uversky vladimir flexible viruses structural disorder in viral proteins



Uversky Vladimir Flexible Viruses. Structural Disorder in Viral Proteins Uversky Vladimir Flexible Viruses. Structural Disorder in Viral Proteins Новинка

Uversky Vladimir Flexible Viruses. Structural Disorder in Viral Proteins

13268.33 руб. или Купить в рассрочку!
This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.
Uversky Vladimir Instrumental Analysis of Intrinsically Disordered Proteins. Assessing Structure and Conformation Uversky Vladimir Instrumental Analysis of Intrinsically Disordered Proteins. Assessing Structure and Conformation Новинка

Uversky Vladimir Instrumental Analysis of Intrinsically Disordered Proteins. Assessing Structure and Conformation

14125.98 руб. или Купить в рассрочку!
Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.
Anne Bridgen Reverse Genetics of RNA Viruses. Applications and Perspectives Anne Bridgen Reverse Genetics of RNA Viruses. Applications and Perspectives Новинка

Anne Bridgen Reverse Genetics of RNA Viruses. Applications and Perspectives

12537.24 руб. или Купить в рассрочку!
Reverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applications may lead in the future. It will prove invaluable to bioscience, medical and veterinary students, those starting research in this area as well as other researchers and teachers needing to update their knowledge of this fast-moving field. An authoritative, comprehensive overview of reverse genetics in RNA Viruses. Includes numerous examples of cutting- edge applications of reverse genetics within each of the RNA viral groups. Written by a team of international experts, including some of the leading researchers in the field.
Christon Hurst J. Studies in Viral Ecology. Animal Host Systems Christon Hurst J. Studies in Viral Ecology. Animal Host Systems Новинка

Christon Hurst J. Studies in Viral Ecology. Animal Host Systems

12802.64 руб. или Купить в рассрочку!
This book explains the ecology of viruses by examining their interactive dynamics with their hosting species (in this volume, in animals), including the types of transmission cycles that viruses have evolved encompassing principal and alternate hosts, vehicles and vectoring species. Examining virology from an organismal biology approach and focusing on the concept that viral infections represent areas of overlap in the ecologies of the involved species, Viral Ecology is essential for students and professionals who either may be non-virologists or virologists whose previous familiarity has been very specialized.
Marina Lotti Protein Aggregation in Bacteria. Functional and Structural Properties of Inclusion Bodies in Bacterial Cells Marina Lotti Protein Aggregation in Bacteria. Functional and Structural Properties of Inclusion Bodies in Bacterial Cells Новинка

Marina Lotti Protein Aggregation in Bacteria. Functional and Structural Properties of Inclusion Bodies in Bacterial Cells

10180.65 руб. или Купить в рассрочку!
Focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies—and on their use in biotechnological and medical applications The first book devoted specifically to the topic of aggregation in bacteria, Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells provides a large overview of protein folding and aggregation, including cell biology and methodological aspects. It summarizes, for the first time in one book, ideas and technical approaches that pave the way for a direct use of inclusion bodies in biotechnological and medical applications. Protein Aggregation in Bacteria covers: Molecular and cellular mechanisms of protein folding, aggregation, and disaggregation in bacteria Physiological importance and consequences of aggregation for the bacterial cell Factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble Structural properties of proteins expressed as soluble aggregates and as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids Control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine Protein Aggregation in Bacteria is ideal for researchers in protein science, biochemistry, bioengineering, biophysics, microbiology, medicine, and biotechnology, particularly if they are related with the production of recombinant proteins and pharmaceutical science.
Anne Bridgen Reverse Genetics of RNA Viruses. Applications and Perspectives Anne Bridgen Reverse Genetics of RNA Viruses. Applications and Perspectives Новинка

Anne Bridgen Reverse Genetics of RNA Viruses. Applications and Perspectives

12802.64 руб. или Купить в рассрочку!
Reverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applications may lead in the future. It will prove invaluable to bioscience, medical and veterinary students, those starting research in this area as well as other researchers and teachers needing to update their knowledge of this fast-moving field. An authoritative, comprehensive overview of reverse genetics in RNA Viruses. Includes numerous examples of cutting- edge applications of reverse genetics within each of the RNA viral groups. Written by a team of international experts, including some of the leading researchers in the field.
Christon Hurst J. Studies in Viral Ecology. Microbial and Botanical Host Systems Christon Hurst J. Studies in Viral Ecology. Microbial and Botanical Host Systems Новинка

Christon Hurst J. Studies in Viral Ecology. Microbial and Botanical Host Systems

12802.64 руб. или Купить в рассрочку!
This book explains the ecology of viruses by examining their interactive dynamics with their hosting species (in this volume, in microbes and plants), including the types of transmission cycles that viruses have evolved encompassing principal and alternate hosts, vehicles, and vectoring species. Examining virology from an organismal biology approach and focusing on the concept that viral infections represent areas of overlap in the ecologies of the involved species, Viral Ecology is essential for students and professionals who either may be non-virologists or virologists whose previous familiarity has been very specialized.
Christon Hurst J. Studies in Viral Ecology. Microbial and Botanical Host Systems Christon Hurst J. Studies in Viral Ecology. Microbial and Botanical Host Systems Новинка

Christon Hurst J. Studies in Viral Ecology. Microbial and Botanical Host Systems

12537.24 руб. или Купить в рассрочку!
This book explains the ecology of viruses by examining their interactive dynamics with their hosting species (in this volume, in microbes and plants), including the types of transmission cycles that viruses have evolved encompassing principal and alternate hosts, vehicles, and vectoring species. Examining virology from an organismal biology approach and focusing on the concept that viral infections represent areas of overlap in the ecologies of the involved species, Viral Ecology is essential for students and professionals who either may be non-virologists or virologists whose previous familiarity has been very specialized.
Finizia Auriemma Crystals and Crystallinity in Polymers. Diffraction Analysis of Ordered and Disordered Crystals Finizia Auriemma Crystals and Crystallinity in Polymers. Diffraction Analysis of Ordered and Disordered Crystals Новинка

Finizia Auriemma Crystals and Crystallinity in Polymers. Diffraction Analysis of Ordered and Disordered Crystals

12161.54 руб. или Купить в рассрочку!
Provides the tools needed to master and apply the fundamentals of polymer crystallography Using core concepts in physics, chemistry, polymer science and engineering, this book sheds new light on the complex field of polymer crystallography, enabling readers to evaluate polymer crystallization data and determine the best methods to use for their investigations. The authors set forth a variety of tested and proven methods for analyzing ordered and disordered structures in polymer crystals, including X-ray diffraction, electron diffraction, and microscopy. In addition to the basics, the book explores several advanced and emerging topics in the field such as symmetry breaking, frustration, and the principle of density-driven phase formation. Crystals and Crystallinity in Polymers introduces two new concepts in crystallinity and crystals in synthetic polymers. First, crystallinity in polymeric materials is compatible with the absence of true three-dimensional long-range order. Second, the disorder may be described as a structural feature, using the methods of X-ray scattering and electron diffraction analysis. The book begins by introducing the basic principles and methods for building structural models for the conformation of polymer crystal chains. Next, it covers: Packing of macromolecules in polymer crystals Methods for extracting structural parameters from diffraction data Defects and disorder in polymer crystals Analytical methods for diffuse scattering from disordered polymer structures Crystal habit Influence of crystal defects and structural disorder on the physical and mechanical properties of polymeric materials Crystals and Crystallinity in Polymers examines all the possible types of structural disorder generally present in polymer crystals and describes the influence of each kind of disorder on X-ray and electron diffraction patterns. Its comprehensive, expert coverage makes it possible for readers to learn and apply the fundamentals of polymer crystallography to solve a broad range of problems.
Andrew Easton J. Introduction to Modern Virology Andrew Easton J. Introduction to Modern Virology Новинка

Andrew Easton J. Introduction to Modern Virology

6076.08 руб. или Купить в рассрочку!
Praised forits clarity of presentation and accessibility, Introduction to Modern Virology has been a successful student text for over 30 years. It provides a broad introduction to virology, which includes the nature of viruses, the interaction of viruses with their hosts and the consequences of those interactions that lead to the diseases we see. This new edition contains a number of important changes and innovations including: The consideration of immunology now covers two chapters, one on innate immunity and the other on adaptive immunity, reflecting the explosion in knowledge of viral interactions with these systems. The coverage of vaccines and antivirals has been expanded and separated into two new chapters to reflect the importance of these approaches to prevention and treatment. Virus infections in humans are considered in more detail with new chapters on viral hepatitis, influenza, vector-borne diseases, and exotic and emerging viral infections, complementing an updated chapter on HIV. The final section includes three new chapters on the broader aspects of the influence of viruses on our lives, focussing on the economic impact of virus infections, the ways we can use viruses in clinical and other spheres, and the impact that viruses have on the planet and almost every aspect of our lives. A good basic understanding of viruses is important for generalists and specialists alike. The aim of this book is to make such understanding as accessible as possible, allowing students across the biosciences spectrum to improve their knowledge of these fascinating entities.
David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications Новинка

David Weis D. Hydrogen Exchange Mass Spectrometry of Proteins. Fundamentals, Methods, and Applications

9500.64 руб. или Купить в рассрочку!
Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been around for 25 years, this is the first definitive book devoted entirely to the topic. Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications brings into one comprehensive volume the theory, instrumentation and applications of Hydrogen Exchange Mass Spectrometry (HX-MS) – a technique relevant to bioanalytical chemistry, protein science and pharmaceuticals. The book provides a solid foundation in the basics of the technique and data interpretation to inform readers of current research in the method, and provides illustrative examples of its use in bio- and pharmaceutical chemistry and biophysics In-depth chapters on the fundamental theory of hydrogen exchange, and tutorial chapters on measurement and data analysis provide the essential background for those ready to adopt HX-MS. Expert users may advance their current understanding through chapters on methods including membrane protein analysis, alternative proteases, millisecond hydrogen exchange, top-down mass spectrometry, histidine exchange and method validation. All readers can explore the diversity of HX-MS applications in areas such as ligand binding, membrane proteins, drug discovery, therapeutic protein formulation, biocomparability, and intrinsically disordered proteins.
Jeang Kuan-Teh Viral Oncology. Basic Science and Clinical Applications Jeang Kuan-Teh Viral Oncology. Basic Science and Clinical Applications Новинка

Jeang Kuan-Teh Viral Oncology. Basic Science and Clinical Applications

14820.64 руб. или Купить в рассрочку!
A comprehensive look at the latest research findings and clinical applications of oncogenic viruses Written by a panel of academic experts, Viral Oncology is the first self-contained and comprehensive book to present both scientific and clinical information on viruses linked to some of the most important human cancers. Readers can turn to this book for the most in-depth and up-to-date coverage of: HPV-associated cancers; molecular events associated with HPV-induced human cancer; the role of the HPV E6 oncoprotein in malignant progression; virus association with brain tumors; involvement of the polyomavirus JCV in colorectal cancer; possibleassociation of BKV with prostate cancer; oncogenic transformation bypolyomavirus large T antigen; SV40 and human cancer; SV40 and mesothelioma; molecular immunology of hepatitis B–associated viral cancer; hepatitis B vaccine and hepatocellular carcinoma; pathogenesis of acute and chronic hepatitis Cvirus infection; molecular mechanisms of hepatitis C virus-induced cellulartransformation; clinical aspects of HTLV-1 associated cancer; oncogenic potential of the HTLV-1 tax protein; HIV-associated malignancy; HIV-related lymphoma; biology and epidemiology of HHV-8; the role of KSHV in pathogenesis of Kaposi'ssarcoma; molecular pathobiology of EBV infection; and EBV as a pathogen. Several chapters are devoted to the basic science of oncogenic viruses for thestudy of their pathogenesis, drug development, and employment of viral vectorsfor vaccine and gene therapy. The book also includes complementary clinically based chapters describing natural courses and treatments. Additionally, bonusclinical materials are embedded within chapters and an easy-to-use indexcompletes the book. Viral Oncology is an essential resource for clinical and research oncologists in medical facilities and biological research laboratories; clinicians and scientists working in related biomedical areas; medical students working toward a first or higher degree in the life sciences and other biomedical fields; and pharmaceutical scientists and developers.
Eveline Litscher S. A Guide to Zona Pellucida Domain Proteins Eveline Litscher S. A Guide to Zona Pellucida Domain Proteins Новинка

Eveline Litscher S. A Guide to Zona Pellucida Domain Proteins

12917.98 руб. или Купить в рассрочку!
This book provides a coherent, clear, and uniform presentation of structural, genetic, molecular, and biochemical information available for the zona pellucida domain protein family, which impact pathologies such as infertility, deafness, and cancer. Furthermore it: Details information about the structure and function of the ZP domain in ZPDC-proteins Provides illustrations of the organization of ZPDC-proteins, the genes that encode the proteins, and examples of mutations in the ZP domain that cause diseases Speculates as to the evolution of the ZP domain and potential therapeutics for diseases stemming from ZP domain mutations Addresses mammalian and non-mammalian systems
Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors Новинка

Mien-Chie Hung Cancer Gene Therapy by Viral and Non-viral Vectors

11777.18 руб. или Купить в рассрочку!
Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy of Cancer • Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in Gene Therapy • Remaining Obstacles to the Success of Cancer Gene Therapy Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.
Gerd Folkers Transporters as Drug Targets Gerd Folkers Transporters as Drug Targets Новинка

Gerd Folkers Transporters as Drug Targets

15581.05 руб. или Купить в рассрочку!
As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.
Zeynep Ustunol Applied Food Protein Chemistry Zeynep Ustunol Applied Food Protein Chemistry Новинка

Zeynep Ustunol Applied Food Protein Chemistry

15653.88 руб. или Купить в рассрочку!
Food proteins are of great interest, not only because of their nutritional importance and their functionality in foods, but also for their detrimental effects. Although proteins from milk, meats (including fish and poultry), eggs, cereals, legumes, and oilseeds have been the traditional sources of protein in the human diet, potentially any proteins from a biological source could serve as a food protein. The primary role of protein in the diet is to provide the building materials for the synthesis of muscle and other tissues, and they play a critical role in many biological processes. They are also responsible for food texture, color, and flavor. Today, food proteins are extracted, modified, and incorporated into processed foods to impart specific functional properties. They can also have adverse effects in the diet: proteins, such as walnuts, pecans, almonds, and cashews, soybean, wheat, milk, egg, crustacean, and fish proteins can be powerful allergens for some people. Applied Food Protein Chemistry is an applied reference which reviews the properties of food proteins and provides in-depth information on important plant and animal proteins consumed around the world. The book is grouped into three sections: (1) overview of food proteins, (2) plant proteins, and (3) animal proteins. Each chapter discusses world production, distribution, utilization, physicochemical properties, and the functional properties of each protein, as well as its food applications. The authors for each of the chapters are carefully selected experts in the field. This book will be a valuable reference tool for those who work on food proteins. It will also be an important text on applied food protein chemistry for upper-level students and graduate students of food science programs.
Se-Kwon Kim Marine Proteins and Peptides. Biological Activities and Applications Se-Kwon Kim Marine Proteins and Peptides. Biological Activities and Applications Новинка

Se-Kwon Kim Marine Proteins and Peptides. Biological Activities and Applications

20214.18 руб. или Купить в рассрочку!
Food proteins and bioactive peptides play a vital role in the growth and development of the body’s structural integrity and regulation, as well as having a variety of other functional properties. Land animal-derived food proteins such as collagen and gelatine carry risks of contamination (such as BSE). Marine-derived proteins, which can provide equivalents to collagen and gelatin without the associated risks, are becoming more popular among consumers because of their numerous health beneficial effects. Most marine-derived bioactive peptides are currently underutilized. While fish and shellfish are perhaps the most obvious sources of such proteins and peptides, there is also the potential for further development of proteins and peptides from sources like algae, sea cucumber and molluscs. Marine-derived proteins and peptides also have potential uses in novel products, with the possibility of wide commercialization in the food, beverage, pharmaceutical and cosmetic industries, as well as in other fields such as photography, textiles, leather, electronics, medicine and biotechnology. Marine Proteins and Peptides: Biological Activities and Applications presents an overview of the current status, future industrial perspectives and commercial trends of bioactive marine-derived proteins and peptides. Many of the industrial perspectives are drawn from the food industry, but the book also refers to the pharmaceutical and cosmetics industries. There have recently been significant advances in isolating functional ingredients from marine bio-resources and seafood by-products for use in these industries, but little has been published, creating a knowledge gap, particularly with regard to the isolation and purification processes. This book is the first to fill that gap. Marine Proteins and Peptides: Biological Activities and Applications is a valuable resource for researchers in marine biochemistry field as well as food industry managers interested in exploring novel techniques and knowledge on alternative food protein sources. It will become a standard reference book for researchers involved in developing marine bio-resources and seafood by-products for novel nutraceutical, cosmetics, and pharmaceutical applications. It will also appeal to managers and product developers in the food, pharmaceutical and cosmetics industries, particularly those looking to use marine-derived proteins and peptides as substitutes or replacements for unfashionable or outdated food components.
Joseph Bertolini Production of Plasma Proteins for Therapeutic Use Joseph Bertolini Production of Plasma Proteins for Therapeutic Use Новинка

Joseph Bertolini Production of Plasma Proteins for Therapeutic Use

12541.56 руб. или Купить в рассрочку!
Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.
Uversky Vladimir Protein and Peptide Folding, Misfolding, and Non-Folding Uversky Vladimir Protein and Peptide Folding, Misfolding, and Non-Folding Новинка

Uversky Vladimir Protein and Peptide Folding, Misfolding, and Non-Folding

12802.64 руб. или Купить в рассрочку!
Sheds new light on intrinsically disordered proteins and peptides, including their role in neurodegenerative diseases With the discovery of intrinsically disordered proteins and peptides (IDPs), researchers realized that proteins do not necessarily adopt a well defined secondary and tertiary structure in order to perform biological functions. In fact, IDPs play biologically relevant roles, acting as inhibitors, scavengers, and even facilitating DNA/RNA-protein interactions. Due to their propensity for self-aggregation and fibril formation, some IDPs are involved in neurodegenerative diseases such as Parkinson's and Alzheimer's. With contributions from leading researchers, this text reviews the most recent studies, encapsulating our understanding of IDPs. The authors explain how the growing body of IDP research is building our knowledge of the folding process, the binding of ligands to receptor molecules, and peptide self-aggregation. Readers will discover a variety of experimental, theoretical, and computational approaches used to better understand the properties and function of IDPs. Moreover, they'll discover the role of IDPs in human disease and as drug targets. Protein and Peptide Folding, Misfolding, and Non-Folding begins with an introduction that explains why research on IDPs has significantly expanded in the past few years. Next, the book is divided into three sections: Conformational Analysis of Unfolded States Disordered Peptides and Molecular Recognition Aggregation of Disordered Peptides Throughout the book, detailed figures help readers understand the structure, properties, and function of IDPs. References at the end of each chapter serve as a gateway to the growing body of literature in the field. With the publication of Protein and Peptide Folding, Misfolding, and Non-Folding, researchers now have a single place to discover IDPs, their diverse biological functions, and the many disciplines that have contributed to our evolving understanding of them.
Foster Graham Clinical Dilemmas in Viral Liver Disease Foster Graham Clinical Dilemmas in Viral Liver Disease Новинка

Foster Graham Clinical Dilemmas in Viral Liver Disease

Clinical Dilemmas in Viral Liver Disease is a practical up-to-date handbook providing answers to the questions and challenges that arise in day-to-day practice. Each short chapter addresses a different topic and provides evidence-based guidance on subjects ranging from optimizing current management through to special management problems and novel treatments. This book is suitable for all medical professionals involved in the care of patients with viral liver disease: established and trainee hepatologists, pediatric hepatologists, pathologists, radiologists, transplant surgeons and nurse specialists
Lubchenko Vassiliy Structural Glasses and Supercooled Liquids. Theory, Experiment, and Applications Lubchenko Vassiliy Structural Glasses and Supercooled Liquids. Theory, Experiment, and Applications Новинка

Lubchenko Vassiliy Structural Glasses and Supercooled Liquids. Theory, Experiment, and Applications

12107.98 руб. или Купить в рассрочку!
With contributions from 24 global experts in diverse fields, and edited by world-recognized leaders in physical chemistry, chemical physics and biophysics, Structural Glasses and Supercooled Liquids: Theory, Experiment, and Applications presents a modern, complete survey of glassy phenomena in many systems based on firmly established characteristics of the underlying molecular motions as deduced by first principle theoretical calculations, or with direct/single-molecule experimental techniques. A well-rounded view of a variety of disordered systems where cooperative phenomena, which are epitomized by supercooled liquids, take place is provided. These systems include structural glasses and supercooled liquids, polymers, complex liquids, protein conformational dynamics, and strongly interacting electron systems with quenched/self-generated disorder. Detailed calculations and reasoned arguments closely corresponding with experimental data are included, making the book accessible to an educated non-expert reader.
Piorkowska Ewa Handbook of Polymer Crystallization Piorkowska Ewa Handbook of Polymer Crystallization Новинка

Piorkowska Ewa Handbook of Polymer Crystallization

16062.48 руб. или Купить в рассрочку!
Polymeric crystals are more complex in nature than other materials' crystal structures due to significant structural disorder present. The only comprehensive reference on polymer crystallization, Handbook of Polymer Crystallization provides readers with a broad, in-depth guide on the subject, covering the numerous problems encountered during crystallization as well as solutions to resolve those problems to achieve the desired result. Edited by leading authorities in the field, topics explored include neat polymers, heterogeneous systems, polymer blends, polymer composites orientation induced crystallization, crystallization in nanocomposites, and crystallization in complex thermal processing conditions.
R.W. Fairbrother Handbook of Filterable Viruses R.W. Fairbrother Handbook of Filterable Viruses Новинка

R.W. Fairbrother Handbook of Filterable Viruses

Handbook of Filterable Viruses present a general survey of the filterable viruses, particularly those causing disease in man. This book is composed of eight chapters, and begins with an overview of the history and research works on filterable viruses. The next chapters describe the nature, cultivation, and methods of analysis of these viruses, as well as the epidemiology, immunity, and classification of infectious diseases caused by them. The remaining chapters explore the numerous diseases considered to be caused by filterable viruses. This book will prove useful to biochemists, bacteriologists, researchers, and students, as well as the general readers who are interested in disease-causing viruses.Издательство - William Heinemann
Lian Lu-Yun Protein NMR Spectroscopy. Practical Techniques and Applications Lian Lu-Yun Protein NMR Spectroscopy. Practical Techniques and Applications Новинка

Lian Lu-Yun Protein NMR Spectroscopy. Practical Techniques and Applications

9934.76 руб. или Купить в рассрочку!
Nuclear Magnetic Resonance (NMR) spectroscopy, a physical phenomenon based upon the magnetic properties of certain atomic nuclei, has found a wide range of applications in life sciences over recent decades. The dramatic advances in NMR techniques have led to corresponding advances in the ability of NMR to study structure, dynamics and interactions of biological macromolecules in solution under close to physiological conditions. This volume focuses on the use of NMR to study proteins. NMR can be used to determine detailed three-dimensional structures of proteins in solution. Furthermore, it provides information about conformational or chemical exchange, internal mobility and dynamics at timescales varying from pcoseconds to seconds. It is the primary technique used to obtain information on intrinsically disordered (unfolded) proteins, since these proteins will not crystallize easily. NMR is also a very powerful method for the study of interactions of protein with other molecules, whether small molecules (including drugs), nuclear acids or other proteins. This up-to-date volume covers NMR techiniques and their application to proteins, with a focus on practical details. This book will provide a newcomer to NMR with the practical guidance in order to carry out successful experiments with proteins and to analyze the resulting spectra. Those who are familiar with the chemical applications of NMR will also find is useful in understanding the special requirements of protien NMR.
Rao G. V. Elements of Structural Dynamics. A New Perspective Rao G. V. Elements of Structural Dynamics. A New Perspective Новинка

Rao G. V. Elements of Structural Dynamics. A New Perspective

9934.76 руб. или Купить в рассрочку!
Structural dynamics is a subset of structural analysis which covers the behavior of structures subjected to dynamic loading. The subject has seen rapid growth and also change in how the basic concepts can be interpreted. For instance, the classical notions of discretizing the operator of a dynamic structural model have given way to a set-theoretic, function-space based framework, which is more conducive to implementation with a computer. This modern perspective, as adopted in this book, is also helpful in putting together the various tools and ideas in a more integrated style. Elements of Structural Dynamics: A New Perspective is devoted to covering the basic concepts in linear structural dynamics, whilst emphasizing their mathematical moorings and the associated computational aspects that make their implementation in software possible. Key features: Employs a novel ‘top down’ approach to structural dynamics. Contains an insightful treatment of the computational aspects, including the finite element method, that translate into numerical solutions of the dynamic equations of motion. Consistently touches upon the modern mathematical basis for the theories and approximations involved. Elements of Structural Dynamics: A New Perspective is a holistic treatise on structural dynamics and is an ideal textbook for senior undergraduate and graduate students in Mechanical, Aerospace and Civil engineering departments. This book also forms a useful reference for researchers and engineers in industry.
Buchanan Andrew H. Structural Design for Fire Safety Buchanan Andrew H. Structural Design for Fire Safety Новинка

Buchanan Andrew H. Structural Design for Fire Safety

4776.64 руб. или Купить в рассрочку!
Structural Design for Fire Safety, 2nd edition Andrew H. Buchanan, University of Canterbury, New Zealand Anthony K. Abu, University of Canterbury, New Zealand A practical and informative guide to structural fire engineering This book presents a comprehensive overview of structural fire engineering. An update on the first edition, the book describes new developments in the past ten years, including advanced calculation methods and computer programs. Further additions include: calculation methods for membrane action in floor slabs exposed to fires; a chapter on composite steel-concrete construction; and case studies of structural collapses. The book begins with an introduction to fire safety in buildings, from fire growth and development to the devastating effects of severe fires on large building structures. Methods of calculating fire severity and fire resistance are then described in detail, together with both simple and advanced methods for assessing and designing for structural fire safety in buildings constructed from structural steel, reinforced concrete, or structural timber. Structural Design for Fire Safety, 2nd edition bridges the information gap between fire safety engineers, structural engineers and building officials, and it will be useful for many others including architects, code writers, building designers, and firefighters. Key features: • Updated references to current research, as well as new end-of-chapter questions and worked examples. •Authors experienced in teaching, researching, and applying structural fire engineering in real buildings. • A focus on basic principles rather than specific building code requirements, for an international audience. An essential guide for structural engineers who wish to improve their understanding of buildings exposed to severe fires and an ideal textbook for introductory or advanced courses in structural fire engineering.
Brian Henderson Moonlighting Proteins. Novel Virulence Factors in Bacterial Infections Brian Henderson Moonlighting Proteins. Novel Virulence Factors in Bacterial Infections Новинка

Brian Henderson Moonlighting Proteins. Novel Virulence Factors in Bacterial Infections

12917.98 руб. или Купить в рассрочку!
Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science. About the Editor Brian Henderson, Division of Infection and Immunity, University College London, London, UK
Piñeiro Ángel Proteins in Solution and at Interfaces. Methods and Applications in Biotechnology and Materials Science Piñeiro Ángel Proteins in Solution and at Interfaces. Methods and Applications in Biotechnology and Materials Science Новинка

Piñeiro Ángel Proteins in Solution and at Interfaces. Methods and Applications in Biotechnology and Materials Science

16113.23 руб. или Купить в рассрочку!
Explores new applications emerging from our latest understanding of proteins in solution and at interfaces Proteins in solution and at interfaces increasingly serve as the starting point for exciting new applications, from biomimetic materials to nanoparticle patterning. This book surveys the state of the science in the field, offering investigators a current understanding of the characteristics of proteins in solution and at interfaces as well as the techniques used to study these characteristics. Moreover, the authors explore many of the new and emerging applications that have resulted from the most recent studies. Topics include protein and protein aggregate structure; computational and experimental techniques to study protein structure, aggregation, and adsorption; proteins in non-standard conditions; and applications in biotechnology. Proteins in Solution and at Interfaces is divided into two parts: Part One introduces concepts as well as theoretical and experimental techniques that are used to study protein systems, including X-ray crystallography, nuclear magnetic resonance, small angle scattering, and spectroscopic methods Part Two examines current and emerging applications, including nanomaterials, natural fibrous proteins, and biomolecular thermodynamics The book's twenty-three chapters have been contributed by leading experts in the field. These contributions are based on a thorough review of the latest peer-reviewed findings as well as the authors' own research experience. Chapters begin with a discussion of core concepts and then gradually build in complexity, concluding with a forecast of future developments. Readers will not only gain a current understanding of proteins in solution and at interfaces, but also will discover how theoretical and technical developments in the field can be translated into new applications in material design, genetic engineering, personalized medicine, drug delivery, biosensors, and biotechnology.
Peter Privalov L. Microcalorimetry of Macromolecules. The Physical Basis of Biological Structures Peter Privalov L. Microcalorimetry of Macromolecules. The Physical Basis of Biological Structures Новинка

Peter Privalov L. Microcalorimetry of Macromolecules. The Physical Basis of Biological Structures

12026.49 руб. или Купить в рассрочку!
Examining the physical basis of the structure of macromolecules—proteins, nucleic acids, and their complexes—using calorimetric techniques Many scientists working in biology are unfamiliar with the basics of thermodynamics and its role in determining molecular structures. Yet measuring the heat of structural change a molecule undergoes under various conditions yields information on the energies involved and, thus, on the physical bases of the considered structures. Microcalorimetry of Macromolecules offers protein scientists unique access to this important information. Divided into thirteen chapters, the book introduces readers to the basics of thermodynamics as it applies to calorimetry, the evolution of the calorimetric technique, as well as how calorimetric techniques are used in the thermodynamic studies of macromolecules, detailing instruments for measuring the heat effects of various processes. Also provided is general information on the structure of biological macromolecules, proteins, and nucleic acids, focusing on the key thermodynamic problems relating to their structure. The book covers: The use of supersensitive calorimetric instruments, including micro and nano-calorimeters for measuring the heat of isothermal reactions (Isothermal Titration Nano-Calorimeter), the heat capacities over a broad temperature range (Scanning Nano-Calorimeter), and pressure effects (Pressure Perturbation Nano-Calorimeter) Two of the simplest but key structural elements: the α and polyproline helices and their complexes, the α-helical coiled-coil, and the pyroline coiled-coils Complicated macromolecular formations, including small globular proteins, multidomain proteins and their complexes, and nucleic acids Numerous examples of measuring the ground state of protein energetics, as well as changes seen when proteins interact The book also reveals how intertwined structure and thermodynamics are in terms of a macromolecule's organization, mechanism of formation, the stabilization of its three-dimensional structure, and ultimately, its function. The first book to describe microcalorimetric technique in detail, enough for graduate students and research scientists to successfully plumb the structural mysteries of proteins and the double helix, Microcalorimetry of Macromolecules is an essential introduction to using a microcalorimeter in biological studies.
Stefan Schmidt R. Fusion Protein Technologies for Biopharmaceuticals. Applications and Challenges Stefan Schmidt R. Fusion Protein Technologies for Biopharmaceuticals. Applications and Challenges Новинка

Stefan Schmidt R. Fusion Protein Technologies for Biopharmaceuticals. Applications and Challenges

15728.87 руб. или Купить в рассрочку!
The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.
Binghe Wang Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications Binghe Wang Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications Новинка

Binghe Wang Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications

18773.4 руб. или Купить в рассрочку!
Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as: Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions Cross reactivity of zinc-enzyme inhibitors and activators The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins Clinical applications An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.
Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications Новинка

Joaquim Ros Protein Carbonylation. Principles, Analysis, and Biological Implications

13300.89 руб. или Купить в рассрочку!
Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur. The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed. Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways
Birendra Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery Birendra Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery Новинка

Birendra Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery

11856.51 руб. или Купить в рассрочку!
The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.
Peter Gregory H. Computer Viruses For Dummies Peter Gregory H. Computer Viruses For Dummies Новинка

Peter Gregory H. Computer Viruses For Dummies

1163.58 руб. или Купить в рассрочку!
Computer viruses—just the thought of your trusty PC catching one is probably enough to make you sick. Thanks to the cyber-sickies who persist in coming up with new strains, there’s a major new cyberattack nearly every day. Viruses sneak in, usually through e-mail. Fortunately, there are ways to inoculate and protect your computer. Computer Viruses For Dummies helps you: Understand the risks and analyze your PC’s current condition Select, install, and configure antivirus software Scan your computer and e-mail Rid your computer of viruses it’s already caught Update antivirus software and install security patches Use firewalls and spyware blockers Protect handheld PDAs from viruses Adopt safe computing practices, especially with e-mail and when you’re surfing the Net Written by Peter H. Gregory, coauthor of CISSP For Dummies and Security + For Dummies, Computer Viruses For Dummies goes beyond viruses to explain other nasty computer infections like Trojan horses, HiJackers, worms, phishing scams, spyware, and hoaxes. It also profiles major antivirus software to help you choose the best program(s) for your needs. Remember, if you don’t protect your computer, not only do you risk having your computer infiltrated and your data contaminated, you risk unknowingly transmitting a virus, worm, or other foul computer germ to everybody in your address book! This guide will help you properly immunize your PC with antivirus software now and install updates and security patches that are like booster shots to keep your software protected against new viruses.
Anna Lok S.F. Viral Hepatitis Anna Lok S.F. Viral Hepatitis Новинка

Anna Lok S.F. Viral Hepatitis

22270.07 руб. или Купить в рассрочку!
The 4th edition of Viral Hepatitis covers comprehensively the entire complex field of infections caused by all of the different hepatitis viruses, which affect many millions of people throughout the world with considerable morbidity and mortality. Howard Thomas and Arie Zuckerman are joined by Anna Lok from the USA and Stephen Locarnini from Australia as Editors. They have recruited leading researchers and physicians from many countries, who have produced an authoritative account of current knowledge and research on this important infection, including new insights into immune response to HBV and HCV. The result is a comprehensive account on all aspects of viral hepatitis, including rapid advances in the diagnosis, management, treatment and prevention of a complex infection, which in the case of hepatitis B, C and D may lead to severe complications including chronic hepatitis, cirrhosis and hepatocellular carcinoma. The latest edition of Viral Hepatitis offers an essential resource of current information for hepatologists, gastroenterologists, infectious diseases specialists and other clinicians, researchers, public health physicians and National and International Health Authorities.
Norbert Mitzel Structural Methods in Molecular Inorganic Chemistry Norbert Mitzel Structural Methods in Molecular Inorganic Chemistry Новинка

Norbert Mitzel Structural Methods in Molecular Inorganic Chemistry

14516.69 руб. или Купить в рассрочку!
Determining the structure of molecules is a fundamental skill that all chemists must learn. Structural Methods in Molecular Inorganic Chemistry is designed to help readers interpret experimental data, understand the material published in modern journals of inorganic chemistry, and make decisions about what techniques will be the most useful in solving particular structural problems. Following a general introduction to the tools and concepts in structural chemistry, the following topics are covered in detail: • computational chemistry • nuclear magnetic resonance spectroscopy • electron paramagnetic resonance spectroscopy • Mössbauer spectroscopy • rotational spectra and rotational structure • vibrational spectroscopy • electronic characterization techniques • diffraction methods • mass spectrometry The final chapter presents a series of case histories, illustrating how chemists have applied a broad range of structural techniques to interpret and understand chemical systems. Throughout the textbook a strong connection is made between theoretical topics and the real world of practicing chemists. Each chapter concludes with problems and discussion questions, and a supporting website contains additional advanced material. Structural Methods in Molecular Inorganic Chemistry is an extensive update and sequel to the successful textbook Structural Methods in Inorganic Chemistry by Ebsworth, Rankin and Cradock. It is essential reading for all advanced students of chemistry, and a handy reference source for the professional chemist.
Kretsinger Robert H. Calcium Binding Proteins Kretsinger Robert H. Calcium Binding Proteins Новинка

Kretsinger Robert H. Calcium Binding Proteins

14125.98 руб. или Купить в рассрочку!
Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography. The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins. It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.
Vladimir Uversky Protein Oxidation and Aging Vladimir Uversky Protein Oxidation and Aging Новинка

Vladimir Uversky Protein Oxidation and Aging

12537.24 руб. или Купить в рассрочку!
Reviews our current understanding of the role of protein oxidation in aging and age-related diseases Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging. Protein Oxidation and Aging begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers: Major aspects of the protein oxidation process Cellular mechanisms for managing oxidized proteins Role of protein oxidation in aging Influence of genetic and environmental factors on protein oxidation Measuring protein oxidation in the aging process Protein oxidation in age-related diseases References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.
Joseph Stephanos J. Chemistry of Metalloproteins. Problems and Solutions in Bioinorganic Chemistry Joseph Stephanos J. Chemistry of Metalloproteins. Problems and Solutions in Bioinorganic Chemistry Новинка

Joseph Stephanos J. Chemistry of Metalloproteins. Problems and Solutions in Bioinorganic Chemistry

9804.95 руб. или Купить в рассрочку!
Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.
W. Craighead Edward Psychopathology. History, Diagnosis, and Empirical Foundations W. Craighead Edward Psychopathology. History, Diagnosis, and Empirical Foundations Новинка

W. Craighead Edward Psychopathology. History, Diagnosis, and Empirical Foundations

7600.51 руб. или Купить в рассрочку!
Fully revised to incorporate DSM-5 criteria and informed by the most current research in its discussions of diagnosis and treatment Now in a second edition, Psychopathology: History, Diagnosis, and Empirical Foundations thoroughly explores psychopathology with contributions from leading scholars in psycho-pathology. The Second Edition offers an overview of various topics in the context of major changes included in the DSM-5. With new chapters on contextual factors affecting diagnoses and non-alcohol substance abuse, Psychopathology, Second Edition covers the history, theory, and assessment of anxiety disorders, posttraumatic stress disorder, mood disorders, schizophrenia, the psychotic spectrum disorders, eating disorders, borderline personality disorder, alcohol use disorders, psychopathy, sexual dysfunction, and sleep disorders. In addition, each chapter of the Second Edition contains: A description of the disorder, including brief history, case example, and epidemiological findings Empirical foundations of each disorder, including findings regarding neurobiological, behavioral, cognitive, and emotional factors Assessment of each disorder, including interviews, self-reports, neurobiological assessment, and clinical rating scales Brief description and evaluation of the current interventions for each disorder Summary and future directions Practical and thorough, this text is an essential reference for all mental health professionals and a solid introduction for students in psychopathology courses.
Honghui Zhou ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins. Applications in Drug Discovery and Development Honghui Zhou ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins. Applications in Drug Discovery and Development Новинка

Honghui Zhou ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins. Applications in Drug Discovery and Development

11400.76 руб. или Купить в рассрочку!
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
Lappi Douglas Ribosome-inactivating Proteins. Ricin and Related Proteins Lappi Douglas Ribosome-inactivating Proteins. Ricin and Related Proteins Новинка

Lappi Douglas Ribosome-inactivating Proteins. Ricin and Related Proteins

11250.33 руб. или Купить в рассрочку!
This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.
Worden Keith Structural Health Monitoring. A Machine Learning Perspective Worden Keith Structural Health Monitoring. A Machine Learning Perspective Новинка

Worden Keith Structural Health Monitoring. A Machine Learning Perspective

12414.56 руб. или Купить в рассрочку!
Written by global leaders and pioneers in the field, this book is a must-have read for researchers, practicing engineers and university faculty working in SHM. Structural Health Monitoring: A Machine Learning Perspective is the first comprehensive book on the general problem of structural health monitoring. The authors, renowned experts in the field, consider structural health monitoring in a new manner by casting the problem in the context of a machine learning/statistical pattern recognition paradigm, first explaining the paradigm in general terms then explaining the process in detail with further insight provided via numerical and experimental studies of laboratory test specimens and in-situ structures. This paradigm provides a comprehensive framework for developing SHM solutions. Structural Health Monitoring: A Machine Learning Perspective makes extensive use of the authors’ detailed surveys of the technical literature, the experience they have gained from teaching numerous courses on this subject, and the results of performing numerous analytical and experimental structural health monitoring studies. Considers structural health monitoring in a new manner by casting the problem in the context of a machine learning/statistical pattern recognition paradigm Emphasises an integrated approach to the development of structural health monitoring solutions by coupling the measurement hardware portion of the problem directly with the data interrogation algorithms Benefits from extensive use of the authors’ detailed surveys of 800 papers in the technical literature and the experience they have gained from teaching numerous short courses on this subject.
Melissa Kennedy Veterinary Microbiology Melissa Kennedy Veterinary Microbiology Новинка

Melissa Kennedy Veterinary Microbiology

8056.25 руб. или Купить в рассрочку!
Veterinary Microbiology, Third Edition is a comprehensive reference on the bacterial, fungal, and viral pathogenic agents that cause animal disease. Now in full color with improved images throughout, the new edition has been thoroughly updated to reflect information from current research and diagnostic and clinical publications. Key changes include a review of microbial cell structure and function and increased emphasis on the key points of pathogenesis and host responses to infection. Organized into four sections, the Third Edition begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral diseases and viruses. The final section presents a systematic approach of describing infection and disease of animals. Equally useful for beginning veterinary students and seasoned practitioners, Veterinary Microbiology offers a thorough introduction and reference text for veterinary infectious disease.
Wendy Sandoval Analytical Characterization of Biotherapeutics Wendy Sandoval Analytical Characterization of Biotherapeutics Новинка

Wendy Sandoval Analytical Characterization of Biotherapeutics

14821.72 руб. или Купить в рассрочку!
The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.
Ronald Pethig R. Dielectrophoresis. Theory, Methodology and Biological Applications Ronald Pethig R. Dielectrophoresis. Theory, Methodology and Biological Applications Новинка

Ronald Pethig R. Dielectrophoresis. Theory, Methodology and Biological Applications

10640.71 руб. или Купить в рассрочку!
Comprehensive coverage of the basic theoretical concepts and applications of dielectrophoresis from a world-renowned expert. Features hot application topics including: Diagnostics, Cell-based Drug Discovery, Sensors for Biomedical Applications, Characterisation and Sorting of Stem Cells, Separation of Cancer Cells from Blood and Environmental Monitoring Focuses on those aspects of the theory and practice of dielectrophoresis concerned with characterizing and manipulating cells and other bioparticles such as bacteria, viruses, proteins and nucleic acids. Features the relevant chemical and biological concepts for those working in physics and engineering
Sean Garner M. Flexible Glass. Enabling Thin, Lightweight, and Flexible Electronics Sean Garner M. Flexible Glass. Enabling Thin, Lightweight, and Flexible Electronics Новинка

Sean Garner M. Flexible Glass. Enabling Thin, Lightweight, and Flexible Electronics

17101.87 руб. или Купить в рассрочку!
This book details flexible glass properties that enable use in emerging electronic and opto-electronic applications. Discussion includes flexible glass advantages compared to alternative substrate materials. Examples describe flexible glass in processes such as vacuum deposition, monolithic integration, printing, and roll-to-roll. Flexible glass demonstrations in emerging applications such as photovoltaics, flexible displays, and optical interconnects are also detailed. The reader will find in this unique book: Discussion of flexible glass processing and mechanical reliability. Demonstration of flexible glass in roll-to-roll (R2R) fabrication processes. Flexible glass substrate examples in displays, sensors, and photovoltaics. Flexible glass ecosystem description for identification of new applications.
J. Bremner Douglas Posttraumatic Stress Disorder. From Neurobiology to Treatment J. Bremner Douglas Posttraumatic Stress Disorder. From Neurobiology to Treatment Новинка

J. Bremner Douglas Posttraumatic Stress Disorder. From Neurobiology to Treatment

9877.06 руб. или Купить в рассрочку!
Posttraumatic Stress Disorder: From Neurobiology to Treatment presents a comprehensive look at this key neuropsychiatric disorder. The text examines the neurobiological basis of post-traumatic stress and how our understanding of the basic elements of the disease have informed and been translated into new and existing treatment options. The book begins with a section on animal models in posttraumatic stress disorder research, which has served as the basis of much of our neurobiological information. Chapters then delve into applications of the clinical neuroscience of posttraumatic stress disorder. The final part of the books explores treatments and how our basic and clinical research is now being converted into treatment. Taking a unique basic science to translational intervention approach, Posttraumatic Stress Disorder: From Neurobiology to Treatment is an invaluable resource for researchers, students and clinicians dealing with this complex disorder.
Emil Simiu Wind Effects on Structures. Modern Structural Design for Wind Emil Simiu Wind Effects on Structures. Modern Structural Design for Wind Новинка

Emil Simiu Wind Effects on Structures. Modern Structural Design for Wind

12573.68 руб. или Купить в рассрочку!
Provides structural engineers with the knowledge and practical tools needed to perform structural designs for wind that incorporate major technological, conceptual, analytical and computational advances achieved in the last two decades. With clear explanations and documentation of the concepts, methods, algorithms, and software available for accounting for wind loads in structural design, it also describes the wind engineer's contributions in sufficient detail that they can be effectively scrutinized by the structural engineer in charge of the design. Wind Effects on Structures: Modern Structural Design for Wind, 4th Edition is organized in four sections. The first covers atmospheric flows, extreme wind speeds, and bluff body aerodynamics. The second examines the design of buildings, and includes chapters on aerodynamic loads; dynamic and effective wind-induced loads; wind effects with specified MRIs; low-rise buildings; tall buildings; and more. The third part is devoted to aeroelastic effects, and covers both fundamentals and applications. The last part considers other structures and special topics such as trussed frameworks; offshore structures; and tornado effects. Offering readers the knowledge and practical tools needed to develop structural designs for wind loadings, this book: Points out significant limitations in the design of buildings based on such techniques as the high-frequency force balance Discusses powerful algorithms, tools, and software needed for the effective design for wind, and provides numerous examples of application Discusses techniques applicable to structures other than buildings, including stacks and suspended-span bridges Features several appendices on Elements of Probability and Statistics; Peaks-over-Threshold Poisson-Process Procedure for Estimating Peaks; estimates of the WTC Towers’ Response to Wind and their shortcomings; and more Wind Effects on Structures: Modern Structural Design for Wind, 4th Edition is an excellent text for structural engineers, wind engineers, and structural engineering students and faculty.
Konrad Bergmeister Beton-Kalender 2009. Schwerpunkte: Konstruktiver Hochbau - Aktuelle Massivbaunormen Konrad Bergmeister Beton-Kalender 2009. Schwerpunkte: Konstruktiver Hochbau - Aktuelle Massivbaunormen Новинка

Konrad Bergmeister Beton-Kalender 2009. Schwerpunkte: Konstruktiver Hochbau - Aktuelle Massivbaunormen

10941.42 руб. или Купить в рассрочку!
The main themes of this issue are the structural design of building frames and the current state of standards for mass wall structures around DIN 1045. Also in this year's issue: – structural design in existing buildings, – concrete as a building material.
Laura Smith L. Obsessive-Compulsive Disorder For Dummies Laura Smith L. Obsessive-Compulsive Disorder For Dummies Новинка

Laura Smith L. Obsessive-Compulsive Disorder For Dummies

1551.66 руб. или Купить в рассрочку!
Arguably one of the most complex emotional disorders, Obsessive Compulsive Disorder is surprisingly common. Furthermore, most people at some time in their lives exhibit a smattering of OCD-like symptoms. Obsessive Compulsive Disorder For Dummies sorts out the otherwise curious and confusing world of obsessive compulsive disorder. Engaging and comprehensive, it explains the causes of OCD and describes the rainbow of OCD symptoms. The book shows readers whether OCD symptoms represent normal and trivial concerns (for example, a neat freak) or something that should be checked out by a mental health professional (for example, needing to wash hands so often that they become raw and red). In easy to understand steps, the authors lay out the latest treatments that have been proven to work for this disorder, and provide practical and real tools for living well long-term. Whether you or someone you care about has this disorder, Obsessive Compulsive Disorder For Dummies gives you an empathic understanding of this fascinating yet treatable mental disorder.
Justin Weeks W. The Wiley Blackwell Handbook of Social Anxiety Disorder Justin Weeks W. The Wiley Blackwell Handbook of Social Anxiety Disorder Новинка

Justin Weeks W. The Wiley Blackwell Handbook of Social Anxiety Disorder

15131.1 руб. или Купить в рассрочку!
Featuring leading international authors working in clinical psychology and psychiatry, this handbook offer the most in-depth coverage of social anxiety disorder, including personality factors in SAD, and multicultural issues in the diagnosis, case conceptualization, and treatment of SAD. A multi-contributed, internationally diverse handbook covering all major elements of social anxiety disorder, offering an invaluable teaching tool This unique text contributes significantly to the field by summarizing the current state of research in the area and outlining future directions Provides a comprehensive overview of applied, empirically-supported techniques in the conceptualization, assessment, and treatment of SAD
Mike Cheung W.-L. Meta-Analysis. A Structural Equation Modeling Approach Mike Cheung W.-L. Meta-Analysis. A Structural Equation Modeling Approach Новинка

Mike Cheung W.-L. Meta-Analysis. A Structural Equation Modeling Approach

Presents a novel approach to conducting meta-analysis using structural equation modeling. Structural equation modeling (SEM) and meta-analysis are two powerful statistical methods in the educational, social, behavioral, and medical sciences. They are often treated as two unrelated topics in the literature. This book presents a unified framework on analyzing meta-analytic data within the SEM framework, and illustrates how to conduct meta-analysis using the metaSEM package in the R statistical environment. Meta-Analysis: A Structural Equation Modeling Approach begins by introducing the importance of SEM and meta-analysis in answering research questions. Key ideas in meta-analysis and SEM are briefly reviewed, and various meta-analytic models are then introduced and linked to the SEM framework. Fixed-, random-, and mixed-effects models in univariate and multivariate meta-analyses, three-level meta-analysis, and meta-analytic structural equation modeling, are introduced. Advanced topics, such as using restricted maximum likelihood estimation method and handling missing covariates, are also covered. Readers will learn a single framework to apply both meta-analysis and SEM. Examples in R and in Mplus are included. This book will be a valuable resource for statistical and academic researchers and graduate students carrying out meta-analyses, and will also be useful to researchers and statisticians using SEM in biostatistics. Basic knowledge of either SEM or meta-analysis will be helpful in understanding the materials in this book.
Mic Patterson Structural Glass Facades and Enclosures Mic Patterson Structural Glass Facades and Enclosures Новинка

Mic Patterson Structural Glass Facades and Enclosures

6985.38 руб. или Купить в рассрочку!
A COMPREHENSIVE GUIDE TO STRUCTURAL GLASS FACADES FOR ARCHITECTS, ENGINEERS, AND BUILDERS Once an experimental building form, structural glass facades have matured into a fully robust technology. Structural Glass Facades and Enclosures documents, defines, and categorizes the current state of the art in long-span glass facade design and construction, with a focus on structural systems, glass cladding options, and implementation strategies for innovative design. A comparative analysis of these various systems is included, along with designs and design practices for enhancing transparency; engineering issues; material, process, and fabrication considerations; installation means and methods; and project delivery strategies for implementing innovative building technology in today's construction marketplace. The reader will find information here that is not available together in any single resource, including: Structural system types and design options, with integrated glass system options and their application on each of the structural types An in-depth discussion of design, fabrication, and installation issues relative to each system type, accompanied by illustrations and photographs A discussion of the challenges of implementing innovative design and technology in the construction industry, and operational practices to improve the probability of success A series of in-depth case studies documenting representative samples of stunning built works that employ the technology and design principles identified in the book Structural Glass Facades and Enclosures provides expert content for putting cutting-edge technology into real-life practice, creating new potential for fresh applications embracing both aesthetic and performance solutions, and for the adoption of the technology by architects, builders, and facade practitioners.
Anne Robinson Skaja Production of Membrane Proteins. Strategies for Expression and Isolation Anne Robinson Skaja Production of Membrane Proteins. Strategies for Expression and Isolation Новинка

Anne Robinson Skaja Production of Membrane Proteins. Strategies for Expression and Isolation

2169.35 руб. или Купить в рассрочку!
Designed as a research-level guide to current strategies and methods of membrane protein production on the small to intermediate scale, this practice-oriented book provides detailed, step-by-step laboratory protocols as well as an explanation of the principles behind each method, together with a discussion of its relative advantages and disadvantages. Following an introductory section on current challenges in membrane protein production, the book goes on to look at expression systems, emerging methods and approaches, and protein specific considerations. Case studies illustrate how to select or sample the optimal production system for any desired membrane protein, saving both time and money on the laboratory as well as the technical production scale. Unique in its coverage of «difficult» proteins with large membrane-embedded domains, proteins from extremophiles, peripheral membrane proteins, and protein fragments.
Martin Schleef Minicircle and Miniplasmid DNA Vectors. The Future of Non-viral and Viral Gene Transfer Martin Schleef Minicircle and Miniplasmid DNA Vectors. The Future of Non-viral and Viral Gene Transfer Новинка

Martin Schleef Minicircle and Miniplasmid DNA Vectors. The Future of Non-viral and Viral Gene Transfer

11400.76 руб. или Купить в рассрочку!
This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the world's leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.
Brian Henderson Protein Moonlighting in Biology and Medicine Brian Henderson Protein Moonlighting in Biology and Medicine Новинка

Brian Henderson Protein Moonlighting in Biology and Medicine

12917.98 руб. или Купить в рассрочку!
The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.
Guido Sessa Molecular Plant Immunity Guido Sessa Molecular Plant Immunity Новинка

Guido Sessa Molecular Plant Immunity

12802.64 руб. или Купить в рассрочку!
Molecular Plant Immunity provides an integrated look at both well-established and emerging concepts in plant disease resistance providing the most current information on this important vitally important topic within plant biology. Understanding the molecular basis of the plant immune system has implications on the development of new varieties of sustainable crops, understanding the challenges plant life will face in changing environments, as well as providing a window into immune function that could have translational appeal to human medicine. Molecular Plant Immunity opens with chapters reviewing how the first line of plant immune response is activated followed by chapters looking at the molecular mechanisms that allow fungi, bacteria, and oomycetes to circumvent those defenses. Plant resistance proteins, which provide the second line of plant immune defense, are then covered followed by chapters on the role of hormones in immunity and the mechanisms that modulate specific interaction between plants and viruses. The final chapters look at model plant-pathogen systems to review interaction between plants and fungal, bacterial, and viral pathogens. Written by a leading team of international experts, Molecular Plant Immunity will provide a needed resource to diverse research community investigated plant immunity.
Raouf Ibrahim A. Handbook of Structural Life Assessment Raouf Ibrahim A. Handbook of Structural Life Assessment Новинка

Raouf Ibrahim A. Handbook of Structural Life Assessment

17595.83 руб. или Купить в рассрочку!
This important, self-contained reference deals with structural life assessment (SLA) and structural health monitoring (SHM) in a combined form. SLA periodically evaluates the state and condition of a structural system and provides recommendations for possible maintenance actions or the end of structural service life. It is a diversified field and relies on the theories of fracture mechanics, fatigue damage process, and reliability theory. For common structures, their life assessment is not only governed by the theory of fracture mechanics and fatigue damage process, but by other factors such as corrosion, grounding, and sudden collision. On the other hand, SHM deals with the detection, prediction, and location of crack development online. Both SLA and SHM are combined in a unified and coherent treatment.

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Food proteins and bioactive peptides play a vital role in the growth and development of the body’s structural integrity and regulation, as well as having a variety of other functional properties. Land animal-derived food proteins such as collagen and gelatine carry risks of contamination (such as BSE). Marine-derived proteins, which can provide equivalents to collagen and gelatin without the associated risks, are becoming more popular among consumers because of their numerous health beneficial effects. Most marine-derived bioactive peptides are currently underutilized. While fish and shellfish are perhaps the most obvious sources of such proteins and peptides, there is also the potential for further development of proteins and peptides from sources like algae, sea cucumber and molluscs. Marine-derived proteins and peptides also have potential uses in novel products, with the possibility of wide commercialization in the food, beverage, pharmaceutical and cosmetic industries, as well as in other fields such as photography, textiles, leather, electronics, medicine and biotechnology. Marine Proteins and Peptides: Biological Activities and Applications presents an overview of the current status, future industrial perspectives and commercial trends of bioactive marine-derived proteins and peptides. Many of the industrial perspectives are drawn from the food industry, but the book also refers to the pharmaceutical and cosmetics industries. There have recently been significant advances in isolating functional ingredients from marine bio-resources and seafood by-products for use in these industries, but little has been published, creating a knowledge gap, particularly with regard to the isolation and purification processes. This book is the first to fill that gap. Marine Proteins and Peptides: Biological Activities and Applications is a valuable resource for researchers in marine biochemistry field as well as food industry managers interested in exploring novel techniques and knowledge on alternative food protein sources. It will become a standard reference book for researchers involved in developing marine bio-resources and seafood by-products for novel nutraceutical, cosmetics, and pharmaceutical applications. It will also appeal to managers and product developers in the food, pharmaceutical and cosmetics industries, particularly those looking to use marine-derived proteins and peptides as substitutes or replacements for unfashionable or outdated food components.
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