side effects of drugs annual volume 27a worldwide yearly survey of new data trends inadverse drug reactions seda volume 27



János Fischer Successful Drug Discovery, Volume 1 János Fischer Successful Drug Discovery, Volume 1 Новинка

János Fischer Successful Drug Discovery, Volume 1

14247.21 руб.
The first volume of the book series «Successful Drug Discovery» is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
Michael Wink Annual Plant Reviews, Biochemistry of Plant Secondary Metabolism Michael Wink Annual Plant Reviews, Biochemistry of Plant Secondary Metabolism Новинка

Michael Wink Annual Plant Reviews, Biochemistry of Plant Secondary Metabolism

19384.06 руб.
This brand new Annual Plant Reviews volume is the second edition of the highly successful and well-received Annual Plant Reviews, Volume 2. This exciting new volume provides an up-to-date survey of the biochemistry and physiology of plant secondary metabolism. The volume commences with an overview of the biochemistry, physiology and function of secondary metabolism, followed by detailed reviews of the major groups of secondary metabolites: alkaloids and betalains, cyanogenic glucosides, glucosinolates and nonprotein amino acids, phenyl propanoids and related phenolics, terpenoids, cardiac glycosides and saponins. A final chapter discusses the evolution of secondary metabolism. This carefully compiled new edition brings together chapters from some of the world's leading experts in plant secondary metabolism. Completely revised and brought right up to date with much new information, this volume is an essential purchase for advanced students, researchers and professionals in biochemistry, physiology, molecular biology, genetics, plant sciences, agriculture, medicine, pharmacology and pharmacy, working in the academic and industrial sectors, including those working in the pesticide and pharmaceutical industries. Libraries in all universities and research establishments where these subjects are studied and taught will need copies of this excellent volume on their shelves. A companion volume Annual Plant Reviews Volume 39, Functions and Biotechnology of Plant Secondary Metabolites, Second Edition, Edited by M. Wink, is also available.
A. Knipe C. Organic Reaction Mechanisms 2009. An annual survey covering the literature dated January to December 2009 A. Knipe C. Organic Reaction Mechanisms 2009. An annual survey covering the literature dated January to December 2009 Новинка

A. Knipe C. Organic Reaction Mechanisms 2009. An annual survey covering the literature dated January to December 2009

2139.84 руб.
Organic Reaction Mechanisms 2009, the 45th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2009. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. This volume includes a 5-year cumulative index.
A. Knipe C. Organic Reaction Mechanisms 2014. An annual survey covering the literature dated January to December 2014 A. Knipe C. Organic Reaction Mechanisms 2014. An annual survey covering the literature dated January to December 2014 Новинка

A. Knipe C. Organic Reaction Mechanisms 2014. An annual survey covering the literature dated January to December 2014

43864.92 руб.
Organic Reaction Mechanisms 2014, the 50th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2014. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. This volume includes a 5-year cumulative index.
A. Knipe C. Organic Reaction Mechanisms 2010. An annual survey covering the literature dated January to December 2010 A. Knipe C. Organic Reaction Mechanisms 2010. An annual survey covering the literature dated January to December 2010 Новинка

A. Knipe C. Organic Reaction Mechanisms 2010. An annual survey covering the literature dated January to December 2010

2139.84 руб.
Organic Reaction Mechanisms 2010, the 46th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2010. It details the latest progress in a wide range of classes of organic reaction mechanisms, including reactions of different compounds and acids and their derivatives, oxidation and reduction, aliphatic substitutions, elimination reactions, and molecular rearrangements, to name a few. An experienced team of authors compiled these reviews, ensuring the quality of selection and presentation.
János Fischer Analogue-based Drug Discovery III János Fischer Analogue-based Drug Discovery III Новинка

János Fischer Analogue-based Drug Discovery III

16121.04 руб.
Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs. The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and – together with the previous volumes – constitutes the first systematic approach to drug analogue development.
Michael Wink Annual Plant Reviews, Functions and Biotechnology of Plant Secondary Metabolites Michael Wink Annual Plant Reviews, Functions and Biotechnology of Plant Secondary Metabolites Новинка

Michael Wink Annual Plant Reviews, Functions and Biotechnology of Plant Secondary Metabolites

19384.06 руб.
This brand new Annual Plant Reviews volume is the second edition of the highly successful and well-received Functions of Plant Secondary Metabolites and their Exploitation in Biotechnology (Annual Plant Reviews, Volume 3). This exciting new volume provides an up-to-date survey of the functions of plant secondary metabolites, their modes of action and their use in pharmacology as molecular probes, in medicine as therapeutic agents, and in agriculture as biorational pesticides. The possibilities to produce valuable natural products in plant cell and tissue culture and even in recombinant microorganisms are also reviewed. This carefully compiled new edition brings together chapters from some of the world’s leading experts in plant secondary metabolites. Completely revised and brought right up to date with much new information, this volume is an essential purchase for advanced students, researchers and professionals in biochemistry, physiology, molecular biology, genetics, plant sciences, agriculture, medicine, pharmacology and pharmacy, working in the academic and industrial sectors, including those working in the pesticide and pharmaceutical industries. Libraries in all universities and research establishments where these subjects are studied and taught will need copies of this excellent volume on their shelves. A companion volume Annual Plant Reviews Volume 40, Biochemistryof Plant Secondary Metabolism, Second Edition, Edited by M. Wink, is also available.
Florencio Dörwald Zaragoza Side Reactions in Organic Synthesis II. Aromatic Substitutions Florencio Dörwald Zaragoza Side Reactions in Organic Synthesis II. Aromatic Substitutions Новинка

Florencio Dörwald Zaragoza Side Reactions in Organic Synthesis II. Aromatic Substitutions

8548.18 руб.
This new textbook is the successor to the volume «Side Reactions in Organic Synthesis – A Guide to Successful Synthesis Design» (2004), written by the same author. Whereas the predecessor mainly covered the limitations of aliphatic substitution reactions, this new volume focuses on the most important aromatic substitution reactions, both electrophilic and nucleophilic, such as amination reactions, halogenation reactions, Friedel-Crafts acylations, or transition metal-catalyzed arylation reactions. Each chapter not only describes the scope of a specific reaction type, but also reveals what cannot be achieved with this reaction, i.e. what type of side reactions are to be expected with certain starting materials or electrophiles/nucleophiles. With its unique approach, this is a must-have book for graduate students in organic chemistry and synthetic chemists both in academia and industry!
Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling Новинка

Hugo Kubinyi Drug-Membrane Interactions. Analysis, Drug Distribution, Modeling

11247.23 руб.
Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.
János Fischer Successful Drug Discovery, Volume 2 János Fischer Successful Drug Discovery, Volume 2 Новинка

János Fischer Successful Drug Discovery, Volume 2

11662.69 руб.
Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. 11 selected case studies describe recently introduced drugs that have not been previously covered in textbooks or general references. These range across six different therapeutic fields and provide a representative cross-section of the current drug development efforts. Backed by copious data and chemical information, the insight and experience of the contributors makes this one of the most useful training manuals that a junior medicinal chemist can hope to find and has won the support and endorsement of IUPAC.
Talbot John Stephens' Detection and Evaluation of Adverse Drug Reactions. Principles and Practice Talbot John Stephens' Detection and Evaluation of Adverse Drug Reactions. Principles and Practice Новинка

Talbot John Stephens' Detection and Evaluation of Adverse Drug Reactions. Principles and Practice

30576.17 руб.
The detection and evaluation of adverse drug reactions is crucial for understanding the safety of medicines and for preventing harm in patients. Not only is it necessary to detect new adverse drug reactions, but the principles and practice of pharmacovigilance apply to the surveillance of a wide range of medicinal products. Stephens' Detection and Evaluation of Adverse Drug Reactions provides a comprehensive review of all aspects of adverse drug reactions throughout the life cycle of a medicine, from toxicology and clinical trials through to pharmacovigilance, risk management, and legal and regulatory requirements. It also covers the safety of biotherapeutics and vaccines and includes new chapters on pharmacogenetics, proactive risk management, societal considerations, and the safety of drugs used in oncology and herbal medicines. This sixth edition of the classic text on drug safety is an authoritative reference text for all those who work in pharmacovigilance or have an interest in adverse drug reactions, whether in regulatory authorities, pharmaceutical companies, or academia. Praise for previous editions "This book presents a comprehensive and wide-ranging overview of the science of pharmacovigilance. For those entering or already experienced in the pharmaceutical sciences, this is an essential work.” – from a review in E-STREAMS «…a key text in the area of pharmacovigilance…extensively referenced and well-written…a valuable resource…» – from a review in The Pharmaceutical Journal
A. Knipe C. Organic Reaction Mechanisms 2007. An annual survey covering the literature dated January to December 2007 A. Knipe C. Organic Reaction Mechanisms 2007. An annual survey covering the literature dated January to December 2007 Новинка

A. Knipe C. Organic Reaction Mechanisms 2007. An annual survey covering the literature dated January to December 2007

47128.68 руб.
Organic Reaction Mechanisms 2007, the 43rd annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2007. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.
A. Knipe C. Organic Reaction Mechanisms 2012. An annual survey covering the literature dated January to December 2012 A. Knipe C. Organic Reaction Mechanisms 2012. An annual survey covering the literature dated January to December 2012 Новинка

A. Knipe C. Organic Reaction Mechanisms 2012. An annual survey covering the literature dated January to December 2012

41991.1 руб.
Organic Reaction Mechanisms 2012, the 48th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2012. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compiled these reviews, ensuring the quality of selection and presentation.
A. Knipe C. Organic Reaction Mechanisms 2013. An annual survey covering the literature dated January to December 2013 A. Knipe C. Organic Reaction Mechanisms 2013. An annual survey covering the literature dated January to December 2013 Новинка

A. Knipe C. Organic Reaction Mechanisms 2013. An annual survey covering the literature dated January to December 2013

38415.6 руб.
Organic Reaction Mechanisms 2013, the 49th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2013. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.
Scott Denmark E. Organic Reactions, Volume 91 Scott Denmark E. Organic Reactions, Volume 91 Новинка

Scott Denmark E. Organic Reactions, Volume 91

22119.56 руб.
The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.
Scott Denmark E. Organic Reactions, Volume 89 Scott Denmark E. Organic Reactions, Volume 89 Новинка

Scott Denmark E. Organic Reactions, Volume 89

24176.22 руб.
The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.
Scott Denmark E. Organic Reactions, Volume 92 Scott Denmark E. Organic Reactions, Volume 92 Новинка

Scott Denmark E. Organic Reactions, Volume 92

22119.56 руб.
The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.
Scott Denmark E. Organic Reactions, Volume 90 Scott Denmark E. Organic Reactions, Volume 90 Новинка

Scott Denmark E. Organic Reactions, Volume 90

22119.56 руб.
The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.
Scott Denmark E. Organic Reactions, Volume 93 Scott Denmark E. Organic Reactions, Volume 93 Новинка

Scott Denmark E. Organic Reactions, Volume 93

22119.56 руб.
The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.
All-American Volume XIII. Born Ready All-American Volume XIII. Born Ready Новинка

All-American Volume XIII. Born Ready

6980 руб.
All-American XIII is the latest volume in Bruce Weber's annual survey of American legends. This year's theme is speak up and features an eclectic...
Wei-Fang Lin Starting and Sustaining Meaningful Institutional Research at Small Colleges and Universities. Theory and Practice: New Directions for Institutional Research, Number 173 Wei-Fang Lin Starting and Sustaining Meaningful Institutional Research at Small Colleges and Universities. Theory and Practice: New Directions for Institutional Research, Number 173 Новинка

Wei-Fang Lin Starting and Sustaining Meaningful Institutional Research at Small Colleges and Universities. Theory and Practice: New Directions for Institutional Research, Number 173

2174.04 руб.
The focus of this volume is on the work of Institutional Researchers in a small college or university (SCUs) setting. At an SCU, the goal of the IR office is to balance the bureaucratic tendencies of data-driven decision making with the need for collegiality and collaboration. Drawing on numerous examples, it illustrates how IR professionals can leverage their positionality within the institution to design data flows to answer questions by serving as convergent thinkers, connecting disjointed systems and requests. This volume: identifies the challenges that small IR offices face reinforces the idea of collegiality as a defining feature of small IR offices discusses several principles for using data about teaching and learning explores the effects of low response rates in survey data and the effects of nonresponse bias demonstrates the importance of collaborative efforts in enacting change proposes a model of policy development focused on student success presents an effective model of SCU IR office development This is the 173rd volume of this Jossey-Bass quarterly report series. Timely and comprehensive, New Directions for Institutional Research provides planners and administrators in all types of academic institutions with guidelines in such areas as resource coordination, information analysis, program evaluation, and institutional management.
Jane Parker Annual Plant Reviews, Molecular Aspects of Plant Disease Resistance Jane Parker Annual Plant Reviews, Molecular Aspects of Plant Disease Resistance Новинка

Jane Parker Annual Plant Reviews, Molecular Aspects of Plant Disease Resistance

20227.02 руб.
Annual Plant Reviews, Volume 34 Molecular Aspects of Plant Disease Resistance Edited by Jane Parker In recent years, our understanding of the mechanisms involved in plant resistance to disease has seen major advances. This important new volume in Wiley-Blackwell’s Annual Plant Reviews provides cutting edge reviews on major aspects of plant immunity from many of the world's leading researchers in the area. Coverage includes: • Establishment of disease by microbial pathogens • Genomic approaches to understanding host-pathogen interactions • Local and systemic resistance signalling • Activities of small bioactive molecules • Plant-insect ecology This exciting volume is essential reading for all those studying plant-pathogen interactions including plant and agricultural scientists, molecular biologists, geneticists and microbiologists. Libraries in all universities and research establishments where biological and agricultural sciences are studied and taught should have copies of this important volume on their shelves. About the Editor Dr Jane Parker is a Group Leader in the Department of Plant-Microbe Interactions at The Max-Planck Institute of Plant Breeding Research, Cologne and Associate Professor at The Institute of Genetics, University of Cologne, Germany. Also Available Annual Plant Reviews, Volume 33 Intracellular Signaling in Plants Edited by Zhenbiao Yang Print: 9781405160025 Annual Plant Reviews, Volume 32 Cell Cycle Control and Plant Development Edited by Dirk Inzé Print: 9781405150439 Online: 9780470988923 Annual Plant Reviews, Volume 31 Plant Mitochondria Edited by David Logan Print: 9781405149396 Online: 9780470986592 Annual Plant Reviews, Volume 30 Light and Plant Development Edited by Garry C. Whitelam and Karen J. Halliday Print: 9781405145381 Online: 9780470988893
A. Knipe C. Organic Reaction Mechanisms 2008. An annual survey covering the literature dated January to December 2008 A. Knipe C. Organic Reaction Mechanisms 2008. An annual survey covering the literature dated January to December 2008 Новинка

A. Knipe C. Organic Reaction Mechanisms 2008. An annual survey covering the literature dated January to December 2008

47128.68 руб.
This volume is the 44th in this classical series. In every volume relevant reaction mechanisms are featured in chapters entitled: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Addition Reactions: Polar Addition Addition Reactions: Cycloadditions Molecular Rearrangements An experienced team of authors is compiling these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. As a new service to the reader all reaction mechanisms leading to stereospecific products are highlighted. This reflects the needs of the organic synthetic community with leads to chiral reactions. Detailed author and subject indexes help the reader to find the information they are looking for. As a new service to the reader all mechanisms featuring 'Enantiospecific and diastereospecific' reactions are highlighted. This reflects the interest of synthetic organic chemists in such reactions and the pharmaceutical role of chiral molecules.
Giorgio Minotti Cardiotoxicity of Non-Cardiovascular Drugs Giorgio Minotti Cardiotoxicity of Non-Cardiovascular Drugs Новинка

Giorgio Minotti Cardiotoxicity of Non-Cardiovascular Drugs

13487.23 руб.
Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: metabolic targets of cardiotoxicity regulatory aspects translating molecular mechanisms into clinical trials structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs cardiovascular toxicity of antitumor drugs cardiovascular toxicities of non-steroidal anti-inflammatory drugs cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease.
Сlinical symposia 1992 annual. Volume 44 Сlinical symposia 1992 annual. Volume 44 Новинка

Сlinical symposia 1992 annual. Volume 44

129 руб.
Издание на английском языке. Сlinical symposia 1992 annual. Volume 44 / Ежегодный клинический симпозиум, 1992 год, том 44. Content: 1. Ocular complications of diabetes; 2. A tribute to Frank H. Netter, MD 1906-1991; 3. Diagnosis and management of hearing loss.
Brad Edwards Total Survey Error in Practice Brad Edwards Total Survey Error in Practice Новинка

Brad Edwards Total Survey Error in Practice

8622.88 руб.
Featuring a timely presentation of total survey error (TSE), this edited volume introduces valuable tools for understanding and improving survey data quality in the context of evolving large-scale data sets This book provides an overview of the TSE framework and current TSE research as related to survey design, data collection, estimation, and analysis. It recognizes that survey data affects many public policy and business decisions and thus focuses on the framework for understanding and improving survey data quality. The book also addresses issues with data quality in official statistics and in social, opinion, and market research as these fields continue to evolve, leading to larger and messier data sets. This perspective challenges survey organizations to find ways to collect and process data more efficiently without sacrificing quality. The volume consists of the most up-to-date research and reporting from over 70 contributors representing the best academics and researchers from a range of fields. The chapters are broken out into five main sections: The Concept of TSE and the TSE Paradigm, Implications for Survey Design, Data Collection and Data Processing Applications, Evaluation and Improvement, and Estimation and Analysis. Each chapter introduces and examines multiple error sources, such as sampling error, measurement error, and nonresponse error, which often offer the greatest risks to data quality, while also encouraging readers not to lose sight of the less commonly studied error sources, such as coverage error, processing error, and specification error. The book also notes the relationships between errors and the ways in which efforts to reduce one type can increase another, resulting in an estimate with larger total error. This book: • Features various error sources, and the complex relationships between them, in 25 high-quality chapters on the most up-to-date research in the field of TSE • Provides comprehensive reviews of the literature on error sources as well as data collection approaches and estimation methods to reduce their effects • Presents examples of recent international events that demonstrate the effects of data error, the importance of survey data quality, and the real-world issues that arise from these errors • Spans the four pillars of the total survey error paradigm (design, data collection, evaluation and analysis) to address key data quality issues in official statistics and survey research Total Survey Error in Practice is a reference for survey researchers and data scientists in research areas that include social science, public opinion, public policy, and business. It can also be used as a textbook or supplementary material for a graduate-level course in survey research methods. Paul P. Biemer, PhD, is distinguished fellow at RTI International and associate director of Survey Research and Development at the Odum Institute, University of North Carolina, USA. Edith de Leeuw, PhD, is professor of survey methodology in the Department of Methodology and Statistics at Utrecht University, the Netherlands. Stephanie Eckman, PhD, is fellow at RTI International, USA. Brad Edwards is vice president, director of Field Services, and deputy area director at Westat, USA. Frauke Kreuter, PhD, is professor and director of the Joint Program in Survey Methodology, University of Maryland, USA; professor of statistics and methodology at the University of Mannheim, Germany; and head of the Statistical Methods Research Department at the Institute for Employment Research, Germany. Lars E. Lyberg, PhD, is senior advisor at Inizio, Sweden. N. Clyde Tucker, PhD, is principal survey methodologist at the American Institutes for Research, USA. Brady T. West, PhD, is research associate professor in the Survey Resea
Buchwald Peter Retrometabolic Drug Design and Targeting Buchwald Peter Retrometabolic Drug Design and Targeting Новинка

Buchwald Peter Retrometabolic Drug Design and Targeting

12644.28 руб.
Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
Sherrel Howard Drugs of Abuse. Pharmacology and Molecular Mechanisms Sherrel Howard Drugs of Abuse. Pharmacology and Molecular Mechanisms Новинка

Sherrel Howard Drugs of Abuse. Pharmacology and Molecular Mechanisms

6356.62 руб.
Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse. Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up interacts with brain function. The final chapter provides a brief overview of clinical substance abuse treatment. Providing a concise, accessible introductory overview of the topic, Drugs of Abuse: Pharmacology and Molecular Mechanisms will be a valuable resource for students, researchers, and others interested in how drugs interact with the brain. Introduces readers to the basic principles of neuroscience and pharmacology as related to drug use and abuse. Explores how the chemical make-up of drugs interact with the brain and can lead to addiction Includes coverage of a wide array of commonly abused families of drugs, including stimulants, depressants, hallucinogens, and others. Provides an essential introduction to the chemical and molecular underpinnings of drug use and abuse
Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry Новинка

Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry

18851.47 руб.
The book «Drug Selectivity – An Evolving Concept in Medicinal Chemistry» provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Michael B. Smith Compendium of Organic Synthetic Methods Michael B. Smith Compendium of Organic Synthetic Methods Новинка

Michael B. Smith Compendium of Organic Synthetic Methods

14636.71 руб.
The Compendium of Organic Synthetic Methods series facilitates the working chemist's search for the most useful functional group transformations in organic chemistry. Drawn from an exhaustive survey of the literature, Compendium of Organic Synthetic Methods, Volume 12 contains both functional group transformations and carbon-carbon bond-forming reactions. Author Michael Smith adheres to stringent criteria for listing reactions, including real synthetic utility and reagents that are either readily available or easily prepared and handled in the laboratory. A clear organizational scheme-chemical transformations classified first by reacting functional group of starting material, then by functional group formed-allows for quick reference and information retrieval. Compendium of Organic Synthetic Methods, Volume 12 provides an unparalleled source of information on the methods, reactions, and transformations in contemporary organic chemistry for the working chemist and student alike.
Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Новинка

Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery

12261.12 руб.
Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover: A general overview of the discipline, from its foundations to contemporary industrial applications Chemoinformatics-based applications Bioinformatics-based applications Data mining methods in clinical development Data mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.
Chao-Jun Li Silver Catalysis in Organic Synthesis, 2 Volume Set Chao-Jun Li Silver Catalysis in Organic Synthesis, 2 Volume Set Новинка

Chao-Jun Li Silver Catalysis in Organic Synthesis, 2 Volume Set

27140.5 руб.
Covers all the aspects of the recent achievements in silver catalyzed reactions Silver catalysis has emerged as a powerful tool in the field of organic synthesis. This comprehensive book systematically explores the unique performance of silver catalysis, introducing all the recent progress of silver catalysis in organic synthesis. It clearly emphasizes the unique features of silver catalysis and provides the reaction mechanism involved. This two-volume book also provides vivid schematics and tables throughout to enhance the accessibility to the relevant theory and mechanisms. Silver Catalysis in Organic Synthesis begins with an introduction to Silver Chemistry before moving on to chapters covering: Silver-Catalyzed Cycloaddition Reactions; Silver-Catalyzed Cyclizations; Silver-Mediated Radical Reactions; Silver-Mediated Fluorination, Perfluoroalkylation and Trifluoromethylthiolation Reactions; Coupling Reactions and C-H Functionalization; Silver-Catalyzed CO2 Incorporation; Silver-Catalyzed Carbene, Nitrene, and Silylene Transfer Reactions; Asymmetric Silver-Catalyzed Reactions; Silver-Catalyzed Reduction and Oxidation of Aldehydes and Their Derivatives; Silver Complexes in Organic Transformations; and Silver Nanoparticles in Organic Transformations. -Covers recently developed organic reactions catalyzed by silver, along with their reaction mechanism -Introduces many new reactions and mechanisms related to silver catalysis -Offers professionals and newcomers in the related fields a survey of new advances in silver catalysis in organic synthesis Silver Catalysis in Organic Synthesis will appeal to a wide readership including chemists, biochemists, pharmaceutical scientists, biomedical researchers, agriculture scientists, and graduate students in the related fields.
Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Новинка

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis

17548.73 руб.
This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.
Barratt Michael J. Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs Barratt Michael J. Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs Новинка

Barratt Michael J. Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs

10498.58 руб.
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
Anastas Paul T. Green Processes. Green Synthesis Anastas Paul T. Green Processes. Green Synthesis Новинка

Anastas Paul T. Green Processes. Green Synthesis

20154.22 руб.
Edited by Professor CJ Li, one of the leading international experts in the fields of Green Chemistry and Green Synthesis, this volume presents such hot topics as synthesis without protecting groups, multi-component reactions, and synthesis in green solvents. The Handbook of Green Chemistry comprises of 9 volumes in total, split into 3 subject-specific sets. The three sets are available individually. All 9 volumes are available individually, too. Set I: Green Catalysis – Volume 1: Homogeneous Catalysis – Volume 2: Heterogeneous Catalysis – Volume 3: Biocatalysis Set II: Green Solvents – Volume 4: Supercritical Solvents – Volume 5: Reactions in Water – Volume 6: Ionic Liquids Set III: Green Processes – Volume 7: Green Synthesis – Volume 8: Green Nanoscience – Volume 9: Designing Safer Chemicals The Handbook of Green Chemistry is also available as Online Edition. Podcasts Listen to two podcasts in which Professor Paul Anastas and Journals Editor Paul Trevorrow discuss the origin and expansion of Green Chemistry and give an overview of The Handbook of Green Chemistry.
Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines Новинка

Selzer Paul M. Parasitic Helminths. Targets, Screens, Drugs and Vaccines

12257.29 руб.
This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development. With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.
Kenneth Karlin D. Progress in Inorganic Chemistry Kenneth Karlin D. Progress in Inorganic Chemistry Новинка

Kenneth Karlin D. Progress in Inorganic Chemistry

13100.24 руб.
This series provides inorganic chemists and materials scientists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 57 continues to report recent advances with a significant, up-to-date selection of contributions from internationally-recognized researchers. The chapters of this volume are devoted to the following topics: Mechanisms of Water Oxidation Catalyzed by Ruthenium Coordination Complexes; Biomimetic and non-biological dinuclear Mx+-complex catalyzed alcoholysis reactions of phosphoryl transfer reactions; Photoactivated DNA Cleavage and Anticancer Activity of 3d-Metal Complexes; and more.
Roger Prud'homme Flows and Chemical Reactions in Heterogeneous Mixtures Roger Prud'homme Flows and Chemical Reactions in Heterogeneous Mixtures Новинка

Roger Prud'homme Flows and Chemical Reactions in Heterogeneous Mixtures

8173.27 руб.
This book – a sequel of previous publications 'Flows and Chemical Reactions' and 'Chemical Reactions in Flows and Homogeneous Mixtures' – is devoted to flows with chemical reactions in heterogeneous environments. Heterogeneous media in this volume include interfaces and lines. They may be the site of radiation. Each type of flow is the subject of a chapter in this volume. We consider first, in Chapter 1, the question of the generation of environments biphasic individuals: dusty gas, mist, bubble flow. Chapter 2 is devoted to the study at the mesoscopic scale: particle-fluid exchange of momentum and heat with determination of the respective exchange coefficients. In Chapter 3, we establish simplified equations of macroscopic balance for mass, for the momentum and energy, in the case of particles of one size (monodisperse suspension). Radiative phenomena are presented in Chapter 5.
Robert Hall D. Annual Plant Reviews, Biology of Plant Metabolomics Robert Hall D. Annual Plant Reviews, Biology of Plant Metabolomics Новинка

Robert Hall D. Annual Plant Reviews, Biology of Plant Metabolomics

18464.48 руб.
Biology of Plant Metabolomics is an exciting new volume in Wiley-Blackwell's highly successful Annual Plant Reviews series. Concentrating on the biology and biological relevance of plant metabolomics, each chapter, written by internationally-acknowledged experts in the field from at least two different research groups, combines a review of the existing biological results with an extended assessment of possible future developments and the impact that these will have on the type of research needed for the future. Following a general introduction, this exciting volume includes details of metabolomics of model species including Arabidopsis and tomato. Further chapters provide in-depth coverage of abiotic stress, data integration, systems biology, genetics, genomics, chemometrics and biostatisitcs. Applications of plant metabolomics in food science, plant ecology and physiology are also comprehensively covered. Biology of Plant Metabolomics provides cutting edge reviews of many major aspects of this new and exciting subject. It is an essential purchase for plant scientists, plant geneticists and physiologists. All libraries in universities and research establishments where biological sciences are studied and taught should have a copy of this Annual Plant Reviews volume on their shelves.
Joe Murphy Social Media, Sociality, and Survey Research Joe Murphy Social Media, Sociality, and Survey Research Новинка

Joe Murphy Social Media, Sociality, and Survey Research

5620.06 руб.
Provides the knowledge and tools needed for the future of survey research The survey research discipline faces unprecedented challenges, such as falling response rates, inadequate sampling frames, and antiquated approaches and tools. Addressing this changing landscape, Social Media, Sociality, and Survey Research introduces readers to a multitude of new techniques in data collection in one of the fastest developing areas of survey research. The book is organized around the central idea of a «sociality hierarchy» in social media interactions, comprised of three levels: broadcast, conversational, and community based. Social Media, Sociality, and Survey Research offers balanced coverage of the theory and practice of traditional survey research, while providing a conceptual framework for the opportunities social media platforms allow. Demonstrating varying perspectives and approaches to working with social media, the book features: New ways to approach data collection using platforms such as Facebook and Twitter Alternate methods for reaching out to interview subjects Design features that encourage participation with engaging, interactive surveys Social Media, Sociality, and Survey Research is an important resource for survey researchers, market researchers, and practitioners who collect and analyze data in order to identify trends and draw reliable conclusions in the areas of business, sociology, psychology, and population studies. The book is also a useful text for upper-undergraduate and graduate-level courses on survey methodology and market research.
Susheel Kalia Biodegradable and Biobased Polymers for Environmental and Biomedical Applications Susheel Kalia Biodegradable and Biobased Polymers for Environmental and Biomedical Applications Новинка

Susheel Kalia Biodegradable and Biobased Polymers for Environmental and Biomedical Applications

16871.56 руб.
This volume incorporates 13 contributions from renowned experts from the relevant research fields that are related biodegradable and biobased polymers and their environmental and biomedical applications. Specifically, the book highlights: Developments in polyhydroxyalkanoates applications in agriculture, biodegradable packaging material and biomedical field like drug delivery systems, implants, tissue engineering and scaffolds The synthesis and elaboration of cellulose microfibrils from sisal fibres for high performance engineering applications in various sectors such as the automotive and aerospace industries, or for building and construction The different classes and chemical modifications of tannins Electro-activity and applications of Jatropha latex and seed The synthesis, properties and applications of poly(lactic acid) The synthesis, processing and properties of poly(butylene succinate), its copolymers, composites and nanocomposites The different routes for preparation polymers from vegetable oil and the effects of reinforcement and nano-reinforcement on the physical properties of such biobased polymers The different types of modified drug delivery systems together with the concept of the drug delivery matrix for controlled release of drugs and for antitumor drugs The use of nanocellulose as sustainable adsorbents for the removal of water pollutants mainly heavy metal ions, organic molecules, dyes, oil and CO2 The main extraction techniques, structure, properties and different chemical modifications of lignins Proteins and nucleic acids based biopolymers The role of tamarind seed polysaccharide-based multiple-unit systems in sustained drug release
Li Di Blood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Li Di Blood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Новинка

Li Di Blood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

11622.14 руб.
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
Guo-Qiang Lin Chiral Drugs. Chemistry and Biological Action Guo-Qiang Lin Chiral Drugs. Chemistry and Biological Action Новинка

Guo-Qiang Lin Chiral Drugs. Chemistry and Biological Action

12818.01 руб.
An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.
Peter Wasserscheid Green Solvents. Ionic Liquids Peter Wasserscheid Green Solvents. Ionic Liquids Новинка

Peter Wasserscheid Green Solvents. Ionic Liquids

19720.72 руб.
The shift towards being as environmentally-friendly as possible has resulted in the need for this important volume on the role of ionic liquids in green chemistry. Edited by Peter Wasserscheid, one of the pioneers of ionic liquid research, and Annegret Stark, this is an essential resource for anyone wishing to gain an understanding of the world of green chemistry, as well as for chemists, environmental agencies and chemical engineers. The Handbook of Green Chemistry comprises of 9 volumes in total, split into 3 subject-specific sets. The three sets are available individually. All 9 volumes are available individually, too. Set I: Green Catalysis – Volume 1: Homogeneous Catalysis – Volume 2: Heterogeneous Catalysis – Volume 3: Biocatalysis Set II: Green Solvents – Volume 4: Supercritical Solvents – Volume 5: Reactions in Water – Volume 6: Ionic Liquids Set III: Green Processes – Volume 7: Green Synthesis – Volume 8: Green Nanoscience – Volume 9: Designing Safer Chemicals The Handbook of Green Chemistry is also available as Online Edition. Podcasts Listen to two podcasts in which Professor Paul Anastas and Journals Editor Paul Trevorrow discuss the origin and expansion of Green Chemistry and give an overview of The Handbook of Green Chemistry.
Lowe Robert C. Pocket Guide to GastrointestinaI Drugs Lowe Robert C. Pocket Guide to GastrointestinaI Drugs Новинка

Lowe Robert C. Pocket Guide to GastrointestinaI Drugs

5364.24 руб.
Learn all you need to know about gastrointestinal drugs and their clinical use with this one-stop, rapid reference pocket guide. Brought to you by many of the world's leading GI drug experts, Pocket Guide to Gastrointestinal Drugs provides comprehensive guidance to the pharmacological properties of drugs used to treat gastrointestinal conditions, including mechanisms of action, appropriate administration, and potential adverse effects associated with their use. Organized by class of drug and ranging from PPIs to immunosupressants, each chapter first examines the specific agents within that class and then their appropriate and judicious use across a range of specific GI disorders. Key features include: Introduction of drug class Basic pharmacology, including mechanism of action, bioavailability, metabolism, interactions, adverse effects, toxicity, and special considerations Dosing information for each GI condition and on- and off-label use Consistent use of both generic and trade names throughout Specific reference to drug use in pediatric patients and during pregnancy Perfect for quick consultation on the wards and in the office, Pocket Guide to Gastrointestinal Drugs is the ideal tool for all those managing patients with GI conditions, including gastroenterologists, GI trainees, emergency physicians, GI specialist nurses, primary care physicians and residents, intensivists and pharmacists.
Tse-lok Ho Fiesers' Reagents for Organic Synthesis, Volume 27 Tse-lok Ho Fiesers' Reagents for Organic Synthesis, Volume 27 Новинка

Tse-lok Ho Fiesers' Reagents for Organic Synthesis, Volume 27

12640.45 руб.
The highly successful Fieser & Fieser series has provided several generations of professional chemists and students with an timely survey of the reagent literature. Providing an up-to-date, A-to-Z listing of reagents cited in synthetic literature, Fiesers' Reagents for Organic Synthesis, Volume 27 encompasses chemical literature from the end of 2009 to the end of 2011. Listed by common name, each entry feature a concise description, illustrations of chemical reactions, selected examples of applications, how to make it or buy it, what it is good for, and where to find complete details.
Jacques Robert ABC Transporters and Multidrug Resistance Jacques Robert ABC Transporters and Multidrug Resistance Новинка

Jacques Robert ABC Transporters and Multidrug Resistance

11997.76 руб.
A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.
Hugo Kubinyi Molecular Descriptors for Chemoinformatics. Volume I: Alphabetical Listing / Volume II: Appendices, References Hugo Kubinyi Molecular Descriptors for Chemoinformatics. Volume I: Alphabetical Listing / Volume II: Appendices, References Новинка

Hugo Kubinyi Molecular Descriptors for Chemoinformatics. Volume I: Alphabetical Listing / Volume II: Appendices, References

39740.23 руб.
The number-one reference on the topic now contains a wealth of new data: The entire relevant literature over the past six years has been painstakingly surveyed, resulting in hundreds of new descriptors being added to the list, and some 3,000 new references in the bibliography section. Volume 1 contains an alphabetical listing of more than 3300 descriptors and related terms for chemoinformatic analysis of chemical compound properties, while the second volume lists over 6,000 references selected from 450 journals. To make the data even more accessible, the introductory section has been completely re-written and now contains several «walk-through» reading lists of selected keywords for novice users.
Elaine Biech The 2010 Pfeiffer Annual. Training Elaine Biech The 2010 Pfeiffer Annual. Training Новинка

Elaine Biech The 2010 Pfeiffer Annual. Training

7280.04 руб.
This volume of the popular Pfeiffer Annuals series offers unique activities, articles, and an instrument from experts and practitioners in the field of managerial training. It addresses the design, delivery, and evaluation of interventions that can be used to improve the performance of managers across all sorts of disciplines. This year’s Annual puts the spotlight on communications and offers value information on such topics as negotiation, leadership, situational training, informal learning, trust, and distance learning. The Annual features an international list of expert contributors. Purchase of an Annual includes access to an associated website which features customizable versions of the reproducible items associated with each activity included in the volume.
Antonio de la Hoz Microwaves in Organic Synthesis, 2 Volume Set Antonio de la Hoz Microwaves in Organic Synthesis, 2 Volume Set Новинка

Antonio de la Hoz Microwaves in Organic Synthesis, 2 Volume Set

37041.18 руб.
The third edition of the bestselling two-volume reference covers everything you need to know about microwave technology for synthesis – from the best equipment to nonthermal effects, from solid-support reactions to catalysis. Completely revised and updated with half of the authors completely new to the project, this comprehensive work is clearly divided into two parts on the fundamentals of microwave irradiation, and application of microwaves and synergies with other enabling techniques. Also new to this edition are chapters on on-line monitoring, flow chemistry, combination with ultrasounds and natural products, including multicomponent reactions. An indispensable source for organic, catalytic, physical, and medicinal chemists.
Lars Ostergaard Annual Plant Reviews, Fruit Development and Seed Dispersal Lars Ostergaard Annual Plant Reviews, Fruit Development and Seed Dispersal Новинка

Lars Ostergaard Annual Plant Reviews, Fruit Development and Seed Dispersal

19384.06 руб.
Fruit development and seed dispersal are major topics within plant and crop sciences research with important developments in research being reported regularly. Drawing together reviews by some of the world's leading experts in these areas, the Editor of this volume, Lars Ostergaard has provided a volume which is an essential purchase for all those working in plant and crop sciences worldwide.
A. Knipe C. Organic Reaction Mechanisms 2011. An annual survey covering the literature dated January to December 2011 A. Knipe C. Organic Reaction Mechanisms 2011. An annual survey covering the literature dated January to December 2011 Новинка

A. Knipe C. Organic Reaction Mechanisms 2011. An annual survey covering the literature dated January to December 2011

43297.08 руб.
The only book series to summarize the latest progress on organic reaction mechanisms, Organic Reaction Mechanisms, 2011 surveys the development in understanding of the main classes of organic reaction mechanisms reported in the primary scientific literature in 2011. The 47th annual volume in this highly successful series highlights mechanisms of stereo-specific reactions. Reviews are compiled by a team of experienced editors and authors, allowing advanced undergraduates, graduate students, postdocs, and chemists to rely on the volume's continuing quality of selection and presentation.
Anastas Paul T. Green Solvents. Reactions in Water Anastas Paul T. Green Solvents. Reactions in Water Новинка

Anastas Paul T. Green Solvents. Reactions in Water

20154.22 руб.
There has been dramatic growth in the community of researchers and industrialists working in the area of Green Chemistry. There has been an increasing recognition by a wide-range of scientists and engineers in the chemical enterprise that the framework of Green Chemistry is relevant and enabling to their work. There has been a significant body of work that has accumulated over the past decade that details the breakthroughs, innovation and creativity within Green Chemistry and Engineering. While there have been edited volumes on Green Chemistry that collect a limited number of papers often on a particular topic area, there is not currently a series that seeks to provide a more comprehensive overview of the current state of the science. The lack of this type of series is a notable niche for which the continually growing Green Chemistry and engineering community would value and welcome. The Handbook of Green Chemistry comprises of 9 volumes in total, split into 3 subject-specific sets. The three sets are available individually. All 9 volumes are available individually, too. Set I: Green Catalysis – Volume 1: Homogeneous Catalysis – Volume 2: Heterogeneous Catalysis – Volume 3: Biocatalysis Set II: Green Solvents – Volume 4: Supercritical Solvents – Volume 5: Reactions in Water – Volume 6: Ionic Liquids Set III: Green Processes – Volume 7: Green Synthesis – Volume 8: Green Nanoscience – Volume 9: Designing Safer Chemicals The Handbook of Green Chemistry is also available as Online Edition. Podcasts Listen to two podcasts in which Professor Paul Anastas and Journals Editor Paul Trevorrow discuss the origin and expansion of Green Chemistry and give an overview of The Handbook of Green Chemistry.
Michael McManus T. Annual Plant Reviews, The Plant Hormone Ethylene Michael McManus T. Annual Plant Reviews, The Plant Hormone Ethylene Новинка

Michael McManus T. Annual Plant Reviews, The Plant Hormone Ethylene

18464.48 руб.
The plant hormone ethylene is one of the most important, being one of the first chemicals to be determined as a naturally-occurring growth regulator and influencer of plant development. It was also the first hormone for which significant evidence was found for the presence of receptors. This important new volume in Annual Plant Reviews is broadly divided into three parts. The first part covers the biosynthesis of ethylene and includes chapters on S-adenosylmethionine and the formation and fate of ACC in plant cells. The second part of the volume covers ethylene signaling, including the perception of ethylene by plant cells, CTR proteins, MAP kinases and EIN2 / EIN3. The final part covers the control by ethylene of cell function and development, including seed development, germination, plant growth, cell separation, fruit ripening, senescent processes, and plant-pathogen interactions. The Plant Hormone Ethylene is an extremely valuable addition to Wiley-Blackwell's Annual Plant Reviews. With contributions from many of the world's leading researchers in ethylene, and edited by Professor Michael McManus of Massey University, this volume will be of great use and interest to a wide range of plant scientists, biochemists and chemists. All universities and research establishments where plant sciences, biochemistry, chemistry, life sciences and agriculture are studied and taught should have access to this important volume.
Alvise Perosa Green Processes. Green Nanoscience Alvise Perosa Green Processes. Green Nanoscience Новинка

Alvise Perosa Green Processes. Green Nanoscience

19720.72 руб.
The shift towards being as environmentally-friendly as possible has resulted in the need for this important volume on the topic of green nanoscience. Edited by two rising stars in the community, Alvise Perosa and Maurizio Selva, this is an essential resource for anyone wishing to gain an understanding of the world of green chemistry, as well as for chemists, environmental agencies and chemical engineers. The Handbook of Green Chemistry comprises of 9 volumes in total, split into 3 subject-specific sets. The three sets are available individually. All 9 volumes are available individually, too. Set I: Green Catalysis – Volume 1: Homogeneous Catalysis – Volume 2: Heterogeneous Catalysis – Volume 3: Biocatalysis Set II: Green Solvents – Volume 4: Supercritical Solvents – Volume 5: Reactions in Water – Volume 6: Ionic Liquids Set III: Green Processes – Volume 7: Green Synthesis – Volume 8: Green Nanoscience – Volume 9: Designing Safer Chemicals The Handbook of Green Chemistry is also available as Online Edition. Podcasts Listen to two podcasts in which Professor Paul Anastas and Journals Editor Paul Trevorrow discuss the origin and expansion of Green Chemistry and give an overview of The Handbook of Green Chemistry.
Paul T. Anastas Green Processes. Designing Safer Chemicals Paul T. Anastas Green Processes. Designing Safer Chemicals Новинка

Paul T. Anastas Green Processes. Designing Safer Chemicals

19720.72 руб.
The shift towards being as environmentally-friendly as possible has resulted in the need for this important reference on the topic of designing safer chemicals. Edited by the leading international experts in the field, Robert Boethling and Adelina Votchkova, this volume covers such topics as toxicity, reducing hazards and biochemical pesticides. An essential resource for anyone wishing to gain an understanding of the world of green chemistry, as well as for chemists, environmental agencies and chemical engineers. The Handbook of Green Chemistry comprises of 9 volumes in total, split into 3 subject-specific sets. The three sets are available individually. All 9 volumes are available individually, too. Set I: Green Catalysis – Volume 1: Homogeneous Catalysis – Volume 2: Heterogeneous Catalysis – Volume 3: Biocatalysis Set II: Green Solvents – Volume 4: Supercritical Solvents – Volume 5: Reactions in Water – Volume 6: Ionic Liquids Set III: Green Processes – Volume 7: Green Synthesis – Volume 8: Green Nanoscience – Volume 9: Designing Safer Chemicals The Handbook of Green Chemistry is also available as Online Edition. Podcasts Listen to two podcasts in which Professor Paul Anastas and Journals Editor Paul Trevorrow discuss the origin and expansion of Green Chemistry and give an overview of The Handbook of Green Chemistry.
Scott Denmark E. Organic Reactions, Volume 88 Scott Denmark E. Organic Reactions, Volume 88 Новинка

Scott Denmark E. Organic Reactions, Volume 88

14622.12 руб.
Volume 88 represents the tenth single-chapter-volume produced in our 73-year history. Such single-chapter volumes represent definitive treatises on extremely important chemical transformations. The success of the research efforts over the past 20 years forms the basis for the single chapter in this volume namely, Hydroamination of Alkenes by Alexander L. Reznichenko and Kai C. Hultzsch. The authors have compiled an enormous (and growing) literature and distilled it into an extraordinarily useful treatise on all aspects of the hydroamination process.
Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts Новинка

Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts

11997.76 руб.
Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug–drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.
John Dickenson Molecular Pharmacology. From DNA to Drug Discovery John Dickenson Molecular Pharmacology. From DNA to Drug Discovery Новинка

John Dickenson Molecular Pharmacology. From DNA to Drug Discovery

12368.4 руб.
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current – focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge – highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied – includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible – contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book. A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies Новинка

Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies

13100.24 руб.
Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a «drug detection» procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.

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Featuring a timely presentation of total survey error (TSE), this edited volume introduces valuable tools for understanding and improving survey data quality in the context of evolving large-scale data sets This book provides an overview of the TSE framework and current TSE research as related to survey design, data collection, estimation, and analysis. It recognizes that survey data affects many public policy and business decisions and thus focuses on the framework for understanding and improving survey data quality. The book also addresses issues with data quality in official statistics and in social, opinion, and market research as these fields continue to evolve, leading to larger and messier data sets. This perspective challenges survey organizations to find ways to collect and process data more efficiently without sacrificing quality. The volume consists of the most up-to-date research and reporting from over 70 contributors representing the best academics and researchers from a range of fields. The chapters are broken out into five main sections: The Concept of TSE and the TSE Paradigm, Implications for Survey Design, Data Collection and Data Processing Applications, Evaluation and Improvement, and Estimation and Analysis. Each chapter introduces and examines multiple error sources, such as sampling error, measurement error, and nonresponse error, which often offer the greatest risks to data quality, while also encouraging readers not to lose sight of the less commonly studied error sources, such as coverage error, processing error, and specification error. The book also notes the relationships between errors and the ways in which efforts to reduce one type can increase another, resulting in an estimate with larger total error. This book: • Features various error sources, and the complex relationships between them, in 25 high-quality chapters on the most up-to-date research in the field of TSE • Provides comprehensive reviews of the literature on error sources as well as data collection approaches and estimation methods to reduce their effects • Presents examples of recent international events that demonstrate the effects of data error, the importance of survey data quality, and the real-world issues that arise from these errors • Spans the four pillars of the total survey error paradigm (design, data collection, evaluation and analysis) to address key data quality issues in official statistics and survey research Total Survey Error in Practice is a reference for survey researchers and data scientists in research areas that include social science, public opinion, public policy, and business. It can also be used as a textbook or supplementary material for a graduate-level course in survey research methods. Paul P. Biemer, PhD, is distinguished fellow at RTI International and associate director of Survey Research and Development at the Odum Institute, University of North Carolina, USA. Edith de Leeuw, PhD, is professor of survey methodology in the Department of Methodology and Statistics at Utrecht University, the Netherlands. Stephanie Eckman, PhD, is fellow at RTI International, USA. Brad Edwards is vice president, director of Field Services, and deputy area director at Westat, USA. Frauke Kreuter, PhD, is professor and director of the Joint Program in Survey Methodology, University of Maryland, USA; professor of statistics and methodology at the University of Mannheim, Germany; and head of the Statistical Methods Research Department at the Institute for Employment Research, Germany. Lars E. Lyberg, PhD, is senior advisor at Inizio, Sweden. N. Clyde Tucker, PhD, is principal survey methodologist at the American Institutes for Research, USA. Brady T. West, PhD, is research associate professor in the Survey Resea
Продажа side effects of drugs annual volume 27a worldwide yearly survey of new data trends inadverse drug reactions seda volume 27 лучших цены всего мира
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