the role of 99tc in clinical chemistry



Caroli Sergio Analytical Techniques for Clinical Chemistry. Methods and Applications Caroli Sergio Analytical Techniques for Clinical Chemistry. Methods and Applications Новинка

Caroli Sergio Analytical Techniques for Clinical Chemistry. Methods and Applications

15983.6 руб. или Купить в рассрочку!
Discover how analytical chemistry supports the latest clinical research This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab. Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as: Uncertainty in clinical chemistry measurements Metal toxicology in clinical, forensic, and chemical pathology Role of analytical chemistry in the safety of drug therapy Atomic spectrometric techniques for the analysis of clinical samples Biosensors for drug analysis Use of X-ray techniques in medical research Each chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth. Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques.
Philip Jevon Clinical Diagnosis Philip Jevon Clinical Diagnosis Новинка

Philip Jevon Clinical Diagnosis

3467.51 руб. или Купить в рассрочку!
The role and function of the nurse is rapidly changing. Some nurses are now required to undertake clinical diagnosis of the patient, a responsibility traditionally undertaken by a doctor. Clinical Diagnosis helps prepare nurses to fulfill this role, providing them with the skills and underpinning knowledge to make clinical diagnoses of patients effectively. Each chapter follows the same layout for each symptom or sign, exploring the definition, causes, history, precipitating factors, associated signs and symptoms, important considerations, relevant clinical examination, and investigations and tests. The first UK text to explore clinical diagnosis from a nursing perspective In the Essential Clinical Skills for Nurses series Written by an authority in the field Concise, accessible, and evidence-based
Hani Amouri Chirality in Transition Metal Chemistry. Molecules, Supramolecular Assemblies and Materials Hani Amouri Chirality in Transition Metal Chemistry. Molecules, Supramolecular Assemblies and Materials Новинка

Hani Amouri Chirality in Transition Metal Chemistry. Molecules, Supramolecular Assemblies and Materials

18233.5 руб. или Купить в рассрочку!
Chirality in Transition Metal Chemistry is an essential introduction to this increasingly important field for students and researchers in inorganic chemistry. Emphasising applications and real-world examples, the book begins with an overview of chirality, with a discussion of absolute configurations and system descriptors, physical properties of enantiomers, and principles of resolution and preparation of enantiomers. The subsequent chapters deal with the the specifics of chirality as it applies to transition metals. Some reviews of Chirality in Transition Metal Chemistry «…useful to students taking an advanced undergraduate course and particularly to postgraduates and academics undertaking research in the areas of chiral inorganic supramolecular complexes and materials.» Chemistry World, August 2009 “…the book offers an extremely exciting new addition to the study of inorganic chemistry, and should be compulsory reading for students entering their final year of undergraduate studies or starting a Ph.D. in structural inorganic chemistry.” Applied Organometallic Chemistry Volume 23, Issue 5, May 2009 “…In conclusion the book gives a wonderful overview of the topic. It is helpful for anyone entering the field through systematic and detailed introduction of basic information. It was time to publish a new and topical text book covering the important aspect of coordination chemistry. It builds bridges between Inorganic, organic and supramolecular chemistry. I can recommend the book to everybody who is interested in the chemistry of chiral coordination compounds .” Angew. chem. Volume 48, Issue 18, April 2009 About the Series Chirality in Transition Metal Chemistry is the latest addition to the Wiley Inorganic Chemistry Advanced Textbook series. This series reflects the pivotal role of modern inorganic and physical chemistry in a whole range of emerging areas such as materials chemistry, green chemistry and bioinorganic chemistry, as well as providing a solid grounding in established areas such as solid state chemistry, coordination chemistry, main group chemistry and physical inorganic chemistry.
Lue Neal Telomerases. Chemistry, Biology and Clinical Applications Lue Neal Telomerases. Chemistry, Biology and Clinical Applications Новинка

Lue Neal Telomerases. Chemistry, Biology and Clinical Applications

10329.02 руб. или Купить в рассрочку!
This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.
Attanasio Ronald Dental Management of Sleep Disorders Attanasio Ronald Dental Management of Sleep Disorders Новинка

Attanasio Ronald Dental Management of Sleep Disorders

9649.84 руб. или Купить в рассрочку!
Dental Management of Sleep Disorders focuses on the dentist’s role in treating patients with sleep problems, chiefly sleep disordered breathing and bruxism. A practical clinical book, Dental Management of Sleep Disorders highlights the background to these problems, discusses the dentist’s role in their diagnosis and treatment, and outlines clinical strategies and guidance. The book features a full discussion of the use of appliances, an overview of current treatment modalities, and investigates the relationship of sleep disorders to dental and orofacial causes.
Nicola Pusterla Interpretation of Equine Laboratory Diagnostics Nicola Pusterla Interpretation of Equine Laboratory Diagnostics Новинка

Nicola Pusterla Interpretation of Equine Laboratory Diagnostics

9301.74 руб. или Купить в рассрочку!
Interpretation of Equine Laboratory Diagnostics offers a comprehensive approach to equine laboratory diagnostics, including hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics. Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applicationsCovers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnosticsIntroduces the underlying principles of laboratory diagnosticsProvides clinically oriented guidance on performing and interpreting laboratory testsPresents a complete reference to establish and new diagnostic proceduresOffers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to established and new diagnostic procedures
Alan Katritzky R. Heterocycles in Life and Society. An Introduction to Heterocyclic Chemistry, Biochemistry and Applications Alan Katritzky R. Heterocycles in Life and Society. An Introduction to Heterocyclic Chemistry, Biochemistry and Applications Новинка

Alan Katritzky R. Heterocycles in Life and Society. An Introduction to Heterocyclic Chemistry, Biochemistry and Applications

13098.27 руб. или Купить в рассрочку!
Heterocycles in Life and Society is an introduction to the chemistry of heterocyclic compounds, focusing on their origin and occurrence in nature, biochemical significance and wide range of applications. Written in a readable and accessible style, the book takes a multidisciplinary approach to this extremely important area of organic chemistry. Topics covered include an introduction to the structure and properties of heterocycles; the key role of heterocycles in important life processes such as the transfer of hereditary information, how enzymes function, the storage and transport of bioenergy, and photosynthesis; applications of heterocycles in medicine, agriculture and industry; heterocycles in supramolecular chemistry; the origin of heterocycles on primordial Earth; and how heterocycles can help us solve 21st century challenges. For this second edition, Heterocycles in Life and Society has been completely revised and expanded, drawing on a decade of innovation in heterocyclic chemistry. The new edition includes discussions of the role of heterocycles in nanochemistry, green chemistry, combinatorial chemistry, molecular devices and sensors, and supramolecular chemistry. Impressive achievements include the creation of various molecular devices, the recording and storage of information, the preparation of new organic conductors, and new effective drugs and pesticides with heterocyclic structures. Much new light has been thrown on various life processes, while the chemistry of heterocycles has expanded to include new types of heterocyclic structures and reactions, and the use of heterocyclic molecules as ionic liquids and proton sponges. Heterocycles in Life and Society is an essential guide to this important field for students and researchers in chemistry, biochemistry, and drug discovery, and scientists at all levels wishing to expand their scientific horizon.
Elena Serrano-Torregrosa Chemistry Education. Best Practices, Opportunities and Trends Elena Serrano-Torregrosa Chemistry Education. Best Practices, Opportunities and Trends Новинка

Elena Serrano-Torregrosa Chemistry Education. Best Practices, Opportunities and Trends

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Winner of the CHOICE Outstanding Academic Title 2017 Award This comprehensive collection of top-level contributions provides a thorough review of the vibrant field of chemistry education. Highly-experienced chemistry professors and education experts cover the latest developments in chemistry learning and teaching, as well as the pivotal role of chemistry for shaping a more sustainable future. Adopting a practice-oriented approach, the current challenges and opportunities posed by chemistry education are critically discussed, highlighting the pitfalls that can occur in teaching chemistry and how to circumvent them. The main topics discussed include best practices, project-based education, blended learning and the role of technology, including e-learning, and science visualization. Hands-on recommendations on how to optimally implement innovative strategies of teaching chemistry at university and high-school levels make this book an essential resource for anybody interested in either teaching or learning chemistry more effectively, from experience chemistry professors to secondary school teachers, from educators with no formal training in didactics to frustrated chemistry students.
Axel Klein Bioinorganic Chemistry -- Inorganic Elements in the Chemistry of Life. An Introduction and Guide Axel Klein Bioinorganic Chemistry -- Inorganic Elements in the Chemistry of Life. An Introduction and Guide Новинка

Axel Klein Bioinorganic Chemistry -- Inorganic Elements in the Chemistry of Life. An Introduction and Guide

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The field of Bioinorganic Chemistry has grown significantly in recent years; now one of the major sub-disciplines of Inorganic Chemistry, it has also pervaded other areas of the life sciences due to its highly interdisciplinary nature. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Second Edition provides a detailed introduction to the role of inorganic elements in biology, taking a systematic element-by-element approach to the topic. The second edition of this classic text has been fully revised and updated to include new structure information, emerging developments in the field, and an increased focus on medical applications of inorganic compounds. New topics have been added including materials aspects of bioinorganic chemistry, elemental cycles, bioorganometallic chemistry, medical imaging and therapeutic advances. Topics covered include: Metals at the center of photosynthesis Uptake, transport, and storage of essential elements Catalysis through hemoproteins Biological functions of molybdenum, tungsten, vanadium and chromium Function and transport of alkaline and alkaline earth metal cations Biomineralization Biological functions of the non-metallic inorganic elements Bioinorganic chemistry of toxic metals Biochemical behavior of radionuclides and medical imaging using inorganic compounds Chemotherapy involving non-essential elements This full color text provides a concise and comprehensive review of bioinorganic chemistry for advanced students of chemistry, biochemistry, biology, medicine and environmental science.
Xie Haibo The Role of Green Chemistry in Biomass Processing and Conversion Xie Haibo The Role of Green Chemistry in Biomass Processing and Conversion Новинка

Xie Haibo The Role of Green Chemistry in Biomass Processing and Conversion

10329.02 руб. или Купить в рассрочку!
Sets the stage for the development of sustainable, environmentally friendly fuels, chemicals, and materials Taking millions of years to form, fossil fuels are nonrenewable resources; it is estimated that they will be depleted by the end of this century. Moreover, the production and use of fossil fuels have resulted in considerable environmental harm. The generation of environmentally friendly energy from renewable sources such as biomass is therefore essential. This book focuses on the integration of green chemistry concepts into biomass processes and conversion in order to take full advantage of the potential of biomass to replace nonsustainable resources and meet global needs for fuel as well as other chemicals and materials. The Role of Green Chemistry in Biomass Processing and Conversion features contributions from leading experts from Asia, Europe, and North America. Focusing on lignocellulosic biomass, the most abundant biomass resource, the book begins with a general introduction to biomass and biorefineries and then provides an update on the latest advances in green chemistry that support biomass processing and conversion. Next, the authors describe current and emerging biomass processing and conversion techniques that use green chemistry technologies, including: Green solvents such as ionic liquids, supercritical CO2, and water Sustainable energy sources such as microwave irradiation and sonification Green catalytic technologies Advanced membrane separation technologies The last chapter of the book explores the ecotoxicological and environmental effects of converting and using fuels, chemicals, and materials from biomass. Recommended for professionals and students in chemical engineering, green chemistry, and energy and fuels, The Role of Green Chemistry in Biomass Processing and Conversion sets a strong foundation for the development of a competitive and sustainable bioeconomy. This monograph includes a Foreword by James Clark (University of York, UK).
Steven Bachrach M. Computational Organic Chemistry Steven Bachrach M. Computational Organic Chemistry Новинка

Steven Bachrach M. Computational Organic Chemistry

9725.87 руб. или Купить в рассрочку!
The Second Edition demonstrates how computational chemistry continues to shed new light on organic chemistry The Second Edition of author Steven Bachrach’s highly acclaimed Computational Organic Chemistry reflects the tremendous advances in computational methods since the publication of the First Edition, explaining how these advances have shaped our current understanding of organic chemistry. Readers familiar with the First Edition will discover new and revised material in all chapters, including new case studies and examples. There’s also a new chapter dedicated to computational enzymology that demonstrates how principles of quantum mechanics applied to organic reactions can be extended to biological systems. Computational Organic Chemistry covers a broad range of problems and challenges in organic chemistry where computational chemistry has played a significant role in developing new theories or where it has provided additional evidence to support experimentally derived insights. Readers do not have to be experts in quantum mechanics. The first chapter of the book introduces all of the major theoretical concepts and definitions of quantum mechanics followed by a chapter dedicated to computed spectral properties and structure identification. Next, the book covers: Fundamentals of organic chemistry Pericyclic reactions Diradicals and carbenes Organic reactions of anions Solution-phase organic chemistry Organic reaction dynamics The final chapter offers new computational approaches to understand enzymes. The book features interviews with preeminent computational chemists, underscoring the role of collaboration in developing new science. Three of these interviews are new to this edition. Readers interested in exploring individual topics in greater depth should turn to the book’s ancillary website www.comporgchem.com, which offers updates and supporting information. Plus, every cited article that is available in electronic form is listed with a link to the article.
Reed Izatt M. Macrocyclic and Supramolecular Chemistry. How Izatt-Christensen Award Winners Shaped the Field Reed Izatt M. Macrocyclic and Supramolecular Chemistry. How Izatt-Christensen Award Winners Shaped the Field Новинка

Reed Izatt M. Macrocyclic and Supramolecular Chemistry. How Izatt-Christensen Award Winners Shaped the Field

14512.52 руб. или Купить в рассрочку!
This book commemorates the 25th anniversary of the International Izatt-Christensen Award in Macrocyclic and Supramolecular Chemistry. The award, one of the most prestigious of small awards in chemistry, recognizes excellence in the developing field of macrocyclic and supramolecular chemistry Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field features chapters written by the award recipients who provide unique perspectives on the spectacular growth in these expanding and vibrant fields of chemistry over the past half century, and on the role of these awardees in shaping this growth. During this time there has been an upsurge of interest in the design, synthesis and characterization of increasingly more complex macrocyclic ligands and in the application of this knowledge to understanding molecular recognition processes in host-guest chemistry in ways that were scarcely envisioned decades earlier. In October 2016, Professor Jean-Pierre Sauvage and Sir J. Fraser Stoddart (author for chapter 22 «Contractile and Extensile Molecular Systems: Towards Molecular Muscles» by Jean -Pierre Sauvage, Vincent Duplan, and Frédéric Niess and 20 «Serendipity» by Paul R. McGonigal and J. Fraser Stoddart respectively) were awarded the Nobel Prize in Chemistry alongside fellow Wiley author Bernard Feringa, for the design and synthesis of molecular machines.
Terry Campbell Veterinary Hematology and Clinical Chemistry Terry Campbell Veterinary Hematology and Clinical Chemistry Новинка

Terry Campbell Veterinary Hematology and Clinical Chemistry

7888.19 руб. или Купить в рассрочку!
Veterinary Hematology and Clinical Chemistry, Second Edition is a well-illustrated, user-friendly reference on veterinary laboratory diagnostic techniques and interpretation. Covering both hematology and chemistry for a wide range of species, including birds, reptiles, amphibians, and fish, the book provides an overview of these critical veterinary skills. This Second Edition includes many revisions and additions, including new chapters on molecular diagnostics of hematologic malignancies and lipid pathology, updates to reflect advances in diagnostic instrumentation and capabilities, significant revisions to the data interpretation chapter to provide introductory guidance, and current information on immunodiagnostics and laboratory diagnostics of renal, endocrine, and calcium metabolic pathologies. Beginning with the basic principles of laboratory testing and diagnosis, the book moves into in-depth information on hematology and chemistry of common domestic and non-domestic species. Clinical case presentations, supplying case data and offering narrative discussions to promote skills, have been expanded and incorporated into the body of the book. Packed with useful information for veterinary students, technicians, pathologists, and researchers, Veterinary Hematology and Clinical Chemistry is an essential addition to any veterinary library.
Lawrence Kobilinsky Forensic Chemistry Handbook Lawrence Kobilinsky Forensic Chemistry Handbook Новинка

Lawrence Kobilinsky Forensic Chemistry Handbook

10329.02 руб. или Купить в рассрочку!
A concise, robust introduction to the various topics covered by the discipline of forensic chemistry The Forensic Chemistry Handbook focuses on topics in each of the major chemistry-related areas of forensic science. With chapter authors that span the forensic chemistry field, this book exposes readers to the state of the art on subjects such as serology (including blood, semen, and saliva), DNA/molecular biology, explosives and ballistics, toxicology, pharmacology, instrumental analysis, arson investigation, and various other types of chemical residue analysis. In addition, the Forensic Chemistry Handbook: Covers forensic chemistry in a clear, concise, and authoritative way Brings together in one volume the key topics in forensics where chemistry plays an important role, such as blood analysis, drug analysis, urine analysis, and DNA analysis Explains how to use analytical instruments to analyze crime scene evidence Contains numerous charts, illustrations, graphs, and tables to give quick access to pertinent information Media focus on high-profile trials like those of Scott Peterson or Kobe Bryant have peaked a growing interest in the fascinating subject of forensic chemistry. For those readers who want to understand the mechanisms of reactions used in laboratories to piece together crime scenes—and to fully grasp the chemistry behind it—this book is a must-have.
Nancy Obuchowski A. Handbook for Clinical Trials of Imaging and Image-Guided Interventions Nancy Obuchowski A. Handbook for Clinical Trials of Imaging and Image-Guided Interventions Новинка

Nancy Obuchowski A. Handbook for Clinical Trials of Imaging and Image-Guided Interventions

7438.43 руб. или Купить в рассрочку!
Handbook for Clinical Trials of Imaging and Image-Guided Interventions is the first single-source, multi-disciplinary reference, based on the didactic sessions presented at the annual ‘Clinical Trials Methodology Workshop’ for radiologists, radiation oncologists and imaging scientists (sponsored by the Radiological Society of North America (RSNA)). It focuses on educating radiologists, radiation oncologists and those involved in imaging research with how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers. The internationally renowned contributors take a broad approach, starting with principles of technology assessment, and then move into specific topics covering the clinical trials of therapy and clinical research in imaging guided interventions including radiotherapy. They discuss the use of imaging as a predictor of therapeutic response, screening trial design, and the practicalities of how to run an efficient clinical trial and good working practices. Later chapters provide a comprehensive array of quantitative methods including: an introduction to statistical considerations in study design, biostatistical analysis methods and their role in clinical imaging research, methods for quantitative imaging biomarker studies, and an introduction to cost effectiveness analysis. Handbook for Clinical Trials of Imaging and Image-Guided Interventions will educate and prepare radiologists at all levels and in all capacities in planning and conducting clinical imaging trials.
Chiarabelli Cristiano Chemical Synthetic Biology Chiarabelli Cristiano Chemical Synthetic Biology Новинка

Chiarabelli Cristiano Chemical Synthetic Biology

12817.03 руб. или Купить в рассрочку!
Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.
Krishnan Vinod Integrated Clinical Orthodontics Krishnan Vinod Integrated Clinical Orthodontics Новинка

Krishnan Vinod Integrated Clinical Orthodontics

12816.41 руб. или Купить в рассрочку!
Integrated Clinical Orthodontics provides an important new resource on the clinical interactions between the practice of orthodontics and other areas of clinical dentistry and medicine. Having at its heart the paradigm of patient-centred care, the book not only integrates the knowledge, skills, and experience of all the disciplines of dentistry and medicine, but also eases the work of orthodontists in arriving at an accurate diagnosis and a comprehensive treatment plan. Presented in a highly visual and practical format, Integrated Clinical Orthodontics uses clinical case presentations to illustrate the rationale and application of the integrated approach to a variety of clinical scenarios. Integrated Clinical Orthodontics covers areas of complexity in clinical orthodontics, specifically the role of the orthodontist as a member of a multidisciplinary team. The book outlines and details the management of congenital orofacial deformities, sleep disorders, esthetic smile creation and temporomandibular joint problems, and additionally and importantly includes specific protocols for effective communication with experts in other specialties.
Raquel Walton M. Equine Clinical Pathology Raquel Walton M. Equine Clinical Pathology Новинка

Raquel Walton M. Equine Clinical Pathology

10026.82 руб. или Купить в рассрочку!
Equine Clinical Pathology is the first complete resource for hematology and clinical chemistry in horses. Encompassing the basic principles and advanced interpretation, the book’s single-species approach to pathology allows for focused coverage of the unique disease characteristics of equids. Equine Clinical Pathology is equally useful for anyone using clinical pathology as a diagnostic tool, from beginning student to experienced specialist. The heart of the book is organized by body system, making it easy to find and apply information. Chapters cover general laboratory medicine, including instruments and techniques, hematology, and proteins as well as specific organs, such as the kidney and liver. Equine Clinical Pathology is a useful bench-side reference for anyone involved in laboratory medicine for the horse.
Judith Parker Clinical Supervision for Nurses Judith Parker Clinical Supervision for Nurses Новинка

Judith Parker Clinical Supervision for Nurses

5059.68 руб. или Купить в рассрочку!
Clinical supervision provides a framework within which nurses can reflect on their practice, enabling them to face professional challenges with renewed energy and a clearer perspective. Clinical Supervision for Nurses is an accessible, practical guide to clinical supervision itself and implementing the supervision process in nursing practice. Clinical Supervision for Nurses explores the role of clinical supervision, its contribution to practice development and implementation in practice. It discusses the range of approaches to clinical supervision and models of supervision, organisational readiness and other factors influencing success, legal and ethical issues, and perspectives of supervisors and the supervisees.
Brian Burt A. Clinical Research in Oral Health Brian Burt A. Clinical Research in Oral Health Новинка

Brian Burt A. Clinical Research in Oral Health

7664.37 руб. или Купить в рассрочку!
Clinical Research in Oral Health surveys the essentials of clinical research in oral health, anchoring these principles within the specific context of the oral health arena. Addressing research questions exclusively applicable to dentistry and oral health, the book thoroughly illustrates the principles and practice of oral health clinical research. Clinical Research in Oral Health also clarifies the framework of regulatory issues and presents emerging concepts in clinical translation, relating the research principles to clinical improvement.
Marcel Swart Spin States in Biochemistry and Inorganic Chemistry. Influence on Structure and Reactivity Marcel Swart Spin States in Biochemistry and Inorganic Chemistry. Influence on Structure and Reactivity Новинка

Marcel Swart Spin States in Biochemistry and Inorganic Chemistry. Influence on Structure and Reactivity

12200.86 руб. или Купить в рассрочку!
It has long been recognized that metal spin states play a central role in the reactivity of important biomolecules, in industrial catalysis and in spin crossover compounds. As the fields of inorganic chemistry and catalysis move towards the use of cheap, non-toxic first row transition metals, it is essential to understand the important role of spin states in influencing molecular structure, bonding and reactivity. Spin States in Biochemistry and Inorganic Chemistry provides a complete picture on the importance of spin states for reactivity in biochemistry and inorganic chemistry, presenting both theoretical and experimental perspectives. The successes and pitfalls of theoretical methods such as DFT, ligand-field theory and coupled cluster theory are discussed, and these methods are applied in studies throughout the book. Important spectroscopic techniques to determine spin states in transition metal complexes and proteins are explained, and the use of NMR for the analysis of spin densities is described. Topics covered include: DFT and ab initio wavefunction approaches to spin states Experimental techniques for determining spin states Molecular discovery in spin crossover Multiple spin state scenarios in organometallic reactivity and gas phase reactions Transition-metal complexes involving redox non-innocent ligands Polynuclear iron sulfur clusters Molecular magnetism NMR analysis of spin densities This book is a valuable reference for researchers working in bioinorganic and inorganic chemistry, computational chemistry, organometallic chemistry, catalysis, spin-crossover materials, materials science, biophysics and pharmaceutical chemistry.
Antoni Bayés de Luna Clinical Arrhythmology Antoni Bayés de Luna Clinical Arrhythmology Новинка

Antoni Bayés de Luna Clinical Arrhythmology

13265.63 руб. или Купить в рассрочку!
The study and management of abnormal heart rhythms is the core of Electrophysiology, but the successful identification and management of arrhythmias is important to a much wider range of physicians, from trainees in cardiology to general clinical cardiologists to practitioners in other areas of specialization, for example internists. This book is a thorough overview of clinical arrhythmology designed to help general clinical cardiologists and trainees in the fields of clinical cardiology and electrophysiology achieve the competency they need for clinical practice or for further specialization in the topics covered within the book.
Rafia Bashir Chemistry of Heterocyclic Compounds Rafia Bashir Chemistry of Heterocyclic Compounds Новинка

Rafia Bashir Chemistry of Heterocyclic Compounds

Scientific Study from the year 2018 in the subject Chemistry - Organic Chemistry, grade: A, , language: English, abstract: Heterocyclic chemistry is one of the largest branches of chemistry. Well over six million discrete heterocyclic compounds are known, reflecting their central and important role in Science and Technology. The usefulness of heterocycles is due to their combination of compact and robust molecular structures with a high degree of molecular diversity that results in properties, which can be finely adjusted to the needs of sophisticated applications. This is well illustrated by the functions of many naturally occurring heterocycles that are essential components of living cells, including DNA in which specific nitrogen heterocycles are directly responsible for encoding all genetic information. Morphine and quinine, two of the earliest compounds to be used in therapy and in use today, are both heterocyclic natural products. William Perkin's synthesis of the lucrative quinine molecule in 1856 led to the discovery of an important synthetic heterocycle, mauveine, and this laid the foundation of the synthetic dye industry. This in turn gave birth to the modern industry when in 1932 the antibacterial properties of the dye lead to the discovery of heterocyclic sulfapyridines. These antibacterial agents were the first major life saving synthetic drugs and they quickly had a dramatic effect on the quality of life.
Philip Jevon Clinical Examination Skills Philip Jevon Clinical Examination Skills Новинка

Philip Jevon Clinical Examination Skills

3869.25 руб. или Купить в рассрочку!
The role and function of the nurse is rapidly changing, and nurses are now required to undertake a comprehensive clinical examination of patients, a responsibility traditionally undertaken by a doctor. Clinical Examination Skills is an accessible, introductory guide to helping nurses fulfil this role, enabling them to understand the core skills and knowledge needed to assess patients competently. This practice-based book will be invaluable to pre-registration nursing students and newly qualified nursing staff, empowering them to meet the challenges of autonomous practice.
Davis Kate A Clinical Trials Manual From The Duke Clinical Research Institute. Lessons from a Horse Named Jim Davis Kate A Clinical Trials Manual From The Duke Clinical Research Institute. Lessons from a Horse Named Jim Новинка

Davis Kate A Clinical Trials Manual From The Duke Clinical Research Institute. Lessons from a Horse Named Jim

6781.72 руб. или Купить в рассрочку!
The publication of the second edition of this manual comes at an important juncture in the history of clinical research. As advances in information technology make it possible to link individuals and groups in diverse locations in jointly seeking the answers to pressing global health problems, it is critically important to remain vigilant about moral and ethical safeguards for every patient enrolled in a trial. Those who study this manual will be well aware of how to ensure patient safety along with fiscal responsibility, trial efficiency, and research integrity. —Robert Harrington, Professor of Medicine, Director, Duke Clinical Research Institute, Durham, North Carolina, USA The Duke Clinical Research Institute (DCRI) is one of the world's leading academic clinical research organizations; its mission is to develop and share knowledge that improves the care of patients around the world through innovative clinical research. This concise handbook provides a practical «nuts and bolts» approach to the process of conducting clinical trials, identifying methods and techniques that can be replicated at other institutions and medical practices. Designed for investigators, research coordinators, CRO personnel, students, and others who have a desire to learn about clinical trials, this manual begins with an overview of the historical framework of clinical research, and leads the reader through a discussion of safety concerns and resulting regulations. Topics include Good Clinical Practice, informed consent, management of subject safety and data, as well as monitoring and reporting adverse events. Updated to reflect recent regulatory and clinical developments, the manual reviews the conduct of clinical trials research in an increasingly global context. This new edition has been further expanded to include: In-depth information on conducting clinical trials of medical devices and biologics The role and responsibilities of Institutional Review Boards, and Recent developments regarding subject privacy concerns and regulations. Ethical documents such as the Belmont Report and the Declaration of Helsinki are reviewed in relation to all aspects of clinical research, with a discussion of how researchers should apply the principles outlined in these important documents. This graphically appealing and eminently readable manual also provides sample forms and worksheets to facilitate data management and regulatory record retention; these can be modified and adapted for use at investigative sites.
Rainer Haag Multivalency. Concepts, Research and Applications Rainer Haag Multivalency. Concepts, Research and Applications Новинка

Rainer Haag Multivalency. Concepts, Research and Applications

8930.35 руб. или Купить в рассрочку!
Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics and the principle of effective molarity are described, and characterisation methods, experimental methodologies and data treatment methods are also discussed. Parts two and three provide an overview of current systems in which multivalency plays an important role in chemistry and biology, with a focus on the design rules, underlying chemistry and the fundamental principles of multivalency. The systems covered range from chemical/materials-based ones such as dendrimers and sensors, to biological systems including cell recognition and protein binding. Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book. Introduces students and young scientists to the field of multivalent interactions and assists experienced researchers utilising the methodologies in their work Features examples and case studies from biochemistry/bioorganic chemistry, as well as synthetic systems throughout the book Edited by leading experts in the field with contributions from established scientists Multivalency: Concepts, Research & Applications is recommended for graduate students and junior scientists in supramolecular chemistry and related fields, looking for an introduction to multivalent interactions. It is also highly useful to experienced academics and scientists in industry working on research relating to multivalent and cooperative systems in supramolecular chemistry, organic chemistry, pharmaceutical chemistry, chemical biology, biochemistry, materials science and nanotechnology.
Silvana Galderisi Standard Electroencephalography in Clinical Psychiatry. A Practical Handbook Silvana Galderisi Standard Electroencephalography in Clinical Psychiatry. A Practical Handbook Новинка

Silvana Galderisi Standard Electroencephalography in Clinical Psychiatry. A Practical Handbook

5205.84 руб. или Купить в рассрочку!
This book provides a concise overview of the possible clinical applications of standard EEG in clinical psychiatry. After a short history, the book describes the physiologic basis of the EEG signal, then reviews the principles of EEG in terms of technical backgrounds and requirements, EEG recording and signal analysis, with plentiful illustrations of the most frequent biological or technical artefacts. Normal EEG patterns and waveforms for easy reference are clearly presented, before the detailed description of abnormal patterns. With the basic information in hand, the reader progresses to an account of the role of EEG in the diagnostic work up in psychiatry, covering nonconvulsive status epilepticus, frontal lobe seizures and non-epileptic seizures. The clinical application of EEG in both childhood and adult disorders follows, including many case vignettes. The effects of psychotropic drugs on EEG are highlighted. The book closes with a discussion of currently available certification venues for Clinical Neurophysiology along with limitations of each venue. It calls for the development of training guidelines and certification processes specific to Psychiatric Electrophysiology. The material is clearly presented throughout, with plenty of figures, tables with summaries of relevant findings, flow diagrams for diagnostic work-up, boxes with learning points, and short lists of key references. We fully expect the book will become the standard teaching source for psychiatry residents and fellows, as well as a useful resource for practising psychiatrists and clinical psychologists. Praise for the book: «This distinguished group of editors has put together chapters that represent an excellent practical handbook on electroencephalography in clinical psychiatry, now a very important topic. I highly recommend it not only to psychiatrists, but also to anyone interested in neuroscience.» John R. Hughes, DM (Oxon), MD, PhD, Professor of Neurology, University of Illinois Medical Center, at Chicago, Illinois, USA
Jickells Tim D. Marine Geochemistry Jickells Tim D. Marine Geochemistry Новинка

Jickells Tim D. Marine Geochemistry

12436.29 руб. или Купить в рассрочку!
Marine Geochemistry offers a fully comprehensive and integrated treatment of the chemistry of the oceans, their sediments and biota. The first edition of the book received strong critical acclaim and was described as ‘a standard text for years to come.’ This third edition of Marine Geochemistry has been written at a time when the role of the oceans in the Earth System is becoming increasingly apparent. Following the successful format adopted previously, this new edition treats the oceans as a unified entity, and addresses the question ‘how do the oceans work as a chemical system?’ To address this question, the text has been updated to cover recent advances in our understanding of topics such as the carbon chemistry of the oceans, nutrient cycling and its effect on marine chemistry, the acidification of sea water, and the role of the oceans in climate change. In addition, the importance of shelf seas in oceanic cycles has been re-evaluated in the light of new research. Marine Geochemistry offers both undergraduate and graduate students and research workers an integrated approach to one of the most important reservoirs in the Earth System. Additional resources for this book can be found at: www.wiley.com/go/chester/marinegeochemistry.
V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science Новинка

V. Nenajdenko Isocyanide Chemistry. Applications in Synthesis and Material Science

2107.27 руб. или Купить в рассрочку!
The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.
Kursad Turksen Wound Healing. Stem Cells Repair and Restorations, Basic and Clinical Aspects Kursad Turksen Wound Healing. Stem Cells Repair and Restorations, Basic and Clinical Aspects Новинка

Kursad Turksen Wound Healing. Stem Cells Repair and Restorations, Basic and Clinical Aspects

13391.99 руб. или Купить в рассрочку!
A comprehensive resource on the recent developments of stem cell use in wound healing With contributions from experts in the field, Wound Healing offers a thorough review of the most recent findings on the use of stem cells to heal wounds. This important resource covers both the basic and translational aspects of the field. The contributors reveal the great progress that has been made in recent years and explore a wide range of topics from an overview of the stem cell process in wound repair to inflammation and cancer. They offer a better understanding of the identities of skin stem cells as well as the signals that govern their behavior that contributes to the development of improved therapies for scarring and poorly healing wounds. Comprehensive in scope, this authoritative resource covers a wealth of topics such as: an overview of stem cell regeneration and repair, wound healing and cutaneous wound healing, the role of bone marrow derived stems cells, inflammation in wound repair, role and function of inflammation in wound repair, and much more. This vital resource: Provides a comprehensive overview of stem cell use in wound healing, including both the basic and translational aspects of the field Covers recent developments and emerging subtopics within the field Offers an invaluable resource to clinical and basic researchers who are interested in wound healing, stem cells, and regenerative medicine Contains contributions from leading experts in the field of wound healing and care Wound Healing offers clinical researchers and academics a much-needed resource written by noted experts in the field that explores the role of stem cells in the repair and restoration of healing wounds.
Juntunen Marianne, Aksela Maija Holistic education for sustainable development in chemistry Juntunen Marianne, Aksela Maija Holistic education for sustainable development in chemistry Новинка

Juntunen Marianne, Aksela Maija Holistic education for sustainable development in chemistry

New education for sustainable development in chemistry is holistic, inquiry-based and socio-constructivist. The topic of this book is both internationally and nationally interesting and current. Chemistry is related to numerous aspects of daily-life. In the field of education, chemistry should be approached in a more relevant and socially activating manner. The holistic and inquiry-based chemistry education presented in this book supports versatile studying and citizenship skills in a new way. It motivates students to study chemistry and guides them to take sustainable development into account. Education for sustainable development is needed at all school levels. The approaches presented in this book may be applied on all levels of education. The results may be used to promote sustainable development in the planning of chemistry education and the education of chemistry teachers.
Charles Sell S. Chemistry and the Sense of Smell Charles Sell S. Chemistry and the Sense of Smell Новинка

Charles Sell S. Chemistry and the Sense of Smell

11531.5 руб. или Купить в рассрочку!
“I cannot recommend this fascinating book highly enough.” –Simon Cotton, Chemistry & Industry, September 2014 “In conclusion: A comprehensive introduction to the world of odours, not only for chemists.” –review in German: Monika Paduch, Gefahrstoffe – Reinhaltung Luft, October 2014 A comprehensive overview of fragrance chemistry Fragrance materials are universal, from personal care products to household cleaners, laundry products, and more. Although many of the scents themselves are synthesized in a lab, the actual mechanism of odour has long baffled chemists who attempt to model it for research. In Chemistry and the Sense of Smell, industry chemist Charles S. Sell explores the chemistry and biology surrounding the human detection and processing of odour, providing a comprehensive, single-volume guide to the totality of fragrance chemistry. The correlation between molecular structure and odour is much more complex than initially thought, and the intricacies of the mechanism by which the brain interprets scent signals leaves much to be discovered. This book provides a solid foundation of fragrance chemistry and highlights the relationship between research and industry with topics such as: The analysis and characterization of odour The role scent plays in our lives The design and manufacture of new fragrance ingredients The relationship between molecular structure and odour The mechanism of olfaction Intellectual challenges and the future of the field Complete with illustrations that clarify difficult concepts and the structures of the molecules under discussion, Chemistry and the Sense of Smell is an all-inclusive guide to the science of scent. For professionals in the fragrance industry or related fields, this book is one resource that should not be overlooked.
Farid Khan Toothwear. The ABC of the Worn Dentition Farid Khan Toothwear. The ABC of the Worn Dentition Новинка

Farid Khan Toothwear. The ABC of the Worn Dentition

6846.04 руб. или Купить в рассрочку!
This is one of the first books to provide a clinically focussed account of the diagnosis, prevention and treatment of all forms of toothwear. Bringing together the latest research, it is compiled by international leaders in the field to create an essential clinical guide for dental practitioners. The book covers all forms of toothwear and dental erosion, and is presented in a practical format that allows for ease of reference and helps assimilate clinical information quickly. It defines the stages of toothwear, provides schematic approaches to allow better understanding of the key role that saliva plays, and highlights the differences between acid erosion and dental caries. Importantly for clinicians, it provides a framework for developing best practice management strategies by discussing diagnostic skills, treatment planning and therapeutic modalities. An essential resource based on a solid research platform, this book will provide dental clinical professionals with the missing links they seek to diagnose, prevent, manage, restore and rehabilitate the worn dentition more confidently. It will be of value to dentists, dental therapists, dental hygienists, and students in these areas. KEY FEATURES • Covers all forms of toothwear and dental erosion across all age-groups • Includes discussion of best practice management strategies • Discusses aetiology, diagnosis, prevention and treatment in a clinical context • Contains many full colour clinical illustrations and schematic conceptualisations • Brings together the latest clinical views and research with a wide range of international contributors
Helen Chapel Essentials of Clinical Immunology Helen Chapel Essentials of Clinical Immunology Новинка

Helen Chapel Essentials of Clinical Immunology

5432.49 руб. или Купить в рассрочку!
Essentials of Clinical Immunology provides the most up-to-date, core information required to understand diseases with an immunological basis. Clinically focussed, the sixth edition of this classic text presents theoretical and practical information in a simple yet thorough way. Essentials of Clinical Immunology covers the underlying pathophysiology, the signs and symptoms of disease, the investigations required and guidance on the management of patients. Perfect for clinical medical students, junior doctors and medical professionals seeking a refresher in the role of immunology in clinical medicine, this comprehensive text features fully updated clinical information, boxes with key points, real-life case histories to illustrate key concepts and an index of contents at the start of each chapter. A companion website at www.immunologyclinic.com provides additional learning tools, including more case studies, interactive multiple-choice questions and answers, all of the photographs and illustrations from the book, links to useful websites, and a selection of review articles from the journal Clinical and Experimental Immunology. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
John Moore T. Chemistry II For Dummies John Moore T. Chemistry II For Dummies Новинка

John Moore T. Chemistry II For Dummies

1255.93 руб. или Купить в рассрочку!
The tools you need to ace your Chemisty II course College success for virtually all science, computing, engineering, and premedical majors depends in part on passing chemistry. The skills learned in chemistry courses are applicable to a number of fields, and chemistry courses are essential to students who are studying to become nurses, doctors, pharmacists, clinical technicians, engineers, and many more among the fastest-growing professions. But if you're like a lot of students who are confused by chemistry, it can seem like a daunting task to tackle the subject. That's where Chemistry II For Dummies can help! Here, you'll get plain-English, easy-to-understand explanations of everything you'll encounter in your Chemistry II class. Whether chemistry is your chosen area of study, a degree requirement, or an elective, you'll get the skills and confidence to score high and enhance your understanding of this often-intimidating subject. So what are you waiting for? Presents straightforward information on complex concepts Tracks to a typical Chemistry II course Serves as an excellent supplement to classroom learning Helps you understand difficult subject matter with confidence and ease Packed with approachable information and plenty of practice opportunities, Chemistry II For Dummies is just what you need to make the grade.
Zhang Wei Green Techniques for Organic Synthesis and Medicinal Chemistry Zhang Wei Green Techniques for Organic Synthesis and Medicinal Chemistry Новинка

Zhang Wei Green Techniques for Organic Synthesis and Medicinal Chemistry

16134.38 руб. или Купить в рассрочку!
An updated overview of the rapidly developing field of green engineering techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.
Helen Zulch Stress and Pheromonatherapy in Small Animal Clinical Behaviour Helen Zulch Stress and Pheromonatherapy in Small Animal Clinical Behaviour Новинка

Helen Zulch Stress and Pheromonatherapy in Small Animal Clinical Behaviour

5580.76 руб. или Купить в рассрочку!
Stress and Pheromonatherapy in Small Animal Clinical Behaviour is about how stress impacts on animal behaviour and welfare and what we can do about it, especially by using chemical signals more effectively. This readily accessible text starts from first principles and is useful to both academics and practitioners alike. It offers a framework for understanding how pheromonatherapy can be used to encourage desirable behaviour in dogs and cats and also a fresh approach to understanding the nature of clinical animal behaviour problems. The authors have pioneered the use of pheromone therapy within the field of clinical animal behaviour. As the culmination of many years of research and experience, they offer sound evidence-based advice on how and when pheromones can be used most effectively. The first part of the book deals with some fundamental concepts, focusing on the key concepts of stress, communication and perception. It then provides a framework for the evaluation of problem behaviour to allow consideration of the possible role or not of pheromonatherapy. Part 2 covers the application of these concepts to a range of specific situations, concentrating on conditions in which there has been most research to support the efficacy of pheromonatherapy. Suitable for veterinarians in small animal practice, students of clinical animal behaviour, veterinary nurses and technicians, as well as specialists and researchers in animal behaviour therapy.
Jeang Kuan-Teh Viral Oncology. Basic Science and Clinical Applications Jeang Kuan-Teh Viral Oncology. Basic Science and Clinical Applications Новинка

Jeang Kuan-Teh Viral Oncology. Basic Science and Clinical Applications

14396.55 руб. или Купить в рассрочку!
A comprehensive look at the latest research findings and clinical applications of oncogenic viruses Written by a panel of academic experts, Viral Oncology is the first self-contained and comprehensive book to present both scientific and clinical information on viruses linked to some of the most important human cancers. Readers can turn to this book for the most in-depth and up-to-date coverage of: HPV-associated cancers; molecular events associated with HPV-induced human cancer; the role of the HPV E6 oncoprotein in malignant progression; virus association with brain tumors; involvement of the polyomavirus JCV in colorectal cancer; possibleassociation of BKV with prostate cancer; oncogenic transformation bypolyomavirus large T antigen; SV40 and human cancer; SV40 and mesothelioma; molecular immunology of hepatitis B–associated viral cancer; hepatitis B vaccine and hepatocellular carcinoma; pathogenesis of acute and chronic hepatitis Cvirus infection; molecular mechanisms of hepatitis C virus-induced cellulartransformation; clinical aspects of HTLV-1 associated cancer; oncogenic potential of the HTLV-1 tax protein; HIV-associated malignancy; HIV-related lymphoma; biology and epidemiology of HHV-8; the role of KSHV in pathogenesis of Kaposi'ssarcoma; molecular pathobiology of EBV infection; and EBV as a pathogen. Several chapters are devoted to the basic science of oncogenic viruses for thestudy of their pathogenesis, drug development, and employment of viral vectorsfor vaccine and gene therapy. The book also includes complementary clinically based chapters describing natural courses and treatments. Additionally, bonusclinical materials are embedded within chapters and an easy-to-use indexcompletes the book. Viral Oncology is an essential resource for clinical and research oncologists in medical facilities and biological research laboratories; clinicians and scientists working in related biomedical areas; medical students working toward a first or higher degree in the life sciences and other biomedical fields; and pharmaceutical scientists and developers.
David Lillicrap Von Willebrand Disease. Basic and Clinical Aspects David Lillicrap Von Willebrand Disease. Basic and Clinical Aspects Новинка

David Lillicrap Von Willebrand Disease. Basic and Clinical Aspects

11382.52 руб. или Купить в рассрочку!
Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease. This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding. Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy. Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.
Michael Carroll Clinical Reproductive Science Michael Carroll Clinical Reproductive Science Новинка

Michael Carroll Clinical Reproductive Science

5968.72 руб. или Купить в рассрочку!
The comprehensive and authoritative guide to clinical reproductive science The field of clinical reproductive science continues to evolve; this important resource offers the basics of reproductive biology as well as the most recent advance in clinical embryology. The author – a noted expert in the field – focuses on the discipline and covers all aspects of this field. The text explores causes of male and female infertility and includes information on patient consultation and assessment, gamete retrieval and preparation, embryo culture, embryo transfer and cryopreservation. Comprehensive in scope, the text contains an introduction to the field of clinical reproductive science and a review of assisted reproductive technology. The author includes information on a wide range of topics such as gonadal development, the regulation of meiotic cell cycle, the biology of sperm and spermatogenesis, in vitro culture, embryo transfer techniques, fundamentals of fertilisation, oocyte activation and much more. This important resource: Offers an accessible guide to the most current research and techniques to the science of clinical reproduction Covers the fundamental elements of reproductive science Includes information on male and the female reproductive basics – everything from sexual differentiation to foetal development and parturition Explores the long-term health of children conceived through IVF Contains the newest developments in assisted reproductive technology Clinical Reproductive Science is a valuable reference written for professionals in academia, research and clinical professionals working in the field of reproductive science, clinical embryology and reproductive medicine.
Sergio Pizzini Physical Chemistry of Semiconductor Materials and Processes Sergio Pizzini Physical Chemistry of Semiconductor Materials and Processes Новинка

Sergio Pizzini Physical Chemistry of Semiconductor Materials and Processes

6100.43 руб. или Купить в рассрочку!
The development of solid state devices began a little more than a century ago, with the discovery of the electrical conductivity of ionic solids. Today, solid state technologies form the background of the society in which we live. The aim of this book is threefold: to present the background physical chemistry on which the technology of semiconductor devices is based; secondly, to describe specific issues such as the role of defects on the properties of solids, and the crucial influence of surface properties; and ultimately, to look at the physics and chemistry of semiconductor growth processes, both at the bulk and thin-film level, together with some issues relating to the properties of nano-devices. Divided into five chapters, it covers: Thermodynamics of solids, including phases and their properties and structural order Point defects in semiconductors Extended defects in semiconductors and their interactions with point defects and impurities Growth of semiconductor materials Physical chemistry of semiconductor materials processing With applications across all solid state technologies,the book is useful for advanced students and researchers in materials science, physics, chemistry, electrical and electronic engineering. It is also useful for those in the semiconductor industry.
Sandra Aitken Community Palliative Care. The Role of the Clinical Nurse Specialist Sandra Aitken Community Palliative Care. The Role of the Clinical Nurse Specialist Новинка

Sandra Aitken Community Palliative Care. The Role of the Clinical Nurse Specialist

2107.27 руб. или Купить в рассрочку!
Community Palliative Care examines the complex support and information needs of seriously ill patients and their families and will encompass not only the patient’s journey, but that of the family during the illness trajectory and into the bereavement period. The text is divided into three sections- professionals, patients and carers. The first section discusses the roles and contributions made by other members of the primary health care team and examines the role of the nurse. Section two explores the psychosocial support needed by patients receiving palliative care, and looks at the community palliative care clinical nurse specialists’ role in relation to psychological, as well as practical problems surrounding a life threatening illness. The final section will look at the needs of the family and carers and the support that the community palliative care clinical nurse specialist can offer to the individuals. Included in this segment will be the complex issues faced by carers in relation to the changing roles within the family, children, death and bereavement.
Salah Abdel-aleem M. Design, Execution, and Management of Medical Device Clinical Trials Salah Abdel-aleem M. Design, Execution, and Management of Medical Device Clinical Trials Новинка

Salah Abdel-aleem M. Design, Execution, and Management of Medical Device Clinical Trials

8745.74 руб. или Купить в рассрочку!
An essential introduction to conducting the various stages of medical device clinical trials Clinical research continues to be one of the most vital components of pharmaceutical, biostatistical, and medical studies. Design, Execution, and Management of Medical Device Clinical Trials provides a uniform methodology for conducting and managing clinical trials. Written in a style that is accessible to readers from diverse educational and professional backgrounds, this book provides an in-depth and broad overview for successfully performing clinical tasks and activities. Throughout the book, practical examples compiled from both the author's and other researchers' previous clinical trial experiences are discussed in a sequential manner as they occur in the study, starting from the development of the clinical protocol and the selection of clinical sites and ending with the completion of the final clinical study report. Next, readers are guided through the development of important clinical documents, including informed consent forms, case report forms, and study logs. A careful review of the Food and Drug Administration (FDA) and International Conference on Harmonisation (ICH) regulations applicable to medical devices is also featured. Additional coverage includes: Qualification and selection of investigators Study monitoring visits Definitions and reporting procedures for adverse events The use of biostatistical methodology in clinical research, including the use of biostatistics for sample size determination and study endpoints The roles and responsibilities of all members of a clinical research team The book concludes with an insightful discussion of special ethical conduct for human research and challenging issues to consider during the design of clinical studies. A glossary lists important clinical and statistical terms used in clinical research, and an extensive reference section provides additional resources for the most up-to-date literature on the topic. Design, Execution, and Management of Medical Device Clinical Trials is an excellent book for clinical research or epidemiology courses at the upper-undergraduate and graduate levels. It is also an indispensable reference for clinical research associates, clinical managers, clinical scientists, biostatisticians, pharmacologists, and any professional working in the field of clinical research who would like to better understand clinical research practices.
Peter Wasserscheid Green Solvents. Ionic Liquids Peter Wasserscheid Green Solvents. Ionic Liquids Новинка

Peter Wasserscheid Green Solvents. Ionic Liquids

19572.91 руб. или Купить в рассрочку!
The shift towards being as environmentally-friendly as possible has resulted in the need for this important volume on the role of ionic liquids in green chemistry. Edited by Peter Wasserscheid, one of the pioneers of ionic liquid research, and Annegret Stark, this is an essential resource for anyone wishing to gain an understanding of the world of green chemistry, as well as for chemists, environmental agencies and chemical engineers. The Handbook of Green Chemistry comprises of 9 volumes in total, split into 3 subject-specific sets. The three sets are available individually. All 9 volumes are available individually, too. Set I: Green Catalysis – Volume 1: Homogeneous Catalysis – Volume 2: Heterogeneous Catalysis – Volume 3: Biocatalysis Set II: Green Solvents – Volume 4: Supercritical Solvents – Volume 5: Reactions in Water – Volume 6: Ionic Liquids Set III: Green Processes – Volume 7: Green Synthesis – Volume 8: Green Nanoscience – Volume 9: Designing Safer Chemicals The Handbook of Green Chemistry is also available as Online Edition. Podcasts Listen to two podcasts in which Professor Paul Anastas and Journals Editor Paul Trevorrow discuss the origin and expansion of Green Chemistry and give an overview of The Handbook of Green Chemistry.
Salah Abdel-aleem M. Design, Execution, and Management of Medical Device Clinical Trials Salah Abdel-aleem M. Design, Execution, and Management of Medical Device Clinical Trials Новинка

Salah Abdel-aleem M. Design, Execution, and Management of Medical Device Clinical Trials

8633.09 руб. или Купить в рассрочку!
An essential introduction to conducting the various stages of medical device clinical trials Clinical research continues to be one of the most vital components of pharmaceutical, biostatistical, and medical studies. Design, Execution, and Management of Medical Device Clinical Trials provides a uniform methodology for conducting and managing clinical trials. Written in a style that is accessible to readers from diverse educational and professional backgrounds, this book provides an in-depth and broad overview for successfully performing clinical tasks and activities. Throughout the book, practical examples compiled from both the author's and other researchers' previous clinical trial experiences are discussed in a sequential manner as they occur in the study, starting from the development of the clinical protocol and the selection of clinical sites and ending with the completion of the final clinical study report. Next, readers are guided through the development of important clinical documents, including informed consent forms, case report forms, and study logs. A careful review of the Food and Drug Administration (FDA) and International Conference on Harmonisation (ICH) regulations applicable to medical devices is also featured. Additional coverage includes: Qualification and selection of investigators Study monitoring visits Definitions and reporting procedures for adverse events The use of biostatistical methodology in clinical research, including the use of biostatistics for sample size determination and study endpoints The roles and responsibilities of all members of a clinical research team The book concludes with an insightful discussion of special ethical conduct for human research and challenging issues to consider during the design of clinical studies. A glossary lists important clinical and statistical terms used in clinical research, and an extensive reference section provides additional resources for the most up-to-date literature on the topic. Design, Execution, and Management of Medical Device Clinical Trials is an excellent book for clinical research or epidemiology courses at the upper-undergraduate and graduate levels. It is also an indispensable reference for clinical research associates, clinical managers, clinical scientists, biostatisticians, pharmacologists, and any professional working in the field of clinical research who would like to better understand clinical research practices.
Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster Новинка

Patrizia Diana Biosynthesis of Heterocycles. From Isolation to Gene Cluster

14954.52 руб. или Купить в рассрочку!
This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. • Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification • Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance • Explains the role of natural products in chemistry and their formation • Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application
Malcolm Forbes D. Carbon-Centered Free Radicals and Radical Cations. Structure, Reactivity, and Dynamics Malcolm Forbes D. Carbon-Centered Free Radicals and Radical Cations. Structure, Reactivity, and Dynamics Новинка

Malcolm Forbes D. Carbon-Centered Free Radicals and Radical Cations. Structure, Reactivity, and Dynamics

12063.09 руб. или Купить в рассрочку!
Covers the most advanced computational and experimental methods for studying carbon-centered radical intermediates With its focus on the chemistry of carbon-centered radicals and radical cations, this book helps readers fully exploit the synthetic utility of these intermediates in order to prepare fine chemicals and pharmaceutical products. Moreover, it helps readers better understand their role in complex atmospheric reactions and biological systems. Thoroughly up to date, the book highlights the most advanced computational and experimental methods available for studying and using these critically important intermediates. Carbon-Centered Free Radicals and Radical Cations begins with a short history of the field of free radical chemistry, and then covers: A discussion of the relevant theory Mechanistic chemistry, with an emphasis on synthetic utility Molecular structure and mechanism, focusing on computational methods Spectroscopic investigations of radical structure and kinetics, including demonstrations of spin chemistry techniques such as CIDNP and magnetic field effects Free radical chemistry in macromolecules Each chapter, written by one or more leading experts, explains difficult concepts clearly and concisely, with references to facilitate further investigation of individual topics. The authors were selected in order to provide insight into a broad range of topics, including small molecule synthesis, polymer degradation, computational chemistry as well as highly detailed experimental work in the solid, liquid, and gaseous states. This volume is essential for students or researchers interested in building their understanding of the role of carbon-centered radical intermediates in complex systems and how they may be used to develop a broad range of useful products.
Gomtsyan Arthur Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders Gomtsyan Arthur Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders Новинка

Gomtsyan Arthur Vanilloid Receptor TRPV1 in Drug Discovery. Targeting Pain and Other Pathological Disorders

12063.09 руб. или Купить в рассрочку!
Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it «the holy grail» of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arthritis, and cancer pain. The book discusses: Recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of the dynamic area of TRPV1 drug discovery research The potential for drugs targeting TRPV1 in painful conditions such as inflammation, arthritis, and cancer The development of analgesic drugs Other applications for TRPV1, including the treatment of respiratory disease and diabetes Featuring data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is a key tool for researchers in the pharmaceutical industry and academia involved in pain, ion channels, and analgesic drug development.
Robert Scott A. Applications of Physical Methods to Inorganic and Bioinorganic Chemistry Robert Scott A. Applications of Physical Methods to Inorganic and Bioinorganic Chemistry Новинка

Robert Scott A. Applications of Physical Methods to Inorganic and Bioinorganic Chemistry

20168.13 руб. или Купить в рассрочку!
Modern spectroscopic and instrumental techniques are essential to the practice of inorganic and bioinorganic chemistry. This first volume in the new Wiley Encyclopedia of Inorganic Chemistry Methods and Applications Series provides a consistent and comprehensive description of the practical applicability of a large number of techniques to modern problems in inorganic and bioinorganic chemistry. The outcome is a text that provides invaluable guidance and advice for inorganic and bioinorganic chemists to select appropriate techniques, whilst acting as a source to the understanding of these methods. This volume is also available as part of Encyclopedia of Inorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007 to 2010, representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. Find out more.
Vera Mihajlovic-Madzarevic Clinical Trials Audit Preparation. A Guide for Good Clinical Practice (GCP) Inspections Vera Mihajlovic-Madzarevic Clinical Trials Audit Preparation. A Guide for Good Clinical Practice (GCP) Inspections Новинка

Vera Mihajlovic-Madzarevic Clinical Trials Audit Preparation. A Guide for Good Clinical Practice (GCP) Inspections

8289.61 руб. или Купить в рассрочку!
A must-have guide for any professional in the drug manufacturing industry The Good Clinical Practice (GCP) audit is a tedious but necessary exercise that assures that all parties do their job properly and in compliance with the applicable FDA code. Clinical Trials Audit Preparation demystifies the audit process for all parties involved, including clinical research sponsors, clinical investigators, and institutional review boards. This book provides a step-by-step explanation of the FDA audit procedures for clinical trials and of how pharmaceutical companies, clinical investigators, and institutional review boards should prepare for regulatory audits. The book emphasizes the processes and procedures that should be implemented before a clinical audit occurs, making this an imperative guide to any professional in the drug manufacturing industry, including drug manufacturing companies, regulatory affairs personnel, clinical investigators, and quality assurance professionals. Among the topics discussed: Good Clinical Practices and therapeutic product development in clinical research The roles of the sponsor of a clinical investigation, the IRB, or independent ethics committee The roles and responsibilities of the clinical trial investigator The inspection preparation The Audit Report and the Form 483 Warning letters issued to clinical investigators and clinical trial sponsors and their impact on product development
Jay Siegel Forensic Chemistry. Fundamentals and Applications Jay Siegel Forensic Chemistry. Fundamentals and Applications Новинка

Jay Siegel Forensic Chemistry. Fundamentals and Applications

Forensic Chemistry: Fundamentals and Applications presents a new approach to the study of applications of chemistry to forensic science. It is edited by one of the leading forensic scientists with each chapter written by international experts specializing in their respective fields, and presents the applications of chemistry, especially analytical chemistry, to various topics that make up the forensic scientists toolkit. This comprehensive, textbook includes in-depth coverage of the major topics in forensic chemistry including: illicit drugs, fibers, fire and explosive residues, soils, glass and paints, the chemistry of fingerprint recovery on porous surfaces, the chemistry of firearms analysis, as well as two chapters on the key tools of forensic science, microscopy and chemometrics. Each topic is explored at an advanced college level, with an emphasis, throughout the text, on the use of chemical tools in evidence analysis. Forensic Chemistry: Fundamentals and Applications is essential reading for advanced students of forensic science and analytical chemistry, as well as forensic science practitioners, researchers and faculty, and anyone who wants to learn about the fascinating subject of forensic chemistry in some depth. This book is published as part of the AAFS series ‘Forensic Science in Focus’.
Andreja Bakac Physical Inorganic Chemistry. Reactions, Processes, and Applications Andreja Bakac Physical Inorganic Chemistry. Reactions, Processes, and Applications Новинка

Andreja Bakac Physical Inorganic Chemistry. Reactions, Processes, and Applications

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This go-to text provides information and insight into physical inorganic chemistry essential to our understanding of chemical reactions on the molecular level. One of the only books in the field of inorganic physical chemistry with an emphasis on mechanisms, it features contributors at the forefront of research in their particular fields. This essential text discusses the latest developments in a number of topics currently among the most debated and researched in the world of chemistry, related to the future of solar energy, hydrogen energy, biorenewables, catalysis, environment, atmosphere, and human health.
Sarah Pitt Jane Clinical Microbiology for Diagnostic Laboratory Scientists Sarah Pitt Jane Clinical Microbiology for Diagnostic Laboratory Scientists Новинка

Sarah Pitt Jane Clinical Microbiology for Diagnostic Laboratory Scientists

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A modern, evaluative, and integrative approach to diagnostic microbiology encouraging problem-solving in the clinical laboratory context through the use of examples to illustrate clinical and diagnostic issues Clinical Microbiology for Diagnostic Laboratory Scientists is designed to encourage readers to develop a way of thinking that can be applied to any diagnostic scenario in microbiology. Through consideration of a selected range of infections caused by pathogenic bacteria, viruses, fungi, protozoa, and helminths, the book encourages readers to explore connections between the available information about clinical symptoms, pathogenesis of infections, and the approaches used in laboratory diagnosis, in order to develop new insights. The book begins with an introductory chapter that outlines the scope of clinical diagnostic microbiology and the key areas for the laboratory scientist to be aware of. The subsequent six chapters review a type of infection in depth, using particular pathogenic microorganisms to illustrate salient points. At the end of each chapter there are three exercises related to management of a diagnostic service and assessing the suitability of test methods to specific contexts. There are no right or wrong answers to these, but the reader can discuss them with their laboratory colleagues or university tutor. Makes extensive use of published research in the form of journal articles, publically available epidemiological data, professional guidelines, and specialist websites Stimulates the reader in critical appraisal of published evidence and encourages problem-solving in the laboratory Outlines the scope of clinical diagnostic microbiology and the key areas for the laboratory scientist to be aware of Considers topics relevant to professional scientists working in the area of diagnostic microbiology Clinical Microbiology for Diagnostic Laboratory Scientists is ideal for post graduate scientists intending to pursue careers in diagnostic clinical microbiology and for biomedical scientists, clinical scientists, and full time students studying for upper level qualifications in biomedical science, microbiology, or virology.
Montgomery Stuart A. Treatment-Resistant Depression Montgomery Stuart A. Treatment-Resistant Depression Новинка

Montgomery Stuart A. Treatment-Resistant Depression

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Successful management of patients with treatment-resistant depression is going to require a thorough understanding of the biological basis for both the depression and its failure to respond to standard treatments. This book clearly and succinctly summarizes the latest scientific research and its applications in clinical practice. A first step is a clear definition of what constitutes treatment-resistant depression so that clinical trials and other studies are using common criteria, enabling comparison and meta-analysis of their outcomes. The opening chapter reviews definitions and predictors of originating from different fields and discusses their usefulness in clinical practice and clinical research. The next chapter proposes a new definition, adapting terminology from medicine. Biological classification requires identification of genetic risk factors: with gene variants accounting for 50% of the variance in the clinical outcomes of antidepressant treatments this is clearly a fruitful area of research. Chapter 3 describes several genes already associated with treatment-resistant depression and, while further work is needed to translate findings into clinical recommendations, predicts that genetic prediction of TRD could became a widespread clinical reality within a few years. Most patients with TRD will be treated pharmacologically and three chapters review the latest evidence for pharmacological best practice, including switching strategies for antidepressants, the role of antipsychotics and augmentation strategies to complement lithium. There are two major alternatives to pharmacotherapy: neuromodulation and psychotherapy. The brain intervention chapter summarizes clinical research and experience with electroconvulsive therapy, transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy. The final chapter reviews the literature pertaining to the effectiveness of various forms of psychotherapy in patients who have not responded to antidepressant pharmacotherapy, revealing that patients who have not responded to one or two trials of antidepressant medication have a 30%-50% chance of responding to a focused psychotherapy. It proposes indications for psychotherapy in TRD and summarizes general therapeutic principles.
Nicola Cooper ABC of Clinical Communication Nicola Cooper ABC of Clinical Communication Новинка

Nicola Cooper ABC of Clinical Communication

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Clinical communication underpins safe patient care. The effective health professional sees illness through the patient’s eyes and understands what matters most to him or her. Effectiveness means gathering hard clinical data about the physical changes affecting the patient, understanding why the patient is concerned, conveying this to other health care professionals and involving the patient at every stage of management decisions. The evidence for good clinical communication is well established, although there are challenges. While listening is the basis of sound diagnosis and clinical reasoning, its absence affects patient outcomes particularly when patients are not permitted to make their concerns known or when there are gaps in information flow or communication between the professionals caring for them. The ABC of Clinical Communication considers the evidence pertinent to individual encounters between patients and their health professionals, how to achieve efficient flow of information, the function of clinical teams and developing a teaching programme. Topics covered include: The consultation Clinical communication and personality type Shared decision making Communication in clinical teams Communication in medical records Communication in specific situations, including mental health and end of life Teaching clinical communication The chapter authors are clinicians involved in communicating with patients, research and training healthcare professionals of the future. This team reflects the multidisciplinary approach required to develop effective clinical communication.
Edward Hamilton The Chemistry of Low Valent Sulfur Compounds in the S-H2O System Edward Hamilton The Chemistry of Low Valent Sulfur Compounds in the S-H2O System Новинка

Edward Hamilton The Chemistry of Low Valent Sulfur Compounds in the S-H2O System

Master's Thesis from the year 1991 in the subject Chemistry - Anorganic Chemistry, University of Minnesota - Twin Cities, language: English, abstract: The primary goal of this thesis is to analyze geometrical trends of thermodynamic and related functions of low valent sulfur polymer groups in order to determine the thermodynamic properties of these species.
Brown Jo Through the Looking Glass. Communication in the Clinical Workplace Brown Jo Through the Looking Glass. Communication in the Clinical Workplace Новинка

Brown Jo Through the Looking Glass. Communication in the Clinical Workplace

This qualitative study investigates the subject of Clinical Communication and how it is taught, learned and practised in one London Medical School and Hospital. It is informed by theoretical perspectives from workplace learning. Teachers and medical students took part in a series of interviews and ward observations over a period of four months. Teachers were interviewed about their teaching practice, they were asked to observe students in the clinical workplace and finally were asked to reflect upon whether these observations had informed their teaching practice. Students were interviewed about how they had learned and subsequently practised clinical communication in the clinical workplace. Conceptually, this research shifts focus to the clinical workplace as the legitimate location for teaching and learning clinical communication and proposes a new and expanded way of understanding learning in this context.
Guosheng Yin Clinical Trial Design. Bayesian and Frequentist Adaptive Methods Guosheng Yin Clinical Trial Design. Bayesian and Frequentist Adaptive Methods Новинка

Guosheng Yin Clinical Trial Design. Bayesian and Frequentist Adaptive Methods

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A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
Singh Nirmal, Kaur Japinder, Jaggi Amteshwar S K-Channels in cerebroprotective mechanism of ischemic postconditioning Singh Nirmal, Kaur Japinder, Jaggi Amteshwar S K-Channels in cerebroprotective mechanism of ischemic postconditioning Новинка

Singh Nirmal, Kaur Japinder, Jaggi Amteshwar S K-Channels in cerebroprotective mechanism of ischemic postconditioning

Stroke is the third most common cause of death and has profound negative social and economic effects. The failure, of various clinical trials of exogenously administered drugs as potential stroke therapy has enhanced the ongoing search to identify endogenous mechanisms activated after cerebral ischemia that might be harnessed as neuroprotectants in stroke. Postconditioning (PoCo), is an adaptive technique, whereby brief repetitive cycles of ischemia with intermittent reperfusion immediately following prolonged ischemia elicits tissue protection. Protective role of PoCo has been reported in different organs and animal species. PoCo is recently reported to produce some protective effects in clinical settings and hence it appears to hold great potential at clinical level. However usefulness of PoCo in cerebral ischemia & stroke remains to be explored so there is a need to investigate neuroprotective mechanism of PoCo. Present study investigates the role of K-channels in neuroprotective mechanism of PoCo. Delineating neuroprotective mechanism of PoCo will help in better understanding of its usefulness in ischemic stroke and boost the therapeutic management in a significant manner.
Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery Новинка

Ekins Sean Pharmaceutical Data Mining. Approaches and Applications for Drug Discovery

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Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover: A general overview of the discipline, from its foundations to contemporary industrial applications Chemoinformatics-based applications Bioinformatics-based applications Data mining methods in clinical development Data mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.

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The publication of the second edition of this manual comes at an important juncture in the history of clinical research. As advances in information technology make it possible to link individuals and groups in diverse locations in jointly seeking the answers to pressing global health problems, it is critically important to remain vigilant about moral and ethical safeguards for every patient enrolled in a trial. Those who study this manual will be well aware of how to ensure patient safety along with fiscal responsibility, trial efficiency, and research integrity. —Robert Harrington, Professor of Medicine, Director, Duke Clinical Research Institute, Durham, North Carolina, USA The Duke Clinical Research Institute (DCRI) is one of the world's leading academic clinical research organizations; its mission is to develop and share knowledge that improves the care of patients around the world through innovative clinical research. This concise handbook provides a practical «nuts and bolts» approach to the process of conducting clinical trials, identifying methods and techniques that can be replicated at other institutions and medical practices. Designed for investigators, research coordinators, CRO personnel, students, and others who have a desire to learn about clinical trials, this manual begins with an overview of the historical framework of clinical research, and leads the reader through a discussion of safety concerns and resulting regulations. Topics include Good Clinical Practice, informed consent, management of subject safety and data, as well as monitoring and reporting adverse events. Updated to reflect recent regulatory and clinical developments, the manual reviews the conduct of clinical trials research in an increasingly global context. This new edition has been further expanded to include: In-depth information on conducting clinical trials of medical devices and biologics The role and responsibilities of Institutional Review Boards, and Recent developments regarding subject privacy concerns and regulations. Ethical documents such as the Belmont Report and the Declaration of Helsinki are reviewed in relation to all aspects of clinical research, with a discussion of how researchers should apply the principles outlined in these important documents. This graphically appealing and eminently readable manual also provides sample forms and worksheets to facilitate data management and regulatory record retention; these can be modified and adapted for use at investigative sites.
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