structure based drug design a practical approach



Sandra Gemma Structure-based Design of Drugs and Other Bioactive Molecules. Tools and Strategies Sandra Gemma Structure-based Design of Drugs and Other Bioactive Molecules. Tools and Strategies Новинка

Sandra Gemma Structure-based Design of Drugs and Other Bioactive Molecules. Tools and Strategies

10269.76 руб. или Купить в рассрочку!
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present «best practice» methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
Raimund Mannhold Biomolecular Simulations in Structure-Based Drug Discovery Raimund Mannhold Biomolecular Simulations in Structure-Based Drug Discovery Новинка

Raimund Mannhold Biomolecular Simulations in Structure-Based Drug Discovery

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A timely and topical survey of modern simulation tools and their applications in real-life drug discovery, allowing for better and quicker results in structure-based drug design. The first part of this practical guide for industry professionals describes common tools used in the biomolecular simulation of drugs and their targets. A critical analysis of the accuracy of the predictions, the integration of modeling with other experimental data combined with numerous case studies from different therapeutic fields enable users to quickly adopt these new methods for their current projects. The second part then shows how these tools can be applied to drug discovery and development projects. Modeling experts from the pharmaceutical industry and from leading academic institutions present real-life examples for important target classes such as GPCRs, kinases and amyloids as well as for common challenges in structure-based drug discovery. With its inclusion of novel methods and strategies for the modeling of drug-target interactions in the framework of real-life drug discovery and development, this application-oriented reference is tailor-made for medicinal chemists and those working in the pharmaceutical industry.
Buchwald Peter Retrometabolic Drug Design and Targeting Buchwald Peter Retrometabolic Drug Design and Targeting Новинка

Buchwald Peter Retrometabolic Drug Design and Targeting

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Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
Robert H. Sturges, Jr. Practical Field Robotics. A Systems Approach Robert H. Sturges, Jr. Practical Field Robotics. A Systems Approach Новинка

Robert H. Sturges, Jr. Practical Field Robotics. A Systems Approach

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Practical Field Robotics: A Systems Approach is an introductory book in the area of field robotics. It approaches the subject with a systems design methodology, showing the reader every important decision made in the process of planning, designing, making and testing a field robot. Key features: • Takes a practical approach to field robotics, presenting the design and implementation of a robot from start to end • Provides multiple robot examples including those used in in nuclear service, underground coal mining and mowing • Bridges the gap between existing mathematically based texts and the real work that goes on in research labs all over the world • Establishes a structured approach to thinking about hardware and software design • Includes problems and is accompanied by a website providing supporting videos and additional problems
Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery Новинка

Rachel Cerdan Comprehensive Analysis of Parasite Biology. From Metabolism to Drug Discovery

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Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art «omics» technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.
Robert A. Goodnow, Jr. A Handbook for DNA-Encoded Chemistry. Theory and Applications for Exploring Chemical Space and Drug Discovery Robert A. Goodnow, Jr. A Handbook for DNA-Encoded Chemistry. Theory and Applications for Exploring Chemical Space and Drug Discovery Новинка

Robert A. Goodnow, Jr. A Handbook for DNA-Encoded Chemistry. Theory and Applications for Exploring Chemical Space and Drug Discovery

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This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
Mohammad Sadraey H. Aircraft Design. A Systems Engineering Approach Mohammad Sadraey H. Aircraft Design. A Systems Engineering Approach Новинка

Mohammad Sadraey H. Aircraft Design. A Systems Engineering Approach

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A comprehensive approach to the air vehicle design process using the principles of systems engineering Due to the high cost and the risks associated with development, complex aircraft systems have become a prime candidate for the adoption of systems engineering methodologies. This book presents the entire process of aircraft design based on a systems engineering approach from conceptual design phase, through to preliminary design phase and to detail design phase. Presenting in one volume the methodologies behind aircraft design, this book covers the components and the issues affected by design procedures. The basic topics that are essential to the process, such as aerodynamics, flight stability and control, aero-structure, and aircraft performance are reviewed in various chapters where required. Based on these fundamentals and design requirements, the author explains the design process in a holistic manner to emphasise the integration of the individual components into the overall design. Throughout the book the various design options are considered and weighed against each other, to give readers a practical understanding of the process overall. Readers with knowledge of the fundamental concepts of aerodynamics, propulsion, aero-structure, and flight dynamics will find this book ideal to progress towards the next stage in their understanding of the topic. Furthermore, the broad variety of design techniques covered ensures that readers have the freedom and flexibility to satisfy the design requirements when approaching real-world projects. Key features: • Provides full coverage of the design aspects of an air vehicle including: aeronautical concepts, design techniques and design flowcharts • Features end of chapter problems to reinforce the learning process as well as fully solved design examples at component level • Includes fundamental explanations for aeronautical engineering students and practicing engineers • Features a solutions manual to sample questions on the book’s companion website Companion website – www.wiley.com/go/sadraey
Shang-Cheng Hung Glycochemical Synthesis. Strategies and Applications Shang-Cheng Hung Glycochemical Synthesis. Strategies and Applications Новинка

Shang-Cheng Hung Glycochemical Synthesis. Strategies and Applications

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This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development
Scott Sudhoff D. Power Magnetic Devices. A Multi-Objective Design Approach Scott Sudhoff D. Power Magnetic Devices. A Multi-Objective Design Approach Новинка

Scott Sudhoff D. Power Magnetic Devices. A Multi-Objective Design Approach

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Presents a multi-objective design approach to the many power magnetic devices in use today Power Magnetic Devices: A Multi-Objective Design Approach addresses the design of power magnetic devices—including inductors, transformers, electromagnets, and rotating electric machinery—using a structured design approach based on formal single- and multi-objective optimization. The book opens with a discussion of evolutionary-computing-based optimization. Magnetic analysis techniques useful to the design of all the devices considered in the book are then set forth. This material is then used for inductor design so readers can start the design process. Core loss is next considered; this material is used to support transformer design. A chapter on force and torque production feeds into a chapter on electromagnet design. This is followed by chapters on rotating machinery and the design of a permanent magnet AC machine. Finally, enhancements to the design process including thermal analysis and AC conductor losses due to skin and proximity effects are set forth. Power Magnetic Devices: Focuses on the design process as it relates to power magnetic devices such as inductors, transformers, electromagnets, and rotating machinery Offers a structured design approach based on single- and multi-objective optimization Helps experienced designers take advantage of new techniques which can yield superior designs with less engineering time Provides numerous case studies throughout the book to facilitate readers’ comprehension of the analysis and design process Includes Powerpoint-slide-based student and instructor lecture notes and MATLAB-based examples, toolboxes, and design codes Designed to support the educational needs of students, Power Magnetic Devices: A Multi-Objective Design Approach also serves as a valuable reference tool for practicing engineers and designers. MATLAB examples are available via the book support site.
D. Young C. Computational Drug Design. A Guide for Computational and Medicinal Chemists D. Young C. Computational Drug Design. A Guide for Computational and Medicinal Chemists Новинка

D. Young C. Computational Drug Design. A Guide for Computational and Medicinal Chemists

10102.84 руб. или Купить в рассрочку!
Helps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. Following an introduction, the book is divided into three parts: Part One, The Drug Design Process, sets forth a variety of design processes suitable for a number of different drug development scenarios and drug targets. The author demonstrates how computational techniques are typically used during the design process, helping readers choose the best computational tools to meet their goals. Part Two, Computational Tools and Techniques, offers a series of chapters, each one dedicated to a single computational technique. Readers discover the strengths and weaknesses of each technique. Moreover, the book tabulates comparative accuracy studies, giving readers an unbiased comparison of all the available techniques. Part Three, Related Topics, addresses new, emerging, and complementary technologies, including bioinformatics, simulations at the cellular and organ level, synthesis route prediction, proteomics, and prodrug approaches. The book's accompanying CD-ROM, a special feature, offers graphics of the molecular structures and dynamic reactions discussed in the book as well as demos from computational drug design software companies. Computational Drug Design is ideal for both students and professionals in drug design, helping them choose and take full advantage of the best computational tools available. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
Latchford Gary Maximising the Benefits of Psychotherapy. A Practice-based Evidence Approach Latchford Gary Maximising the Benefits of Psychotherapy. A Practice-based Evidence Approach Новинка

Latchford Gary Maximising the Benefits of Psychotherapy. A Practice-based Evidence Approach

8741.97 руб. или Купить в рассрочку!
Maximising the Benefits of Psychotherapy critiques Evidence-Based Practice and describes other approaches to improving the effectiveness of therapy, such as Practice-Based Evidence and the use of client feedback. The authors include a summary of key research findings and an accessible guide to applying these ideas to therapeutic practice. Puts forward a critique of existing research claiming that certain psychotherapy programmes are more effective than others in treating specific disorders Includes an accessible summary of key research findings, a practical introduction to a practice-based evidence approach, and a series of detailed case studies Offers a timely alternative to the prevailing wisdom in the mental health field by challenging the practical logic of the Evidence-Based Practice approach Reviews the empirical evidence examining the effects of client feedback on psychotherapy outcomes
Gregory Parnell S. Decision Making in Systems Engineering and Management Gregory Parnell S. Decision Making in Systems Engineering and Management Новинка

Gregory Parnell S. Decision Making in Systems Engineering and Management

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Decision Making in Systems Engineering and Management is a comprehensive textbook that provides a logical process and analytical techniques for fact-based decision making for the most challenging systems problems. Grounded in systems thinking and based on sound systems engineering principles, the systems decisions process (SDP) leverages multiple objective decision analysis, multiple attribute value theory, and value-focused thinking to define the problem, measure stakeholder value, design creative solutions, explore the decision trade off space in the presence of uncertainty, and structure successful solution implementation. In addition to classical systems engineering problems, this approach has been successfully applied to a wide range of challenges including personnel recruiting, retention, and management; strategic policy analysis; facilities design and management; resource allocation; information assurance; security systems design; and other settings whose structure can be conceptualized as a system.
Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery Новинка

Juergen Siepmann Computational Pharmaceutics. Application of Molecular Modeling in Drug Delivery

11907.84 руб. или Купить в рассрочку!
Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.
Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies Новинка

Eric Marsault Practical Medicinal Chemistry with Macrocycles. Design, Synthesis, and Case Studies

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Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. • Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations • Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts • Covers design criteria, typical profile of current macrocycles, applications, and limitations
Daniel Norwood L. Leachables and Extractables Handbook. Safety Evaluation, Qualification, and Best Practices Applied to Inhalation Drug Products Daniel Norwood L. Leachables and Extractables Handbook. Safety Evaluation, Qualification, and Best Practices Applied to Inhalation Drug Products Новинка

Daniel Norwood L. Leachables and Extractables Handbook. Safety Evaluation, Qualification, and Best Practices Applied to Inhalation Drug Products

10790.84 руб. или Купить в рассрочку!
A practical and science-based approach for addressing toxicological concerns related to leachables and extractables associated with inhalation drug products Packaging and device components of Orally Inhaled and Nasal Drug Products (OINDP)—such as metered dose inhalers, dry powder inhalers, and nasal sprays—pose potential safety risks from leachables and extractables, chemicals that can be released or migrate from these components into the drug product. Addressing the concepts, background, historical use, and development of safety thresholds and their utility for qualifying leachables and extractables in OINDP, the Leachables and Extractables Handbook takes a practical approach to familiarize readers with the recent recommendations for safety and risk assessment established through a joint effort of scientists from the FDA, academia, and industry. Coverage includes best practices for the chemical evaluation and management of leachables and extractables throughout the pharmaceutical product life cycle, as well as: Guidance for pharmaceutical professionals to qualify and risk-assess container closure system leachables and extractables in drug products Principles for defining toxicological safety thresholds that are applicable to OINDP and potentially applicable to other drug products Regulatory perspectives, along with an appendix of key terms and definitions, case studies, and sample protocols Analytical chemists, packaging and device engineers, formulation development scientists, component suppliers, regulatory affairs specialists, and toxicologists will all benefit from the wealth of information offered in this important text.
Jean Brunel L.P. Goals-Based Wealth Management. An Integrated and Practical Approach to Changing the Structure of Wealth Advisory Practices Jean Brunel L.P. Goals-Based Wealth Management. An Integrated and Practical Approach to Changing the Structure of Wealth Advisory Practices Новинка

Jean Brunel L.P. Goals-Based Wealth Management. An Integrated and Practical Approach to Changing the Structure of Wealth Advisory Practices

3769.72 руб. или Купить в рассрочку!
Take a more active role in strategic asset allocation Goals-Based Wealth Management is a manual for protecting and growing client wealth in a way that changes both the services and profitability of the firm. Written by a 35-year veteran of international wealth education and analysis, this informative guide explains a new approach to wealth management that allows individuals to take on a more active role in the allocation of their assets. Coverage includes a detailed examination of the goals-based approach, including what works and what needs to be revisited, and a clear, understandable model that allows advisors to help individuals to navigate complex processes. The companion website offers ancillary readings, practice management checklists, and assessments that help readers secure a deep understanding of the key ideas that make goals-based wealth management work. The goals-based wealth management approach was pioneered in 2002, but has seen a slow evolution and only modest refinements largely due to a lack of wide-scale adoption. This book takes the first steps toward finalizing the approach, by delineating the effective and ineffective aspects of traditional approaches, and proposing changes that could bring better value to practitioners and their clients. Understand the challenges faced by the affluent and wealthy Examine strategic asset allocation and investment policy formulation Learn a model for dealing with the asset allocation process Learn why the structure of the typical advisory firm needs to change High-net-worth individuals face very specific challenges. Goals-Based Wealth Management focuses on how those challenges can be overcome while adhering to their goals, incorporating constraints, and working within the individual's frame of reference to drive strategic allocation of their financial assets.
Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer Новинка

Sara A. Hurvitz Antibody-Drug Conjugates. Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

11162.94 руб. или Купить в рассрочку!
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
János Fischer Analogue-based Drug Discovery III János Fischer Analogue-based Drug Discovery III Новинка

János Fischer Analogue-based Drug Discovery III

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Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs. The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and – together with the previous volumes – constitutes the first systematic approach to drug analogue development.
John Dickenson Molecular Pharmacology. From DNA to Drug Discovery John Dickenson Molecular Pharmacology. From DNA to Drug Discovery Новинка

John Dickenson Molecular Pharmacology. From DNA to Drug Discovery

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This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current – focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge – highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied – includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible – contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book. A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
Alexander Papusha N. Beam Theory for Subsea Pipelines. Analysis and Practical Applications Alexander Papusha N. Beam Theory for Subsea Pipelines. Analysis and Practical Applications Новинка

Alexander Papusha N. Beam Theory for Subsea Pipelines. Analysis and Practical Applications

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Introducing a new practical approach within the field of applied mechanics developed to solve beam strength and bending problems using classical beam theory and beam modeling, this outstanding new volume offers the engineer, scientist, or student a revolutionary new approach to subsea pipeline design. Integrating use of the Mathematica program into these models and designs, the engineer can utilize this unique approach to build stronger, more efficient and less costly subsea pipelines, a very important phase of the world's energy infrastructure. Significant advances have been achieved in implementation of the applied beam theory in various engineering design technologies over the last few decades, and the implementation of this theory also takes an important place within the practical area of re-qualification and reassessment for onshore and offshore pipeline engineering. A general strategy of applying beam theory into the design procedure of subsea pipelines has been developed and already incorporated into the ISO guidelines for reliability-based limit state design of pipelines. This work is founded on these significant advances. The intention of the book is to provide the theory, research, and practical applications that can be used for educational purposes by personnel working in offshore pipeline integrity and engineering students. A must-have for the veteran engineer and student alike, this volume is an important new advancement in the energy industry, a strong link in the chain of the world's energy production.
Senaratne Sepani Managing Change in Construction Projects. A Knowledge-Based Approach Senaratne Sepani Managing Change in Construction Projects. A Knowledge-Based Approach Новинка

Senaratne Sepani Managing Change in Construction Projects. A Knowledge-Based Approach

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Managing Change in Construction Projects: a knowledge-based approach offers a new perspective on construction project change by viewing the process of change management as a knowledge-intensive activity, where team members bring their tacit and explicit knowledge into the situation; share, create and capture this collective knowledge for future re-use in similar situations. Through this knowledge-based approach, construction teams can successfully resolve and learn from change events, leading to an overall improved performance of the industry. The book will make a significant contribution to our understanding of construction project change by offering new theoretical and practical insights and models grounded in results of case studies conducted within two collaborative construction project team settings. By demonstrating how the social construction of knowledge works in construction settings, the authors challenge the prevailing change management solutions based on ‘hard’ IT approaches. They put forward a balanced view that incorporates both IT–based and socially constructed approaches to effective management of construction project change. helps construction managers to improve and learn through the process of construction project change presents new theoretical models and offers practical guidelines first research-based book to directly address project change from a knowledge-based perspective draws on detailed studies with construction companies, including Ballast Construction and Kier Construction encourages a move from the information driven, process integrated approach to a knowledge-based view
Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies Новинка

Young Richard Drug Discrimination. Applications to Medicinal Chemistry and Drug Studies

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Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a «drug detection» procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.
Rankovic Zoran Lead Generation Approaches in Drug Discovery Rankovic Zoran Lead Generation Approaches in Drug Discovery Новинка

Rankovic Zoran Lead Generation Approaches in Drug Discovery

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An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or «virtual» screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Qiuliang Wang Practical Design of Magnetostatic Structure Using Numerical Simulation Qiuliang Wang Practical Design of Magnetostatic Structure Using Numerical Simulation Новинка

Qiuliang Wang Practical Design of Magnetostatic Structure Using Numerical Simulation

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Magnets are widely used in industry, medical, scientific instruments, and electrical equipment. They are the basic tools for scientific research and electromagnetic devices. Numerical methods for the magnetic field analysis combined with mathematical optimization from practical applications of the magnets have been widely studied in recent years. It is necessary for professional researchers, engineers, and students to study these numerical methods for the complex magnet structure design instead of using traditional «trial-and-error» methods. Those working in this field will find this book useful as a reference to help reduce costs and obtain good magnetic field quality. Presents a clear introduction to magnet technology, followed by basic theories, numerical analysis, and practical applications Emphasizes the latest developments in magnet design, including MRI systems Provides comprehensive numerical techniques that provide solutions to practical problems Introduces the latest computation techniques for optimizing and characterizing the magnetostatic structure design Well organized and adaptable by researchers, engineers, lecturers, and students Appendix available on the Wiley Companion Website As a comprehensive treatment of the topic, Practical Design of Magnetostatic Structure Using Numerical Simulation is ideal for researchers in the field of magnets and their applications, materials scientists, structural engineers, and graduate students in electrical engineering. The book will also better equip mechanical engineers and aerospace engineers.
Tomalia Donald A. Dendrimer-Based Drug Delivery Systems. From Theory to Practice Tomalia Donald A. Dendrimer-Based Drug Delivery Systems. From Theory to Practice Новинка

Tomalia Donald A. Dendrimer-Based Drug Delivery Systems. From Theory to Practice

14551.1 руб. или Купить в рассрочку!
The opportunities and challenges of using dendrimers to improve drug delivery Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication to targeted human organs. With contributions from an international team of pioneers and experts in dendrimer research, this book provides a comprehensive overview of the latest research efforts in designing and optimizing dendrimer-based drug delivery systems. The book analyzes key issues, demonstrating the critical connections that link fundamental concepts, design, synthesis, analytical methodology, and biological assessment to the practical use of dendrimers in drug delivery applications. Topics covered include: Dendrimer history Synthesis Physicochemical properties Principles of drug delivery Applications in diverse biomedical fields Dendrimer-Based Drug Delivery Systems reflects the authors' thorough review and analysis of the current literature as well as their own firsthand experience in the lab. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research. References at the end of each chapter serve as a gateway to the growing body of literature in the field, enabling readers to explore each individual topic in greater depth. Pharmaceutical and biomedical researchers will find this book a unique and essential guide to the opportunities, issues, and challenges involved in fully exploiting the potential of dendrimers to improve drug delivery.
Arthur Dexter L. Monitoring and Control of Information-Poor Systems. An Approach based on Fuzzy Relational Models Arthur Dexter L. Monitoring and Control of Information-Poor Systems. An Approach based on Fuzzy Relational Models Новинка

Arthur Dexter L. Monitoring and Control of Information-Poor Systems. An Approach based on Fuzzy Relational Models

11535.03 руб. или Купить в рассрочку!
The monitoring and control of a system whose behaviour is highly uncertain is an important and challenging practical problem. Methods of solution based on fuzzy techniques have generated considerable interest, but very little of the existing literature considers explicit ways of taking uncertainties into account. This book describes an approach to the monitoring and control of information-poor systems that is based on fuzzy relational models which generate fuzzy outputs. The first part of Monitoring and Control of Information-Poor Systems aims to clarify why design decisions must take account of the uncertainty associated with optimal choices, and to explain how a fuzzy relational model can be used to generate a fuzzy output, which reflects the uncertainties associated with its predictions. Part two gives a brief introduction to fuzzy decision-making and shows how it can be used to design a predictive control scheme that is suitable for controlling information-poor systems using inaccurate measurements. Part three describes different ways in which fuzzy relational models can be generated online and explains the practical issues associated with their identification and application. The final part of the book provides examples of the use of the previously described techniques in real applications. Key features: Describes techniques applicable to a wide range of engineering, environmental, medical, financial and economic applications Uses simple examples to help explain the basic techniques for dealing with uncertainty Describes a novel design approach based on the use of fuzzy relational models Considers practical issues associated with applying the techniques to real systems Monitoring and Control of Information-Poor Systems forms an invaluable resource for a wide range of graduate students, and is also a comprehensive reference for researchers and practitioners working on problems involving mathematical modelling and control.
Varghese John BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease Varghese John BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease Новинка

Varghese John BACE. Lead Target for Orchestrated Therapy of Alzheimer's Disease

9650.47 руб. или Купить в рассрочку!
BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.
Dag Hanssen H. Programmable Logic Controllers. A Practical Approach to IEC 61131-3 using CoDeSys Dag Hanssen H. Programmable Logic Controllers. A Practical Approach to IEC 61131-3 using CoDeSys Новинка

Dag Hanssen H. Programmable Logic Controllers. A Practical Approach to IEC 61131-3 using CoDeSys

7625.53 руб. или Купить в рассрочку!
Widely used across industrial and manufacturing automation, Programmable Logic Controllers (PLCs) perform a broad range of electromechanical tasks with multiple input and output arrangements, designed specifically to cope in severe environmental conditions such as automotive and chemical plants. Programmable Logic Controllers: A Practical Approach using CoDeSys is a hands-on guide to rapidly gain proficiency in the development and operation of PLCs based on the IEC 61131-3 standard. Using the freely-available* software tool CoDeSys, which is widely used in industrial design automation projects, the author takes a highly practical approach to PLC design using real-world examples. The design tool, CoDeSys, also features a built in simulator/soft PLC enabling the reader to undertake exercises and test the examples. Key features: Introduces to programming techniques using IEC 61131-3 guidelines in the five PLC-recognised programming languages. Focuses on a methodical approach to programming, based on Boolean algebra, flowcharts, sequence diagrams and state-diagrams. Contains a useful methodology to solve problems, develop a structured code and document the programming code. Covers I/O like typical sensors, signals, signal formats, noise and cabling. Features Power Point slides covering all topics, example programs and solutions to end-of-chapter exercises via companion website. No prior knowledge of programming PLCs is assumed making this text ideally suited to electronics engineering students pursuing a career in electronic design automation. Experienced PLC users in all fields of manufacturing will discover new possibilities and gain useful tips for more efficient and structured programming. * Register at www.codesys.com www.wiley.com/go/hanssen/logiccontrollers
Fotios Spyropoulos Practical Food Rheology. An Interpretive Approach Fotios Spyropoulos Practical Food Rheology. An Interpretive Approach Новинка

Fotios Spyropoulos Practical Food Rheology. An Interpretive Approach

17857.17 руб. или Купить в рассрочку!
Rheology is fundamentally important in food manufacturing in two major senses. Understanding the way in which a substance moves and behaves is essential in order to be able to transport and mix it during processing. Secondly, the rheology of a product dictates much of the consumer experience, e.g. in relation to texture and mouthfeel. This book doesn’t overwhelm the reader with complex mathematical equations but takes a simple and practically-focused approach, interpreting the implications of rheological data for use in different food systems. Through this approach industry-based food developers / rheologists, students, and academics are given clear, concise interpretation of rheological data which directly relates to actual perceived functionality in the food. The functionality may relate to texture, structure and mouthfeel, and may result as a function of temperature, pH, flocculation, concentration effects, and mixing. The interpretative view is based on the principle that the food rheologist will produce a graph, for example of viscosity or gelation profiling, and then have to extract a practical meaning from it. For example, if viscosity falls with time as a function of pH, this knowledge can be used to tell the customer that the viscosity can be followed with just a pH meter and a stopwatch. Rheological measurements have shown that once the pH has dropped 1 unit after 10 minutes, the viscosity has been halved. This is the type of practical and valuable information for customers of the industrial food rheologist which the book will enable readers to access. Key features: A uniquely practical approach to the often difficult science of food rheology Includes chapters introducing the basics of food rheology before moving on to how data can be usefully and easily interpreted by the food scientist Can be used as a teaching aid on academic or industry-based courses
Holger Kampffmeyer Formalization of Design Patterns by Means of Ontologies Holger Kampffmeyer Formalization of Design Patterns by Means of Ontologies Новинка

Holger Kampffmeyer Formalization of Design Patterns by Means of Ontologies

Diploma Thesis from the year 2007 in the subject Computer Science - Software, grade: 1, Dresden Technical University, language: English, abstract: Design patterns have proven to be important building blocks and means of reuse in software design. However, the mere number of available design patterns complicates the decision-making which design pattern to choose and demands tools assisting in this process. We hence propose a knowledge-based formal representation of design patterns, a representation that is accessible by tools. Existing approaches to formalizing design patterns generally cover solely the formal description of the structure of design patterns. However, an important part of a design pattern description is the intent section, because the intent describes what the design pattern does and which design problems a pattern addresses. In this work, we develop a novel approach of formalizing design patterns by their intent. The formal representation is based on OWL, the web ontology language. The developed ontology can serve as support for the decision-making of choosing the right design pattern. We furthermore develop a tool that uses the ontology as a knowledge-base. The tool allows the user to visually describe design problems and gives suggestions of design patterns that solve a given design problem.
Ben Reason Service Design for Business. A Practical Guide to Optimizing the Customer Experience Ben Reason Service Design for Business. A Practical Guide to Optimizing the Customer Experience Новинка

Ben Reason Service Design for Business. A Practical Guide to Optimizing the Customer Experience

A practical approach to better customer experience through service design Service Design for Business helps you transform your customer's experience and keep them engaged through the art of intentional service design. Written by the experts at Livework, this practical guide offers a tangible, effective approach for better responding to customers' needs and demands, and provides concrete strategy that can be implemented immediately. You'll learn how taking a design approach to problem solving helps foster creativity, and how to apply it to the real issues that move businesses forward. Highly visual and organized for easy navigation, this quick read is a handbook for connecting market factors to the organizational challenge of customer experience by seeing your company through the customers' eyes. Livework pioneered the service design industry, and guides organizations including Sony, the British Government, Volkswagen Procter & Gamble, the BBC, and more toward a more carefully curated customer experience. In this book, the Livework experts show you how to put service design to work in your company to solve the ongoing challenge of winning with customers. Approach customer experience from a design perspective See your organization through the lens of the customer Make customer experience an organization-wide responsibility Analyze the market factors that dovetail with customer experience design The Internet and other digital technology has brought the world to your customers' fingertips. With unprecedented choice, consumers are demanding more than just a great product—the organizations coming out on top are designing and delivering experiences tailored to their customers' wants. Service Design for Business gives you the practical insight and service design perspective you need to shape the way your customers view your organization.
Ben Dunn M. Peptide Chemistry and Drug Design Ben Dunn M. Peptide Chemistry and Drug Design Новинка

Ben Dunn M. Peptide Chemistry and Drug Design

11535.03 руб. или Купить в рассрочку!
This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. • Identifies promising new areas in peptide drug discovery • Includes chapters on discovery from natural sources, metabolic modification, and drug delivery • Overviews separation methods and techniques for analysis, bond formation, and purification • Offers readers both a professional reference and a text or resource for graduate-level students
Plevris John N. Problem-based Approach to Gastroenterology and Hepatology Plevris John N. Problem-based Approach to Gastroenterology and Hepatology Новинка

Plevris John N. Problem-based Approach to Gastroenterology and Hepatology

6932.51 руб. или Купить в рассрочку!
Taking the problem-based approach, this text helps clinicians improve their diagnostic and therapeutic skills in a focused and practical manner. The cases included demonstrate the diversity of clinical practice in the specialty worldwide, and are divided into five major sections: Upper GI, Pancreato-Biliary, Liver, Small and Large Bowel, and Miscellaneous.
Martin Fridson S. Corporate Finance Workbook. A Practical Approach Martin Fridson S. Corporate Finance Workbook. A Practical Approach Новинка

Martin Fridson S. Corporate Finance Workbook. A Practical Approach

2827.29 руб. или Купить в рассрочку!
The workbook to accompany Corporate Finance: A Practical Approach, Second Edition
Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development Новинка

Surapaneni Sekhar ADME-Enabling Technologies in Drug Design and Development

14475.71 руб. или Купить в рассрочку!
A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Ganellin C. Robin Analogue-based Drug Discovery II Ganellin C. Robin Analogue-based Drug Discovery II Новинка

Ganellin C. Robin Analogue-based Drug Discovery II

17868.45 руб. или Купить в рассрочку!
Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development. Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.
Matlock Marty D. Ecological Engineering Design. Restoring and Conserving Ecosystem Services Matlock Marty D. Ecological Engineering Design. Restoring and Conserving Ecosystem Services Новинка

Matlock Marty D. Ecological Engineering Design. Restoring and Conserving Ecosystem Services

11309.15 руб. или Купить в рассрочку!
Ecologically-sensitive building and landscape design is a broad, intrinsically interdisciplinary field. Existing books independently cover narrow aspects of ecological design in depth (hydrology, ecosystems, soils, flora and fauna, etc.), but none of these books can boast of the integrated approach taken by this one. Drawing on the experience of the authors, this book begins to define explicit design methods for integrating consideration of ecosystem processes and services into every facet of land use design, management, and policy. The approach is to provide a prescriptive approach to ecosystem design based upon ecological engineering principles and practices. This book will include a novel collection of design methods for the non-built and built environments, linking landscape design explicitly to ecosystem services.
Donald Huddler Applied Biophysics for Drug Discovery Donald Huddler Applied Biophysics for Drug Discovery Новинка

Donald Huddler Applied Biophysics for Drug Discovery

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Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: • Design considerations in biophysical-based lead screening • Thermodynamic characterization of protein-compound interactions • Characterizing targets and screening reagents with HDX-MS • Microscale thermophoresis methods (MST) • Screening with Weak Affinity Chromatography • Methods to assess compound residence time • 1D-NMR methods for hit identification • Protein-based NMR methods for SAR development • Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.
Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics Новинка

Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics

10027.44 руб. или Купить в рассрочку!
Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.
Kiyohiko Sugano Biopharmaceutics Modeling and Simulations. Theory, Practice, Methods, and Applications Kiyohiko Sugano Biopharmaceutics Modeling and Simulations. Theory, Practice, Methods, and Applications Новинка

Kiyohiko Sugano Biopharmaceutics Modeling and Simulations. Theory, Practice, Methods, and Applications

10329.02 руб. или Купить в рассрочку!
A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs. A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses: The central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS) The concept of drug concentration How to simulate key drug absorption processes The physiological and drug property data used for biopharmaceutical modeling Reliable practices for reporting results With over 200 figures and illustrations and a peerless examination of all the key aspects of drug research—including running and interpreting models, validation, and compound and formulation selection—this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow.
Christopher Twelves J. A Practical Guide to Designing Phase II Trials in Oncology Christopher Twelves J. A Practical Guide to Designing Phase II Trials in Oncology Новинка

Christopher Twelves J. A Practical Guide to Designing Phase II Trials in Oncology

5804.59 руб. или Купить в рассрочку!
How to identify optimal phase II trial designs Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomization, and considering both academic and industry perspectives. A comprehensive and systematic library of available phase II trial designs is included, saving time otherwise spent considering multiple manuscripts, and real-life practical examples of using this approach to design phase II trials in cancer are given. A Practical Guide to Designing Phase II Trials in Oncology: Offers a structured and practical approach to phase II trial design. Considers trial design from both an academic and industry perspective. Includes a structured library of available phase II trial designs. Is relevant to both clinical and statistical researchers at all levels Includes real life examples of applying this approach. For those new to trial design, A Practical Guide to Designing Phase II Trials in Oncology will be a unique and practical learning tool, providing an introduction to the concepts behind informed decision making in phase II trials. For more experienced practitioners, the book will offer an overview of new, less familiar approaches to phase II trial design, providing alternative options to those which they may have previously used.
Ellen Simon Design Thinking in the Automotive Industry. Creativity and Innovation Ellen Simon Design Thinking in the Automotive Industry. Creativity and Innovation Новинка

Ellen Simon Design Thinking in the Automotive Industry. Creativity and Innovation

This book explores the application of Design Thinking in the automotive industry in order to explain which factors influence the innovativeness of Design Thinking teams. Seeking for innovation leadership, automotive manufacturers apply Design Thinking to enhance their competitiveness with customer-oriented products and services. Design Thinking is a multidisciplinary team-based methodology that adopts design principles to business management. In the literature and practice, however, it is not clear, what constitutes the relationship between the application of Design Thinking and team's innovativeness. A grounded theory and template analysis approach is used to develop a framework which explains this relationship. Managers and decision-makers of multinationals are provided with practical recommendations about how to implement Design Thinking to produce innovative products and services.
Jens-Uwe Peters Polypharmacology in Drug Discovery Jens-Uwe Peters Polypharmacology in Drug Discovery Новинка

Jens-Uwe Peters Polypharmacology in Drug Discovery

10329.02 руб. или Купить в рассрочку!
An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the «one drug, one target» philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.
Rohde Ulrich L. RF / Microwave Circuit Design for Wireless Applications Rohde Ulrich L. RF / Microwave Circuit Design for Wireless Applications Новинка

Rohde Ulrich L. RF / Microwave Circuit Design for Wireless Applications

12436.29 руб. или Купить в рассрочку!
Provides researchers and engineers with a complete set of modeling, design, and implementation tools for tackling the newest IC technologies Revised and completely updated, RF/Microwave Circuit Design for Wireless Applications, Second Edition is a unique, state-of-the-art guide to wireless integrated circuit design that provides researchers and engineers with a complete set of modeling, design, and implementation tools for tackling even the newest IC technologies. It emphasizes practical design solutions for high-performance devices and circuitry, incorporating ample examples of novel and clever circuits from high-profile companies. Complete with excellent appendices containing working models and CAD-based applications, this powerful one-stop resource: Covers the entire area of circuit design for wireless applications Discusses the complete system for which circuits are designed as well as the device technologies on which the devices and circuits are based Presents theory as well as practical issues Introduces wireless systems and modulation types Takes a systematic approach that differentiates between designing for battery-operated devices and base-station design RF/Microwave Circuit Design for Wireless Applications, Second Edition is an indispensable tool for circuit designers; engineers who design wireless communications systems; and researchers in semiconductor technologies, telecommunications, and wireless transmission systems.
Hugo Kubinyi Prodrugs and Targeted Delivery. Towards Better ADME Properties Hugo Kubinyi Prodrugs and Targeted Delivery. Towards Better ADME Properties Новинка

Hugo Kubinyi Prodrugs and Targeted Delivery. Towards Better ADME Properties

15628.11 руб. или Купить в рассрочку!
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
Tsaioun Katya ADMET for Medicinal Chemists. A Practical Guide Tsaioun Katya ADMET for Medicinal Chemists. A Practical Guide Новинка

Tsaioun Katya ADMET for Medicinal Chemists. A Practical Guide

11535.33 руб. или Купить в рассрочку!
This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.
Jay Galbraith R. Designing Organizations. Strategy, Structure, and Process at the Business Unit and Enterprise Levels Jay Galbraith R. Designing Organizations. Strategy, Structure, and Process at the Business Unit and Enterprise Levels Новинка

Jay Galbraith R. Designing Organizations. Strategy, Structure, and Process at the Business Unit and Enterprise Levels

4465.17 руб. или Купить в рассрочку!
This Third Edition of the groundbreaking book Designing Organizations offers a guide to the process of creating and managing an organization (no matter how complex) that will be positioned to respond effectively and rapidly to customer demands and have the ability to achieve unique competitive advantage. This latest edition includes fresh illustrative examples and references, while the foundation of the book remains the author’s popular and widely used Star Model. Includes a comprehensive explanation of the basics of organization design Outlines a strategic approach to design that is based on the Star Model, a holistic framework for combining strategy, structure, processes, rewards, and people Describes the different types of single-business, functional organizations and focuses on the functional structure and the cross-functional lateral processes that characterize most single-business organizations. Features a special section on the effects of big data on organization design, and whether or not it will result in a new dimension of organizational structure Highlighting the social technologies used to coordinate work flows, products, and services across the company, this new edition of Designing Organizations brings theory to life with a wealth of examples from such well-known companies as Disney, Nike, IBM, and Rovio (Angry Birds) to show how various kinds of organization designs operate differently.
Hugo Kubinyi Aspartic Acid Proteases as Therapeutic Targets Hugo Kubinyi Aspartic Acid Proteases as Therapeutic Targets Новинка

Hugo Kubinyi Aspartic Acid Proteases as Therapeutic Targets

17266.19 руб. или Купить в рассрочку!
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.
Henry Riordan Critical Pathways to Success in CNS Drug Development Henry Riordan Critical Pathways to Success in CNS Drug Development Новинка

Henry Riordan Critical Pathways to Success in CNS Drug Development

13764.09 руб. или Купить в рассрочку!
Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials. The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future. Animal-based models of major CNS disorders are described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attention is given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations
Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry Новинка

Raimund Mannhold Drug Selectivity. An Evolving Concept in Medicinal Chemistry

The book «Drug Selectivity – An Evolving Concept in Medicinal Chemistry» provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Ronald Capelle G. Optimizing Organization Design. A Proven Approach to Enhance Financial Performance, Customer Satisfaction and Employee Engagement Ronald Capelle G. Optimizing Organization Design. A Proven Approach to Enhance Financial Performance, Customer Satisfaction and Employee Engagement Новинка

Ronald Capelle G. Optimizing Organization Design. A Proven Approach to Enhance Financial Performance, Customer Satisfaction and Employee Engagement

3769.72 руб. или Купить в рассрочку!
Optimizing Organization Design offers a comprehensive resource and valued guide for anyone interested in improving organization performance. The book presents an approach to optimizing organization design that is based on over 100 large scale projects and 23 research studies that have been completed by Capelle Associates over the past 25 years. In addition, the book includes insightful comments from executives on their success in using this approach. Capelle’s research and client experience reveal that optimizing organization design leads to better financial performance, customer satisfaction and employee engagement. It can provide a competitive advantage and a significant return on investment. It can also become the foundation of both strategy implementation and human resources management. Capelle shows that organization design includes the alignment of a number of critical factors, including positions (vertical and functional); accountabilities and authorities (managerial and cross functional); people; deliverables and tasks. He shows that manager – direct report alignment is the single most important organization design variable. His research also shows that it is suboptimal nearly half the time. This is a horrendous waste of talent and capability, but also provides a significant opportunity for improvement in organization performance. Optimizing Organization Design clearly explains how to implement organization design improvements. This approach includes people change management, project management, and a cascading, iterative approach that is based on teams and involves education, doing real work and feedback. In addition, Optimizing Organization Design includes special sections on the role of the Board of Directors, project management, process management and compensation. In addition, the author has included four case studies and a useful glossary.
Laurence Davaine Design of Plated Structures. Eurocode 3: Design of Steel Structures, Part 1-5: Design of Plated Structures Laurence Davaine Design of Plated Structures. Eurocode 3: Design of Steel Structures, Part 1-5: Design of Plated Structures Новинка

Laurence Davaine Design of Plated Structures. Eurocode 3: Design of Steel Structures, Part 1-5: Design of Plated Structures

5432.49 руб. или Купить в рассрочку!
The main aim of this book is to provide practical advice to designers of plated structures for correct and efficient application of EN 1993-1-5 design rules. In chapter 1 the purpose, the scope and the structure of the book is explained. In chapter 2 a rather detailed and commented overview of EN 1993-1-5 design rules is given following the structure of the standard. Shear lag effect as well as plate buckling problems due to direct stresses, shear forces, transverse forces and interactions of these effects are covered. This chapter also includes a reduced stress method and a finite element analysis approach to plate buckling problems. A large number of design examples illustrate the proper application of individual design rules. Chapter 3 and 4 bring two complete design examples on a crane runway and a box-girder bridge.
Gerald S. Martin Capital Structure and Corporate Financing Decisions. Theory, Evidence, and Practice Gerald S. Martin Capital Structure and Corporate Financing Decisions. Theory, Evidence, and Practice Новинка

Gerald S. Martin Capital Structure and Corporate Financing Decisions. Theory, Evidence, and Practice

6282.86 руб. или Купить в рассрочку!
A comprehensive guide to making better capital structure and corporate financing decisions in today's dynamic business environment Given the dramatic changes that have recently occurred in the economy, the topic of capital structure and corporate financing decisions is critically important. The fact is that firms need to constantly revisit their portfolio of debt, equity, and hybrid securities to finance assets, operations, and future growth. Capital Structure and Corporate Financing Decisions provides an in-depth examination of critical capital structure topics, including discussions of basic capital structure components, key theories and practices, and practical application in an increasingly complex corporate world. Throughout, the book emphasizes how a sound capital structure simultaneously minimizes the firm's cost of capital and maximizes the value to shareholders. Offers a strategic focus that allows you to understand how financing decisions relates to a firm's overall corporate policy Consists of contributed chapters from both academics and experienced professionals, offering a variety of perspectives and a rich interplay of ideas Contains information from survey research describing actual financial practices of firms This valuable resource takes a practical approach to capital structure by discussing why various theories make sense and how firms use them to solve problems and create wealth. In the wake of the recent financial crisis, the insights found here are essential to excelling in today's volatile business environment.
Sell Ravio Model Based Mechatronic Systems Modeling Methodology Sell Ravio Model Based Mechatronic Systems Modeling Methodology Новинка

Sell Ravio Model Based Mechatronic Systems Modeling Methodology

This book is focused on the model based design methodology for mechatronic systems in the conceptual stage. It proposes a generic framework model for effective and semi-automated design candidate generation in the conceptual design stage. The specific application is focused on the mobile robots. An application specific toolkit was developed as a tool based on the developed methodology. The methodology specifies toolkits and model libraries which are realized on the example of mobile robotic platform design. Additional toolkits can be developed according to this methodology. The practical implementation of the Mobile Platform Toolkit is presented based on real examples. Two similar mobile robots in a different design stage were selected to illustrate the use of the toolkit. The Workpartner robot from Aalto University is used as an analytical example and the UGV platform from Tallinn University of Technology is utilized as a synthesis example where the developed approach was applied in the conceptual design stage.
Clark Ruth C. Scenario-based e-Learning. Evidence-Based Guidelines for Online Workforce Learning Clark Ruth C. Scenario-based e-Learning. Evidence-Based Guidelines for Online Workforce Learning Новинка

Clark Ruth C. Scenario-based e-Learning. Evidence-Based Guidelines for Online Workforce Learning

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Scenario-Based e-Learning Scenario-Based e-Learning offers a new instructional design approach that can accelerate expertise, build critical thinking skills, and promote transfer of learning. This book focuses on the what, when, and how of scenario-based e-learning for workforce learning. Throughout the book, Clark defines and demystifies scenario-based e-learning by offering a practical design model illustrated with examples from veterinary science, automotive troubleshooting, sales and loan analysis among other industries. Filled with helpful guidelines and a wealth of illustrative screen shots, this book offers you the information needed to: Identify the benefits of a SBeL design for learners and learning outcomes Determine when SBeL might be appropriate for your needs Identify specific outcomes of SBeL relevant to common organizational goals Classify specific instructional goals into one or more learning domains Apply a design model to present content in a task-centered context Evaluate outcomes from SBeL lessons Identify tacit expert knowledge using cognitive task analysis techniques Make a business case for SBeL in your organization Praise for Scenario-Based e-Learning «Clark has done it again—with her uncanny ability to make complex ideas accessible to practitioners, the guidelines in this book provide an important resource for you to build your own online, problem-centered instructional strategies.» —M. David Merrill, professor emeritus at Utah State University; author, First Principles of Instruction «Clark's wonderful book provides a solid explanation of the how, what, and why of scenario-based e-learning. The tools, techniques, and resources in this book provide a roadmap for creating engaging, informative scenarios that lead to tangible, measurable learning outcomes. If you want to design more engaging e-learning, you need to read this book.» —Karl M. Kapp, Professor of Instructional Technology, Bloomsburg University; author, The Gamification of Learning and Instruction
Ann Newman Pharmaceutical Amorphous Solid Dispersions Ann Newman Pharmaceutical Amorphous Solid Dispersions Новинка

Ann Newman Pharmaceutical Amorphous Solid Dispersions

13470.37 руб. или Купить в рассрочку!
Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry. • Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems • Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations • Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach • Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the world
Klineberg Iven Oral Rehabilitation. A Case-Based Approach Klineberg Iven Oral Rehabilitation. A Case-Based Approach Новинка

Klineberg Iven Oral Rehabilitation. A Case-Based Approach

7764.99 руб. или Купить в рассрочку!
This book provides its readers with a structured approach to decision-making and case management in oral rehabilitation. It is built around actual patient cases from simple prosthodontics to complex full-mouth reconstructions, demonstrating a formal process by which a diagnosis and treatment plan is reached. Grounded firmly in evidence-based principles, the book also includes a chapter on literature searching in dentistry, which is critical for acquiring a knowledge-base for informed decisions in clinical treatment. Featuring an approach to prosthodontics and oral rehabilitation that is both instructional and practical, Oral Rehabilitation: A Case-Based Approach will help clinicians to develop the necessary skills to make consistent, evidence-based clinical decisions. KEY FEATURES • Presents a case-based process showing how diagnosis and treatment is achieved • Covers a range of clinical scenarios from simple to complex presentations • Illustrates each case fully, with stages documented by colour photographs • Emphasises inter-disciplinary management in prosthodontics • Accompanied by a website containing illustrative video clips
Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery Новинка

Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery

14475.71 руб. или Купить в рассрочку!
Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.
Gray Robin Temporomandibular Disorders. A Problem-Based Approach Gray Robin Temporomandibular Disorders. A Problem-Based Approach Новинка

Gray Robin Temporomandibular Disorders. A Problem-Based Approach

5427.76 руб. или Купить в рассрочку!
A quick, systematic and logical approach to diagnosing and treating temporomandibular disorders (TMD), this latest book in the Dental Update series is an essential clinical companion for dental students and practising dentists. Starting with an overview of the basic principles of TMD, such as the anatomy of the temporomandibular joint and its physiology and pathology in relation to clinical treatment, the book goes on to present the realities of managing patients, using a case-based approach to help readers understand and engage with the information. Each later chapter presents a different problem in the form of a case study, and each study features a systematic approach to aid learning. Temporomandibular Disorders: A Problem-Based Approach promotes learning as a dynamic process of active involvement. It encourages valuation by self-assessment with questions at the end of the book, and a unique link to an online interactive quiz where readers can test their knowledge of TMD. The final chapters include practical guides of how to make splints and samples of patient information sheets that can be used as templates. The book is illustrated in full colour, with helpful clinical images and diagrams. KEY FEATURES Uses a case-based approach to promote effective management of TMD Covers basic scientific background as well as clinical scenarios Addresses not only ‘why’ but also ‘how’ with a highly practical focus Includes a unique link to an online interactive quiz (visit www.wiley.com/go/gray) Contains many full colour clinical images and diagrams
Michel Thomatis Network Design Cookbook. 2nd Edition Michel Thomatis Network Design Cookbook. 2nd Edition Новинка

Michel Thomatis Network Design Cookbook. 2nd Edition

The second edition of the Network Design Cookbook provides a new approach for building a network design by selecting design modules (or PODs) based on the business requirements, engineer's preferences, andrecommendations. This new approach provides a structured process that you,as a network engineer or consultant, can use to meet the critical technical objectives while keeping within the parameters of industry best practices. In this book, you will find valuable resources and tools for constructing the topology and services you need for many solutions such as LAN, WAN, Data Center, Internet Edge, Firewall, to Collaboration. This book will be a valuable tool in both learning how to design a network, as well as a reference as you advance in your career.

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This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current – focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge – highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied – includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible – contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book. A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
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