption window drug baclofen.
Laurent Simon Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering Laurent Simon Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering Новинка

Laurent Simon Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering

8822.26 руб.
Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.
Tomalia Donald A. Dendrimer-Based Drug Delivery Systems. From Theory to Practice Tomalia Donald A. Dendrimer-Based Drug Delivery Systems. From Theory to Practice Новинка

Tomalia Donald A. Dendrimer-Based Drug Delivery Systems. From Theory to Practice

15346.51 руб.
The opportunities and challenges of using dendrimers to improve drug delivery Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication to targeted human organs. With contributions from an international team of pioneers and experts in dendrimer research, this book provides a comprehensive overview of the latest research efforts in designing and optimizing dendrimer-based drug delivery systems. The book analyzes key issues, demonstrating the critical connections that link fundamental concepts, design, synthesis, analytical methodology, and biological assessment to the practical use of dendrimers in drug delivery applications. Topics covered include: Dendrimer history Synthesis Physicochemical properties Principles of drug delivery Applications in diverse biomedical fields Dendrimer-Based Drug Delivery Systems reflects the authors' thorough review and analysis of the current literature as well as their own firsthand experience in the lab. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research. References at the end of each chapter serve as a gateway to the growing body of literature in the field, enabling readers to explore each individual topic in greater depth. Pharmaceutical and biomedical researchers will find this book a unique and essential guide to the opportunities, issues, and challenges involved in fully exploiting the potential of dendrimers to improve drug delivery.
Ryan Donnelly F. Novel Delivery Systems for Transdermal and Intradermal Drug Delivery Ryan Donnelly F. Novel Delivery Systems for Transdermal and Intradermal Drug Delivery Новинка

Ryan Donnelly F. Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

11232.84 руб.
This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.
Zhongwei Gu Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery Zhongwei Gu Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery Новинка

Zhongwei Gu Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery

13944.21 руб.
Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.
Priya Patel,Tejal Soni and Vaishali Thakkar Nanoparticle For Pulmonary Drug Delivery System Priya Patel,Tejal Soni and Vaishali Thakkar Nanoparticle For Pulmonary Drug Delivery System Новинка

Priya Patel,Tejal Soni and Vaishali Thakkar Nanoparticle For Pulmonary Drug Delivery System

3212 руб.
A new value paradigm is taking shape in the drug delivery market. Nanotechnology delivery techniques will shape the future of drug delivery. ”Nanotechnology-enabled drug delivery systems (DDS) over the next five years are forecast to dramatically reshape the way existing drugs are delivered”. The growing range of nanotechnology enabled drug delivery methods is poised to change the way new compounds are formulated, and to extend the life cycle of existing compounds. Nanoparticles hold promise as therapeutic agents for a number of diseases. In this book give a brief introduction regarding pulmonary drug delivery system. Determining the physicochemical characteristics of inhaled nanoparticles on their ability to cross the lungs alveolar epithelial surface is an important step in understanding the biological effects associated with exposure to these particles.
Avinash Hosmani,Pramod Kasture and Yogesh Thorat Mucoadhesive Drug Delivery System Avinash Hosmani,Pramod Kasture and Yogesh Thorat Mucoadhesive Drug Delivery System Новинка

Avinash Hosmani,Pramod Kasture and Yogesh Thorat Mucoadhesive Drug Delivery System

7558 руб.
In the recent days, the technology of Mucoadhesive drug delivery system has gained so much attention from the researchers in the field of formulation development. The drug delivery system enables the formulator to bring the drug in the close proximity to the mucus membrane with enhanced contact time and contact area. Thus the technology has been successful to bring out benefits like bio-availability enhancement along with the extended release. The book gives the idea about the basic fundamentals of Mucoadhesive systems. From the presented work, one may get information about the properties of mucoadhesive polymers. One may study the formulation of different mucoadhesive drug delivery systems like tablet, suspension and microsphere.
Kumkum Sarangdevot,Bhawani Singh Sonigara and Khem Chand Gupta Nasal drug delivery system Kumkum Sarangdevot,Bhawani Singh Sonigara and Khem Chand Gupta Nasal drug delivery system Новинка

Kumkum Sarangdevot,Bhawani Singh Sonigara and Khem Chand Gupta Nasal drug delivery system

3212 руб.
The novel carriers have been exploited through almost all the routes of administration. Many newer carriers are evolving with the advent of technology and the demand of targeted delivery like microemulsions. Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant. These systems are currently of interest because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. In addition to oral and intravenous delivery, they are amenable for sustained and targeted delivery through nasal, pulmonary, vaginal and topical routes. Intranasal drug delivery system is a promising alternative route of administration for poor bioavailability drugs and it has advantages in term of increase patient acceptibility and compliance.The intent of the paper focuses on use of microemulsion technology in intranasal drug delivery along with mechanism.
Suryakanta Swain,Subas Chandra Dinda and Muddana Eswara Bhanoji Rao Liposome as a Drug Delivery Vehicle Suryakanta Swain,Subas Chandra Dinda and Muddana Eswara Bhanoji Rao Liposome as a Drug Delivery Vehicle Новинка

Suryakanta Swain,Subas Chandra Dinda and Muddana Eswara Bhanoji Rao Liposome as a Drug Delivery Vehicle

4749 руб.
Liposomes are found to be having passively targeted drug carrier to tumor cells because of its enhanced permeability and retention effect. Liposomes remain at the front of the drug delivery systems owing to its non-toxic, bio-degradable and non-immunogenic nature. It has been explored as carrier for delivery of drug molecules such as protein and peptides, genes, vaccines, genosomes, lipopolyplex, fusogenic liposomes and virsomes, etc. Stealth liposomes utilized for targeting hydrophilic anticancer drugs such as doxorubicin, mitoxantrone, etc. Still there is quest in developing drug delivery and drug targeting system utilizing liposomal formulations in the thrust area of cancer chemotherapy, antiviral, and such other biotechnological products.
Ryan Donnelly F. Microneedle-mediated Transdermal and Intradermal Drug Delivery Ryan Donnelly F. Microneedle-mediated Transdermal and Intradermal Drug Delivery Новинка

Ryan Donnelly F. Microneedle-mediated Transdermal and Intradermal Drug Delivery

12003.84 руб.
Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery. By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.
Tabasubano Shekh,Amit Bhople and Sunil Jaiswal Development of Osmotically Controlled Drug Delivery System Tabasubano Shekh,Amit Bhople and Sunil Jaiswal Development of Osmotically Controlled Drug Delivery System Новинка

Tabasubano Shekh,Amit Bhople and Sunil Jaiswal Development of Osmotically Controlled Drug Delivery System

2890 руб.
Etoricoxib is non steroidal anti-inflammatory drug specifically Cyclooxygenase 2 (COX-2) enzyme inhibitor. Etoricoxib have serious side effect like gastric disturbance, gastric ulceration, gastrointestinal (GIT) bleeding. Conventional drug delivery systems do not have much control over the drug release and effective concentration of drug reach at the target site. It may lead to unsteady plasma drug level result into adverse effect due to plasma drug level crossing therapeutic window and undertherparutic response because of plasma drug level below therapeutic window. GIT side effect of Etoricoxib due to unsteady plasma drug level when administered in conventional dosage form. Development of elementary osmotic pump for etoricoxib release the drug in controlled fashion by zero order result in mentainance of constant plasma drug level for long period of time lead to diminished serious GIT side effect of etoricoxib.
Ravi Parsotambhai Gondaliya and Alpesh Arvadiya Formulation & Development of Gastro-retentive Anti-Diabetic Tablet Ravi Parsotambhai Gondaliya and Alpesh Arvadiya Formulation & Development of Gastro-retentive Anti-Diabetic Tablet Новинка

Ravi Parsotambhai Gondaliya and Alpesh Arvadiya Formulation & Development of Gastro-retentive Anti-Diabetic Tablet

3944 руб.
Gastro-retentive Tablets are primarily controlled release drug delivery systems, which gets retained in the stomach for longer period of time, thus helping in absorption of drug for the intended duration of time. This in turn improves bioavailability, reduces drug wastage, improves solubility of drugs that are less soluble at high pH environment. It also helps in achieving local delivery of drug to the stomach and proximal small intestine.
Mecozzi Sandro Thermodynamics of Pharmaceutical Systems. An introduction to Theory and Applications Mecozzi Sandro Thermodynamics of Pharmaceutical Systems. An introduction to Theory and Applications Новинка

Mecozzi Sandro Thermodynamics of Pharmaceutical Systems. An introduction to Theory and Applications

8742.74 руб.
Designed for pharmacy students Now updated for its Second Edition, Thermodynamics of Pharmaceutical Systems provides pharmacy students with a much-needed introduction to the mathematical intricacies of thermodynamics in relation to practical laboratory applications. Designed to meet the needs of the contemporary curriculum in pharmacy schools, the text makes these connections clear, emphasizing specific applications to pharmaceutical systems including dosage forms and newer drug delivery systems. Students and practitioners involved in drug discovery, drug delivery, and drug action will benefit from Connors' and Mecozzi's authoritative treatment of the fundamentals of thermodynamics as well as their attention to drug molecules and experimental considerations. They will appreciate, as well, the significant revisions to the Second Edition. Expanding the book's scope and usefulness, the new edition: Explores in greater depth topics most relevant to the pharmacist such as drug discovery and drug delivery, supramolecular chemistry, molecular recognition, and nanotechnologies Moves the popular review of mathematics, formerly an appendix, to the front of the book Adds new textual material and figures in several places, most notably in the chapter treating noncovalent chemical interactions Two new appendices provide ancillary material that expands on certain matters bordering the subject of classical thermodynamics Thermodynamics need not be a mystery nor confined to the realm of mathematical theory. Thermodynamics of Pharmaceutical Systems, Second Edition demystifies for students the profound thermodynamic applications in the laboratory while also serving as a handy resource for practicing researchers.
Buchwald Peter Retrometabolic Drug Design and Targeting Buchwald Peter Retrometabolic Drug Design and Targeting Новинка

Buchwald Peter Retrometabolic Drug Design and Targeting

13120.07 руб.
Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
Ramanathan Nagarajan Self-Assembly. From Surfactants to Nanoparticles Ramanathan Nagarajan Self-Assembly. From Surfactants to Nanoparticles Новинка

Ramanathan Nagarajan Self-Assembly. From Surfactants to Nanoparticles

11596.03 руб.
An introduction to the state-of-the-art of the diverse self-assembly systems Self-Assembly: From Surfactants to Nanoparticles provides an effective entry for new researchers into this exciting field while also giving the state of the art assessment of the diverse self-assembling systems for those already engaged in this research. Over the last twenty years, self-assembly has emerged as a distinct science/technology field, going well beyond the classical surfactant and block copolymer molecules, and encompassing much larger and complex molecular, biomolecular and nanoparticle systems. Within its ten chapters, each contributed by pioneers of the respective research topics, the book: Discusses the fundamental physical chemical principles that govern the formation and properties of self-assembled systems Describes important experimental techniques to characterize the properties of self-assembled systems, particularly the nature of molecular organization and structure at the nano, meso or micro scales. Provides the first exhaustive accounting of self-assembly derived from various kinds of biomolecules including peptides, DNA and proteins. Outlines methods of synthesis and functionalization of self-assembled nanoparticles and the further self-assembly of the nanoparticles into one, two or three dimensional materials. Explores numerous potential applications of self-assembled structures including nanomedicine applications of drug delivery, imaging, molecular diagnostics and theranostics, and design of materials to specification such as smart responsive materials and self-healing materials. Highlights the unifying as well as contrasting features of self-assembly, as we move from surfactant molecules to nanoparticles. Written for students and academic and industrial scientists and engineers, by pioneers of the research field, Self-Assembly: From Surfactants to Nanoparticles is a comprehensive resource on diverse self-assembly systems, that is simultaneously introductory as well as the state of the art.
Ravi Patel and Jitendra Bhangale Anti Hypertensive drug- Formulation and its characterization Ravi Patel and Jitendra Bhangale Anti Hypertensive drug- Formulation and its characterization Новинка

Ravi Patel and Jitendra Bhangale Anti Hypertensive drug- Formulation and its characterization

4749 руб.
Conventional oral dosage forms provide a specific drug concentration in the systemic circulation without offering any control over the rate of drug delivery. Controlled-release drug delivery systems (CRDDS) provide drug release at a predetermined, predictable, and controlled rate. It was attempt to develop a gastro retentive drug delivery system of anti hypertensive drug using different polymers like that HPMCK4M, Xanthangum, PolyoxWSR303as matrixing agent, swelling agent, respectivel. A simplex lattice design was applied to combined effect of three formulation variables (ie, amount of HPMCK4M (X1), xanthangum (X2), and PolyoxWSR303 (X3). Results of multiple regression analysis indicated that low level of X1 and X 2 and high level of X3 should be used to manufacture the tablet formulation with desired in % swelling index and % drug release profile . When Polyox 303 was used, % swelling index increased, with increase on the total amount of drug released. Decreasing the amount of HPMC K4M while maintaining the total amount of polymer constant increased the release rate and total amount released. Decreasing the total amount of polymer decreases the swelling and work of penetration,
Amit Misra Delivery Systems for Tuberculosis Prevention and Treatment Amit Misra Delivery Systems for Tuberculosis Prevention and Treatment Новинка

Amit Misra Delivery Systems for Tuberculosis Prevention and Treatment

13169.53 руб.
Provides a review of novel pharmaceutical approaches for Tuberculosis drugs Presents a novel perspective on tuberculosis prevention and treatment Considers the nature of disease, immunological responses, vaccine and drug delivery, disposition and response Multidisciplinary appeal, with contributions from microbiology, immunology, molecular biology, pharmaceutics, pharmacokinetics, chemical and mechanical engineering
Susheel Kalia Biodegradable and Biobased Polymers for Environmental and Biomedical Applications Susheel Kalia Biodegradable and Biobased Polymers for Environmental and Biomedical Applications Новинка

Susheel Kalia Biodegradable and Biobased Polymers for Environmental and Biomedical Applications

17431 руб.
This volume incorporates 13 contributions from renowned experts from the relevant research fields that are related biodegradable and biobased polymers and their environmental and biomedical applications. Specifically, the book highlights: Developments in polyhydroxyalkanoates applications in agriculture, biodegradable packaging material and biomedical field like drug delivery systems, implants, tissue engineering and scaffolds The synthesis and elaboration of cellulose microfibrils from sisal fibres for high performance engineering applications in various sectors such as the automotive and aerospace industries, or for building and construction The different classes and chemical modifications of tannins Electro-activity and applications of Jatropha latex and seed The synthesis, properties and applications of poly(lactic acid) The synthesis, processing and properties of poly(butylene succinate), its copolymers, composites and nanocomposites The different routes for preparation polymers from vegetable oil and the effects of reinforcement and nano-reinforcement on the physical properties of such biobased polymers The different types of modified drug delivery systems together with the concept of the drug delivery matrix for controlled release of drugs and for antitumor drugs The use of nanocellulose as sustainable adsorbents for the removal of water pollutants mainly heavy metal ions, organic molecules, dyes, oil and CO2 The main extraction techniques, structure, properties and different chemical modifications of lignins Proteins and nucleic acids based biopolymers The role of tamarind seed polysaccharide-based multiple-unit systems in sustained drug release
Ganesh Kumar Target Oriented Drug Delivery System Ganesh Kumar Target Oriented Drug Delivery System Новинка

Ganesh Kumar Target Oriented Drug Delivery System

4500 руб.
Target drug delivery system is a special form of drug delivery system where the pharmacologically active agent or medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells. Targeted drug delivery implies for selective and effective localization of pharmacologically active moiety at pre identified (preselected) target in therapeutic concentration, while restricting its access to non-target normal cellular linings, thus minimizing toxic effects and maximizing therapeutic index. Targeting of drugs to special cells and tissues of the body without their becoming a part of systemic circulation is a very novel idea. If a drug can be administered in a form such that it reaches the receptor sites in sufficient concentration without disturbing in extraneous tissue cells. Targeted drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. . There are many examples of drug delivery system by which we can target the drug to specific tissues/ cells i.e. liposomes, prodrug, niosomes, Mab etc.
Young Daniel L. Systems Biology in Drug Discovery and Development Young Daniel L. Systems Biology in Drug Discovery and Development Новинка

Young Daniel L. Systems Biology in Drug Discovery and Development

10098.48 руб.
The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.
Sachin Narayanbhai Patel,Kanu R. Patel and Mukesh R. Patel Formulation and Evaluation of ER Tablet of Antipsychotic Drug Sachin Narayanbhai Patel,Kanu R. Patel and Mukesh R. Patel Formulation and Evaluation of ER Tablet of Antipsychotic Drug Новинка

Sachin Narayanbhai Patel,Kanu R. Patel and Mukesh R. Patel Formulation and Evaluation of ER Tablet of Antipsychotic Drug

4983 руб.
The antipsychotic drugs are being used mainly for treatment of schizophrenia. Schizophrenia is a mental disorder characterized by a breakdown of typical emotional responses. Modified drug delivery systems (MDDS) of antipsychotics offer advantages over conventional formulations in provison of convenience, side effects and efficacy. Extended Release tablet of Antipsychotic drug were prepared using varying ratios of drug and polymers were selected for the study. After fixing the ratio of drug and polymer to control the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material. The effect of polymer concentration and channelizer concentration were studied. Drug release was observed upto 24 hrs.
Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery Новинка

Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery

15267 руб.
Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.
Paola Ceroni Electrochemistry of Functional Supramolecular Systems Paola Ceroni Electrochemistry of Functional Supramolecular Systems Новинка

Paola Ceroni Electrochemistry of Functional Supramolecular Systems

14796.06 руб.
With contributions from the most prominent experts around the world, this resource provides an accessible summary of electrochemical techniques and the applications of electrochemical concepts to molecular-level systems. It describes the most important electro-active functional supramolecular systems developed so far, including rotaxanes and catenanes as molecular machines and as elements for information processing; dendrimers as molecular batteries, sensors, light harvesting antennae, and drug delivery systems; and bio-hybrid devices.
Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development Новинка

Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development

11052.67 руб.
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
D. Bhattacharyya Responsive Membranes and Materials D. Bhattacharyya Responsive Membranes and Materials Новинка

D. Bhattacharyya Responsive Membranes and Materials

13169.53 руб.
The development of new multifunctional membranes and materials which respond to external stimuli, such as pH, temperature, light, biochemicals or magnetic or electrical signals, represents new approaches to separations, reactions, or recognitions. With multiple cooperative functions, responsive membranes and materials have applications which range from biopharmaceutical, to drug delivery systems to water treatment. This book covers recent advances in the generation and application of responsive materials and includes: Development and design of responsive membranes and materials Carbon nanotube membranes Tunable separations, reactions and nanoparticle synthesis Responsive membranes for water treatment Pore-filled membranes for drug release Biologically-inspired responsive materials and hydrogels Biomimetic polymer gels Responsive Membranes and Materials provides a cutting-edge resource for researchers and scientists in membrane science and technology, as well as specialists in separations, biomaterials, bionanotechnology, drug delivery, polymers, and functional materials.
Sami Al-Harbi,Hammed Al-Saidi and Abdelaziz Sayed El-Ahl Smart Universal Chitosan Nanoformulations Sami Al-Harbi,Hammed Al-Saidi and Abdelaziz Sayed El-Ahl Smart Universal Chitosan Nanoformulations Новинка

Sami Al-Harbi,Hammed Al-Saidi and Abdelaziz Sayed El-Ahl Smart Universal Chitosan Nanoformulations

7075 руб.
This book provides an overview in recent progress in the field of chitosan based smart nanoformulations and describes the basic concepts of passive and active cancer targeting chitosan based drug delivery vehicles including organ-specific drug delivery systems. Also, the construction and applications of multifunctional chitosan nanoparticulates used in cancer diagnosis, imaging and therapy have been described. The book also introduced an insight into various, mono, dual and multi-responsive smart chitosan nanoparticles that respond to their environment and their application in controlled gene and drug release nanoformulations.
Cheng Kun Advanced Delivery and Therapeutic Applications of RNAi Cheng Kun Advanced Delivery and Therapeutic Applications of RNAi Новинка

Cheng Kun Advanced Delivery and Therapeutic Applications of RNAi

16455.75 руб.
RNA interference (RNAi) is a process in living cells whereby small double stranded RNA interferes with the expression of specific genes with complementary nucleotide sequence. Like many nucleic acid-based therapies, RNAi has great potential in treating various life-threatening diseases. However, the poor stability and cellular uptake of RNAi molecules remain considerable barriers to their efficient delivery which is paramount to a successful therapy. This book provides a comprehensive introduction to RNAi delivery, then goes on to discuss different delivery strategies, and concludes with current applications in various diseases. It covers: Mechanisms, Barriers, and Analysis of RNAi Delivery Nonclinical Safety Assessments and Clinical Pharmacokinetics: A Regulatory Perspective Bioconjugation of siRNA for Site Specifi c Delivery Nanoscale Delivery Systems for RNAi Environmentally-Responsive Delivery Systems for RNAi Light-sensitive RNAi Viral-Mediated Delivery of shRNA and miRNA RNAi applications in Cancer Therapy, Liver Diseases, Hepatitis B, and Ocular Disease miRNA as therapeutic agents and targets Advanced Delivery and Therapeutic Applications of RNAi combines the essential aspects of developing RNAi therapeutics from bench to clinic, and is invaluable for researchers working on RNAi, drug discovery and delivery, biomedical engineering, biomaterials, molecular biology, and biotechnology.
Ashutosh Tiwari Advanced Theranostic Materials Ashutosh Tiwari Advanced Theranostic Materials Новинка

Ashutosh Tiwari Advanced Theranostic Materials

15106.96 руб.
The present book is covers the recent advances in the development on the regulation of such theragnosis system and their biomedical perspectives to act as a future nanomedicine. Advanced Theranostics Materialsis written by a distinguished group of contributors and provides comprehensive coverage of the current literature, up-to-date overview of all aspects of advanced theranostics materials ranging from system biology, diagnostics, imaging, image-guided therapy, therapeutics, biosensors, and translational medicine and personalized medicine, as well as the much broader task of covering most topics of biomedical research. The books focusses on the following topics: Part 1: System biology and translational medicine Aberrant Signaling Pathways: Hallmark of Cancer Cells and Target for Nanotherapeutics Application of Nanoparticles in Cancer Treatment Biomacromolecule-Gated Mesoporous Silica Drug Delivery Systems Construction of Functional DNA Nanostructures for Theranostic Applications Smart Polypeptide Nanocarriers for Malignancy Therapeutics Part 2: Imaging and therapeutics Dimercaptosuccinic acid-coated magnetic nanoparticles as a localized delivery system in cancer immunotherapy Cardiovascular nanomedicine Chitosan-based systems for sustained drug release Nanocapsules in biomedicine: promises and challenges Chitosan-based polyelectrolyte complexes: characteristics and application in formulation of particulate drug carriers Part 3: Diagnostics and featured prognostics Non-invasive Glucose Biosensors based on Nanomaterials Self/directed Assembly of Nanoparticles: A review on various approaches Ion exchangers – an open window for the development of advanced materials with pharmaceutical and medical applications New Titanium Alloys for Biomedical Applications
Koteswara Rao Valasani Novel Organophosphorus Compounds Koteswara Rao Valasani Novel Organophosphorus Compounds Новинка

Koteswara Rao Valasani Novel Organophosphorus Compounds

4749 руб.
The delivery of drug species to the brain and other organs is often seriously limited by transport and metabolism factors, including biological membranes; specifically, in the case of the brain, the functional barrier of the endothelial brain capillary wall, i.e. BBB, limits delivery. Site-specific and sustained delivery of drugs to the brain or other organs, i.e. targeted drug delivery, is even more difficult. Phosphorus compounds, are readily penetrates biological membranes such as the BBB and enters the target organ. According, phosphate esters are frequently used as a prodrug strategy, especially for water insoluble compounds, since the phosphate group enables following characteristic features to the xenobiotic:1) decreases the adverse effects of the drugs, 2) help in readily crossing the BBB and enters the target organ, 3) increases water solubility and thereby enables delivery of the drug parenterally, 4) Cleavage of the phosphonate carrier/drug entity in vivo provides a hydrophilic, negatively charged intermediate which is “locked” in the brain or other organ and which provides significant and sustained delivery of the active drug species to the target organ.
Bhargabjyoti Sahariah Formulation, Development, And In-vivo Studies Of Anti-hiv Vaginal Film Bhargabjyoti Sahariah Formulation, Development, And In-vivo Studies Of Anti-hiv Vaginal Film Новинка

Bhargabjyoti Sahariah Formulation, Development, And In-vivo Studies Of Anti-hiv Vaginal Film

3212 руб.
A tremendous development has been made in the field of controlled drug delivery system in the last few decades. The term control release has a meaning not only the scope of sustained action but also it implies a predictability and reproducibility in the drug release kinetics, which means the release of drug ingredients from the delivery system produce at a rate profile that is not only predictable kinetically, but also reproducible from one unit to another. Recently, several technical advancements have been made. The vagina is perhaps a less explored but efficient route for drug administration due to presence of dense blood vessels network and avoids liver first-pass. To date, most vaginal drug delivery systems have been formulated as conventional / traditional formulations such as gel, tablet etc. However, a clear justification subsists for providing long-term, controlled release of vaginal anti-retroviral in order to provide continuous protection against heterosexually transmitted HIV infection and to improve user compliance. The study is devoted to the development and characterization of Bio-adhesive Vaginal Film.
Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Новинка

Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

11620.18 руб.
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
Faisal A. Bughdadi,Abdel-Aziz S. El-Ahl and Adel Emara Chitosan Based Nanostructures Faisal A. Bughdadi,Abdel-Aziz S. El-Ahl and Adel Emara Chitosan Based Nanostructures Новинка

Faisal A. Bughdadi,Abdel-Aziz S. El-Ahl and Adel Emara Chitosan Based Nanostructures

5473 руб.
This book highlighted the use of chitosan nanostructures in drug delivery, which facilitate the ability of the drug to cross the biological barriers. Chitosan has the desired properties for safe use as a pharmaceutical excipient. This has prompted accelerated research activities worldwide on chitosan nanoparticles as drug delivery vehicles. These systems have great utility in controlled release and targeting studies of almost all class of bioactive molecules as discussed in this book. Recently, chitosan is also extensively explored in gene delivery. However, studies toward optimization of process parameters and scale up from the laboratory to pilot plant and then, to production level are yet to be undertaken. Majority of studies carried out so far are only in vitro conditions. More in vivo studies need to be carried out. Chemical modifications of chitosan are important to get the desired physicochemical properties such as solubility, hydrophilicity, etc. The published literature indicates that in the near future, chitosan-based particulate systems will have more commercial status in the market than in the past.
Dennis Douroumis Hot-Melt Extrusion. Pharmaceutical Applications Dennis Douroumis Hot-Melt Extrusion. Pharmaceutical Applications Новинка

Dennis Douroumis Hot-Melt Extrusion. Pharmaceutical Applications

15267 руб.
Hot-melt extrusion (HME) – melting a substance and forcing it through an orifice under controlled conditions to form a new material – is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.
Akira Harada Supramolecular Polymer Chemistry Akira Harada Supramolecular Polymer Chemistry Новинка

Akira Harada Supramolecular Polymer Chemistry

16455.75 руб.
Presenting the work of pioneering experts in this exciting field of supramolecular polymer chemistry, this monograph covers an extensive range of applications, including drug delivery and catalysis. It focuses on new structures and phenomena of cyclodextrin-based supramolecular polymers and many other compound classes. While providing a deeper insight in macromolecular recognition and the mechanisms of living systems, this book also introduces fascinating novel phenomena beyond natural systems.
Smita Mohanty Trends and Applications in Advanced Polymeric Materials Smita Mohanty Trends and Applications in Advanced Polymeric Materials Новинка

Smita Mohanty Trends and Applications in Advanced Polymeric Materials

15106.96 руб.
The book comprises recent innovations and developments in various high performance applications of advanced polymeric materials. It is a compilation of work from eminent academicians and scientists and the chapters provide insight into the effect of tailoring the polymeric systems, blending matrices with nano / micro fillers for improved performance and properties. The book details the following topics: Smart & high performance coatings High barrier packaging Solar energy harvesting Power generation using polymers Polymer sensors Conducting polymers Gas transport membranes Smart drug delivery systems
Tharwat Tadros F. Self-Organized Surfactant Structures Tharwat Tadros F. Self-Organized Surfactant Structures Новинка

Tharwat Tadros F. Self-Organized Surfactant Structures

17254.89 руб.
Highlighting recent developments as well as future challenges, this series of volumes covers such topics as emulsions, nano-emulsions, nano-dispersions and novel techniques for their investigation. It also considers the fundamental approach in areas such as controlled release, drug delivery and various applications of nanotechnology.
Hyojung Kang Healthcare Systems Engineering Hyojung Kang Healthcare Systems Engineering Новинка

Hyojung Kang Healthcare Systems Engineering

9683.48 руб.
Apply engineering and design principles to revitalize the healthcare delivery system Healthcare Systems Engineering is the first engineering book to cover this emerging field, offering comprehensive coverage of the healthcare system, healthcare delivery, and healthcare systems modeling. Written by leading industrial engineering authorities and a medical doctor specializing in healthcare delivery systems, this book provides a well-rounded resource for readers of a variety of backgrounds. Examples, case studies, and thoughtful learning activities are used to thoroughly explain the concepts presented, including healthcare systems, delivery, quantification, and design. You'll learn how to approach the healthcare industry as a complex system, and apply relevant design and engineering principles and processes to advance improvements. Written with an eye toward practicality, this book is designed to maximize your understanding and help you quickly apply toward solutions for a variety of healthcare challenges. Healthcare systems engineering is a new and complex interdisciplinary field that has emerged to address the myriad challenges facing the healthcare industry in the wake of reform. This book functions as both an introduction and a reference, giving you the knowledge you need to move toward better healthcare delivery. Understand the healthcare delivery context Use appropriate statistical and quantitative models Improve existing systems and design new ones Apply systems engineering to a variety of healthcare contexts Healthcare systems engineering overlaps with industrial engineering, operations research, and management science, uniting the principles and practices of these fields together in pursuit of optimal healthcare operations. Although collaboration is focused on practitioners, professionals in information technology, policy and administration, public health, and law all play crucial roles in revamping health care systems. Healthcare Systems Engineering is a complete and authoritative reference for stakeholders in any field.
Kalpana Swain and Satyanarayan Pattnaik Transdermal Therapeutic System Of Ondansetron Kalpana Swain and Satyanarayan Pattnaik Transdermal Therapeutic System Of Ondansetron Новинка

Kalpana Swain and Satyanarayan Pattnaik Transdermal Therapeutic System Of Ondansetron

5787 руб.
Ondansetron hydrochloride has been used orally or intravenously to prevent and control nausea and vomiting after cancer chemotherapy, radiotherapy and surgery. Transdermal route for delivery of antiemetic agents would be an ideal alternative. Transdermal delivery is influenced by various design factors such as polymer species, internal structure of the polymer matrix, permeation enhancement strategies and drug loading dose apart from other physicochemical properties of the drug. In this book attempts has been made to elucidate the development of ondansetron transdermal films.Application of design of experiment (DOE) to study the influence of formulation variables and optimization of formulations has been explained in detail. Physicochemical characterization and evaluation of transdermal systems has been discussed. This book would be of immense use to undergraduate/graduate students, teachers, all those researchers pursuing transdermal research, chemists and professionals.
Paolo Colombo Inhalation Drug Delivery. Techniques and Products Paolo Colombo Inhalation Drug Delivery. Techniques and Products Новинка

Paolo Colombo Inhalation Drug Delivery. Techniques and Products

7588.03 руб.
There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalation products and specific equipment and techniques used in manufacturing and quality control, the book balances research with the industrial aspects of creating the drugs, and features a highly regarded author team with both academic and industry experience.
Whitehouse David Molecular and Cellular Therapeutics Whitehouse David Molecular and Cellular Therapeutics Новинка

Whitehouse David Molecular and Cellular Therapeutics

8822.26 руб.
Molecular and Cellular Therapeutics aims to bring together key developments in the areas of molecular diagnostics, therapeutics and drug discovery. The book covers topics including diagnostics, therapeutics, model systems, clinical trials and drug discovery. The developing approaches to molecular and cellular therapies, diagnostics and drug discovery are presented in the context of the pathologies they are devised to treat.
Hongyan Wang Airdrop Recovery Systems With Self-Inflating Airbag. Modeling And Analysis Hongyan Wang Airdrop Recovery Systems With Self-Inflating Airbag. Modeling And Analysis Новинка

Hongyan Wang Airdrop Recovery Systems With Self-Inflating Airbag. Modeling And Analysis

10845.5 руб.
A complete reference text to airdrop recovery systems with self-inflating airbags, focusing on analysis, test data, and engineering practicalities Comprehensively covers the fundamental theories, design, matching, and analysis of airdrop recovery systems that include a parachute and self-inflating airbag system Gives step-by-step guidance to aid readers in analyzing and designing their own recovery systems Highlights advanced research programs in the field of airdrop recovery systems, such as simulation and optimization methods.
Mustafa Guler O. Therapeutic Nanomaterials Mustafa Guler O. Therapeutic Nanomaterials Новинка

Mustafa Guler O. Therapeutic Nanomaterials

11620.18 руб.
Addressing a cutting-edge, multidisciplinary field, this book reviews nanomaterials and their biomedical applications. It covers regeneration, implants, adhesives, and biosensors and strategies for more efficient therapy, diagnosis, and drug delivery with the use of nanotechnology. • Addresses the increasing demand for nanomedicine in a cutting-edge, multidisciplinary field • Introduces concepts, strategies, and requirements of developing materials • Discusses hot topics in drug delivery, such as neural regeneration, cartilage regeneration, bone tissue regeneration, dental regeneration, biomedical imaging, tissue adhesives and biosensors • Includes a chapter about nanotoxicology to help readers further understand the biocompatability of nanomaterials
Arjun Singh Drug Discovery Technology Arjun Singh Drug Discovery Technology Новинка

Arjun Singh Drug Discovery Technology

4419 руб.
Drug Discovery Technology is versatile research area in the field of medicine, biotechnology, and pharmacology. Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques, tools and technologies used in drug discovery and development technology. The major techniques and tools are used in drug discovery, drug design, clinical trial studies and thematic issues describing novel approaches and cutting edge technologies used in all stages of drug discovery. The Book addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process. This Book is essential for all science students, biological scientists and researchers involved in drug discovery who wish to keep abreast of all the modern techniques and technologies used in drug discovery and development. The major topics of discussion related to drug, discovery and therapy will included in the next volume : Pharmaceutical Research & Development, Translational Medicine, Regenerative Medicine, Enabling Technologies, Structural Biology, Drug Delivery & Targeting, Antiinfectives, Biologics, CNS Drug Discovery & Therapy.
Yoon Lee S. Self-Assembly and Nanotechnology Systems. Design, Characterization, and Applications Yoon Lee S. Self-Assembly and Nanotechnology Systems. Design, Characterization, and Applications Новинка

Yoon Lee S. Self-Assembly and Nanotechnology Systems. Design, Characterization, and Applications

12404.43 руб.
A fundamental resource for understanding and developing effective self-assembly and nanotechnology systems Systematically integrating self-assembly, nanoassembly, and nanofabrication into one easy-to-use source, Self-Assembly and Nanotechnology Systems effectively helps students, professors, and researchers comprehend and develop applicable techniques for use in the field. Through case studies, countless examples, clear questions, and general applications, this book provides experiment-oriented techniques for designing, applying, and characterizing self-assembly and nanotechnology systems. Self-Assembly and Nanotechnology Systems includes: Techniques for identifying assembly building units Practical assembly methods to focus on when developing nanomaterials, nanostructures, nanoproperties, nanofabricated systems, and nanomechanics Algorithmic diagrams in each chapter for a general overview Schematics designed to link assembly principles with actual systems Hands-on lab activities This informative reference also analyzes the diverse origins and structures of assembly building units, segmental analysis, and selection of assembly principles, methods, characterization techniques, and predictive models. Complementing the author's previous conceptually based book on this topic, Self-Assembly and Nanotechnology Systems is a practical guide that grants practitioners not only the skills to properly analyze assembly building units but also how to work with applications to exercise and develop their knowledge of this rapidly advancing scientific field.
Natanya Civjan Chemical Biology. Approaches to Drug Discovery and Development to Targeting Disease Natanya Civjan Chemical Biology. Approaches to Drug Discovery and Development to Targeting Disease Новинка

Natanya Civjan Chemical Biology. Approaches to Drug Discovery and Development to Targeting Disease

10893.64 руб.
An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.
Benson Heather A.E. Topical and Transdermal Drug Delivery. Principles and Practice Benson Heather A.E. Topical and Transdermal Drug Delivery. Principles and Practice Новинка

Benson Heather A.E. Topical and Transdermal Drug Delivery. Principles and Practice

11529.76 руб.
Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.
Sarmento Bruno Chitosan-Based Systems for Biopharmaceuticals. Delivery, Targeting and Polymer Therapeutics Sarmento Bruno Chitosan-Based Systems for Biopharmaceuticals. Delivery, Targeting and Polymer Therapeutics Новинка

Sarmento Bruno Chitosan-Based Systems for Biopharmaceuticals. Delivery, Targeting and Polymer Therapeutics

17413.92 руб.
Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules – making it a valuable component in the formulation of biopharmaceutical drugs. Chitosan-Based Systems for Biopharmaceuticals provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. The book is divided in four different parts. Part I discusses general aspects of chitosan and its derivatives, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems. Part II deals with the use of chitosan and derivatives in the formulation and delivery of biopharmaceuticals, and focuses on the synergistic effects between chitosan and this particular subset of pharmaceuticals. Part III discusses specific applications of chitosan and its derivatives for biopharmaceutical use. Finally, Part IV presents diverse viewpoints on different issues such as regulatory, manufacturing and toxicological requirements of chitosan and its derivatives related to the development of biopharmaceutical products, as well as their patent status, and clinical application and potential. Topics covered include: chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals physical properties of chitosan and derivatives in sol and gel states absorption promotion properties of chitosan and derivatives biocompatibility and biodegradation of chitosan and derivatives biological and pharmacological activity of chitosan and derivatives biological, chemical and physical compatibility of chitosan and biopharmaceuticals approaches for functional modification or crosslinking of chitosan use of chitosan and derivatives in conventional biopharmaceutical dosage forms manufacture techniques of chitosan-based microparticles and nanoparticles for biopharmaceuticals chitosan and derivatives for biopharmaceutical use: mucoadhesive properties chitosan-based systems for mucosal delivery of biopharmaceuticals chitosan-based delivery systems for mucosal vaccination chitosan-based nanoparticulates for oral delivery of biopharmaceuticals chitosan-based systems for ocular delivery of biopharmaceuticals chemical modification of chitosan for delivery of DNA and siRNA target-specific chitosan-based nanoparticle systems for nucleic acid delivery functional PEGylated chitosan systems for biopharmaceuticals stimuli-sensitive chitosan-based systems for biopharmaceuticals chitosan copolymers for biopharmaceuticals application of chitosan for anti-cancer biopharmaceutical delivery chitosan-based biopharmaceuticals scaffolds in tissue engineering and regenerative medicine wound healing properties of chitosan and its use in wound dressing biopharmaceuticals toxicological properties of chitosan and derivatives for biopharmaceutical applications regulatory status of chitosan and derivatives patentability and intellectual property issues quality control and good manufacturing practice preclinical and clinical use of chitosan and derivatives for biopharmaceuticals Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development.
SuPing Lyu Drug-device Combinations for Chronic Diseases SuPing Lyu Drug-device Combinations for Chronic Diseases Новинка

SuPing Lyu Drug-device Combinations for Chronic Diseases

11616.5 руб.
This book covers two areas, the first detailing the concepts and technologies of drug-device combination products. The second area includes case studies of important products that either significantly shape our technologies and thinking, or contribute to current healthcare practice. The book: Discusses where drugs and devices work, where they fail, and when they need to work with each other Reviews interactions between human bodies and the drug-device combination products the measurements of these interactions Covers how a drug-device combination product is developed, tested, and regulated Includes case studies of steroid releasing leads, AOA treated tissue heart valves, intrathecal drug delivery pumps, infuse bone grafts, drug eluting stents, and antimicrobial meshes
Bob Boiko Content Management Bible Bob Boiko Content Management Bible Новинка

Bob Boiko Content Management Bible

3975.12 руб.
Written by one of the leading experts in content management systems (CMS), this newly revised bestseller guides readers through the confusing-and often intimidating-task of building, implementing, running, and managing a CMS Updated to cover recent developments in online delivery systems, as well as XML and related technologies Reflects valuable input from CMS users who attended the author's workshops, conferences, and courses An essential reference showing anyone involved in information delivery systems how to plan and implement a system that can handle large amounts of information and help achieve an organization's overall goals
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This book will advance the understanding and application of self-adaptive intelligent systems; therefore it will potentially benefit the long-term goal of replicating certain levels of brain-like intelligence in complex and networked engineering systems. It will provide new approaches for adaptive systems within uncertain environments. This will provide an opportunity to evaluate the strengths and weaknesses of the current state-of-the-art of knowledge, give rise to new research directions, and educate future professionals in this domain. Self-adaptive intelligent systems have wide applications from military security systems to civilian daily life. In this book, different application problems, including pattern recognition, classification, image recovery, and sequence learning, will be presented to show the capability of the proposed systems in learning, memory, and prediction. Therefore, this book will also provide potential new solutions to many real-world applications.
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In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.

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Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules – making it a valuable component in the formulation of biopharmaceutical drugs. Chitosan-Based Systems for Biopharmaceuticals provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. The book is divided in four different parts. Part I discusses general aspects of chitosan and its derivatives, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems. Part II deals with the use of chitosan and derivatives in the formulation and delivery of biopharmaceuticals, and focuses on the synergistic effects between chitosan and this particular subset of pharmaceuticals. Part III discusses specific applications of chitosan and its derivatives for biopharmaceutical use. Finally, Part IV presents diverse viewpoints on different issues such as regulatory, manufacturing and toxicological requirements of chitosan and its derivatives related to the development of biopharmaceutical products, as well as their patent status, and clinical application and potential. Topics covered include: chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals physical properties of chitosan and derivatives in sol and gel states absorption promotion properties of chitosan and derivatives biocompatibility and biodegradation of chitosan and derivatives biological and pharmacological activity of chitosan and derivatives biological, chemical and physical compatibility of chitosan and biopharmaceuticals approaches for functional modification or crosslinking of chitosan use of chitosan and derivatives in conventional biopharmaceutical dosage forms manufacture techniques of chitosan-based microparticles and nanoparticles for biopharmaceuticals chitosan and derivatives for biopharmaceutical use: mucoadhesive properties chitosan-based systems for mucosal delivery of biopharmaceuticals chitosan-based delivery systems for mucosal vaccination chitosan-based nanoparticulates for oral delivery of biopharmaceuticals chitosan-based systems for ocular delivery of biopharmaceuticals chemical modification of chitosan for delivery of DNA and siRNA target-specific chitosan-based nanoparticle systems for nucleic acid delivery functional PEGylated chitosan systems for biopharmaceuticals stimuli-sensitive chitosan-based systems for biopharmaceuticals chitosan copolymers for biopharmaceuticals application of chitosan for anti-cancer biopharmaceutical delivery chitosan-based biopharmaceuticals scaffolds in tissue engineering and regenerative medicine wound healing properties of chitosan and its use in wound dressing biopharmaceuticals toxicological properties of chitosan and derivatives for biopharmaceutical applications regulatory status of chitosan and derivatives patentability and intellectual property issues quality control and good manufacturing practice preclinical and clinical use of chitosan and derivatives for biopharmaceuticals Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development.
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