synthesis and utility of acid hydrazides



Christian Rojas M. Molecular Rearrangements in Organic Synthesis Christian Rojas M. Molecular Rearrangements in Organic Synthesis Новинка

Christian Rojas M. Molecular Rearrangements in Organic Synthesis

14526.97 руб. или Купить в рассрочку!
Designed for practitioners of organic synthesis, this book helps chemists understand and take advantage of rearrangement reactions to enhance the synthesis of useful chemical compounds. Provides ready access to the genesis, mechanisms, and synthetic utility of rearrangement reactions Emphasizes strategic synthetic planning and implementation Covers 20 different rearrangement reactions Includes applications for synthesizing compounds useful as natural products, medicinal compounds, functional materials, and physical organic chemistry
Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Новинка

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis

17260.98 руб. или Купить в рассрочку!
This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.
Gunter Mayer The Chemical Biology of Nucleic Acids Gunter Mayer The Chemical Biology of Nucleic Acids Новинка

Gunter Mayer The Chemical Biology of Nucleic Acids

14302.92 руб. или Купить в рассрочку!
With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.
Gunter Mayer The Chemical Biology of Nucleic Acids Gunter Mayer The Chemical Biology of Nucleic Acids Новинка

Gunter Mayer The Chemical Biology of Nucleic Acids

14472.09 руб. или Купить в рассрочку!
With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.
Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry Новинка

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

17260.98 руб. или Купить в рассрочку!
This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first section deals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.
Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry Новинка

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

17059.33 руб. или Купить в рассрочку!
This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first section deals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.
Mike Martin Kwabena Boysen Carbohydrates. Tools for Stereoselective Synthesis Mike Martin Kwabena Boysen Carbohydrates. Tools for Stereoselective Synthesis Новинка

Mike Martin Kwabena Boysen Carbohydrates. Tools for Stereoselective Synthesis

15420.33 руб. или Купить в рассрочку!
Closing a gap in the literature, this comprehensive book presents the utility of carbohydrate derivatives as chiral auxiliaries, reagents, complex ligands and organocatalysts, together with details of their preparation, as well as their successful application in stereoselective synthesis. Divided into four parts: * Carbohydrate Auxiliaries * Carbohydrate Reagents * Carbohydrate Ligands * Carbohydrate Organocatalysts It is an indispensable source for every organic chemist.
Ari M. P. Koskinen Asymmetric Synthesis of Natural Products Ari M. P. Koskinen Asymmetric Synthesis of Natural Products Новинка

Ari M. P. Koskinen Asymmetric Synthesis of Natural Products

12813.83 руб. или Купить в рассрочку!
Asymmetric Synthesis of Natural Products, 2nd Edition introduces students to this rapidly growing field of organic chemistry. The initial chapters present the foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions. This is followed by chapters on each of the major individual classes of natural products; their structures, biosynthesis and interrelationships as well as examples of asymmetric syntheses and the practical value of these compounds. Natural product classes covered include carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, polyketides, isoprenoids, shikamic acid derivatives and alkaloids. For this second edition the text has been thoroughly updated and expanded, and includes new discussions and examples covering atom and redox economies, practical aspects and environmental awareness. Organocatalysis has emerged completely in the last ten years, and has been fully integrated into this new edition.
Vikas Mittal High Performance Polymers and Engineering Plastics Vikas Mittal High Performance Polymers and Engineering Plastics Новинка

Vikas Mittal High Performance Polymers and Engineering Plastics

14698.22 руб. или Купить в рассрочку!
This book describes advances in synthesis, processing, and technology of environmentally friendly polymers generated from renewable resources. With contents based on a wide range of functional monomers and contributions from eminent researchers, this volume demonstrates the design, synthesis, properties and applications of plant oil based polymers, presenting an elaborate review of acid mediated polymerization techniques for the generation of green polymers. Chemical engineers are provided with state-of-the-art information that acts to further progress research in this direction.
Armando Cordova Catalytic Asymmetric Conjugate Reactions Armando Cordova Catalytic Asymmetric Conjugate Reactions Новинка

Armando Cordova Catalytic Asymmetric Conjugate Reactions

16507.23 руб. или Купить в рассрочку!
This unique and long-awaited handbook on this important topic in the hot field of stereoselective organic synthesis covers several types of nucleophiles. Top international authors deal with modern forms of achieving stereoselective conjugate additions based on the use of chiral auxiliaries or asymmetric catalysis, such as P-N ligands, organocatalysis, domino reactions, Lewis acid and base catalysis. There is also a discussion of the employment of enantioselective conjugate addition transformations in total synthesis of important molecules. With its reliable and previously unpublished experimental procedures, this is a true source of high quality information.
Loong-Tak Lim Poly(lactic acid). Synthesis, Structures, Properties, Processing, and Applications Loong-Tak Lim Poly(lactic acid). Synthesis, Structures, Properties, Processing, and Applications Новинка

Loong-Tak Lim Poly(lactic acid). Synthesis, Structures, Properties, Processing, and Applications

13557.99 руб. или Купить в рассрочку!
This book describes the synthesis, properties, and processing methods of poly(lactic acid) (PLA), an important family of degradable plastics. As the need for environmentally-friendly packaging materials increases, consumers and companies are in search for new materials that are largely produced from renewable resources, and are recyclable. To that end, an overall theme of the book is the biodegradability, recycling, and sustainability benefits of PLA. The chapters, from a base of international expert contributors, describe specific processing methods, spectroscopy techniques for PLA analysis, and and applications in medical items, packaging, and environmental use.
Alexandros Zografos L. From Biosynthesis to Total Synthesis. Strategies and Tactics for Natural Products Alexandros Zografos L. From Biosynthesis to Total Synthesis. Strategies and Tactics for Natural Products Новинка

Alexandros Zografos L. From Biosynthesis to Total Synthesis. Strategies and Tactics for Natural Products

14526.97 руб. или Купить в рассрочку!
Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
René Peters Cooperative Catalysis. Designing Efficient Catalysts for Synthesis René Peters Cooperative Catalysis. Designing Efficient Catalysts for Synthesis Новинка

René Peters Cooperative Catalysis. Designing Efficient Catalysts for Synthesis

15792.8 руб. или Купить в рассрочку!
Written by experts in the field, this is a much-needed overview of the rapidly emerging field of cooperative catalysis. The authors focus on the design and development of novel high-performance catalysts for applications in organic synthesis (particularly asymmetric synthesis), covering a broad range of topics, from the latest progress in Lewis acid / Br?nsted base catalysis to e.g. metal-assisted organo catalysis, cooperative metal/enzyme catalysis, and cooperative catalysis in polymerization reactions and on solid surfaces. The chapters are classified according to the type of cooperating activating groups, and describe in detail the different strategies of cooperative activation, highlighting their respective advantages and pitfalls. As a result, readers will learn about the different concepts of cooperative catalysis, their corresponding modes of operation and their applications, thus helping to find a solution to a specific synthetic catalysis problem.
Lam Yulin Solid-Phase Organic Synthesis. Concepts, Strategies, and Applications Lam Yulin Solid-Phase Organic Synthesis. Concepts, Strategies, and Applications Новинка

Lam Yulin Solid-Phase Organic Synthesis. Concepts, Strategies, and Applications

11761.4 руб. или Купить в рассрочку!
Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.
Peter Langer Asymmetric Synthesis of Non-Proteinogenic Amino Acids Peter Langer Asymmetric Synthesis of Non-Proteinogenic Amino Acids Новинка

Peter Langer Asymmetric Synthesis of Non-Proteinogenic Amino Acids

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Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.
Johnson Douglas S. Modern Drug Synthesis Johnson Douglas S. Modern Drug Synthesis Новинка

Johnson Douglas S. Modern Drug Synthesis

10027.35 руб. или Купить в рассрочку!
Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.
Kathy Lu Advances in Synthesis, Processing, and Applications of Nanostructures Kathy Lu Advances in Synthesis, Processing, and Applications of Nanostructures Новинка

Kathy Lu Advances in Synthesis, Processing, and Applications of Nanostructures

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With contributed papers from the 2011 Materials Science and Technology symposia, this is a useful one-stop resource for understanding the most important issues in advances in the synthesis, processing, and applications of nanostructures. Logically organized and carefully selected, the articles cover the themes of the symposia: Nanotechnology for Energy, Healthcare and Industry; Controlled Synthesis Processing and Applications of Structural and Functional Nanomaterials; and Synthesis, Properties, and Applications of Noble Metal Nanostructures. A must for academics in mechanical and chemical engineering, materials and or ceramics, and chemistry.
Vikas Mittal Renewable Polymers. Synthesis, Processing, and Technology Vikas Mittal Renewable Polymers. Synthesis, Processing, and Technology Новинка

Vikas Mittal Renewable Polymers. Synthesis, Processing, and Technology

14698.22 руб. или Купить в рассрочку!
Presents the synthesis, technology and processing details of a large range of polymers derived from renewable resources It has been a long-term desire to replace polymers from fossil fuels with the more environmentally friendly polymers generated from renewable resources. Now, with the recent advancements in synthesis technologies and the finding of new functional monomers, research in this field has shown strong potential in generating better property polymers from renewable resources. A text describing these advances in synthesis, processing, and technology of such polymers not only provides the state-of-the-art information to researchers, but also acts to stimulate research in this direction. The contents are based on a wide range of functional monomers and the contributions are written by eminent researchers. Specifically Renewable Polymers: Demonstrates the design, synthesis, properties and applications of plant oil-based polymers Presents an elaborate review of acid mediated polymerization techniques for the generation of green polymers Details the production of polyhydroxyalkanoates (PHA) from olive oil based wastewater Describes the use of atom transfer radical polymerization (ATRP) techniques Reviews the renewable polymers derived from transgenic crop plants Provides an overview of a range of biomass-based polymers Concludes with the recent efforts and approaches exploiting the natural materials in developing drug delivery systems.
Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators Новинка

Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators

12813.83 руб. или Купить в рассрочку!
Many small molecules occur naturally as «messenger» chemicals which regulate the behaviour and functions of microbes, plants, insects and animals. Examples include hormones, pheromones, phytoalexins, and antifeedants. These biofunctional molecules are of great interest to researchers in helping develop our understanding of biological function and in the development of new drugs. However extracting them from nature can be prohibitively expensive, so there is great interest in devising methods of synthesising them from simple starting materials in the laboratory. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is an introduction to the techniques and strategies for the synthesis of biofunctional small molecules. Topics include: what are biofunctional molecules? why must biofunctional molecules be synthesized? how can we synthesize biofunctional molecules? the synthesis of phytohormones, phytoalexins and other biofunctional molecules of plant origin the synthesis of insect juvenile hormones and antifeedants the synthesis of pheromones and the significance of chirality in pheromone science the synthesis of microbial hormones and pheromones, antibiotics, and other biofunctional molecules of microbial origin the synthesis of marine antifeedants and medicinal candidates a synthetic examination of incorrectly proposed structures of biomolecules reflections on science as a human endeavor Drawing on a career of almost 50 years researching and teaching this subject, Kenji Mori's Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is a must-have textbook for students and researchers of organic synthesis and natural products, and a stimulating and inspiring account of a distinguished chemical career.
Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators Новинка

Kenji Mori Chemical Synthesis of Hormones, Pheromones and Other Bioregulators

12663.92 руб. или Купить в рассрочку!
Many small molecules occur naturally as «messenger» chemicals which regulate the behaviour and functions of microbes, plants, insects and animals. Examples include hormones, pheromones, phytoalexins, and antifeedants. These biofunctional molecules are of great interest to researchers in helping develop our understanding of biological function and in the development of new drugs. However extracting them from nature can be prohibitively expensive, so there is great interest in devising methods of synthesising them from simple starting materials in the laboratory. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is an introduction to the techniques and strategies for the synthesis of biofunctional small molecules. Topics include: what are biofunctional molecules? why must biofunctional molecules be synthesized? how can we synthesize biofunctional molecules? the synthesis of phytohormones, phytoalexins and other biofunctional molecules of plant origin the synthesis of insect juvenile hormones and antifeedants the synthesis of pheromones and the significance of chirality in pheromone science the synthesis of microbial hormones and pheromones, antibiotics, and other biofunctional molecules of microbial origin the synthesis of marine antifeedants and medicinal candidates a synthetic examination of incorrectly proposed structures of biomolecules reflections on science as a human endeavor Drawing on a career of almost 50 years researching and teaching this subject, Kenji Mori's Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is a must-have textbook for students and researchers of organic synthesis and natural products, and a stimulating and inspiring account of a distinguished chemical career.
Xiao-Feng Wu Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation Xiao-Feng Wu Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation Новинка

Xiao-Feng Wu Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation

11704.13 руб. или Купить в рассрочку!
Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.
Jay Lehr H. Acid Mine Drainage, Rock Drainage, and Acid Sulfate Soils. Causes, Assessment, Prediction, Prevention, and Remediation Jay Lehr H. Acid Mine Drainage, Rock Drainage, and Acid Sulfate Soils. Causes, Assessment, Prediction, Prevention, and Remediation Новинка

Jay Lehr H. Acid Mine Drainage, Rock Drainage, and Acid Sulfate Soils. Causes, Assessment, Prediction, Prevention, and Remediation

11542.98 руб. или Купить в рассрочку!
Provides the tools needed to analyze and solve acid drainage problems Featuring contributions from leading experts in science and engineering, this book explores the complex biogeochemistry of acid mine drainage, rock drainage, and acid sulfate soils. It describes how to predict, prevent, and remediate the environmental impact of acid drainage and the oxidation of sulfides, offering the latest sampling and analytical methods. Moreover, readers will discover new approaches for recovering valuable resources from acid mine drainage, including bioleaching. Acid Mine Drainage, Rock Drainage, and Acid Sulfate Soils reviews the most current findings in the field, offering new insights into the underlying causes as well as new tools to minimize the harm of acid drainage: Part I: Causes of Acid Mine Drainage, Rock Drainage and Sulfate Soils focuses on the biogeochemistry of acid drainage in different environments. Part II: Assessment of Acid Mine Drainage, Rock Drainage and Sulfate Soils covers stream characterization, aquatic and biological sampling, evaluation of aquatic resources, and some unusual aspects of sulfide oxidation. Part III: Prediction and Prevention of Acid Drainage discusses acid-base accounting, kinetic testing, block modeling, petrology, and mineralogy studies. It also explains relevant policy and regulations. Part IV: Remediation of Acid Drainage, Rock Drainage and Sulfate Soils examines both passive and active cleanup methods to remediate acid drainage. Case studies from a variety of geologic settings highlight various approaches to analyzing and solving acid drainage problems. Replete with helpful appendices and an extensive list of web resources, Acid Mine Drainage, Rock Drainage, and Acid Sulfate Soils is recommended for mining engineers and scientists, regulatory officials, environmental scientists, land developers, and students.
Laurie Starkey S. Introduction to Strategies for Organic Synthesis Laurie Starkey S. Introduction to Strategies for Organic Synthesis Новинка

Laurie Starkey S. Introduction to Strategies for Organic Synthesis

The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities. Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis. Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made. Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.
Andrea Trabocchi Diversity-Oriented Synthesis. Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology Andrea Trabocchi Diversity-Oriented Synthesis. Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology Новинка

Andrea Trabocchi Diversity-Oriented Synthesis. Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology

11919.69 руб. или Купить в рассрочку!
Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.
Raquel Herrera P. Multicomponent Reactions. Concepts and Applications for Design and Synthesis Raquel Herrera P. Multicomponent Reactions. Concepts and Applications for Design and Synthesis Новинка

Raquel Herrera P. Multicomponent Reactions. Concepts and Applications for Design and Synthesis

14526.97 руб. или Купить в рассрочку!
Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies and applications for multicomponent reactions – including key routes for synthesizing complex molecules. • Illustrates the crucial role and the important utility of multicomponent reactions (MCRs) to organic syntheses • Compiles novel and efficient synthetic multicomponent procedures to give readers a complete picture of this class of organic reactions • Helps readers to design efficient and practical transformations using multicomponent reaction strategies • Describes reaction background, applications to synthesize complex molecules and drugs, and reaction mechanisms
Mohamed Nemr Review article on Solid Phase Synthesis Mohamed Nemr Review article on Solid Phase Synthesis Новинка

Mohamed Nemr Review article on Solid Phase Synthesis

The first concept of solid phase synthesis was performed by Merrifield (1) in a dipeptide synthesis from two amino acids. Not surprisingly, Solid phase synthesis did not remain limited to peptides, but also it was extended to heterocycles, so many synthesis methods in solution phase had been transferred to solid phase processes.So, solid phase organic synthesis had become very attractive route of synthesis due to its simplicity of separation of synthetic intermediates from soluble components of a reaction mixture by simple filtration and washing of the resin bound reaction product.
Pher Andersson G. Innovative Catalysis in Organic Synthesis. Oxidation, Hydrogenation, and C-X Bond Forming Reactions Pher Andersson G. Innovative Catalysis in Organic Synthesis. Oxidation, Hydrogenation, and C-X Bond Forming Reactions Новинка

Pher Andersson G. Innovative Catalysis in Organic Synthesis. Oxidation, Hydrogenation, and C-X Bond Forming Reactions

2107.25 руб. или Купить в рассрочку!
C-H, C-O, C-C, and C-Heteroatom bond forming processes by using metal-ligand approaches for the synthesis of organic compounds of biological, pharmacological and organic nanotechnological utility are the key areas addressed in this book. Authored by a European team of leaders in the field, it brings together innovative approaches for a variety of catalysis reactions and processes frequently applied in organic synthesis into a handy reference work. It covers all major types of catalysis, including homogeneous, heterogeneous, and organocatalysis, as well as mechanistic and computational studies. Special attention is paid to the improvements in efficiency and sustainability of important catalytic processes, such as selective oxidations, hydrogenation, and cross-coupling reactions, and to their utilization in industry. The result is a valuable resource for advanced researchers in both academia and industry, as well as graduate students in organic chemistry aiming for chemo-, regio- or stereoselective synthesis of organic compounds by using novel catalytic systems.
Giacalone Francesco Catalytic Methods in Asymmetric Synthesis. Advanced Materials, Techniques, and Applications Giacalone Francesco Catalytic Methods in Asymmetric Synthesis. Advanced Materials, Techniques, and Applications Новинка

Giacalone Francesco Catalytic Methods in Asymmetric Synthesis. Advanced Materials, Techniques, and Applications

12885.44 руб. или Купить в рассрочку!
This book covers advances in the methods of catalytic asymmetric synthesis and their applications. Coverage moves from new materials and technologies to homogeneous metal-free catalysts and homogeneous metal catalysts. The applications of several methodologies for the synthesis of biologically active molecules are discussed. Part I addresses recent advances in new materials and technologies such as supported catalysts, supports, self-supported catalysts, chiral ionic liquids, supercritical fluids, flow reactors and microwaves related to asymmetric catalysis. Part II covers advances and milestones in organocatalytic, enzymatic and metal-based mediated asymmetric synthesis, including applications for the synthesis of biologically active molecules. Written by leading international experts, this book consists of 16 chapters with 2000 References and illustrations of 560 schemes and figures.
Swapna Suresh Multi-Step Synthesis of Solid Support with Protected 5.-Aminouridine Swapna Suresh Multi-Step Synthesis of Solid Support with Protected 5.-Aminouridine Новинка

Swapna Suresh Multi-Step Synthesis of Solid Support with Protected 5.-Aminouridine

During my M.S. thesis work I was involved in a multistep synthesis of solid support bearing a modified nucleoside for automated synthesis of siRNAs. First, I developed a three-step synthesis of protected 5'-amino uridine from uridine. Next I prepared the 3'-succinate of 5'-amino uridine in a one-pot two-step synthesis and attached it to a solid support via a succinamide linker. I had analyzed and characterized all new compounds using NMR techniques. Others in our laboratory used this solid support for synthesis of amide-modified siRNAs. We anticipate that the amide linkages will facilitate crossing the cellular membrane and improve nuclease resistance, biodistribution and pharmacokinetics of modified siRNAs.
Felix Polyak Hyaluronic Acid. Production, Properties, Application in Biology and Medicine Felix Polyak Hyaluronic Acid. Production, Properties, Application in Biology and Medicine Новинка

Felix Polyak Hyaluronic Acid. Production, Properties, Application in Biology and Medicine

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Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar industry, as it is believed to be a key factor in fighting the aging process. Hyaluronic Acid: Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5, the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical applications of this polysaccharide have been extensively studied and this book provides a wealth of scientific data demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule. Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions, structure and physical–chemical properties. It will be an invaluable resource to researchers, both industrial and academic, involved in all aspects of hyaluronan-based technologies.
Srinivasan Chandrasekaran Click Reactions in Organic Synthesis Srinivasan Chandrasekaran Click Reactions in Organic Synthesis Новинка

Srinivasan Chandrasekaran Click Reactions in Organic Synthesis

14154.5 руб. или Купить в рассрочку!
This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.
Mohammad Jawaid Synthesis and Tribological Applications of Hybrid Materials Mohammad Jawaid Synthesis and Tribological Applications of Hybrid Materials Новинка

Mohammad Jawaid Synthesis and Tribological Applications of Hybrid Materials

13115.33 руб. или Купить в рассрочку!
In-depth knowledge on tribological applications of hybrid composites Synthesis and Tribological Applications of Hybrid Materials provides a comprehensive overview of tribological properties of hybrid composites. The book offers an understanding of the processes, materials, techniques and mechanisms related to the tribological concepts and includes information on the most recent developments in the field. With contributions from an international panel of experts, the book discusses the synthesis and characterization of hybrid materials, as well as their applications in biotechnological and biomedical fields. The book covers a wide-range of versatile topics such as: Tribological assessment on accelerated aging bones in polymeric condition; Nano fracture and wear testing on natural bones; Tribological behaviour of glass fiber with fillers reinforced hybrid polymer composites and jute/glass hybrid composites; Wear properties of glass fiber hybrid, and acid- and silane-modified CNT filled hybrid glass/kenaf epoxy composites; Hybrid natural fibre composites as a friction material; and much more. This important resource: -Discusses recent advancements in the field of tribology and hybrid materials -Offers a guide for professionals in the fields of materials science, mechanical engineering, biomaterials, chemistry, physics and nanotechnology -Integrates theory, synthesis and properties of nybrid materals as well as their applications -Offers an outlook to the future of this burgeoning technology Written for materials scientists, surface chemists, bioengineers, mechanical engineers, engineering scientists and chemical industry professionals, Synthesis and Tribological Applications of Hybrid Materials is a comprehensive resource that explores the most recent developments in the field.
Cossy Janine Modern Tools for the Synthesis of Complex Bioactive Molecules Cossy Janine Modern Tools for the Synthesis of Complex Bioactive Molecules Новинка

Cossy Janine Modern Tools for the Synthesis of Complex Bioactive Molecules

12436.17 руб. или Купить в рассрочку!
All the latest tools needed to plan and perform the synthesis of complex bioactive molecules Focusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements. Modern Tools for the Synthesis of Complex Bioactive Molecules features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including: Modern catalysis, emphasizing key transformations such as C-H functionalizations, cross-couplings, gold-catalyzed reactions, metathesis-based syntheses, and asymmetric organocatalysis Eco-compatible transformations, including rearrangements and domino reactions Tools for the synthesis of carbohydrates and alkaloids New techniques, including the use of fluorous tags and engineered biosynthesis The last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex Bioactive Molecules is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.
Susheel Kalia Biodegradable and Biobased Polymers for Environmental and Biomedical Applications Susheel Kalia Biodegradable and Biobased Polymers for Environmental and Biomedical Applications Новинка

Susheel Kalia Biodegradable and Biobased Polymers for Environmental and Biomedical Applications

16761.78 руб. или Купить в рассрочку!
This volume incorporates 13 contributions from renowned experts from the relevant research fields that are related biodegradable and biobased polymers and their environmental and biomedical applications. Specifically, the book highlights: Developments in polyhydroxyalkanoates applications in agriculture, biodegradable packaging material and biomedical field like drug delivery systems, implants, tissue engineering and scaffolds The synthesis and elaboration of cellulose microfibrils from sisal fibres for high performance engineering applications in various sectors such as the automotive and aerospace industries, or for building and construction The different classes and chemical modifications of tannins Electro-activity and applications of Jatropha latex and seed The synthesis, properties and applications of poly(lactic acid) The synthesis, processing and properties of poly(butylene succinate), its copolymers, composites and nanocomposites The different routes for preparation polymers from vegetable oil and the effects of reinforcement and nano-reinforcement on the physical properties of such biobased polymers The different types of modified drug delivery systems together with the concept of the drug delivery matrix for controlled release of drugs and for antitumor drugs The use of nanocellulose as sustainable adsorbents for the removal of water pollutants mainly heavy metal ions, organic molecules, dyes, oil and CO2 The main extraction techniques, structure, properties and different chemical modifications of lignins Proteins and nucleic acids based biopolymers The role of tamarind seed polysaccharide-based multiple-unit systems in sustained drug release
Shinichi Itsuno Polymeric Chiral Catalyst Design and Chiral Polymer Synthesis Shinichi Itsuno Polymeric Chiral Catalyst Design and Chiral Polymer Synthesis Новинка

Shinichi Itsuno Polymeric Chiral Catalyst Design and Chiral Polymer Synthesis

12508.56 руб. или Купить в рассрочку!
This book reviews chiral polymer synthesis and its application to asymmetric catalysis. It features the design and use of polymer-immobilized catalysts and methods for their design and synthesis. Chapters cover peptide-catalyzed and enantioselective synthesis, optically-active polymers, and continuous flow processes. It collects recent advances in an important field of polymer and organic chemistry, with leading researchers explaining applications in academic and industry R & D.
Mohammad Mehdi Ghanbari Synthesis of New Hydantoins and Thiohydantoins Mohammad Mehdi Ghanbari Synthesis of New Hydantoins and Thiohydantoins Новинка

Mohammad Mehdi Ghanbari Synthesis of New Hydantoins and Thiohydantoins

Hydantoins and thiohydantoins exhibit a wide range of biological activities, including anticonvulsant, antiarrhythmic, anti-inflammatory, and antidiabetic prop erties, as well as herbicidal and fungicidal activity. The formation of a carbon-nitrogen bond is of importance for the synthesis of nitrogen-containing natural products and biologically active systems. As part of our study on the development of new routes to heterocyclic systems, we now report on the synthesis of functionalized hydantoins and thiohydantoins.
Tomislav Rovis Essential Reagents for Organic Synthesis Tomislav Rovis Essential Reagents for Organic Synthesis Новинка

Tomislav Rovis Essential Reagents for Organic Synthesis

7633.13 руб. или Купить в рассрочку!
From Boron Trifluoride to Zinc, the 52 most widely used reagents in organic synthesis are described in this unique desktop reference for every organic chemist. The list of reagents contains classics such as N-Bromosuccinimide (NBS) and Trifluoromethanesulfonic Acid side by side with recently developed ones like Pinacolborane and Tetra-n-propylammonium Perruthenate (TPAP). For each reagent, a concise article provides a brief description of all important reactions for which the reagent is being used, including yields and reaction conditions, an overview of the physical properties of the reagent, its storage conditions, safe handling, laboratory synthesis and purification methods. Advantages and disadvantages of the reagent compared to alternative synthesis methods are also discussed. Reagents have been hand-picked from among the 5000 reagents contained in EROS, the Encyclopedia of Reagents for Organic Synthesis. Every organic chemist should be familiar with these key reagents that can make almost every reaction work.
Jhuma Sadhukhan Biorefineries and Chemical Processes. Design, Integration and Sustainability Analysis Jhuma Sadhukhan Biorefineries and Chemical Processes. Design, Integration and Sustainability Analysis Новинка

Jhuma Sadhukhan Biorefineries and Chemical Processes. Design, Integration and Sustainability Analysis

9311.71 руб. или Купить в рассрочку!
As the range of feedstocks, process technologies and products expand, biorefineries will become increasingly complex manufacturing systems. Biorefineries and Chemical Processes: Design, Integration and Sustainability Analysis presents process modelling and integration, and whole system life cycle analysis tools for the synthesis, design, operation and sustainable development of biorefinery and chemical processes. Topics covered include: Introduction: An introduction to the concept and development of biorefineries. Tools: Included here are the methods for detailed economic and environmental impact analyses; combined economic value and environmental impact analysis; life cycle assessment (LCA); multi-criteria analysis; heat integration and utility system design; mathematical programming based optimization and genetic algorithms. Process synthesis and design: Focuses on modern unit operations and innovative process flowsheets. Discusses thermochemical and biochemical processing of biomass, production of chemicals and polymers from biomass, and processes for carbon dioxide capture. Biorefinery systems: Presents biorefinery process synthesis using whole system analysis. Discusses bio-oil and algae biorefineries, integrated fuel cells and renewables, and heterogeneous catalytic reactors. Companion website: Four case studies, additional exercises and examples are available online, together with three supplementary chapters which address waste and emission minimization, energy storage and control systems, and the optimization and reuse of water. This textbook is designed to bridge a gap between engineering design and sustainability assessment, for advanced students and practicing process designers and engineers.
Niederreither Karen The Retinoids. Biology, Biochemistry, and Disease Niederreither Karen The Retinoids. Biology, Biochemistry, and Disease Новинка

Niederreither Karen The Retinoids. Biology, Biochemistry, and Disease

13186.94 руб. или Купить в рассрочку!
The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
Wyatt Paul Workbook for Organic Synthesis: The Disconnection Approach Wyatt Paul Workbook for Organic Synthesis: The Disconnection Approach Новинка

Wyatt Paul Workbook for Organic Synthesis: The Disconnection Approach

13718.34 руб. или Купить в рассрочку!
One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student’s experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.
Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides Новинка

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides

17260.98 руб. или Купить в рассрочку!
This is the last of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides Volume 5 of this series presents a wealth of methods to analyze amino acids and peptides. Classical approaches are described, such as X-ray analysis, chromatographic methods, NMR, AFM, mass spectrometry and 2D-gel electrophoresis, as well as newer approaches, including Surface Plasmon Resonance and array technologies. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.
Piet W. N. M. van Leeuwen Phosphorus(III) Ligands in Homogeneous Catalysis. Design and Synthesis Piet W. N. M. van Leeuwen Phosphorus(III) Ligands in Homogeneous Catalysis. Design and Synthesis Новинка

Piet W. N. M. van Leeuwen Phosphorus(III) Ligands in Homogeneous Catalysis. Design and Synthesis

15225.85 руб. или Купить в рассрочку!
Over the last 60 years the increasing knowledge of transition metal chemistry has resulted in an enormous advance of homogeneous catalysis as an essential tool in both academic and industrial fields. Remarkably, phosphorus(III) donor ligands have played an important role in several of the acknowledged catalytic reactions. The positive effects of phosphine ligands in transition metal homogeneous catalysis have contributed largely to the evolution of the field into an indispensable tool in organic synthesis and the industrial production of chemicals. This book aims to address the design and synthesis of a comprehensive compilation of P(III) ligands for homogeneous catalysis. It not only focuses on the well-known traditional ligands that have been explored by catalysis researchers, but also includes promising ligand types that have traditionally been ignored mainly because of their challenging synthesis. Topics covered include ligand effects in homogeneous catalysis and rational catalyst design, P-stereogenic ligands, calixarenes, supramolecular approaches, solid phase synthesis, biological approaches, and solubility and separation. Ligand families covered in this book include phosphine, diphosphine, phosphite, diphosphite, phosphoramidite, phosphonite, phosphinite, phosphole, phosphinine, phosphinidenene, phosphaalkenes, phosphaalkynes, P-chiral ligands, and cage ligands. Each ligand class is accompanied by detailed and reliable synthetic procedures. Often the rate limiting step in the application of ligands in catalysis is the synthesis of the ligands themselves, which can often be very challenging and time consuming. This book will provide helpful advice as to the accessibility of ligands as well as their synthesis, thereby allowing researchers to make a more informed choice. Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis is an essential overview of this important class of catalysts for academic and industrial researchers working in catalyst development, organometallic and synthetic chemistry.
Erwan Poupon Biomimetic Organic Synthesis Erwan Poupon Biomimetic Organic Synthesis Новинка

Erwan Poupon Biomimetic Organic Synthesis

37988.23 руб. или Купить в рассрочку!
In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of complex natural products is laid out, backed by abundant practical examples from the authors' own work as well as from the published literature. Volume 1 describes the biomimetic synthesis of alkaloids. Volume 2 covers terpenes, polyketides, and polyphenols. A discussion of the current challenges and frontiers in biomimetic synthesis concludes this comprehensive handbook. Key features: Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists. The synthetic applications are overwhelming, making this comprehensive 2 volume work a must-have for everyone working in the field. Unifying both synthetic and biosynthetic aspects, this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry.
T. Sokolova Soil acidity and the acid-base buffering of soils. Manual T. Sokolova Soil acidity and the acid-base buffering of soils. Manual Новинка

T. Sokolova Soil acidity and the acid-base buffering of soils. Manual

The manual considers natural and anthropogenic factors of soil acidification, forms and parameters of soil acidity and methods of their determination, reclamation principles of acid soils, the concept of the acid−base buffering of soils. The main educational sources are cited.The manual can be used for the courses of lectures in Soil Science, Soil Chemistry, and Ecology.
V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science Новинка

V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science

2107.25 руб. или Купить в рассрочку!
The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.
Janine Cossy Metathesis in Natural Product Synthesis. Strategies, Substrates and Catalysts Janine Cossy Metathesis in Natural Product Synthesis. Strategies, Substrates and Catalysts Новинка

Janine Cossy Metathesis in Natural Product Synthesis. Strategies, Substrates and Catalysts

16314.39 руб. или Купить в рассрочку!
Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this is a comprehensive view of a hot topic. Written by top international authors, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications. A real must-have for anyone working in natural product synthesis.
Michael Williams T. Sustainable Catalysis. Challenges and Practices for the Pharmaceutical and Fine Chemical Industries Michael Williams T. Sustainable Catalysis. Challenges and Practices for the Pharmaceutical and Fine Chemical Industries Новинка

Michael Williams T. Sustainable Catalysis. Challenges and Practices for the Pharmaceutical and Fine Chemical Industries

9907.52 руб. или Купить в рассрочку!
Opens the door to the sustainable production of pharmaceuticals and fine chemicals Driven by both public demand and government regulations, pharmaceutical and fine chemical manufacturers are increasingly seeking to replace stoichiometric reagents used in synthetic transformations with catalytic routes in order to develop greener, safer, and more cost-effective chemical processes. This book supports the discovery, development, and implementation of new catalytic methodologies on a process scale, opening the door to the sustainable production of pharmaceuticals and fine chemicals. Pairing contributions from leading academic and industrial researchers, Sustainable Catalysis focuses on key areas that are particularly important for the fine chemical and pharmaceutical industries, including chemo-, bio-, and organo-catalytic approaches to C–H, C–N, and C–C bond-forming reactions. Chapters include academic overviews of current innovations and industrial case studies at the process scale, providing new insights into green catalytic methodologies from proof-of-concept to their applications in the synthesis of target organic molecules. Sustainable Catalysis provides the foundation needed to develop sustainable green synthetic procedures, with coverage of such emerging topics as: Catalytic reduction of amides avoiding LiAlH4 or B2H6 Synthesis of chiral amines using transaminases Industrial applications of boric acid and boronic acid catalyzed direct amidation reactions C–H activation of heteroaromatics Organocatalysis for asymmetric synthesis Offering a balanced perspective on current limitations, challenges, and solutions, Sustainable Catalysis is recommended for synthetic organic chemists seeking to develop new methodologies and for industrial chemists dedicated to large-scale process development.
Jie Jack Li Innovative Drug Synthesis Jie Jack Li Innovative Drug Synthesis Новинка

Jie Jack Li Innovative Drug Synthesis

9311.71 руб. или Купить в рассрочку!
This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery
SELCUK CALIMSIZ Total Synthesis of Callipeltin E and Towards Papuamide B SELCUK CALIMSIZ Total Synthesis of Callipeltin E and Towards Papuamide B Новинка

SELCUK CALIMSIZ Total Synthesis of Callipeltin E and Towards Papuamide B

Callipeltins and Papuamides -novel families of cyclic depsipeptides- were shown to possess potent anti-HIV activity as well as cytotoxicity against several multidrug resistant cancer cell lines. The novel structural features and diverse biological effects of these peptides metabolites have generated considerable interest among synthetic chemistry groups. In this book, discovery of the lanthanide catalyzed transamidation of Fmoc protected lactams, solid-phase synthesis and configurational reassignment of Callipeltin E, synthesis of N-Fmoc- (2S,3S,4R)-3,4-dimethylglutamine and an efficient method for the on-resin synthesis and macrocylization of a simplified Papuamide B model system are summarized.
John Tebby C. Alkynes in Cycloadditions John Tebby C. Alkynes in Cycloadditions Новинка

John Tebby C. Alkynes in Cycloadditions

14601.18 руб. или Купить в рассрочку!
Acetylene systems present a new route to cyclic compounds as an alternative to more traditional methods employed in classical organic chemistry. The synthesis of cyclic structures based on acetylene systems has important applications in the formation of nanostructures, naturally occurring compounds and chemosensory materials for the design of nonlinear optics, electronic and photonic devices. Alkynes in Cycloadditions presents a modern review of regioselective synthesis of aromatic and non-aromatic carbocyclic and heterocyclic ring systems based primarily on [2+2+2] and [4+2] cycloadditions, and other reactions of acetylenic units including enediynes and enyne-allenes. Topics covered include: New strategies for the formation of aromatic and polynuclear hydrocarbons based on (Z)-hex-3-en-1,5-diyne and (Z)-hepta-1,2,4-triene-6-yne blocks. One-step synthesis of benzene derivatives, β-substituted naphthalenes and acenes by the cycloaromatization of enediynes and enyne-allenes by Bergman, Myers-Saito and Shmittel. Mechanisms of cycloaromatization resulting in the formation of fulvene and indene systems. Heterocyclization involving enyne-carbodiimides. New achievements in classical cycloaddition reactions such as the Diels-Alder condensation with acetylenic dienophiles and [2+2] cycloadditions with acetylene components Alkynes in Cycloadditions presents a comprehensive summary of the literature on methods for the synthesis of ring systems from acetylenes for academic researchers working in the fields of organic synthesis, physical organic chemistry, organometallic chemistry, catalysis, materials science, nanomaterials and biochemistry.
Andrushko Natalia Stereoselective Synthesis of Drugs and Natural Products Andrushko Natalia Stereoselective Synthesis of Drugs and Natural Products Новинка

Andrushko Natalia Stereoselective Synthesis of Drugs and Natural Products

39572.13 руб. или Купить в рассрочку!
Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.
Toshio Fuchigami Fundamentals and Applications of Organic Electrochemistry. Synthesis, Materials, Devices Toshio Fuchigami Fundamentals and Applications of Organic Electrochemistry. Synthesis, Materials, Devices Новинка

Toshio Fuchigami Fundamentals and Applications of Organic Electrochemistry. Synthesis, Materials, Devices

7747.62 руб. или Купить в рассрочку!
This textbook is an accessible overview of the broad field of organic electrochemistry, covering the fundamentals and applications of contemporary organic electrochemistry. The book begins with an introduction to the fundamental aspects of electrode electron transfer and methods for the electrochemical measurement of organic molecules. It then goes on to discuss organic electrosynthesis of molecules and macromolecules, including detailed experimental information for the electrochemical synthesis of organic compounds and conducting polymers. Later chapters highlight new methodology for organic electrochemical synthesis, for example electrolysis in ionic liquids, the application to organic electronic devices such as solar cells and LEDs, and examples of commercialized organic electrode processes. Appendices present useful supplementary information including experimental examples of organic electrosynthesis, and tables of physical data (redox potentials of various organic solvents and organic compounds and physical properties of various organic solvents).
Chao-Jun Li Silver Catalysis in Organic Synthesis, 2 Volume Set Chao-Jun Li Silver Catalysis in Organic Synthesis, 2 Volume Set Новинка

Chao-Jun Li Silver Catalysis in Organic Synthesis, 2 Volume Set

26695.48 руб. или Купить в рассрочку!
Covers all the aspects of the recent achievements in silver catalyzed reactions Silver catalysis has emerged as a powerful tool in the field of organic synthesis. This comprehensive book systematically explores the unique performance of silver catalysis, introducing all the recent progress of silver catalysis in organic synthesis. It clearly emphasizes the unique features of silver catalysis and provides the reaction mechanism involved. This two-volume book also provides vivid schematics and tables throughout to enhance the accessibility to the relevant theory and mechanisms. Silver Catalysis in Organic Synthesis begins with an introduction to Silver Chemistry before moving on to chapters covering: Silver-Catalyzed Cycloaddition Reactions; Silver-Catalyzed Cyclizations; Silver-Mediated Radical Reactions; Silver-Mediated Fluorination, Perfluoroalkylation and Trifluoromethylthiolation Reactions; Coupling Reactions and C-H Functionalization; Silver-Catalyzed CO2 Incorporation; Silver-Catalyzed Carbene, Nitrene, and Silylene Transfer Reactions; Asymmetric Silver-Catalyzed Reactions; Silver-Catalyzed Reduction and Oxidation of Aldehydes and Their Derivatives; Silver Complexes in Organic Transformations; and Silver Nanoparticles in Organic Transformations. -Covers recently developed organic reactions catalyzed by silver, along with their reaction mechanism -Introduces many new reactions and mechanisms related to silver catalysis -Offers professionals and newcomers in the related fields a survey of new advances in silver catalysis in organic synthesis Silver Catalysis in Organic Synthesis will appeal to a wide readership including chemists, biochemists, pharmaceutical scientists, biomedical researchers, agriculture scientists, and graduate students in the related fields.
David Liss Acid-Base and Electrolyte Handbook for Veterinary Technicians David Liss Acid-Base and Electrolyte Handbook for Veterinary Technicians Новинка

David Liss Acid-Base and Electrolyte Handbook for Veterinary Technicians

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Acid-Base and Electrolyte Handbook for Veterinary Technicians provides an easy to understand yet comprehensive approach to acid-base and electrolyte balance. Covers the physiology of fluids and their effect on acid-base and electrolyte balance Offers detailed information on managing acid-base and electrolyte derangements in disease Includes access to a companion website with case studies and multiple choice questions
Horikoshi Satoshi Microwaves in Nanoparticle Synthesis. Fundamentals and Applications Horikoshi Satoshi Microwaves in Nanoparticle Synthesis. Fundamentals and Applications Новинка

Horikoshi Satoshi Microwaves in Nanoparticle Synthesis. Fundamentals and Applications

14773.59 руб. или Купить в рассрочку!
For the first time, this comprehensive handbook presents the emerging field of microwave technology for the synthesis of nanoparticles. Divided into three parts–fundamentals, methods, and applications–it covers topics including microwave theory, scale-up, microwave plasma synthesis, characterization, and more. This offers both an important volume for academic researchers, and a resource for those in industry exploring the applications of nanoparticles in semiconductors, electronics, catalysis, sensors, and more.
Rasmus Fehrmann Supported Ionic Liquids. Fundamentals and Applications Rasmus Fehrmann Supported Ionic Liquids. Fundamentals and Applications Новинка

Rasmus Fehrmann Supported Ionic Liquids. Fundamentals and Applications

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This unique book gives a timely overview about the fundamentals and applications of supported ionic liquids in modern organic synthesis. It introduces the concept and synthesis of SILP materials and presents important applications in the field of catalysis (e.g. hydroformylation, hydrogenation, coupling reactions, fine chemical synthesis) as well as energy technology and gas separation. Written by pioneers in the field, this book is an invaluable reference book for organic chemists in academia or industry.
Rosaleen Anderson Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications Rosaleen Anderson Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications Новинка

Rosaleen Anderson Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

13557.99 руб. или Купить в рассрочку!
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes – sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis – β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
Ken Tanaka Rhodium Catalysis in Organic Synthesis. Methods and Reactions Ken Tanaka Rhodium Catalysis in Organic Synthesis. Methods and Reactions Новинка

Ken Tanaka Rhodium Catalysis in Organic Synthesis. Methods and Reactions

20803.63 руб. или Купить в рассрочку!
An essential reference to the highly effective reactions applied to modern organic synthesis Rhodium complexes are one of the most important transition metals for organic synthesis due to their ability to catalyze a variety of useful transformations. Rhodium Catalysis in Organic Synthesis: Methods and Reactions explores the most recent progress and new developments particularly in the field of catalytic cyclization reactions using rhodium(I) complexes and catalytic carbon-hydrogen bond activation reactions using rhodium(II) and rhodium(III) complexes. Edited by a noted expert in the field with contributions from a panel of leading international scientists, Rhodium Catalysis in Organic Synthesis: Methods and Reactions presents the essential information in one comprehensive volume. Designed to be an accessible resource, the book is arranged by different reaction types. All the chapters provide insight into each transformation and include information on the history, selectivity, scope, mechanism, and application. In addition, the chapters offer a summary and outlook of each transformation. This important resource: Offers a comprehensive review of how rhodium complexes catalyze a variety of highly useful reactions for organic synthesis (e.g. coupling reactions, CH-bond functionalization, hydroformylation, cyclization reactions and others) Includes information on the most recent developments that contain a range of new, efficient, elegant, reliable and useful reactions Presents a volume edited by one of the international leading scientists working in the field today Contains the information that can be applied by researchers in academia and also professionals in pharmaceutical, agrochemical and fine chemical companies Written for academics and synthetic chemists working with organometallics, Rhodium Catalysis in Organic Synthesis: Methods and Reactions contains the most recent information available on the developments and applications in the field of catalytic cyclization reactions using rhodium complexes.
Anbanandam Parthiban Synthesis and Applications of Copolymers Anbanandam Parthiban Synthesis and Applications of Copolymers Новинка

Anbanandam Parthiban Synthesis and Applications of Copolymers

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Understanding the reactivity of monomers is crucial in creating copolymers and determining the outcome of copolymerization. Covering the fundamental aspects of polymerization, Synthesis and Applications of Copolymers explores the reactivity of monomers and reaction conditions that ensure that the newly formed polymeric materials exhibit desired properties. Referencing a wide-range of disciplines, the book provides researchers, students, and scientists with the preparation of a diverse variety of copolymers and their recent developments, with a particular focus on copolymerization, crystallization, and techniques like nanoimprinting and micropatterning.
Pedro Merino Chemical Synthesis of Nucleoside Analogues Pedro Merino Chemical Synthesis of Nucleoside Analogues Новинка

Pedro Merino Chemical Synthesis of Nucleoside Analogues

14377.14 руб. или Купить в рассрочку!
Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.

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One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student’s experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.
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