the beast in ms rooneys room



Rajmund Michalski Application of IC-MS and IC-ICP-MS in Environmental Research Rajmund Michalski Application of IC-MS and IC-ICP-MS in Environmental Research Новинка

Rajmund Michalski Application of IC-MS and IC-ICP-MS in Environmental Research

9372.7 руб.
Introduces the reader to the field of ion chromatography, species analysis and hyphenated methods IC-MS and IC-ICP-MS including the theory and theirs applications Covers the importance of species analysis and hyphenated methods in ion chromatography Includes practical applications of IC-MS and IC-ICP-MS in environmental analysis Details sample preparation methods for ion chromatography Discusses hyphenated methods IC-MS and IC-ICP-MS used in determining both the total element contents and its elements Details speciation analysis used in studying biochemical cycles of selected chemical compounds; determining toxicity and ecotoxicity of elements; food and pharmaceuticals quality control; and in technological process control and clinical analytics
Santos Leonardo S. Reactive Intermediates. MS Investigations in Solution Santos Leonardo S. Reactive Intermediates. MS Investigations in Solution Новинка

Santos Leonardo S. Reactive Intermediates. MS Investigations in Solution

14713.34 руб.
During the last two decades there has been considerable growth in the development of electrospray ionization mass spectrometry (ESI-MS) as a practical method in the study of reaction mechanisms. This method allows the interception and characterization of key intermediates, either as transient species or as protonated/deprotonated forms of neutral species by API-MS. The outstanding features and advantages of ESI-MS make it one of the most suitable tools for the fast screening of intermediates directly from solution, providing hitherto unavailable chemical information to organic chemists. This monograph provides an overview of the mechanisms involved in ESI-MS, the historical perspectives before looking further in-depth at specific reactions and intermediates. Written by researchers in the field, this book is an unique resource for the understanding of this cutting-edge technique.
Degryse Patrick Isotopic Analysis. Fundamentals and Applications Using ICP-MS Degryse Patrick Isotopic Analysis. Fundamentals and Applications Using ICP-MS Новинка

Degryse Patrick Isotopic Analysis. Fundamentals and Applications Using ICP-MS

10192.06 руб.
Edited by two very well-known and respected scientists in the field, this excellent practical guide is the first to cover the fundamentals and a wide range of applications, as well as showing readers how to efficiently use this increasingly important technique. From the contents: * The Isotopic Composition of the Elements * Single-Collector ICP-MS * Multi-Collector ICP-MS * Advances in Laser Ablation – Multi-Collector ICP-MS * Correction for Instrumental Mass Discrimination in Isotope Ratio Determination with Multi-Collector ICP-MS * Reference Materials in Isotopic Analysis * Quality Control in Isotope Ratio Applications * Determination of Trace Elements and Elemental Species Using Isotope Dilution ICP-MS * Geochronological Dating * Application of Multi-Collector ICP-MS to Isotopic Analysis in Cosmochemistry * Establishing the Basis for Using Stable Isotope Ratios of Metals as Paleoredox Proxies * Isotopes as Tracers of Elements Across the Geosphere-Biosphere Interface * Archaeometric Applications * Forensics Applications * Nuclear Applications * The Use of Stable Isotope Techniques for Studying Mineral and Trace Element Metabolism in Humans * Isotopic Analysis via Multi-Collector ICP-MS in Elemental Speciation A must-have for newcomers as well as established scientists seeking an overview of isotopic analysis via ICP-MS.
Taylor Dan Beauty and the Beast Taylor Dan Beauty and the Beast Новинка

Taylor Dan Beauty and the Beast

647 руб.
First Stories: Beauty and the Beast is the perfect introduction, for young children, to this classic fairy tale. Push, pull and turn mechanisms bring the story to life and reveal favourite scenes, as Beauty joins the scary Beast in his mysterious castle. This well-loved fairy tale is beautifully re-imagined for a new generation by children's illustrator Dan Taylor.
Andrew Ellis M. Proton Transfer Reaction Mass Spectrometry. Principles and Applications Andrew Ellis M. Proton Transfer Reaction Mass Spectrometry. Principles and Applications Новинка

Andrew Ellis M. Proton Transfer Reaction Mass Spectrometry. Principles and Applications

13197.18 руб.
Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a rapidly growing analytical technique for detecting and identifying very small quantities of chemical compounds in air. It has seen widespread use in atmospheric monitoring and food science and shows increasing promise in applications such as industrial process monitoring, medical science and in crime and security scenarios. Written by leading researchers, this is the first book devoted to PTR-MS and it provides a comprehensive account of the basic principles, the experimental technique and various applications, thus making this book essential reading for researchers, technicians, postgraduate students and professionals in industry. The book contains nine chapters and is divided into two parts. The first part describes the underlying principles of the PTR-MS technique, including • the relevant ion-molecule chemistry • thermodynamics and reaction kinetics • a discussion of ion sources, drift tubes and mass spectrometers • practical aspects of PTR-MS, including calibration. The second part of the book turns its attention to some of the many applications of PTR-MS, demonstrating the scope and benefits, as well as the limitations, of the technique. The chapters that make up the second part of the book build upon the material presented in the first part and are essentially self-contained reviews focusing on the following topics: • environmental science • food science • medicine • homeland security, and • applications of PTR-MS in liquid analysis.
Despina Tsipi Mass Spectrometry for the Analysis of Pesticide Residues and their Metabolites Despina Tsipi Mass Spectrometry for the Analysis of Pesticide Residues and their Metabolites Новинка

Despina Tsipi Mass Spectrometry for the Analysis of Pesticide Residues and their Metabolites

9372.7 руб.
Provides an overview of the use of mass spectrometry (MS) for the analysis of pesticide residues and their metabolites. Presents state of the-art MS techniques for the identification of pesticides and their transformation products in food and environment Covers important advances in MS techniques including MS instrumentation and chromatographic separations (e.g. UPLC, HILIC, comprehensive GCxGC) and applications Illustrates the main sample preparation techniques (SPE, QuEChERS, microextraction) used in combination with MS for the analysis of pesticides Describes various established and new ionization techniques as well as the main MS platforms, software tools and mass spectral libraries
Кукла бэлль в роскошном платье DISNEY BEAUTY & THE BEAST Кукла бэлль в роскошном платье DISNEY BEAUTY & THE BEAST Новинка

Кукла бэлль в роскошном платье DISNEY BEAUTY & THE BEAST

2729 руб.
Торговая марка — DISNEY BEAUTY & THE BEAST
Кукла бэлль в повседневном платье DISNEY BEAUTY & THE BEAST Кукла бэлль в повседневном платье DISNEY BEAUTY & THE BEAST Новинка

Кукла бэлль в повседневном платье DISNEY BEAUTY & THE BEAST

999 руб.
Торговая марка — DISNEY BEAUTY & THE BEAST
Wolfram Weckwerth Metabolomics in Practice. Successful Strategies to Generate and Analyze Metabolic Data Wolfram Weckwerth Metabolomics in Practice. Successful Strategies to Generate and Analyze Metabolic Data Новинка

Wolfram Weckwerth Metabolomics in Practice. Successful Strategies to Generate and Analyze Metabolic Data

9748.31 руб.
Unlike other handbooks in this emerging field, this guide focuses on the challenges and critical parameters in running a metabolomics study, including such often-neglected issues as sample preparation, choice of separation and detection method, recording and evaluating data as well as method validation. By systematically covering the entire workflow, from sample preparation to data processing, the insight and advice offered here helps to clear the hurdles in setting up and running a successful analysis, resulting in high-quality data from every experiment. Based on more than a decade of practical experience in developing, optimizing and validating metabolomics approaches as a routine technology in the academic and industrial research laboratory, the lessons taught here are highly relevant for all systems-level approaches, whether in systems biology, biotechnology, toxicology or pharmaceutical sciences. From the Contents: * Sampling and Sample Preparation in Microbial Metabolomics * Tandem Mass Spectrometry Hyphenated with HPLC and UHPLC for Targeted Metabolomics * GC-MS, LC-MS, CE-MS and Ultrahigh Resolution MS (FTICR-MS) in Metabolomics * NMR-based metabolomics analysis * Potential of Microfluidics and Single Cell Analysis in Metabolomics * Data Processing in Metabolomics * Validation and Measurement Uncertainty in Metabolomic Studies * Metabolomics and its Role in the Study of Mammalian Systems and in Plant Sciences * Metabolomics in Biotechnology and Nutritional Metabolomics and more.
Beauty and the Beast. Reader. Книга для чтения Beauty and the Beast. Reader. Книга для чтения Новинка

Beauty and the Beast. Reader. Книга для чтения

539 руб.
Вашему вниманию предлагается книга для чтения "Beauty and the Beast". """Beauty, I love you. Do you love me? Will you marry me?" What should she say? She was afraid of him ... And so she said, "No, Beast. You are kind, but I don´t love you. And I don´t want to marry you." At this the Beast let out a roar of anger and pain. "Why don´t you love me? Am I so ugly?!" he shouted at the terrified Beauty and left the room..."
Gerhardus Jong de Capillary Electrophoresis - Mass Spectrometry (CE-MS). Principles and Applications Gerhardus Jong de Capillary Electrophoresis - Mass Spectrometry (CE-MS). Principles and Applications Новинка

Gerhardus Jong de Capillary Electrophoresis - Mass Spectrometry (CE-MS). Principles and Applications

13121.77 руб.
This monograph offers the reader a complete overview on both principles and applications of CE-MS. Starting with an introductory chapter on detection in CE, also related and more specialized techniques such as electrophoretic and chromatographic preconcentration are discussed. A special emphasis is put on CE-MS interfaces, which are described in detail. In a separate chapter, attention is paid to sheath-liquid interfacing. The developments and possibilities of microchip CE-MS are also described. Applications to all relevant areas are discussed in distinct chapters, each written by experts in the respective fields. Besides applications in pharmaceutical analysis and bioanalysis, recent implementations in food science, forensic analysis, analysis of intact proteins, metabolomics and proteomics are highlighted. MS is a perfectly appropriate detection system for CE, as efficient separation is coupled to sensitive and selection detection. Moreover, MS can provide structure information on the separated compounds. CE-MS has now been developed into a strong hyphenated system complementary to LC-MS. This monograph is an unique source of knowledge for everyone dealing with and interested in CE-MS.
Franz Hillenkamp MALDI MS. A Practical Guide to Instrumentation, Methods and Applications Franz Hillenkamp MALDI MS. A Practical Guide to Instrumentation, Methods and Applications Новинка

Franz Hillenkamp MALDI MS. A Practical Guide to Instrumentation, Methods and Applications

10419.16 руб.
This authoritative book on MALDI MS, now finally available in its second edition and edited by one of its inventors, gives an in-depth description of the many different applications, along with a detailed discussion of the technology itself. Thoroughly updated and expanded, with contributions from key players in the field, this unique book provides a comprehensive overview of MALDI MS along with its possibilities and limitations. The initial chapters deal with the technology and the instrumental setup, followed by chapters on the use of MALDI MS in protein research (including proteomics), genomics, glycomics and lipidomics. The option of MALDI-MS for the analysis of polymers and small molecules are also covered in separate chapters, while new to this edition is a section devoted to the interplay of MALDI MS and bioinformatics. A much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.
Cole Stephen Doctor Who. Sting of the Zygons Cole Stephen Doctor Who. Sting of the Zygons Новинка

Cole Stephen Doctor Who. Sting of the Zygons

1156 руб.
The TARDIS lands the Doctor and Martha in the Lake District in 1909, where a small village has been terrorised by a giant, scaly monster. The search is on for the elusive `Beast of Westmorland', and explorers, naturalists and hunters from across the country are descending on the fells. King Edward VII himself is on his way to join the search, with a knighthood for whoever finds the Beast. But there is a more sinister presence at work in the Lakes than a mere monster on the rampage, and the Doctor is soon embroiled in the plans of an old and terrifying enemy. And as the hunters become the hunted, a desperate battle of wits begins - with the future of the entire world at stake... An adventure featuring the Tenth Doctor, as played by David Tennant, and his companion Martha
Wilfried M. A. Niessen Interpretation of MS-MS Mass Spectra of Drugs and Pesticides Wilfried M. A. Niessen Interpretation of MS-MS Mass Spectra of Drugs and Pesticides Новинка

Wilfried M. A. Niessen Interpretation of MS-MS Mass Spectra of Drugs and Pesticides

10123.22 руб.
Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
Le Fanu Joseph Sheridan In a Glass Darkly 2. The Room in the Dragon Volant Le Fanu Joseph Sheridan In a Glass Darkly 2. The Room in the Dragon Volant Новинка

Le Fanu Joseph Sheridan In a Glass Darkly 2. The Room in the Dragon Volant

385 руб.
Joseph Thomas Sheridan Le Fanu (1814 -1873) was an Irish writer of Gothic novels, one of the most influential ghost story writers of the nineteenth century. Filled with mystery and gothic horror elements, "The Room in the Dragon Volant" takes place in post-Napoleonic Wars France. Young Englishman Richard Beckett falls in love with the mysterious Countess. To be closer to her, he takes a room in the "Dragon Volant" inn, which has a rather nasty reputation.
Dixie Browning The Beauty, The Beast And The Baby Dixie Browning The Beauty, The Beast And The Baby Новинка

Dixie Browning The Beauty, The Beast And The Baby

116.67 руб.
MAN OF THE MONTH TALL, DARK AND HANDSOMEMR. MARCHThe Beast: Gus Wydowski, a brooding bachelor with a weakness for beautiful women – but not for bouncing babies!The Beauty: Mariah Brady didn't need a man who knew nothing about babies – especially when she was juggling a newborn!The Baby: Was cute little Jessie going to hook Mariah a husband? Gus couldn’t diaper an infant to save his life, but he also couldn't stay away from Mariah Brady.And Mariah and baby Jessie were a package deal, so before he knew it, he was knee-deep in bottles and diaper pins. And now the beauty was trying to turn the beast-bachelor into a family man!Man of the Month: Can the beauty transform the already-handsome beast into a husband?
Mackinnon Mairi Beauty and the Beast Mackinnon Mairi Beauty and the Beast Новинка

Mackinnon Mairi Beauty and the Beast

938 руб.
One of the best-loved fairy tales. Beauty goes to the Beast's castle in order to save her father's life and help her family. The Beast is kind to her, but when he asks her to marry him, she can't bring herself to say yes. Then Beauty returns home and dreams that the Beast is dying. Can she save him? The Usborne English Readers series is a new range of graded readers in simplified English for younger learners. They include activities, glossaries and a full audio recording of the text in both British English and American English.
Blacker Terence Fangtastic, Ms Wiz Blacker Terence Fangtastic, Ms Wiz Новинка

Blacker Terence Fangtastic, Ms Wiz

641 руб.
Ms Wiz Loves Dracula: Ms Wiz is dancing with a tall, dark-haired man with white fangs! The children of Class Three go into action when they realize that Ms Wiz is falling in love - with Dracula! Ms Wiz and the Sister of Doom: When Ms Wiz's evil sister kidnaps Pongo and takes him back to her home dimension, the children stop at nothing to get him back.
Hans-Joachim Hübschmann Handbook of GC-MS. Fundamentals and Applications Hans-Joachim Hübschmann Handbook of GC-MS. Fundamentals and Applications Новинка

Hans-Joachim Hübschmann Handbook of GC-MS. Fundamentals and Applications

18371.19 руб.
The only comprehensive reference on this popular and rapidly developing technique provides a detailed overview, ranging from fundamentals to applications, including a section on the evaluation of GC-MS analyses. As such, it covers all aspects, including the theory and principles, as well as a broad range of real-life examples taken from laboratories in environmental, food, pharmaceutical and clinical analysis. It also features a glossary of approximately 300 terms and a substance index that facilitates finding a specific application. For this new edition the work has been now extended to two volumes, reflecting the latest developments in the technique and related instrumentation, while also incorporating several new examples of applications in many fields. The first two editions were very well received, making this handbook a must-have in all analytical laboratories using GC-MS.
Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient Новинка

Mike Lee S. Protein Analysis using Mass Spectrometry. Accelerating Protein Biotherapeutics from Lab to Patient

13121.77 руб.
Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
Garth Nix One Beastly Beast: Two aliens, three inventors, four fantastic tales Garth Nix One Beastly Beast: Two aliens, three inventors, four fantastic tales Новинка

Garth Nix One Beastly Beast: Two aliens, three inventors, four fantastic tales

116.67 руб.
A funny, magical, colourful story collection for young children.The stories are:• Serena and the Sea Serpent – in which a small girl discovers that being a Penguinmaid is too much fun!• Bill the Inventor – in which a young orphan discovers that finding ideal parents is very tricky indeed!• Blackbread the Pirate – in which Peter discovers that the world beneath his feet is fraught with rude rats!• The Princess and the Beastly Beast – in which Rinda discovers that monsters are not always so terrible on the inside…Garth Nix takes on a younger audience with this collection of magical adventures. His trademark fertile imagination and spellbinding storytelling is sure to capture a whole new generation of fans.
Aphrodite's Child ‎– 666 Aphrodite's Child ‎– 666 Новинка

Aphrodite's Child ‎– 666

3590 руб.
The System Babylon Loud, Loud, Loud The Four Horsemen The Lamb The Seventh Seal Aegian Sea Seven Bowls The Wakening Beast Lament The Marching Beast The Battle...
C.J. Skuse Monster: The perfect boarding school thriller to keep you up all night C.J. Skuse Monster: The perfect boarding school thriller to keep you up all night Новинка

C.J. Skuse Monster: The perfect boarding school thriller to keep you up all night

236.18 руб.
Every girl at Bathory School has heard stories about The Beast. No one believed they were true.Until Now.'Grisly, nail-biting fun!' – Lovereading4kids.co.ukAt sixteen Nash thought that the fight to become Head Girl of prestigious boarding school Bathory would be the biggest battle she’d face. Until her brother’s disappearance leads to Nash being trapped at the school over Christmas with Bathory’s assorted misfits.As a blizzard rages outside, strange things are afoot in the school’s hallways, and legends of the mysterious Beast of Bathory – a big cat rumoured to room the moors outside the school – run wild.Yet when the girls’ Matron goes missing it’s clear that something altogether darker is to blame – and that they’ll have to stick together if they hope to survive.
Liang Li MALDI Mass Spectrometry for Synthetic Polymer Analysis Liang Li MALDI Mass Spectrometry for Synthetic Polymer Analysis Новинка

Liang Li MALDI Mass Spectrometry for Synthetic Polymer Analysis

8885.48 руб.
Principles and Practices of Polymer Mass Spectrometry helps readers acquire the skills necessary for selecting the optimal methods, handling samples, analyzing the data, and interpreting the results of the mass spectrometry of polymers. This guide describes the principles of polymer MS and best practices in polymer characterization. It discusses different approaches, including MALDI, ESI, TOF MS, and FT-MS. It provides a guide to developing appropriate sample preparation protocols for different polymers. Complete with examples of applications and experiments, this is an excellent reference for scientists, researchers, graduate students, and others.
Beauty and the Beast Beauty and the Beast Новинка

Beauty and the Beast

420 руб.
This beautiful hardback Ladybird edition of Beauty and the Beast is a perfect first illustrated introduction to this classic fairy tale for young readers from 3+. The tale is sensitively retold, retaining all the key parts of the story beginning with Beauty's father traveling to the beast's castle through to the day Beauty returns to the castle to find the beast alone in the rose garden. Other exciting titles in the Ladybird Tales series include The Three Billy Goats Gruff, Cinderella, The Three Little Pigs, Jack and the Beanstalk, Goldilocks and the Three Little Pigs, The Gingerbread Man, Hansel and Gretel, Little Red Riding Hood, Sleeping Beauty, Rumpelstiltskin, Snow White and the Seven Dwarfs, Rapunzel, The Magic Porridge Pot, The Enormous Turnip, Puss in Boots, The Elves and the Shoemaker, The Big Pancake, Dick Whittington and The Princess and the Pea. Ladybird Tales are based on the original Ladybird retellings by Vera Southgate, with beautiful pictures of the kind children like best - full of richness and detail. Children have always loved, and will always remember, these classic fairy tales and sharing them together is an experience to treasure. Ladybird has published fairy tales for over forty-five years, bringing the magic of traditional stories to each new generation of children. Retold by Vera Southgate.
Saheer Gharbia E. MALDI-TOF and Tandem MS for Clinical Microbiology Saheer Gharbia E. MALDI-TOF and Tandem MS for Clinical Microbiology Новинка

Saheer Gharbia E. MALDI-TOF and Tandem MS for Clinical Microbiology

11997.76 руб.
This book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade. This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss: Challenges of Identifying Mycobacterium to the Species level Identification of Bacteroides and Other Clinically Relevant Anaerobes Identification of Species in Mixed Microbial Populations Detection of Resistance Mechanisms Proteomics as a biomarker discovery and validation platform Determination of Antimicrobial Resistance using Tandem Mass Spectrometry
Zane Grey The Day of the Beast Zane Grey The Day of the Beast Новинка
Syriana Way The Beast Syriana Way The Beast Новинка

Syriana Way The Beast

214.13 руб.
Dani Sinclair Beautiful Beast Dani Sinclair Beautiful Beast Новинка

Dani Sinclair Beautiful Beast

354.99 руб.
Breaking in to the home of the man suspected of killing her father was reckless. But Cassy Richards had to confront Lieutenant Gabriel Lowe and learn the truth. She found a man with the aura of a predator–and the scars of a wounded soldier. His eyes held a conviction that told her this man was innocent. And by coming there, she'd put them both in imminent danger.Gabe had lost his memory of the day a bomb exploded, killing the man he'd been ordered to protect and covering the theft of a deadly toxin. He'd retreated to heal from his wounds–and to investigate outside the bounds of military law. Cassy led the enemy to his door. And now the beast would protect his beauty and see that justice was finally served.
Jie Zhang Handbook of LC-MS Bioanalysis. Best Practices, Experimental Protocols, and Regulations Jie Zhang Handbook of LC-MS Bioanalysis. Best Practices, Experimental Protocols, and Regulations Новинка

Jie Zhang Handbook of LC-MS Bioanalysis. Best Practices, Experimental Protocols, and Regulations

11993.49 руб.
Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.
Birendra Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery Birendra Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery Новинка

Birendra Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery

11696.84 руб.
The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.
The Ugly Duckling The Ugly Duckling Новинка

The Ugly Duckling

864 руб.
First Stories: The Ugly Duckling is the perfect introduction for young children to this classic fairy tale. Push, pull and turn mechanisms bring the story of the lonely duckling to life. This well-loved fairy tale is beautifully imagined for a new generation by children's illustrator Dean Gray. Titles to collect: Snow White, Alice in Wonderland, Cinderella, Rapunzel, The Jungle Book, Little Red Riding Hood, Jack and the Beanstalk, The Nutcracker, Beauty and the Beast, The Little Mermaid, Peter Pan, Goldilocks and the Three Bears, The Three Little Pigs, Hansel and Gretel, Sleeping Beauty, Pinocchio, Puss in Boots.
Le Fanu J.S. In a Glass Darkly 2. The Room in the Dragon Volant = Сквозь тусклое стекло 2. Комната в отеле Летятищий Дракон: на английском языке Le Fanu J.S. In a Glass Darkly 2. The Room in the Dragon Volant = Сквозь тусклое стекло 2. Комната в отеле Летятищий Дракон: на английском языке Новинка

Le Fanu J.S. In a Glass Darkly 2. The Room in the Dragon Volant = Сквозь тусклое стекло 2. Комната в отеле Летятищий Дракон: на английском языке

343 руб.
Joseph Thomas Sheridan Le Fanu (1814 -1873) was an Irish writer of Gothic novels, one of the most influential ghost story writers of the nineteenth century. Filled with mystery and gothic horror elements, "The Room in the Dragon Volant" takes place in post-Napoleonic Wars France. Young Englishman Richard Beckett falls in love with the mysterious Countess. To be closer to her, he takes a room in the "Dragon Volant" inn, which has a rather nasty reputation.
David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications Новинка

David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications

9372.7 руб.
Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been around for 25 years, this is the first definitive book devoted entirely to the topic. Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications brings into one comprehensive volume the theory, instrumentation and applications of Hydrogen Exchange Mass Spectrometry (HX-MS) – a technique relevant to bioanalytical chemistry, protein science and pharmaceuticals. The book provides a solid foundation in the basics of the technique and data interpretation to inform readers of current research in the method, and provides illustrative examples of its use in bio- and pharmaceutical chemistry and biophysics In-depth chapters on the fundamental theory of hydrogen exchange, and tutorial chapters on measurement and data analysis provide the essential background for those ready to adopt HX-MS. Expert users may advance their current understanding through chapters on methods including membrane protein analysis, alternative proteases, millisecond hydrogen exchange, top-down mass spectrometry, histidine exchange and method validation. All readers can explore the diversity of HX-MS applications in areas such as ligand binding, membrane proteins, drug discovery, therapeutic protein formulation, biocomparability, and intrinsically disordered proteins.
CATHERINE GEORGE Under the Brazilian Sun CATHERINE GEORGE Under the Brazilian Sun Новинка

CATHERINE GEORGE Under the Brazilian Sun

354.99 руб.
Beauty and the beast… Roberto de Sousa lived for the sound of crowds chanting his name. But now all he hears are thoughts of bitterness and regret. One look at his scarred face in the mirror and he’s back in his car as it crashes, his racing career destroyed.No one has tempted the reclusive champion out from his mansion, and Dr Katherine Lister is the only person to be invited in… She’s there to value a rare piece of art. But under Roberto’s sultry gaze she feels like a priceless jewel…

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Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.
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