somatosensory and visceral receptor mechanisms43



Michael Roberts F. Receptor Biology Michael Roberts F. Receptor Biology Новинка

Michael Roberts F. Receptor Biology

6862.49 руб.
This book is geared to every student in biology, pharmacy and medicine who needs to become familiar with receptor mediated signaling. The text starts with explaining some basics in membrane biochemistry, hormone biology and the concept of receptor based signaling as the main form of communication between cells and of cells with the environment. It goes on covering each receptor superfamily in detail including their structure and evolutionary context. The last part focusses exclusively on examples where thorough knowledge of receptors is critical: pharmaceutical research, developmental biology, neurobiology and evolutionary biology. Richly illustrated, the book is perfectly suited for all courses covering receptor based signaling, regardless whether they are part of the biology, medicine or pharmacology program.
Raimo Pohjanvirta The AH Receptor in Biology and Toxicology Raimo Pohjanvirta The AH Receptor in Biology and Toxicology Новинка

Raimo Pohjanvirta The AH Receptor in Biology and Toxicology

12622.94 руб.
This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.
Gomtsyan Arthur Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders Gomtsyan Arthur Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders Новинка

Gomtsyan Arthur Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders

11814.39 руб.
Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it «the holy grail» of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arthritis, and cancer pain. The book discusses: Recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of the dynamic area of TRPV1 drug discovery research The potential for drugs targeting TRPV1 in painful conditions such as inflammation, arthritis, and cancer The development of analgesic drugs Other applications for TRPV1, including the treatment of respiratory disease and diabetes Featuring data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is a key tool for researchers in the pharmaceutical industry and academia involved in pain, ion channels, and analgesic drug development.
Yatsimirsky Anatoly Artificial Receptors for Chemical Sensors Yatsimirsky Anatoly Artificial Receptors for Chemical Sensors Новинка

Yatsimirsky Anatoly Artificial Receptors for Chemical Sensors

15801.75 руб.
The first to provide systematically organized information on all three important aspects of artificial receptor design, this book brings together knowledge on an exceptionally hot and multidisciplinary field of research. Strong emphasis is placed on the methodology for discovering artificial receptors, with both definitions for chemosensitivity as well as experimental setups supplied. There follows coverage of numerous classes of artificial receptors, including synthesis, immobilization on surfaces, and quantitative data on properties. The third part of the book focuses on receptor arrays for artificial nose and tongue applications and the whole is rounded off with an outlook and an appendix with all relevant quantitative data on artificial receptors.
Tahira Farooqui Metabolic Syndrome and Neurological Disorders Tahira Farooqui Metabolic Syndrome and Neurological Disorders Новинка

Tahira Farooqui Metabolic Syndrome and Neurological Disorders

15382.86 руб.
Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome – abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension – to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders. Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.
Alderman Naomi The Power (Bailey's Women's Prize'17) Alderman Naomi The Power (Bailey's Women's Prize'17) Новинка

Alderman Naomi The Power (Bailey's Women's Prize'17)

1078 руб.
*WINNER of the THE 2017 BAILEYS WOMEN'S PRIZE FOR FICTION* What if the power to hurt were in women's hands? Suddenly - tomorrow or the day after - teenage girls find that with a flick of their fingers, they can inflict agonizing pain and even death. With this single twist, the four lives at the heart of Naomi Alderman's extraordinary, visceral novel are utterly transformed.
Andreev Leonid Seven Hanged Andreev Leonid Seven Hanged Новинка

Andreev Leonid Seven Hanged

424 руб.
From their arrest to their final breaths, the last days of seven prisoners condemned to death in Tsarist Russia are described in this visceral, heart-stopping novella.
Jill Sorenson Backwoods Jill Sorenson Backwoods Новинка

Jill Sorenson Backwoods

341.99 руб.
The more you trust, the more you risk…When plans for a wilderness retreat with her teenage daughter Brooke go awry, Abby Hammond reluctantly pairs up with Brooke's stepbrother and his dad, Nathan Strom, for the weeklong trek. The only thing Abby has in common with the bad-boy former pro athlete is that their exes cheated with each other. That…and a visceral attraction that's growing more complicated with every step through the picturesque woods.Nathan's wild-card reputation lost him his career and his family. After years of regret, he's ready to fight for what truly matters–and that includes Abby's hard-won trust. When Brooke goes missing, Nathan knows he's her best and only hope of rescue. But the deeper into the rugged mountains they go, the more dangerous the territory will prove–for their safety and for their hearts.
Peter Straub Koko Peter Straub Koko Новинка

Peter Straub Koko

571.59 руб.
Peter Straub’s most acclaimed and biggest-selling novel – a visceral thriller with its roots in Vietnam – now reissued in a different cover style and making its first appearance on the HarperCollins list.‘KOKO… ’ Only four men knew what it meant. Vietnam vets. One was a doctor. One was a lawyer. One was a working stiff. One was a writer. All were as different as men could be – yet all were bound eternally together by a single shattering secret. And now they are joined together again on a quest that could take them from the graveyards and fleshpots of the Far East to the human jungle of New York, hunting an inhuman ghost of the past risen from nightmare darkness to kill and kill…
Nasim Akhtar ABC of Arterial and Venous Disease Nasim Akhtar ABC of Arterial and Venous Disease Новинка

Nasim Akhtar ABC of Arterial and Venous Disease

3472.51 руб.
ABC of Arterial and Venous Disease provides a structured, practical approach to clinical assessment, investigation and management of the most commonly presenting arterial and venous disorders. Structural and functional abnormalities of arteries and veins manifest clinically in a broad spectrum of disorders, including cerebrovascular and carotid artery disease, abdominal aortic aneurysms, acute and chronic limb ischaemia, vasculitis and varicose veins. This revised edition incorporates new chapters on coronary artery disease and acute coronary syndrome, visceral artery stenosis and mesenteric ischaemia, and arteriovenous malformations. Many of these common or chronic conditions first present for initial assessment by primary health care professionals. Case vignettes have been added to relevant chapters to aid understanding and decision making. Fully up to date and from an expert editor and contributor team, ABC of Arterial and Venous Disease remains a useful resource for non-specialist doctors such as general practitioners, family physicians and junior doctors in training. It is also a relevant guide for all other primary health care professionals working within the multidisciplinary teams responsible for patients with chronic arterial and venous disorders.
Ботинки высокие ECCO WHISTLER Ботинки высокие ECCO WHISTLER Новинка

Ботинки высокие ECCO WHISTLER

9499 руб.
Классические высокие ботинки. Прочная и легкая модель имеет анатомическую форму колодки, что обеспечивает удобство при ходьбе. Модель выпонена по технологии Receptor, благодаря которой осуществляется поддержка стопы на всех этапах движения ног. • Мембрана GORE-TEX® - специальный водонепроницаемый материал (климатическая мембрана), который располагается между подкладкой и верхом обуви. Технология надежно защищает от влаги и позволяет ноге "дышать". • Технология FLUIDFORM™ прочно соединяет верх обуви и подошву без клея и швов. • Специальная платформа RECEPTOR® расположена внутри подошвы и помогает осуществлять амортизацию движения. Каждый раз, когда вы делаете шаг, ваша нога последовательно проходит три этапа - удар пятки, горизонтальное положение и отталкивание. Платформа RECEPTOR® учитывает особенности каждого из этапов, благодаря чему удается экономить силы при ходьбе и уменьшать нагрузку на стопу.
Trabocchi Andrea Peptidomimetics in Organic and Medicinal Chemistry Trabocchi Andrea Peptidomimetics in Organic and Medicinal Chemistry Новинка

Trabocchi Andrea Peptidomimetics in Organic and Medicinal Chemistry

12183.59 руб.
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Hugo Kubinyi Thermodynamics and Kinetics of Drug Binding Hugo Kubinyi Thermodynamics and Kinetics of Drug Binding Новинка

Hugo Kubinyi Thermodynamics and Kinetics of Drug Binding

13725.66 руб.
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.
Ботинки высокие ECCO OREGON Ботинки высокие ECCO OREGON Новинка

Ботинки высокие ECCO OREGON

8599 руб.
Инновационный легкий и устойчивый к царапинам материал верха. 100% защита от проникновения влаги и воздухопроницаемость благодаря мембране Gore-Tex®. Превосходная гибкость, амортизация и анатомически правильная форма. • Специальная платформа RECEPTOR® расположена внутри подошвы и помогает осуществлять амортизацию движения. Каждый раз, когда вы делаете шаг, ваша нога последовательно проходит три этапа - удар пятки, горизонтальное положение и отталкивание. Платформа RECEPTOR® учитывает особенности каждого из этапов, благодаря чему удается экономить силы при ходьбе и уменьшать нагрузку на стопу.
Frederick Wasser Steven Spielberg's America Frederick Wasser Steven Spielberg's America Новинка

Frederick Wasser Steven Spielberg's America

4798.72 руб.
Steven Spielberg is known as the most powerful man in New Hollywood and a pioneer of the contemporary blockbuster, America’s most successful export. His career began a new chapter in mass culture. At the same time, American post war liberalism was breaking down. This fascinating new book explains the complex relationship between film and politics through the prism of an iconic filmmaker. Spielberg’s early films were a triumphant emergence of the Sunbelt aesthetic that valued visceral kicks and basic emotions over the ambiguities of history. Such blockbusters have inspired much debate about their negative effect on politics and have been charged as being an expression of the corporatization of life. Here Frederick Wasser argues that the older Spielberg has not fully gone this way, suggesting that the filmmaker recycles the populist vision of older Hollywood because he sincerely believes in both big time moviemaking and liberal democracy. Nonetheless, his stories are burdened by his generation’s hostility to public life, and the book shows how he uses filmmaking tricks to keep his audience with him and to smooth over the ideological contradictions. His audiences have become more global, as his films engage history. This fresh and provocative take on Spielberg in the context of globalization, rampant market capitalism and the hardening socio-political landscape of the United States will be fascinating reading for students of film and for anyone interested in contemporary America and its culture.
Emanuela Corsini Molecular Immunotoxicology Emanuela Corsini Molecular Immunotoxicology Новинка

Emanuela Corsini Molecular Immunotoxicology

14086.85 руб.
The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Alan Balfour Solomon's Temple. Myth, Conflict, and Faith Alan Balfour Solomon's Temple. Myth, Conflict, and Faith Новинка

Alan Balfour Solomon's Temple. Myth, Conflict, and Faith

6937.26 руб.
A highly original architectural history of Solomon’s Temple and Islam’s Dome of the Rock that doubles as a social and cultural history of the region The most extensive study of the interrelated history of two monuments, Solomon’s Temple and The Dome of the Rock, drawing on an exhaustive review of all the visual and textual evidence Relayed as a gripping narrative, allowing readers to re-enter and experience the emotions and the visceral reality of the major events in its history Integrates illustration with the text to offer a highly detailed and accurate portrait of the major structures and figures involved in the history of the temple Opens up a fascinating line of questioning into the conventional interpretation of events, particularly Christ’s actions in the Temple Reproduces rarely seen detailed drawings of the subterranean passages beneath Temple Mount as part of the British survey in the 19th century
Mike Tyson Undisputed Truth: My Autobiography Mike Tyson Undisputed Truth: My Autobiography Новинка

Mike Tyson Undisputed Truth: My Autobiography

227.54 руб.
Love him or loathe him, ‘Iron’ Mike Tyson is an icon and one of the most fascinating sporting figures of our time. In this no-holds-barred autobiography, Tyson lays bare his demons and tells his story: from poverty to stardom to hell and back againIn this, his first, autobiography, ‘Iron’ Mike Tyson pulls no punches and lays bare the story of his remarkable life and career. Co-written with Larry Sloman, author of Antony Keidis’s best-selling memoir ‘Scar Tissue’, this is a visceral, and unputdown-able story of a man born and raised to brutality, who reached the heights of stardom before falling to crime, substance abuse and infamy.Full of all the controversy and complexity that you would expect from a man who delighted as much as he shocked, this is a book that will surprise people and reveal a fascinating character beneath the exterior of violence.If you think you know all about Mike Tyson, read this book and think again.
Derald Sue Wing Race Talk and the Conspiracy of Silence. Understanding and Facilitating Difficult Dialogues on Race Derald Sue Wing Race Talk and the Conspiracy of Silence. Understanding and Facilitating Difficult Dialogues on Race Новинка

Derald Sue Wing Race Talk and the Conspiracy of Silence. Understanding and Facilitating Difficult Dialogues on Race

2163.68 руб.
Learn to talk about race openly, honestly, and productively Most people avoid discussion of race-related topics because of the strong emotions and feelings of discomfort that inevitably accompany such conversations. Rather than endure the conflict of racial realities, many people choose instead to avoid the topic altogether, or remain silent when it is raised. Race Talk and the Conspiracy of Silence: Understanding and Facilitating Difficult Dialogues on Race puts an end to that dynamic by sharing strategies for smoothing conversations about race in a productive manner. A guide for facilitating and participating in difficult dialogues about race, author Derald Wing Sue – an internationally recognized expert on multiculturalism, diversity, and microaggressions – explores the characteristics, dynamics, and meaning behind discussions about race as well as the hidden «ground rules» that inhibit honest and productive dialogue. Through emotional and visceral examples, this book explains why conversations revolving around racial issues are so difficult, and provides guidelines, techniques, and advice for navigating and leading honest and forthright discussions. Readers will develop a stronger ability to build rapport with people unlike themselves, and discover how not talking about race impacts society as a whole. Overcome and make visible the fears associated with race talk Learn practical ideas for talking openly about race Facilitate and navigate discussion with expert strategy Examine the hidden rules that govern race talk Understand the benefits of successful conversations Discussions about race do not have to result in disastrous consequences, and can in fact be highly beneficial to all parties involved. It's important that people have the ability to converse openly and honestly with their students, colleagues, children, and neighbors, and Race Talk provides the path for achieving this goal.
Raz Jelinek Lipids and Cellular Membranes in Amyloid Diseases Raz Jelinek Lipids and Cellular Membranes in Amyloid Diseases Новинка

Raz Jelinek Lipids and Cellular Membranes in Amyloid Diseases

14546.47 руб.
Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studes, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation. Required reading for any researcher interested in amyloid formation and amyloid toxicity, and possible avenues for the prevention or treatment of neurodegenerative disorders. From the contents: * Interactions of Alpha-Synuclein with Lipids * Interaction of hIAPP and its Precursors with Membranes * Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine * The Role of Lipid Rafts in Alzheimer's Disease * Alzheimer's Disease as a Membrane-Associated Enzymopathy of Beta-Amyloid Precursor Protein (APP) Secretases * Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer's Disease * Membrane Changes in BSE and Scrapie * Experimental Approaches and Technical Challenges for Studying Amyloid-Membrane Interactions and more
Alan Balfour Solomon's Temple. Myth, Conflict, and Faith Alan Balfour Solomon's Temple. Myth, Conflict, and Faith Новинка

Alan Balfour Solomon's Temple. Myth, Conflict, and Faith

6786.41 руб.
A highly original architectural history of Solomon’s Temple and Islam’s Dome of the Rock that doubles as a social and cultural history of the region The most extensive study of the interrelated history of two monuments, Solomon’s Temple and The Dome of the Rock, drawing on an exhaustive review of all the visual and textual evidence Relayed as a gripping narrative, allowing readers to re-enter and experience the emotions and the visceral reality of the major events in its history Integrates illustration with the text to offer a highly detailed and accurate portrait of the major structures and figures involved in the history of the temple Opens up a fascinating line of questioning into the conventional interpretation of events, particularly Christ’s actions in the Temple Reproduces rarely seen detailed drawings of the subterranean passages beneath Temple Mount as part of the British survey in the 19th century
Mayr Lorenz M. Label-Free Technologies For Drug Discovery Mayr Lorenz M. Label-Free Technologies For Drug Discovery Новинка

Mayr Lorenz M. Label-Free Technologies For Drug Discovery

13438.87 руб.
Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery. Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis. Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.
Dean Koontz The Taking Dean Koontz The Taking Новинка

Dean Koontz The Taking

629.84 руб.
The new thriller from Dean Koontz is a novel of stunning suspense and visceral terror as doomsday dawns.On the morning that will mark the end of the world they have known, Molly and Niel Sloan awaken to the drumbeat of rain. It has haunted their dreams through the night, and now they find an eerily luminous and silver downpour that drenches their small Californian mountain town.As hours pass they hear news of extreme weather phenomena across the globe. An obscuring fog turns once familiar streets into a ghostly labyrinth. By evening, the town has lost all communication with the outside world. First TV and radio go dead, then the Internet and phone lines. The young couple gathers together with some neighbours, sensing a threat they cannot identify or even imagine.The night brings strange noises, and mysterious lights drift among the trees. The rain diminishes with the dawn but a moody grey-purple twilight prevails. Within the misty gloom the small band will encounter something that reveals in a terrifying instant what is happening to the world – something that is hunting them with ruthless efficiency.Epic in scope, searingly intimate and immediate in its perspective, The Taking is a story of a strangely changed and changing world as apocalypse comes to Main Street.
Hugo Kubinyi Chemokine Receptors as Drug Targets Hugo Kubinyi Chemokine Receptors as Drug Targets Новинка

Hugo Kubinyi Chemokine Receptors as Drug Targets

14953.14 руб.
Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.
Craig Clevenger Dermaphoria Craig Clevenger Dermaphoria Новинка

Craig Clevenger Dermaphoria

371.46 руб.
Clandestine chemistry and the LA underworld provide the atmosphere for this kaleidoscopic tale of lost memories and the heartbreak of finding them, from the author of ‘The Contortionist’s Handbook’.When Eric Ashworth wakes in jail, he has no idea how he got there, or why. His only memory is a woman's name: Desiree.Released on bail and holed up in a low-rent motel, Eric starts to piece together his former life as a chemist at the centre of a desert drug ring with the help of a powerful new hallucinogen which simultaneously loosens his grip on the present. As the events of his past begin to emerge from the confusion of his fragmented memory, Eric must contend with a gnawing paranoia and the need for ever-increasing fixes – not to mention disturbing visits from an intimidating police detective, his former associate Manhattan White and the ominously named Toe Tag. As his grip on reality becomes more tenuous, past and present, reality and fantasy begin to bleed into each other, bringing this visceral, shifting novel of love and loss to its climax.
Keesey Douglas Paul Verhoeven Keesey Douglas Paul Verhoeven Новинка

Keesey Douglas Paul Verhoeven

1528 руб.
"As a director, my goal is to be completely open. Just look at how I portray sex in my films. They're considered shocking and obscene because I like to carefully examine human sexuality. It has to be realistic." Known for always pushing the envelope when it comes to showing sex and violence on screen, Paul Verhoeven has directed controversial films in several genres, including the erotic thriller (Basic Instinct), melodrama (Showgirls) and science fiction (RoboCop, Total Recall, Starship Troopers, Hollow Man). However, even before going to Hollywood, Verhoeven had been a succes de scandale in his native Netherlands, where he directed a war saga (Soldier of Orange), a medieval epic (Flesh+Blood), a psychosexual thriller (The Fourth Man) and a sex comedy (Turkish Delight, which was voted Best Dutch Film of the Century at the Netherlands Film Festival). Verhoeven has shown that visceral thrills can be thought provoking, challenging our received notions of heroism, patriotism, and eroticism. He has created some of the most courageous and contentious films of recent years. Made with full access to Paul Verhoeven`s archives! About the author: Douglas Keesey is a professor of film and literature at Cal Poly. He is the author of TASCHEN's Erotic Cinema and Paul Verhoeven. Издание на английском языке.
Jacob Patijn Evidence-based Interventional Pain Practice. According to Clinical Diagnoses Jacob Patijn Evidence-based Interventional Pain Practice. According to Clinical Diagnoses Новинка

Jacob Patijn Evidence-based Interventional Pain Practice. According to Clinical Diagnoses

10687.47 руб.
Unrelieved chronic pain is a worldwide epidemic Chronic pain has been subject to multiple international initiatives through the World Health Organization. Interventional Pain Medicine, the use of minimally invasive techniques to relieve pain, is the best approach when simpler measures such as physical therapy or medications fail. However, these procedures can be associated with significant risk and expense. Establishing uniformity in diagnostic criteria and procedural performance can reduce both morbidity and unnecessary procedures, and hence healthcare expenditures. While other texts explain how to perform these procedures, little focus has been given to diagnostic considerations: if and when these procedures should be performed. Evidence-Based Interventional Pain Medicine focuses on a balance between effectiveness and safety of interventional management for specific diagnoses, across all areas of chronic pain including: Head, neck and shoulder pain Lower back pain Neuropathic pain syndromes Complex Regional Pain Syndrome Pain in patients with cancer Vascular and visceral pain Evidence-Based Interventional Pain Medicine provides essential knowledge for anyone who uses, or intends to use, interventional pain techniques.
Wood Michael W. Targets and Emerging Therapies for Schizophrenia Wood Michael W. Targets and Emerging Therapies for Schizophrenia Новинка

Wood Michael W. Targets and Emerging Therapies for Schizophrenia

14251.11 руб.
New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases. Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined. With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia: Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.
Полуботинки ECCO XPEDITION III Полуботинки ECCO XPEDITION III Новинка

Полуботинки ECCO XPEDITION III

5299 руб.
Отличное сцепление и долговечность материалов. 100% защита от проникновения влаги и воздухопроницаемость благодаря мембране GORE-TEX®. Съемная стелька обеспечивает поглощение влаги и создает оптимальный комфорт. Технология Receptor® обеспечивает стабильность и динамическую поддержку в каждом движении стопы.
Сандалии ECCO ALL TERRAIN LITE Сандалии ECCO ALL TERRAIN LITE Новинка

Сандалии ECCO ALL TERRAIN LITE

2499 руб.
Непревзойденная плотная и комфортная посадка на ноге. Технология Receptor® обеспечивает стабильность в каждой фазе шага. Превосходная амортизация и комфорт на любой поверхности. Подкладка из текстиля обеспечивает благоприятный внутренний климат. Спортивный внешний вид, прочность и комфорт.
Сабо ECCO KAWAII SANDAL Сабо ECCO KAWAII SANDAL Новинка

Сабо ECCO KAWAII SANDAL

2099 руб.
Прекрасная летняя модель. Отличное сцепление подошвы с сухими и влажными поверхностями. Технология Receptor® обеспечивает стабильность во всех трех фазах движения стопы. Мягкая подкладка обеспечивает отличную посадку на ноге.
Сандалии ECCO KAWAII SANDAL Сандалии ECCO KAWAII SANDAL Новинка

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Отличное сцепление с сухими и влажными поверхностями.Технология Receptor® обеспечивает стабильность во всех трех фазах движения стопы.Превосходная гибкость, амортизация и комфорт на любой поверхности.Мягкая подкладка обеспечивают отличную посадку на ноге.Летние женственные сандалии.
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Более надежное сцепление с любой поверхностью. Превосходный комфорт благодаря амортизации и легкому весу. Технология Receptor® обеспечивает стабильность во всех трех фазах движения стопы. Комфортный внутренний климат. Прекрасная посадка на ноге, комфорт и привлекательный внешний вид.
Сандалии ECCO OFFROAD Сандалии ECCO OFFROAD Новинка

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Модные летние сандалии из высококачественного нубука понравятся любителям активного стиля жизни. Технология Receptor® обеспечивает стабильность и динамическую поддержку стопы во время движений. Мягкая и приятная на ощупь стелька подарит дополнительный комфорт вашим ногам. Превосходная гибкая подошва и отличная амортизация идеально подойдут для длительных прогулок.
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Модные сандали спортивного дизайна. Превосходная гибкость, амортизация и комфорт на любой поверхности. Технология Receptor® обеспечивает стабильность и динамическую поддержку. Мягкая стелька для комфортной и длительной ходьбы. Воздухопроницаемые прочные материалы.
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Отличное сцепление и долговечность материалов. 100% защита от проникновения влаги и воздухопроницаемость благодаря мембране GORE-TEX®. Съемная стелька обеспечивает поглощение влаги и создает оптимальный комфорт. Технология Receptor® обеспечивает стабильность и динамическую поддержку в каждом движении стопы.
Сабо ECCO LANAI SANDAL Сабо ECCO LANAI SANDAL Новинка

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2099 руб.
Отличное сцепление с сухими и влажными поверхностями. Технология Receptor® обеспечивает стабильность во всех трех фазах движения стопы. Превосходная гибкость, амортизация и комфорт на любой поверхности. Мягкая подкладка обеспечивают отличную посадку на ноге. Летние женственные сандалии.
Ботинки ECCO RUGGED TERRAIN V Ботинки ECCO RUGGED TERRAIN V Новинка

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Удобная, привлекательная обувь. 100% защита от проникновения влаги, благодаря мембране GORE-TEX®. Технология Receptor® обеспечивает стабильность в каждой фазе шага.
Кроссовки ECCO LIGHT III Кроссовки ECCO LIGHT III Новинка

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3399 руб.
Идеальное сцепление с любой поверхностью. Легкая и гибкая подошва для непревзойденного комфорта. Технология Receptor® обеспечивает стабильность во всех трех фазах движения стопы. Съемная стелька продлевает жизнь обуви и создает оптимальный внутренний климат. Прекрасная посадка на ноге, комфорт и привлекательный внешний вид.
Ботинки ECCO XPEDITION II Ботинки ECCO XPEDITION II Новинка

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4999 руб.
Модель для активного отдыха обеспечивает отличное сцепление с любой поверхностью и долговечность материалов.100% защита от воды и воздухопроницаемость благодаря мембране GORE-TEX®.Съемная стелька обеспечивает поглощение влаги и создает оптимальный комфорт.Технология Receptor® обеспечивает стабильность и динамическую поддержку в каждом движении стопы.
Кроссовки ECCO SIERRA LS Кроссовки ECCO SIERRA LS Новинка

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Модная обувь в спортивном стиле. Великолепное сцепление с любой поверхностью.  Непревзойденный комфорт благодаря мягкости и легкости материалов. Технология Receptor® обеспечивает стабильность и динамическую поддержку в каждом движении стопы.
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Отличное сцепление и долговечность материалов.100% защита от воды и воздухопроницаемость благодаря мембране GORE-TEX®.Съемная стелька обеспечивает поглощение влаги и создает оптимальный комфорт. Технология Receptor® обеспечивает стабильность и динамическую поддержку в каждом движении стопы.
Ботинки ECCO ULTERRA Ботинки ECCO ULTERRA Новинка

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Инновационный легкий и устойчивый к царапинам материал верха из натуральной кожи яка. 100% защита от проникновения влаги и воздухопроницаемость благодаря мембране GORE-TEX®. Превосходная гибкость, амортизация и анатомически правильная форма. Биомеханическая конструкция подошвы обеспечивает наилучшее положение стопы превосходное сцепление на любой поверхности благодаря технологии RECEPTOR.
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5299 руб.
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Uversky Vladimir Protein and Peptide Folding, Misfolding, and Non-Folding Uversky Vladimir Protein and Peptide Folding, Misfolding, and Non-Folding Новинка

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12179.9 руб.
Sheds new light on intrinsically disordered proteins and peptides, including their role in neurodegenerative diseases With the discovery of intrinsically disordered proteins and peptides (IDPs), researchers realized that proteins do not necessarily adopt a well defined secondary and tertiary structure in order to perform biological functions. In fact, IDPs play biologically relevant roles, acting as inhibitors, scavengers, and even facilitating DNA/RNA-protein interactions. Due to their propensity for self-aggregation and fibril formation, some IDPs are involved in neurodegenerative diseases such as Parkinson's and Alzheimer's. With contributions from leading researchers, this text reviews the most recent studies, encapsulating our understanding of IDPs. The authors explain how the growing body of IDP research is building our knowledge of the folding process, the binding of ligands to receptor molecules, and peptide self-aggregation. Readers will discover a variety of experimental, theoretical, and computational approaches used to better understand the properties and function of IDPs. Moreover, they'll discover the role of IDPs in human disease and as drug targets. Protein and Peptide Folding, Misfolding, and Non-Folding begins with an introduction that explains why research on IDPs has significantly expanded in the past few years. Next, the book is divided into three sections: Conformational Analysis of Unfolded States Disordered Peptides and Molecular Recognition Aggregation of Disordered Peptides Throughout the book, detailed figures help readers understand the structure, properties, and function of IDPs. References at the end of each chapter serve as a gateway to the growing body of literature in the field. With the publication of Protein and Peptide Folding, Misfolding, and Non-Folding, researchers now have a single place to discover IDPs, their diverse biological functions, and the many disciplines that have contributed to our evolving understanding of them.
Kevin Nalty Beyond Viral. How to Attract Customers, Promote Your Brand, and Make Money with Online Video Kevin Nalty Beyond Viral. How to Attract Customers, Promote Your Brand, and Make Money with Online Video Новинка

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1536.16 руб.
Promote your product using the most visceral form of social media-online video Learn how to create cost-effective videos, engage your customers, compel them to measurable behaviors (awareness, intent, and purchase), and sustain your brand online. Beyond Viral gives you the tools and tricks to successfully use online video to reach your business goals. Author Kevin Nalty is the only career marketer who doubles as one of the most-viewed YouTube comedians Foreword by veteran vlogger David Meerman Scott First-hand case studies of leading brands include Microsoft, Starbucks, GE, MTV, Mentos, Holiday Inn, and Fox Broadcasting Learn from the successes of top companies and startups as well as the pitfalls and mistakes many of them are making Online video has huge potential, mostly untapped. Put your business at the forefront of this important medium with the proven methods described by Beyond Viral.
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3799 руб.
Зимняя модель для представительниц прекрасного пола. Удобная съемная стелька защищает от холода. Технология Receptor® обеспечивает стабильность в каждой фазе шага. Великолепное сцепление с любой поверхностью.
Ботинки ECCO XPEDITION III Ботинки ECCO XPEDITION III Новинка

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6099 руб.
Отличное сцепление и долговечность материалов.100% защита от воды и воздухопроницаемость благодаря мембране GORE-TEX®.Съемная стелька обеспечивает поглощение влаги и создает оптимальный комфорт.ехнология Receptor® обеспечивает стабильность и динамическую поддержку в каждом движении стопы.
Сандалии ECCO OFFROAD LITE Сандалии ECCO OFFROAD LITE Новинка

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4099 руб.
Превосходная гибкость, амортизация и комфорт на любой поверхности. Технология Receptor® обеспечивает стабильность во всех трех фазах движения стопы. Мягкая стелька для комфортной и длительной ходьбы. Воздухопроницаемые прочные материалы.
Сандалии ECCO OFFROAD Сандалии ECCO OFFROAD Новинка

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4499 руб.
Превосходные сандалии из высококачественной замши с технологией Receptor®, обеспечивающей стабильность и динамическую поддержку стопы при ходьбе. Прекрасная гибкая и легкая подошва, амортизация пр ходьбе, мягкая стелька EVA позволяют вашим ногам не уставать даже при длительной ходьбе.
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6599 руб.
Инновационный легкий и устойчивый к царапинам материал верха из натуральной кожи яка. Превосходная гибкость, амортизация и анатомически правильная форма. Биомеханическая конструкция подошвы обеспечивает наилучшее положение стопы превосходное сцепление на любой поверхности благодаря технологии RECEPTOR.
Кроссовки ECCO SIERRA LS Кроссовки ECCO SIERRA LS Новинка

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3599 руб.
Модная обувь в спортивном стиле. Великолепное сцепление с любой поверхностью.  Непревзойденный комфорт благодаря мягкости и легкости материалов. Технология Receptor® обеспечивает стабильность и динамическую поддержку в каждом движении стопы.
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Настоящая зимняя обувь. Великолепное сцепление с любой поверхностью. Утепленная подкладка сохраняет сухость и тепло в течение всего дня.Съемная термостелька обеспечивает максимальную защиту от холода.Технология Receptor® обеспечивает стабильность и динамическую поддержку в каждом движении стопы.Прочная подошва из плотной резины, предотвращающей скольжение, обеспечивает великолепное сцепление с любой поверхностью.
Кроссовки ECCO LIGHT III Кроссовки ECCO LIGHT III Новинка

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3399 руб.
Идеальное сцепление с любой поверхностью.  Технология Receptor® обеспечивает стабильность в каждом движении стопы.  Комфортный внутренний климат. Легкая и гибкая подошва для непревзойденного комфорта.
Кроссовки ECCO SIERRA II Кроссовки ECCO SIERRA II Новинка

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4399 руб.
Модный спортивный стиль и непревзойденный комфорт. Легкие дышащие материалы подарят ногам первоклассный комфорт. Стелька EVA абсорбирует влагу, создает благоприятный климат. Легкая гибкая подошва идеально подходит как для комфортной ходьбы, так и для занятий спортом. Технология Receptor® обеспечивает стабильность и динамическую поддержку.
Кроссовки ECCO LIGHT III Кроссовки ECCO LIGHT III Новинка

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4599 руб.
Удобные, привлекательные спортивные полуботинки. Технология Receptor® обеспечивает стабильность и динамическую поддержку в каждом движении стопы. Воздухопроницаемая подкладка создает комфортный внутренний климат.100% защита от воды и воздухопроницаемость благодаря мембране GORE-TEX®. Гибкая подошва с резиной, предотвращающей скольжение.
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3199 руб.
Летние сандалии. Отличное сцепление подошвы с сухими и влажными поверхностями. Технология Receptor® обеспечивает стабильность во всех трех фазах движения стопы. Мягкая подкладка обеспечивает отличную посадку на ноге.
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6099 руб.
Инновационный легкий и устойчивый к царапинам материал верха из натуральной кожи яка. 100% защита от проникновения влаги и воздухопроницаемость благодаря мембране GORE-TEX®. Превосходная гибкость, амортизация и анатомически правильная форма. Биомеханическая конструкция подошвы обеспечивает наилучшее положение стопы превосходное сцепление на любой поверхности благодаря технологии RECEPTOR.

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New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases. Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined. With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia: Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.
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